ES2560557T3 - Materiales y métodos con relación a la glicosilación de polipéptidos terapéuticos - Google Patents

Materiales y métodos con relación a la glicosilación de polipéptidos terapéuticos Download PDF

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Publication number
ES2560557T3
ES2560557T3 ES10727485.4T ES10727485T ES2560557T3 ES 2560557 T3 ES2560557 T3 ES 2560557T3 ES 10727485 T ES10727485 T ES 10727485T ES 2560557 T3 ES2560557 T3 ES 2560557T3
Authority
ES
Spain
Prior art keywords
group
alkyl
polypeptide
glycosylation
sugar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10727485.4T
Other languages
English (en)
Spanish (es)
Inventor
Andrew Graham Watts
Amanda Barbara Mackenzie
Terrence Kantner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iksuda Therapeutics Ltd
Original Assignee
Glythera Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glythera Ltd filed Critical Glythera Ltd
Application granted granted Critical
Publication of ES2560557T3 publication Critical patent/ES2560557T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
ES10727485.4T 2009-06-16 2010-06-16 Materiales y métodos con relación a la glicosilación de polipéptidos terapéuticos Active ES2560557T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18743409P 2009-06-16 2009-06-16
US187434P 2009-06-16
PCT/GB2010/001188 WO2010146362A2 (en) 2009-06-16 2010-06-16 Materials and methods relating to glycosylation

Publications (1)

Publication Number Publication Date
ES2560557T3 true ES2560557T3 (es) 2016-02-19

Family

ID=43086298

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10727485.4T Active ES2560557T3 (es) 2009-06-16 2010-06-16 Materiales y métodos con relación a la glicosilación de polipéptidos terapéuticos

Country Status (8)

Country Link
US (1) US9452223B2 (enExample)
EP (1) EP2442831B9 (enExample)
JP (2) JP6091892B2 (enExample)
CN (1) CN102481377B (enExample)
CA (1) CA2768155C (enExample)
ES (1) ES2560557T3 (enExample)
PL (1) PL2442831T3 (enExample)
WO (1) WO2010146362A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2768155C (en) * 2009-06-16 2016-08-23 The University Of Bath Materials and methods relating to glycosylation
TW201442721A (zh) * 2013-01-23 2014-11-16 Daiichi Sankyo Co Ltd 糖鏈修飾心房利尿鈉肽
JP6562942B2 (ja) * 2014-03-27 2019-08-28 アカデミア シニカAcademia Sinica 反応性標識化合物およびその使用
RU2656140C2 (ru) * 2016-11-14 2018-05-31 Федеральное государственное бюджетное учреждение "Государственный научный центр Институт иммунологии" Федерального медико-биологического агентства России Способ получения гибридного белка, состоящего из рекомбинантного белка аналога интерферона гамма, конъюгированного с олигосахаридом

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016640A1 (en) 1991-03-18 1992-10-01 The Scripps Research Institute Oligosaccharide enzyme substrates and inhibitors: methods and compositions
US5770407A (en) * 1996-12-10 1998-06-23 The Scripps Research Institute Process for preparing nucleotide inhibitors of glycosyltransferases
ES2411007T3 (es) * 2001-10-10 2013-07-04 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
US7226903B2 (en) 2001-10-10 2007-06-05 Neose Technologies, Inc. Interferon beta: remodeling and glycoconjugation of interferon beta
CA2500653A1 (en) * 2002-10-16 2004-04-29 The Scripps Research Institute Glycoprotein synthesis
JP2010523582A (ja) 2007-04-03 2010-07-15 バイオジェネリクス アクチェンゲゼルシャフト グリコpeg化g−csfを用いた治療方法
JP2011503101A (ja) 2007-11-09 2011-01-27 バクスター・インターナショナル・インコーポレイテッド 修飾された組換え第viii因子およびフォンウィルブランド因子ならびにその使用方法
CA2768155C (en) * 2009-06-16 2016-08-23 The University Of Bath Materials and methods relating to glycosylation

Also Published As

Publication number Publication date
US20120190631A1 (en) 2012-07-26
CN102481377B (zh) 2014-10-29
WO2010146362A2 (en) 2010-12-23
US9452223B2 (en) 2016-09-27
CA2768155A1 (en) 2010-12-23
JP6091892B2 (ja) 2017-03-08
EP2442831B1 (en) 2015-11-04
JP2015187153A (ja) 2015-10-29
HK1169336A1 (en) 2013-02-22
WO2010146362A3 (en) 2011-06-30
CA2768155C (en) 2016-08-23
JP2012530119A (ja) 2012-11-29
EP2442831B9 (en) 2016-05-11
CN102481377A (zh) 2012-05-30
EP2442831A2 (en) 2012-04-25
PL2442831T3 (pl) 2016-06-30

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