ES2579981T3 - Derivados de triazolopirazina - Google Patents

Derivados de triazolopirazina Download PDF

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Publication number
ES2579981T3
ES2579981T3 ES13704368.3T ES13704368T ES2579981T3 ES 2579981 T3 ES2579981 T3 ES 2579981T3 ES 13704368 T ES13704368 T ES 13704368T ES 2579981 T3 ES2579981 T3 ES 2579981T3
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Spain
Prior art keywords
methyl
triazolo
pyrazin
phenyl
amine
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ES13704368.3T
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English (en)
Spanish (es)
Inventor
Kai Schiemann
Carl Deutsch
Guenter Hoelzemann
Daniel Kuhn
Ansgar Wegener
Dominique Swinnen
Horacio Comas
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
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ES13704368.3T 2012-03-07 2013-02-14 Derivados de triazolopirazina Active ES2579981T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12001568 2012-03-07
EP12001568 2012-03-07
PCT/EP2013/000440 WO2013131609A1 (en) 2012-03-07 2013-02-14 Triazolopyrazine derivatives

Publications (1)

Publication Number Publication Date
ES2579981T3 true ES2579981T3 (es) 2016-08-18

Family

ID=47715983

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13704368.3T Active ES2579981T3 (es) 2012-03-07 2013-02-14 Derivados de triazolopirazina

Country Status (12)

Country Link
US (1) US20150051202A1 (enExample)
EP (1) EP2822948B1 (enExample)
JP (1) JP6049768B2 (enExample)
CN (1) CN104159901B (enExample)
AR (1) AR090240A1 (enExample)
AU (1) AU2013230286B2 (enExample)
CA (1) CA2866450C (enExample)
ES (1) ES2579981T3 (enExample)
HK (1) HK1203948A1 (enExample)
IL (1) IL234466A (enExample)
TW (1) TW201341384A (enExample)
WO (1) WO2013131609A1 (enExample)

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CN104159901A (zh) 2014-11-19
IL234466A (en) 2016-09-29
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AU2013230286B2 (en) 2016-12-22
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AU2013230286A1 (en) 2014-10-16
JP6049768B2 (ja) 2016-12-21
US20150051202A1 (en) 2015-02-19
CA2866450A1 (en) 2013-09-12
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