ES253916A1 - Un metodo para la preparaciën de xantenos y tiaxantenos - Google Patents
Un metodo para la preparaciën de xantenos y tiaxantenosInfo
- Publication number
- ES253916A1 ES253916A1 ES0253916A ES253916A ES253916A1 ES 253916 A1 ES253916 A1 ES 253916A1 ES 0253916 A ES0253916 A ES 0253916A ES 253916 A ES253916 A ES 253916A ES 253916 A1 ES253916 A1 ES 253916A1
- Authority
- ES
- Spain
- Prior art keywords
- alkylpiperazino
- general formula
- compounds
- hydroxy
- piperazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 7
- -1 alkanoyl radical Chemical class 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052749 magnesium Inorganic materials 0.000 abstract 2
- 239000011777 magnesium Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- DPSDUGKUPNOKCP-UHFFFAOYSA-N 2,8-dichloro-2H-thiopyrano[3,2-b]chromen-10-one Chemical compound ClC1SC=2C(C3=CC(=CC=C3OC2C=C1)Cl)=O DPSDUGKUPNOKCP-UHFFFAOYSA-N 0.000 abstract 1
- YNIYMLAHPDIBGJ-UHFFFAOYSA-N 2-butylsulfanyl-2H-thiopyrano[3,2-b]chromen-10-one Chemical compound C(CCC)SC1SC=2C(C3=CC=CC=C3OC2C=C1)=O YNIYMLAHPDIBGJ-UHFFFAOYSA-N 0.000 abstract 1
- ZCDADJXRUCOCJE-UHFFFAOYSA-N 2-chlorothioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC(Cl)=CC=C3SC2=C1 ZCDADJXRUCOCJE-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 150000000994 L-ascorbates Chemical class 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 229940125717 barbiturate Drugs 0.000 abstract 1
- JETFNRIIPBNRAT-UHFFFAOYSA-N butylsulfanylbenzene Chemical compound CCCCSC1=CC=CC=C1 JETFNRIIPBNRAT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 239000012024 dehydrating agents Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000002631 hypothermal effect Effects 0.000 abstract 1
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 abstract 1
- 238000010792 warming Methods 0.000 abstract 1
- RQNAPXJOFAMGPJ-UHFFFAOYSA-N xanthene Chemical compound C1=CC=C2[CH]C3=CC=CC=C3OC2=C1 RQNAPXJOFAMGPJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000007964 xanthones Chemical class 0.000 abstract 1
- JFRMYMMIJXLMBB-UHFFFAOYSA-N xanthydrol Chemical class C1=CC=C2C(O)C3=CC=CC=C3OC2=C1 JFRMYMMIJXLMBB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK447758 | 1958-12-04 | ||
| DK291959A DK107356C (da) | 1959-08-14 | 1959-08-14 | Fremgangsmåde til fremstilling af i 9-stillingen substituerede thiaxantener eller syreadditionssalte heraf. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES253916A1 true ES253916A1 (es) | 1960-05-01 |
Family
ID=26066806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0253916A Expired ES253916A1 (es) | 1958-12-04 | 1959-12-03 | Un metodo para la preparaciën de xantenos y tiaxantenos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3116291A (en, 2012) |
| BE (1) | BE585338A (en, 2012) |
| CH (1) | CH395136A (en, 2012) |
| DE (1) | DE1418517C2 (en, 2012) |
| ES (1) | ES253916A1 (en, 2012) |
| FR (1) | FR505M (en, 2012) |
| GB (1) | GB932494A (en, 2012) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3189657A (en) * | 1960-11-03 | 1965-06-15 | Lilly Co Eli | 5-(3-bromopropylidene) dibenzo-[a, d] cyclohepta (1.4)diene |
| CH410961A (de) * | 1961-02-22 | 1966-04-15 | Yoshitomi Pharmaceutical | Verfahren zur Herstellung N-substituierter Piperazinderivate |
| US3285919A (en) * | 1961-05-10 | 1966-11-15 | Sahyun Melville | Piperazinyl alkyl thiaxanthene derivatives |
| NL283292A (en, 2012) * | 1961-09-29 | |||
| GB1013901A (en) * | 1962-01-26 | 1965-12-22 | Kefalas As | Dihydroanthracene, dibenzocycloheptadiene and dibenzocycloheptatriene derivatives |
| US3609167A (en) * | 1962-04-02 | 1971-09-28 | Smith Kline French Lab | IBENZO{8 b,e{9 {0 THIEPINES |
| US3309404A (en) * | 1962-04-04 | 1967-03-14 | Merck & Co Inc | Derivatives of dibenzocycloheptenes and a process for their preparation |
| US3281469A (en) * | 1962-08-10 | 1966-10-25 | Lilly Co Eli | Process for preparing 5-hydroxy-5-(3-aminoalkynyl) dibenzo [a, d] cyclohepta [1, 4] denes |
| US3282930A (en) * | 1962-08-17 | 1966-11-01 | Smith Kline French Lab | Hydroxyalkylenepiperazine derivatives and analogs thereof |
| US3337407A (en) * | 1965-02-24 | 1967-08-22 | Merck & Co Inc | Uricosuric agent |
| US3474150A (en) * | 1966-10-31 | 1969-10-21 | Merck & Co Inc | Method for the production of 5-gamma-hydroxy - propylidene - substituted dibenzocycloheptenes |
| US3530116A (en) * | 1967-08-21 | 1970-09-22 | Merck & Co Inc | 3(4h)-oxo-2h-thiaxantheno (9,9alpha,1-ef)-1,4-diazepin-8,8-dioxides |
| US3681346A (en) * | 1969-06-20 | 1972-08-01 | Kefalas As | {60 -isomer of the decanoic acid ester of 10-{8 3,-(4-hydroxyethyl-1-piperazinyl)propylidene{9 -2-trifluoro-methyl thiaxanthene, acid addition salts thereof, method of use and compositions |
| GB1453828A (en) * | 1972-12-08 | 1976-10-27 | Kefalas As | Fluoro-substituted thiaxanthene derivatives |
| US4044024A (en) * | 1972-12-08 | 1977-08-23 | Kefalas A/S | Thiaxanthene derivatives |
| CA1010870A (en) * | 1972-12-08 | 1977-05-24 | Niels Lassen | Thiaxanthene derivative and method |
| GB1469108A (en) * | 1973-06-25 | 1977-03-30 | Kefalas As | Thiaxanthene derivative |
| US4076714A (en) * | 1974-11-25 | 1978-02-28 | Merck & Co., Inc. | 1-Methyl-4-(2-carboxy-thioxanthen-9-ylidene)-piperidine an appetite stimulant and antihistaminic agent |
| US4013660A (en) * | 1975-10-30 | 1977-03-22 | Warner-Lambert Company | Indolobenzoxazepines |
| NZ189108A (en) * | 1977-12-29 | 1982-02-23 | Kefalas As | 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and pharmaceutical compositions intermediate 2-methylthio-6-fluoro-9-(1-methyl-4-piperidyl)-thioxanthen-9-ol |
| GB8628903D0 (en) * | 1986-12-03 | 1987-01-07 | Lunbeck A S H | Neuroleptic compounds |
| CN103214453A (zh) * | 2013-04-12 | 2013-07-24 | 张家港威胜生物医药有限公司 | 珠氯噻醇的分离纯化方法 |
| CN105348256B (zh) * | 2015-11-16 | 2018-01-30 | 成都倍特药业有限公司 | 一种药用级盐酸氟哌噻吨的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2996503A (en) * | 1955-09-23 | 1961-08-15 | Merck & Co Inc | Derivatives of heterocyclic compounds |
| DE1044103B (de) * | 1956-06-12 | 1958-11-20 | Hoffmann La Roche | Verfahren zur Herstellung von Xanthen- bzw. Thioxanthenderivaten |
| BE557002A (en, 2012) * | 1956-07-09 | |||
| US2985654A (en) * | 1956-08-09 | 1961-05-23 | Schering Corp | Piperazino derivatives and methods for their manufacture |
| BE568611A (en, 2012) * | 1957-07-18 | |||
| NL112100C (en, 2012) * | 1959-06-08 | 1900-01-01 |
-
0
- BE BE585338D patent/BE585338A/xx unknown
-
1959
- 1959-12-01 US US856353A patent/US3116291A/en not_active Expired - Lifetime
- 1959-12-03 ES ES0253916A patent/ES253916A1/es not_active Expired
- 1959-12-03 DE DE1959K0039339 patent/DE1418517C2/de not_active Expired
- 1959-12-03 GB GB41173/59A patent/GB932494A/en not_active Expired
- 1959-12-04 CH CH8148359A patent/CH395136A/de not_active IP Right Cessation
-
1960
- 1960-08-30 FR FR837271A patent/FR505M/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DE1795506B2 (de) | 1975-12-18 |
| FR505M (en, 2012) | 1961-05-15 |
| DE1795506A1 (de) | 1972-02-10 |
| US3116291A (en) | 1963-12-31 |
| GB932494A (en) | 1963-07-31 |
| DE1418517C2 (de) | 1971-05-27 |
| CH395136A (de) | 1965-07-15 |
| DE1418517B1 (de) | 1970-10-22 |
| BE585338A (en, 2012) |
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