ES2540026B1 - Funcionalización de partículas magnéticas mediante sustitución nucleofilica de haluros orgánicos - Google Patents
Funcionalización de partículas magnéticas mediante sustitución nucleofilica de haluros orgánicos Download PDFInfo
- Publication number
- ES2540026B1 ES2540026B1 ES201301197A ES201301197A ES2540026B1 ES 2540026 B1 ES2540026 B1 ES 2540026B1 ES 201301197 A ES201301197 A ES 201301197A ES 201301197 A ES201301197 A ES 201301197A ES 2540026 B1 ES2540026 B1 ES 2540026B1
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- Spain
- Prior art keywords
- magnetic particles
- functionalization
- sub
- nucleophilic substitution
- chloride
- Prior art date
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- 150000004820 halides Chemical class 0.000 title abstract 4
- 239000006249 magnetic particle Substances 0.000 title abstract 4
- 238000007306 functionalization reaction Methods 0.000 title abstract 3
- 238000010534 nucleophilic substitution reaction Methods 0.000 title abstract 3
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 abstract 2
- QPJDMGCKMHUXFD-UHFFFAOYSA-N cyanogen chloride Chemical compound ClC#N QPJDMGCKMHUXFD-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 abstract 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
- FDRPZJWMPZUHBN-UHFFFAOYSA-N triazin-2-ium;chloride Chemical compound Cl.C1=CN=NN=C1 FDRPZJWMPZUHBN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
- C01G49/06—Ferric oxide [Fe2O3]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
- C01G49/08—Ferroso-ferric oxide [Fe3O4]
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
- C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
- C09C1/22—Compounds of iron
- C09C1/24—Oxides of iron
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/42—Magnetic properties
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Composite Materials (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Soft Magnetic Materials (AREA)
- Compounds Of Iron (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Funcionalización de partículas magnéticas mediante sustitución nucleofílica de haluros orgánicos.#La presente invención desarrolla un método para la funcionalización de partículas magnéticas (tamaños entre 0.001 - 100{mi}m) como por ejemplo: partículas de magnetita Fe{sub,3}O{sub,4}, o de maghemita {ga}-Fe{sub,2}O{sub,3}, mediante la sustitución nucleofílica de derivados halogenados. Estos derivados son compuestos orgánicos que contienen uno o más halógenos en su molécula. Algunos ejemplos de haluros orgánicos capaces de reaccionar con las partículas magnéticas son epiclorhidrina, cloruro de triazina, cloruro y bromuro de cianógeno, cloruro de tosilo u otros mono/di/poli haluros orgánicos capaces de reaccionar con grupos OH. Mediante la aplicación de este método las partículas quedan modificadas con grupos reactivos, como son grupos epóxido, ciano, cloruro o tosilo que permiten unir covalentemente moléculas biológicas tales como proteínas, enzimas, ADN, ARN y anticuerpos.
Description
Claims (1)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201301197A ES2540026B1 (es) | 2013-12-18 | 2013-12-18 | Funcionalización de partículas magnéticas mediante sustitución nucleofilica de haluros orgánicos |
| PCT/ES2014/070935 WO2015092106A1 (es) | 2013-12-18 | 2014-12-18 | Funcionalización de partículas magnéticas mediante sustitución nucleofílica de haluros orgánicos |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201301197A ES2540026B1 (es) | 2013-12-18 | 2013-12-18 | Funcionalización de partículas magnéticas mediante sustitución nucleofilica de haluros orgánicos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2540026A1 ES2540026A1 (es) | 2015-07-07 |
| ES2540026B1 true ES2540026B1 (es) | 2016-04-13 |
Family
ID=53402161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201301197A Active ES2540026B1 (es) | 2013-12-18 | 2013-12-18 | Funcionalización de partículas magnéticas mediante sustitución nucleofilica de haluros orgánicos |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2540026B1 (es) |
| WO (1) | WO2015092106A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180164299A1 (en) * | 2015-06-26 | 2018-06-14 | Maggenome Tech Pvt Ltd | Entrapment of magnetic nanoparticles in a cross-linked protein matrix without affecting the functional properties of the protein |
| JP6955814B2 (ja) | 2016-05-11 | 2021-10-27 | ビーエーエスエフ コーポレーション | 誘導加熱に対して適合された磁性材料を含む触媒組成物 |
| CN106733177B (zh) * | 2016-12-24 | 2018-08-24 | 浙江师范大学 | 一种基于磁流变效应的矿石分离装置 |
| CN106645485A (zh) * | 2016-12-27 | 2017-05-10 | 广州市食品检验所 | 一种利用氨基化磁性纳米材料测定饮料中阴离子合成色素含量的方法 |
| CN113135593B (zh) * | 2021-05-25 | 2022-01-28 | 西南科技大学 | 一种水热辅助溶胶-凝胶法制备高纯纳米二氧化锆的方法 |
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2013
- 2013-12-18 ES ES201301197A patent/ES2540026B1/es active Active
-
2014
- 2014-12-18 WO PCT/ES2014/070935 patent/WO2015092106A1/es active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| ES2540026A1 (es) | 2015-07-07 |
| WO2015092106A1 (es) | 2015-06-25 |
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