ES2546743B1 - Marcadores mitocondriales de enfermedades neurodegenerativas - Google Patents

Marcadores mitocondriales de enfermedades neurodegenerativas Download PDF

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Publication number
ES2546743B1
ES2546743B1 ES201430444A ES201430444A ES2546743B1 ES 2546743 B1 ES2546743 B1 ES 2546743B1 ES 201430444 A ES201430444 A ES 201430444A ES 201430444 A ES201430444 A ES 201430444A ES 2546743 B1 ES2546743 B1 ES 2546743B1
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ES
Spain
Prior art keywords
sites
loop region
chg
disease
cpg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES201430444A
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English (en)
Spanish (es)
Other versions
ES2546743A1 (es
Inventor
Marta Barrachina Castillo
Isidre FERRER ABIZANDA
Marta BLANCH LOZANO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitat de Barcelona UB
Original Assignee
Universitat de Barcelona UB
Fundacio Privada Institut dInvestigacio Biomedica de Bellvitge IDIBELL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54150970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2546743(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Universitat de Barcelona UB, Fundacio Privada Institut dInvestigacio Biomedica de Bellvitge IDIBELL filed Critical Universitat de Barcelona UB
Priority to ES201430444A priority Critical patent/ES2546743B1/es
Priority to PCT/ES2015/070230 priority patent/WO2015144964A2/es
Priority to JP2016560431A priority patent/JP6687532B2/ja
Priority to US15/300,248 priority patent/US11053549B2/en
Priority to AU2015238195A priority patent/AU2015238195C1/en
Priority to EP15770042.8A priority patent/EP3124621B9/en
Priority to PT15770042T priority patent/PT3124621T/pt
Priority to DK15770042.8T priority patent/DK3124621T3/da
Priority to CA2944281A priority patent/CA2944281C/en
Priority to BR112016022582-1A priority patent/BR112016022582B1/pt
Priority to ES15770042T priority patent/ES2744592T3/es
Publication of ES2546743A1 publication Critical patent/ES2546743A1/es
Publication of ES2546743B1 publication Critical patent/ES2546743B1/es
Application granted granted Critical
Priority to US17/337,355 priority patent/US12065702B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES201430444A 2014-03-28 2014-03-28 Marcadores mitocondriales de enfermedades neurodegenerativas Expired - Fee Related ES2546743B1 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ES201430444A ES2546743B1 (es) 2014-03-28 2014-03-28 Marcadores mitocondriales de enfermedades neurodegenerativas
PT15770042T PT3124621T (pt) 2014-03-28 2015-03-27 Marcadores mitocondriais de doenças neurodegenerativas
CA2944281A CA2944281C (en) 2014-03-28 2015-03-27 Mitochondrial markers of neurodegenerative diseases
US15/300,248 US11053549B2 (en) 2014-03-28 2015-03-27 Mitochondrial markers of neurodegenerative diseases
AU2015238195A AU2015238195C1 (en) 2014-03-28 2015-03-27 Mitochondrial markers of neurodegenerative diseases
EP15770042.8A EP3124621B9 (en) 2014-03-28 2015-03-27 Mitochondrial markers of neurodegenerative diseases
PCT/ES2015/070230 WO2015144964A2 (es) 2014-03-28 2015-03-27 Marcadores mitocondriales de enfermedades neurodegenerativas
DK15770042.8T DK3124621T3 (da) 2014-03-28 2015-03-27 Mitokondriemarkører af neurodegenerative sygdomme
JP2016560431A JP6687532B2 (ja) 2014-03-28 2015-03-27 神経変性疾患のミトコンドリアマーカー
BR112016022582-1A BR112016022582B1 (pt) 2014-03-28 2015-03-27 Marcadores mitocondriais de doenças neurodegenerativas
ES15770042T ES2744592T3 (es) 2014-03-28 2015-03-27 Marcadores mitocondriales de enfermedades neurodegenerativas
US17/337,355 US12065702B2 (en) 2014-03-28 2021-06-02 Mitochondrial markers of neurodegenerative diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201430444A ES2546743B1 (es) 2014-03-28 2014-03-28 Marcadores mitocondriales de enfermedades neurodegenerativas

Publications (2)

Publication Number Publication Date
ES2546743A1 ES2546743A1 (es) 2015-09-28
ES2546743B1 true ES2546743B1 (es) 2016-07-07

Family

ID=54150970

Family Applications (2)

Application Number Title Priority Date Filing Date
ES201430444A Expired - Fee Related ES2546743B1 (es) 2014-03-28 2014-03-28 Marcadores mitocondriales de enfermedades neurodegenerativas
ES15770042T Active ES2744592T3 (es) 2014-03-28 2015-03-27 Marcadores mitocondriales de enfermedades neurodegenerativas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15770042T Active ES2744592T3 (es) 2014-03-28 2015-03-27 Marcadores mitocondriales de enfermedades neurodegenerativas

Country Status (10)

Country Link
US (2) US11053549B2 (enExample)
EP (1) EP3124621B9 (enExample)
JP (1) JP6687532B2 (enExample)
AU (1) AU2015238195C1 (enExample)
BR (1) BR112016022582B1 (enExample)
CA (1) CA2944281C (enExample)
DK (1) DK3124621T3 (enExample)
ES (2) ES2546743B1 (enExample)
PT (1) PT3124621T (enExample)
WO (1) WO2015144964A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107904667A (zh) * 2018-01-02 2018-04-13 上海美吉生物医药科技有限公司 一种新型甲基化建库试剂盒及其应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108841928B (zh) * 2018-06-11 2021-11-23 河北医科大学 一种人类线粒体基因组甲基化检测试剂盒及其应用
CN109358194A (zh) * 2018-09-29 2019-02-19 中国海洋大学 凡纳滨对虾高血糖激素间接竞争酶联免疫检测方法
CN112813159B (zh) * 2021-03-23 2023-05-30 广州金域医学检验中心有限公司 帕金森病的生物标志物及其应用
EP4490322A1 (en) * 2022-03-11 2025-01-15 Admit Therapeutics SL Methods of determining the risk of developing alzheimer's disease dementia
WO2024008759A1 (en) 2022-07-04 2024-01-11 Admit Therapeutics Sl Method for identifying dementia with lewy bodies in a subject
CN119144600B (zh) * 2024-11-20 2025-04-01 天津赛萌生物技术有限公司 一种含鲑鱼线粒体基因克隆载体的构建及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT975800E (pt) 1997-02-27 2003-10-31 Ingeneus Corp Doseamento de nucleotidos em solucao usando sondas anp
WO2000063441A2 (en) * 1999-04-20 2000-10-26 Mitokor Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease
WO2003046225A1 (en) 2001-11-26 2003-06-05 Mitokor Mitochondrial dna polymorphisms
JP2005000044A (ja) 2003-06-10 2005-01-06 Masatsugu Tanaka ヒトミトコンドリア遺伝子変異に基づく遺伝子検出法
US20120232016A1 (en) 2011-03-08 2012-09-13 Coleman Paul D Method and system to detect and diagnose alzheimer's disease

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107904667A (zh) * 2018-01-02 2018-04-13 上海美吉生物医药科技有限公司 一种新型甲基化建库试剂盒及其应用

Also Published As

Publication number Publication date
AU2015238195B2 (en) 2019-07-18
JP2017511138A (ja) 2017-04-20
EP3124621B9 (en) 2020-10-21
BR112016022582B1 (pt) 2024-03-12
CA2944281C (en) 2021-05-18
CA2944281A1 (en) 2015-10-01
AU2015238195A1 (en) 2016-10-27
AU2015238195C1 (en) 2022-03-10
EP3124621B1 (en) 2019-06-05
US20170137881A1 (en) 2017-05-18
BR112016022582A2 (pt) 2017-10-10
US20220049307A1 (en) 2022-02-17
WO2015144964A3 (es) 2015-12-17
ES2546743A1 (es) 2015-09-28
EP3124621A2 (en) 2017-02-01
PT3124621T (pt) 2019-09-23
DK3124621T3 (da) 2019-09-09
US12065702B2 (en) 2024-08-20
EP3124621A4 (en) 2018-02-14
US11053549B2 (en) 2021-07-06
JP6687532B2 (ja) 2020-04-28
WO2015144964A2 (es) 2015-10-01
ES2744592T3 (es) 2020-02-25
ES2744592T9 (es) 2020-12-15

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