ES2559007T3 - Alfa1 antitripsina humana recombinante - Google Patents

Alfa1 antitripsina humana recombinante Download PDF

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Publication number
ES2559007T3
ES2559007T3 ES10716318.0T ES10716318T ES2559007T3 ES 2559007 T3 ES2559007 T3 ES 2559007T3 ES 10716318 T ES10716318 T ES 10716318T ES 2559007 T3 ES2559007 T3 ES 2559007T3
Authority
ES
Spain
Prior art keywords
recombinant human
alpha1
human antitrypsin
glucans
antitrypsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10716318.0T
Other languages
English (en)
Inventor
Elisabeth C. M. Brinkman
Cornelis Erik Hack
Ingrid Van Den Nieuwenhof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Vaccines and Prevention BV
Original Assignee
Crucell Holand BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holand BV filed Critical Crucell Holand BV
Application granted granted Critical
Publication of ES2559007T3 publication Critical patent/ES2559007T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

α1-antitripsina humana recombinante (AAThr) que comprende glucanos unidos en N, caracterizado por que: (a) al menos el 10% de dichos glucanos unidos en N son glucanos tetra-antenarios; y (b) el grado de protección con ácido siálico en dichos glucanos unidos en N (Z/A) es de al menos el 50%, en la que al menos el 50% de la sialilación en dichos glucanos unidos en N es α-2,3-sialilación.

Description

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Claims (1)

  1. imagen1
ES10716318.0T 2009-04-23 2010-04-20 Alfa1 antitripsina humana recombinante Active ES2559007T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21449209P 2009-04-23 2009-04-23
US214492P 2009-04-23
EP09158640 2009-04-23
EP09158640 2009-04-23
PCT/EP2010/055177 WO2010127939A1 (en) 2009-04-23 2010-04-20 Recombinant human alpha1-antitrypsin

Publications (1)

Publication Number Publication Date
ES2559007T3 true ES2559007T3 (es) 2016-02-10

Family

ID=40929544

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10716318.0T Active ES2559007T3 (es) 2009-04-23 2010-04-20 Alfa1 antitripsina humana recombinante

Country Status (14)

Country Link
US (1) US8357661B2 (es)
EP (1) EP2421895B1 (es)
JP (1) JP5711215B2 (es)
KR (1) KR101640962B1 (es)
CN (1) CN102439037B (es)
AU (1) AU2010244592B2 (es)
CA (1) CA2756591C (es)
DK (1) DK2421895T3 (es)
EA (1) EA025021B1 (es)
ES (1) ES2559007T3 (es)
IL (1) IL215537A (es)
PL (1) PL2421895T3 (es)
WO (1) WO2010127939A1 (es)
ZA (1) ZA201107416B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2756591C (en) 2009-04-23 2018-11-06 Crucell Holland B.V. Recombinant human alpha1-antitrypsin
CN104302312A (zh) * 2011-12-19 2015-01-21 Lfb美国股份有限公司 用于炎性病症治疗的重组人α-1-抗胰蛋白酶
US9353165B2 (en) 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
CN102994514B (zh) * 2012-11-07 2015-06-10 武汉禾元生物科技股份有限公司 一种从水稻种子生产和分离纯化重组人抗胰蛋白酶(OsrAAT)的方法
BR112015019348A2 (pt) 2013-02-13 2017-08-22 Lab Francais Du Fractionnement Métodos para produção de proteína com glicosilação modificada e com sialilação aumentada, para aumentar a atividade de sialil transferase na glândula mamária e para produzir sialil transferase, proteína com glicosilação modificada ou proteína com sialilação aumentada, composição, sialil transferase, mamífero transgênico, e, célula epitelial mamária
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
WO2018183705A1 (en) 2017-03-29 2018-10-04 Cornell University Oxidation-resistant aat gene therapy
EP3382014A1 (en) * 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
US11624080B2 (en) 2017-11-28 2023-04-11 Danmarks Tekniske Universitet Glycosylation of proteins
CA3127750A1 (en) * 2019-01-24 2020-07-30 Excellgene Sa Methods of producing and using recombinant alpha 1-antitrypsin (aat) and compositions thereof
US20260015410A1 (en) * 2022-10-06 2026-01-15 Kamada Ltd. Highly fucosylated recombinant human alpha 1 antitrypsin (aat) protein having immunomodulatory activity and compositions comprising the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160406A0 (en) 1995-06-15 2004-07-25 Crucell Holland Bv A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products
US7297680B2 (en) * 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
US20050164386A1 (en) 1999-04-15 2005-07-28 Uytdehaag Alphonsus G. Overexpression of enzymes involved in post-translational protein modifications in human cells
IL145849A0 (en) 1999-04-15 2002-07-25 Crucell Holland Bv Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein
KR100979025B1 (ko) * 2001-12-07 2010-08-30 크루셀 홀란드 비.브이. 바이러스, 바이러스 단리물 및 백신의 생산
EA008670B1 (ru) 2003-05-09 2007-06-29 Круселл Холланд Б.В. Культуры e1-иммортализованных клеток и способы их культивирования с целью повышения выхода их продукции
CN101090973B (zh) * 2004-12-30 2012-03-28 克鲁塞尔荷兰公司 从表达腺病毒e1a蛋白的细胞中获得唾液酸化增加的重组蛋白质的方法及由此获得的蛋白质
WO2007102432A1 (ja) * 2006-03-02 2007-09-13 Kyowa Hakko Kogyo Co., Ltd. 糖蛋白質組成物の製造方法
WO2008069244A1 (ja) * 2006-12-05 2008-06-12 Kyowa Hakko Kogyo Co., Ltd. 糖蛋白質組成物の製造方法
CN101883850B (zh) * 2007-07-12 2014-11-12 桑格摩生物科学股份有限公司 用于失活α-1,6岩藻糖基转移酶(FUT8)基因表达的方法和组合物
CA2756591C (en) 2009-04-23 2018-11-06 Crucell Holland B.V. Recombinant human alpha1-antitrypsin

Also Published As

Publication number Publication date
AU2010244592A1 (en) 2011-10-27
US8357661B2 (en) 2013-01-22
ZA201107416B (en) 2017-11-29
KR101640962B1 (ko) 2016-07-19
JP2012524747A (ja) 2012-10-18
DK2421895T3 (en) 2016-01-25
CN102439037A (zh) 2012-05-02
US20120214747A1 (en) 2012-08-23
JP5711215B2 (ja) 2015-04-30
PL2421895T3 (pl) 2016-04-29
AU2010244592B2 (en) 2016-05-19
EA201171275A1 (ru) 2012-03-30
EP2421895A1 (en) 2012-02-29
KR20120096871A (ko) 2012-08-31
IL215537A0 (en) 2011-12-29
WO2010127939A1 (en) 2010-11-11
EP2421895B1 (en) 2015-11-11
CA2756591C (en) 2018-11-06
CA2756591A1 (en) 2010-11-11
EA025021B1 (ru) 2016-11-30
IL215537A (en) 2016-06-30
CN102439037B (zh) 2015-01-07

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