ES2566338T3 - Método para identificación de la sensibilidad de un paciente a la terapia de inhibición de la telomerasa - Google Patents
Método para identificación de la sensibilidad de un paciente a la terapia de inhibición de la telomerasa Download PDFInfo
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- ES2566338T3 ES2566338T3 ES09821131.1T ES09821131T ES2566338T3 ES 2566338 T3 ES2566338 T3 ES 2566338T3 ES 09821131 T ES09821131 T ES 09821131T ES 2566338 T3 ES2566338 T3 ES 2566338T3
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- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q2600/00—Oligonucleotides characterized by their use
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| WO2014085632A1 (en) * | 2012-11-30 | 2014-06-05 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
| EP3318276A1 (en) | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
| KR20250151565A (ko) | 2017-07-28 | 2025-10-21 | 제론 코포레이션 | 골수형성이상 증후군의 치료 방법 |
| CN109662968B (zh) * | 2017-10-13 | 2021-05-18 | 上海奥奇医药科技有限公司 | 含A-失碳-5α雄甾烷化合物的升白制剂及其应用 |
| AU2019389005B2 (en) | 2018-11-29 | 2024-06-20 | Geron Corporation | Methods of treating myelodysplastic syndrome |
| KR20230041707A (ko) * | 2020-07-17 | 2023-03-24 | 제론 코포레이션 | 피하 텔로머라제 억제제 조성물 및 이의 사용 방법 |
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| ATE362546T1 (de) | 1995-10-12 | 2007-06-15 | Lansdorp Peter M | Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül |
| US6444650B1 (en) | 1996-10-01 | 2002-09-03 | Geron Corporation | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
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| JP2001507229A (ja) | 1996-12-20 | 2001-06-05 | ジェロン コーポレイション | テロメラーゼのｒｎａ成分を検出および阻害するための方法 |
| US6156763A (en) * | 1998-02-04 | 2000-12-05 | Board Of Regents, The University Of Texas System | Inhibition of human telomerase by a g-quadruplex-interaction compound |
| US6995145B1 (en) | 1999-06-04 | 2006-02-07 | Au Jessie L-S | Methods and compositions for modulating drug activity through telomere damage |
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| US6331399B1 (en) | 2000-05-16 | 2001-12-18 | Isis Pharmaceuticals, Inc. | Antisense inhibition of tert expression |
| PT1282443E (pt) | 2000-05-19 | 2009-12-04 | Genentech Inc | Análise de detecção génica para melhorar a probabilidade de uma resposta eficaz a uma terapia do cancro com um antagonista de erbb |
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| US9777312B2 (en) * | 2001-06-30 | 2017-10-03 | Enzo Life Sciences, Inc. | Dual polarity analysis of nucleic acids |
| CA2474468C (en) | 2002-01-31 | 2014-03-25 | University Of Utah | Amplifying repetitive nucleic acid sequences |
| US20040234961A1 (en) | 2002-04-22 | 2004-11-25 | Fordyce Colleen A. | Telomere length determination and applications |
| US9169516B2 (en) | 2003-01-24 | 2015-10-27 | University Of Utah Research Foundation | Methods of predicting mortality risk by determining telomere length |
| KR101298493B1 (ko) | 2003-09-09 | 2013-08-21 | 제론 코포레이션 | 텔로머라제 억제를 위한 변형 올리고뉴클레오티드 |
| ME02933B (me) | 2004-07-02 | 2018-04-20 | Geron Corp | Sinteza zaštićenih 3'-amino nukleozionih monomera |
| DE102005024834B3 (de) | 2005-05-31 | 2007-01-04 | Lucas Automotive Gmbh | Verfahren und System zur Steuerung einer Kraftfahrzeug-Feststellbremse während eines Halts |
| NZ565654A (en) * | 2005-07-18 | 2010-10-29 | Bipar Sciences Inc | Use of iodonitrobenzamide compounds for the treatment of ovarian cancer |
| BRPI0619476A2 (pt) | 2005-12-05 | 2011-10-04 | Wyeth Corp | composições de interleucina-11 e métodos de uso |
| ES2407957T3 (es) * | 2007-03-09 | 2013-06-17 | Geron Corporation | Tratamiento de carcinomas con una combinación de inhibidores de la vía EGF y de la telomerasa |
| US20100291560A1 (en) | 2007-03-27 | 2010-11-18 | The Johns Hopkins University | Methods and compositions for diagnosis and treatment of dyskeratosis congenita and related disorders |
| WO2009073751A2 (en) | 2007-12-04 | 2009-06-11 | Geron Corporation | Hair follicle pharmacodynamic assay for telomerase activity |
| US20090298709A1 (en) | 2008-05-28 | 2009-12-03 | Affymetrix, Inc. | Assays for determining telomere length and repeated sequence copy number |
| US20110207128A1 (en) | 2010-02-16 | 2011-08-25 | Cawthon Richard M | Methods and kits for determining biological age and longevity based on gene expression profiles |
| US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| WO2014085632A1 (en) | 2012-11-30 | 2014-06-05 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
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