ES2573522T3 - Composiciones y métodos para el trasplante celular - Google Patents

Composiciones y métodos para el trasplante celular Download PDF

Info

Publication number
ES2573522T3
ES2573522T3 ES12704242.2T ES12704242T ES2573522T3 ES 2573522 T3 ES2573522 T3 ES 2573522T3 ES 12704242 T ES12704242 T ES 12704242T ES 2573522 T3 ES2573522 T3 ES 2573522T3
Authority
ES
Spain
Prior art keywords
cells
hirudin
bivaliriduna
heparin
fondaparinux
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12704242.2T
Other languages
English (en)
Spanish (es)
Inventor
Xavier STEPHENNE
Etienne Sokal
Mustapha Najimi
Stéphane EECKHOUDT
Cédric HERMANS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Catholique de Louvain UCL
Original Assignee
Universite Catholique de Louvain UCL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Catholique de Louvain UCL filed Critical Universite Catholique de Louvain UCL
Application granted granted Critical
Publication of ES2573522T3 publication Critical patent/ES2573522T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
ES12704242.2T 2011-01-25 2012-01-25 Composiciones y métodos para el trasplante celular Active ES2573522T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11152119 2011-01-25
EP11152119 2011-01-25
PCT/EP2012/051157 WO2012101181A1 (en) 2011-01-25 2012-01-25 Compositions and methods for cell transplantation

Publications (1)

Publication Number Publication Date
ES2573522T3 true ES2573522T3 (es) 2016-06-08

Family

ID=45607724

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12704242.2T Active ES2573522T3 (es) 2011-01-25 2012-01-25 Composiciones y métodos para el trasplante celular

Country Status (12)

Country Link
US (3) US20130302291A1 (enExample)
EP (1) EP2667878B1 (enExample)
JP (1) JP6012629B2 (enExample)
CN (1) CN103402527B (enExample)
CA (1) CA2825252C (enExample)
DK (1) DK2667878T3 (enExample)
ES (1) ES2573522T3 (enExample)
IL (1) IL227529A0 (enExample)
PL (1) PL2667878T3 (enExample)
PT (1) PT2667878E (enExample)
SG (1) SG192124A1 (enExample)
WO (1) WO2012101181A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103402527B (zh) 2011-01-25 2016-04-20 鲁汶大学 用于细胞移植的组合物和方法
JP6034406B2 (ja) 2012-01-25 2016-11-30 ユニヴェルシテ カソリック ド ルーヴァンＵｎｉｖｅｒｓｉｔｅ Ｃａｔｈｏｌｉｑｕｅ Ｄｅ Ｌｏｕｖａｉｎ 細胞移植のための組成物および方法
EP2943206A4 (en) * 2013-01-12 2017-01-04 Cesca Therapeutics Inc. Rapid infusion of autologous bone marrow derived stem cells
KR102278652B1 (ko) * 2013-03-15 2021-07-19 미로매트릭스 메디칼 인크. 섬 세포 재세포화를 위한 관류 탈세포화된 간의 용도
DK3016665T3 (da) 2013-07-05 2019-11-25 Univ Catholique Louvain Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser
BR102013033827B1 (pt) * 2013-12-27 2021-09-08 Regenera - Medicina Veterinária Avançada Ltda. Concentrado multipotente e imunocompatível de células-tronco e biofármaco e forma de dosagem que o compreendem
JP6887628B2 (ja) * 2015-06-11 2021-06-16 ユニフェルシテイト マーストリヒトＵｎｉｖｅｒｓｉｔｅｉｔ Ｍａａｓｔｒｉｃｈｔ 被移植体における移植不全を防ぐ方法
CN106995796A (zh) * 2016-01-26 2017-08-01 李建业 基于细胞因子的细胞处理方法、试剂盒及冻干粉
US11253550B2 (en) 2017-03-03 2022-02-22 Rohto Pharmaceutical Co., Ltd. Method for treating fibrotic liver disease
KR20200028391A (ko) * 2017-06-12 2020-03-16 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 세포 생착용 패치 이식편 조성물
JP7264589B2 (ja) * 2017-12-25 2023-04-25 株式会社 資生堂 トロンビンの抑制作用を指標とした皮膚状態改善剤のスクリーニング方法、及びトロンビン作用阻害剤を含む皮膚状態改善剤
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system
JP7452934B2 (ja) * 2019-03-26 2024-03-19 セライオン エスエイ 慢性肝不全の急性憎悪の治療のための成人肝前駆細胞
CN112608890B (zh) * 2020-12-17 2024-08-20 山东佰鸿干细胞生物技术有限公司 一种防止间充质干细胞粘连的培养方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9010552D0 (en) 1990-05-10 1990-07-04 Erba Carlo Spa Method for the recombinant production of hirudins and novel hirudins
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
GB0014136D0 (en) 2000-06-10 2000-08-02 Astrazeneca Ab Combination therapy
DE10202982A1 (de) 2002-01-26 2003-07-31 Augustinus Bader Verfahren und Vorrichtung zum Einbringen von lebenden Zellen in eine biologische Körperflüssigkeit
US20060222640A1 (en) * 2005-03-29 2006-10-05 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of thrombosis
WO2006126219A1 (en) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
EP1996013A4 (en) * 2005-09-21 2010-03-10 Dask Technologies Llc METHODS AND COMPOSITIONS FOR FUNCTIONALITY OF ORGANS AND TISSUES
ATE498005T1 (de) * 2005-12-21 2011-02-15 Univ Catholique Louvain Isolierte leberstammzellen
CN103402527B (zh) 2011-01-25 2016-04-20 鲁汶大学 用于细胞移植的组合物和方法
JP6034406B2 (ja) 2012-01-25 2016-11-30 ユニヴェルシテ カソリック ド ルーヴァンＵｎｉｖｅｒｓｉｔｅ Ｃａｔｈｏｌｉｑｕｅ Ｄｅ Ｌｏｕｖａｉｎ 細胞移植のための組成物および方法

Also Published As

Publication number Publication date
WO2012101181A1 (en) 2012-08-02
DK2667878T3 (en) 2016-06-27
CN103402527A (zh) 2013-11-20
CA2825252C (en) 2018-10-16
US20170354723A1 (en) 2017-12-14
JP6012629B2 (ja) 2016-10-25
US10039789B2 (en) 2018-08-07
EP2667878A1 (en) 2013-12-04
US20170042940A1 (en) 2017-02-16
IL227529A0 (en) 2013-09-30
CA2825252A1 (en) 2012-08-02
US20130302291A1 (en) 2013-11-14
EP2667878B1 (en) 2016-03-30
PT2667878E (pt) 2016-06-03
US10478459B2 (en) 2019-11-19
JP2014508138A (ja) 2014-04-03
PL2667878T3 (pl) 2016-10-31
CN103402527B (zh) 2016-04-20
SG192124A1 (en) 2013-08-30

Similar Documents

Publication Publication Date Title
US10478459B2 (en) Compositions and methods for cell transplantation
EP2806879B1 (en) Compositions and methods for cell transplantation
AR097329A1 (es) Reducción de la deriva del rociado
JP2020050659A (ja) 溶剤／界面活性剤処理された血漿（ｓ／ｄ血漿）を含む製剤及びその使用
EP3856894B1 (en) Methods for differentiating mesenchymal stem cells
Moreno et al. Hyaluronic acid effect on adipose-derived stem cells. Biological in vitro evaluation
Xu et al. Role of endothelial progenitor cell transplantation in rats with sepsis
AR058568A1 (es) Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
BR112021018691A2 (pt) Géis homogêneos injetáveis compreendendo formas múltiplas de ácido hialurônico e métodos para sua fabricação
US20200354682A1 (en) Methods for differentiating mesenchymal stem cells
WANG Anti-thrombus activity of a novel anti-thrombus protein EPR-hirudin
PE20050246A1 (es) Mezclas de oligosacaridos derivados de la heparina, su preparacion y las composiciones farmaceuticas que las contienen
TIAN et al. Liver failure staging and MELD predicted the short term prognosis of HBV-acute-on-chronic liver failure
MX2023011410A (es) Celulas recombinantes productoras de acido hialuronico.
NIU et al. The Role of Thrombomodulin in Diseases
YANG et al. Retrospective study of comorbidities in patients with gout
Lyapina et al. Anticoagulant effects of a complex of high molecular weight heparin and arginine
CA3256041A1 (en) FROZEN FORMULATION CONTAINING APOPTOTIC CELLS
CUI et al. Effect of bone marrow mononuclear cells transplantation on HMGB1 migration in stroke mouse
BAI et al. Immunogenicity, immune mechanisms and immune modulatory effects of mesenchymal stem cells derived from bone marrow of patients with multiple myeloma
ZHOU et al. Effect of hyaluronic acid on mRNA expression of matrix metalloproteinases-3, 9, 13 and tissue in-hibitor of metalloproteinases-1 stimulated by interleukin-113 in chondrocytes from arthritis model in vitro
XIU et al. Effects of bone marrow mesenchymal stem cells on the expressions of inflammatory factors in rats with multiple organ dysfunction syndrome
Rogovskaya et al. Macrophage activation and polarization in post-infarction cardiac remodeling
CAO et al. The allogeneic bone marrow mesenchymal stem cells improve rats cutaneous wound healing
TAN Inhibition of Garcinia Acid to Kidney Cancer Cell Lines via Wnt3α/β-catenin Signal Pathway