WO2015144964A3 - Marcadores mitocondriales de enfermedades neurodegenerativas - Google Patents

Marcadores mitocondriales de enfermedades neurodegenerativas Download PDF

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Publication number
WO2015144964A3
WO2015144964A3 PCT/ES2015/070230 ES2015070230W WO2015144964A3 WO 2015144964 A3 WO2015144964 A3 WO 2015144964A3 ES 2015070230 W ES2015070230 W ES 2015070230W WO 2015144964 A3 WO2015144964 A3 WO 2015144964A3
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WO
WIPO (PCT)
Prior art keywords
neurodegenerative diseases
subject
mitochondrial markers
determination
mitochondrial dna
Prior art date
Application number
PCT/ES2015/070230
Other languages
English (en)
French (fr)
Other versions
WO2015144964A2 (es
Inventor
Marta Barrachina Castillo
Isidre Ferrer Abizanda
Marta BLANCH LOZANO
Original Assignee
Institut D'investigació Biomèdica De Bellvitge (Idibell)
Universitat De Barcelona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54150970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2015144964(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2944281A priority Critical patent/CA2944281C/en
Priority to US15/300,248 priority patent/US11053549B2/en
Priority to BR112016022582-1A priority patent/BR112016022582B1/pt
Priority to JP2016560431A priority patent/JP6687532B2/ja
Priority to AU2015238195A priority patent/AU2015238195C1/en
Application filed by Institut D'investigació Biomèdica De Bellvitge (Idibell), Universitat De Barcelona filed Critical Institut D'investigació Biomèdica De Bellvitge (Idibell)
Priority to EP15770042.8A priority patent/EP3124621B9/en
Priority to DK15770042.8T priority patent/DK3124621T3/da
Priority to ES15770042T priority patent/ES2744592T3/es
Publication of WO2015144964A2 publication Critical patent/WO2015144964A2/es
Publication of WO2015144964A3 publication Critical patent/WO2015144964A3/es
Priority to US17/337,355 priority patent/US20220049307A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a un método in vitro para diagnosticar o para determinar el riesgo de desarrollar una enfermedad neurodegenerativa en un sujeto basado en la determinación del patrón de metilación en ciertas regiones del ADN mitocondrial de dicho sujeto o en la determinación del nucleótido en la posición polimórfica 16519 del ADN mitocondrial de dicho sujeto. Finalmente, la presente invención se refiere a ácidos nucleicos adecuados para poner en práctica la invención.
PCT/ES2015/070230 2014-03-28 2015-03-27 Marcadores mitocondriales de enfermedades neurodegenerativas WO2015144964A2 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES15770042T ES2744592T3 (es) 2014-03-28 2015-03-27 Marcadores mitocondriales de enfermedades neurodegenerativas
US15/300,248 US11053549B2 (en) 2014-03-28 2015-03-27 Mitochondrial markers of neurodegenerative diseases
BR112016022582-1A BR112016022582B1 (pt) 2014-03-28 2015-03-27 Marcadores mitocondriais de doenças neurodegenerativas
JP2016560431A JP6687532B2 (ja) 2014-03-28 2015-03-27 神経変性疾患のミトコンドリアマーカー
AU2015238195A AU2015238195C1 (en) 2014-03-28 2015-03-27 Mitochondrial markers of neurodegenerative diseases
CA2944281A CA2944281C (en) 2014-03-28 2015-03-27 Mitochondrial markers of neurodegenerative diseases
EP15770042.8A EP3124621B9 (en) 2014-03-28 2015-03-27 Mitochondrial markers of neurodegenerative diseases
DK15770042.8T DK3124621T3 (da) 2014-03-28 2015-03-27 Mitokondriemarkører af neurodegenerative sygdomme
US17/337,355 US20220049307A1 (en) 2014-03-28 2021-06-02 Mitochondrial markers of neurodegenerative diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP201430444 2014-03-28
ES201430444A ES2546743B1 (es) 2014-03-28 2014-03-28 Marcadores mitocondriales de enfermedades neurodegenerativas

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US15/300,248 A-371-Of-International US11053549B2 (en) 2014-03-28 2015-03-27 Mitochondrial markers of neurodegenerative diseases
US17/337,355 Continuation US20220049307A1 (en) 2014-03-28 2021-06-02 Mitochondrial markers of neurodegenerative diseases

Publications (2)

Publication Number Publication Date
WO2015144964A2 WO2015144964A2 (es) 2015-10-01
WO2015144964A3 true WO2015144964A3 (es) 2015-12-17

Family

ID=54150970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2015/070230 WO2015144964A2 (es) 2014-03-28 2015-03-27 Marcadores mitocondriales de enfermedades neurodegenerativas

Country Status (10)

Country Link
US (2) US11053549B2 (es)
EP (1) EP3124621B9 (es)
JP (1) JP6687532B2 (es)
AU (1) AU2015238195C1 (es)
BR (1) BR112016022582B1 (es)
CA (1) CA2944281C (es)
DK (1) DK3124621T3 (es)
ES (2) ES2546743B1 (es)
PT (1) PT3124621T (es)
WO (1) WO2015144964A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107904667A (zh) * 2018-01-02 2018-04-13 上海美吉生物医药科技有限公司 一种新型甲基化建库试剂盒及其应用
CN108841928B (zh) * 2018-06-11 2021-11-23 河北医科大学 一种人类线粒体基因组甲基化检测试剂盒及其应用
CN109358194A (zh) * 2018-09-29 2019-02-19 中国海洋大学 凡纳滨对虾高血糖激素间接竞争酶联免疫检测方法
CN112813159B (zh) * 2021-03-23 2023-05-30 广州金域医学检验中心有限公司 帕金森病的生物标志物及其应用
WO2023170307A1 (en) 2022-03-11 2023-09-14 Admit Therapeutics Sl Methods of determining the risk of developing alzheimer's disease dementia
WO2024008759A1 (en) 2022-07-04 2024-01-11 Admit Therapeutics Sl Method for identifying dementia with lewy bodies in a subject

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063441A2 (en) * 1999-04-20 2000-10-26 Mitokor Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease
WO2003046225A1 (en) * 2001-11-26 2003-06-05 Mitokor Mitochondrial dna polymorphisms
JP2005000044A (ja) * 2003-06-10 2005-01-06 Masatsugu Tanaka ヒトミトコンドリア遺伝子変異に基づく遺伝子検出法
US20120232016A1 (en) * 2011-03-08 2012-09-13 Coleman Paul D Method and system to detect and diagnose alzheimer's disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69814848T2 (de) 1997-02-27 2004-05-06 Ingeneus Corp. Untersuchung von nukleotiden in loesung mit hilfe von pna-sonden

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063441A2 (en) * 1999-04-20 2000-10-26 Mitokor Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease
WO2003046225A1 (en) * 2001-11-26 2003-06-05 Mitokor Mitochondrial dna polymorphisms
JP2005000044A (ja) * 2003-06-10 2005-01-06 Masatsugu Tanaka ヒトミトコンドリア遺伝子変異に基づく遺伝子検出法
US20120232016A1 (en) * 2011-03-08 2012-09-13 Coleman Paul D Method and system to detect and diagnose alzheimer's disease

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
AUTERE, J. ET AL.: "Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia", HUMAN GENETICS, vol. 115, no. 1, 2004, pages 29 - 35, XP055245908, ISSN: 0340-6717 *
COPPIETERS, N. ET AL.: "Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain", NEUROBIOLOGY OF AGING, vol. 35, no. 6, June 2014 (2014-06-01), pages 1334 - 1344, XP028631594, ISSN: 1558-1497 *
IACOBAZZI, V. ET AL.: "Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool", MOLECULAR GENETICS AND METABOLISM, vol. 110, no. 1-2, September 2013 (2013-09-01), pages 25 - 34, XP028695388, ISSN: 1096-7192 *
LAKATOS, A. ET AL.: "Association between mitochondrial DNA variations and Alzheimer's Disease in the ADNI cohort", NEUROBIOLOGY OF AGING, vol. 31, no. 8, 2010, pages 1355 - 1363, XP027106800, ISSN: 0197-4580 *
MANCUSO, M ET AL.: "Mitochondrial DNA sequence variation and neurodegeneration", HUMAN GENOMICS, vol. 3, no. 1, 2008, pages 71 - 78, XP021126893, ISSN: 1473-9542 *
MASLIAH, E. ET AL.: "Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes", EPIGENETICS, vol. 8, no. 10, October 2013 (2013-10-01), pages 1030 - 1038, XP055245894, ISSN: 1559-2294 *
PARK, CHAN BAE ET AL.: "Mitochondrial DNA mutations in disease and aging", JOURNAL OF CELL BIOLOGY, vol. 17, no. 15, 2011, pages 809 - 818, XP055245903, ISSN: 0021-9525 *
SHARMA, S. ET AL.: "Biomarkers in Parkinson's disease (recent update", NEUROCHEMISTRY INTERNATIONAL, vol. 63, no. 3, September 2013 (2013-09-01), pages 201 - 229, XP028685882, ISSN: 0197-0186 *
TAKASAKI, S.: "Japanese Alzheimer's disease and other complex disorders diagnosis based on mitochondrial SNP haplogroups", INTERNATIONAL JOURNAL OF A LZHEIMER'S DISEASE, vol. 2012, 2012, pages 245038, XP055245889, ISSN: 2090-0252 *
TAKASAKI, S.: "Mitochondrial haplogroups associated with Japanese centenarians, Alzheimer's patients, Parkinson's patients, type 2 diabetic patients and healthy non-obese young males", JOURNAL OF GENETICS AND GENOMICS, vol. 36, no. 7, 2009, pages 425 - 434, XP026352177, ISSN: 1673-8527 *
TAKASAKI, S.: "Mitochondrial SNPs associated with Japanese centenarians, Alzheimer's patients, and Parkinson's patients", COMPUTATIONAL BIOLOGY AND CHEMISTRY, vol. 32, no. 5, 2008, pages 332 - 337, XP024338543, ISSN: 1476-9271 *
WONG, M. ET AL.: "Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS", FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 7, 2013, pages 279, XP055245900, ISSN: 1662-5102 *

Also Published As

Publication number Publication date
US20220049307A1 (en) 2022-02-17
EP3124621A4 (en) 2018-02-14
CA2944281A1 (en) 2015-10-01
US11053549B2 (en) 2021-07-06
AU2015238195A1 (en) 2016-10-27
JP6687532B2 (ja) 2020-04-28
EP3124621B1 (en) 2019-06-05
CA2944281C (en) 2021-05-18
ES2546743B1 (es) 2016-07-07
EP3124621A2 (en) 2017-02-01
EP3124621B9 (en) 2020-10-21
BR112016022582B1 (pt) 2024-03-12
JP2017511138A (ja) 2017-04-20
ES2744592T3 (es) 2020-02-25
US20170137881A1 (en) 2017-05-18
DK3124621T3 (da) 2019-09-09
AU2015238195C1 (en) 2022-03-10
PT3124621T (pt) 2019-09-23
AU2015238195B2 (en) 2019-07-18
ES2744592T9 (es) 2020-12-15
BR112016022582A2 (pt) 2017-10-10
ES2546743A1 (es) 2015-09-28
WO2015144964A2 (es) 2015-10-01

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