ES2535961T3 - Bacteria pasteurelácea atenuada que tiene una mutación en un gen de virulencia - Google Patents

Bacteria pasteurelácea atenuada que tiene una mutación en un gen de virulencia Download PDF

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Publication number
ES2535961T3
ES2535961T3 ES10181686.6T ES10181686T ES2535961T3 ES 2535961 T3 ES2535961 T3 ES 2535961T3 ES 10181686 T ES10181686 T ES 10181686T ES 2535961 T3 ES2535961 T3 ES 2535961T3
Authority
ES
Spain
Prior art keywords
mutation
virulence gene
attenuated
seq
bacterium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES10181686.6T
Other languages
English (en)
Spanish (es)
Inventor
David E. Lowery
Michael J. Kennedy
Troy E. Fuller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis Services LLC
Original Assignee
Zoetis P&U LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis P&U LLC filed Critical Zoetis P&U LLC
Application granted granted Critical
Publication of ES2535961T3 publication Critical patent/ES2535961T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES10181686.6T 1999-04-09 2000-04-06 Bacteria pasteurelácea atenuada que tiene una mutación en un gen de virulencia Expired - Lifetime ES2535961T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12868999P 1999-04-09 1999-04-09
US128689P 1999-04-09
US15345399P 1999-09-10 1999-09-10
US153453P 1999-09-10

Publications (1)

Publication Number Publication Date
ES2535961T3 true ES2535961T3 (es) 2015-05-19

Family

ID=26826843

Family Applications (2)

Application Number Title Priority Date Filing Date
ES10181686.6T Expired - Lifetime ES2535961T3 (es) 1999-04-09 2000-04-06 Bacteria pasteurelácea atenuada que tiene una mutación en un gen de virulencia
ES10181691.6T Expired - Lifetime ES2439645T3 (es) 1999-04-09 2000-04-06 Bacteria pasteurelácea atenuada que tiene una mutación en un gen de virulencia

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES10181691.6T Expired - Lifetime ES2439645T3 (es) 1999-04-09 2000-04-06 Bacteria pasteurelácea atenuada que tiene una mutación en un gen de virulencia

Country Status (14)

Country Link
US (5) US20070237793A1 (enExample)
EP (5) EP2281833B1 (enExample)
JP (4) JP4892134B2 (enExample)
KR (4) KR20010112937A (enExample)
CN (1) CN1351653A (enExample)
AR (1) AR029622A1 (enExample)
AU (2) AU780887B2 (enExample)
BR (1) BR0009663A (enExample)
CA (1) CA2366520C (enExample)
ES (2) ES2535961T3 (enExample)
HK (1) HK1045856A1 (enExample)
MX (1) MXPA01010207A (enExample)
NZ (2) NZ530012A (enExample)
WO (1) WO2000061724A2 (enExample)

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WO2000061724A2 (en) * 1999-04-09 2000-10-19 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
US6790950B2 (en) 1999-04-09 2004-09-14 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
WO2003029470A1 (en) * 2001-09-26 2003-04-10 Kyowa Hakko Kogyo Co., Ltd. PROCESS FOR PRODUCING α1,4-GALACTOSYLTRANSFERASE AND GALACTOSE-CONTAINING COMPLEX SUGAR
EP1350796B1 (en) * 2002-04-05 2009-01-07 Merial Attenuated gram negative bacteria
US7449178B2 (en) * 2002-04-05 2008-11-11 Merial Limited Attenuated gram negative bacteria
GB0228691D0 (en) * 2002-12-09 2003-01-15 Imp College Innovations Ltd Bacterial virulence genes
JP4463198B2 (ja) * 2003-03-05 2010-05-12 財団法人化学及血清療法研究所 大腸菌における異種蛋白質の製造方法
US8937154B2 (en) 2006-10-05 2015-01-20 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
US8940864B2 (en) * 2006-10-05 2015-01-27 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
CA2725227A1 (en) 2008-05-06 2009-11-12 Asim Kumar Debnath Antiviral cell penetrating peptides
DE102011016772B8 (de) * 2011-04-12 2024-08-14 Mercedes-Benz Group AG Verfahren und Vorrichtung zur Überwachung zumindest eines Fahrzeuginsassen und Verfahren zum Betrieb zumindest einer Assistenzvorrichtung
EP3062816B1 (en) 2013-11-01 2020-08-05 Boehringer Ingelheim Animal Health USA Inc. Attenuated pasteurella multocida vaccines & methods of making & use thereof
ES2945137T3 (es) 2017-02-10 2023-06-28 Epitopix Llc Proteínas y composiciones inmunitarias que contienen proteínas de Pasteurella y métodos de uso
TW202219269A (zh) * 2020-09-30 2022-05-16 美國農業部 新型多殺性巴斯德氏菌株及具有ｈｙａＣ與ｎａｎＰ缺失之疫苗
WO2022072431A1 (en) 2020-09-30 2022-04-07 Zoetis Services Llc Novel pasteurella multocida strains and vaccines having hyac and nanp deletions
CN113567415A (zh) * 2021-07-05 2021-10-29 广西大学 表面增强拉曼散射结合免疫层析技术检测布鲁氏杆菌方法
CN115925536B (zh) * 2022-08-01 2025-02-28 北京农学院 靶向抑制DksA的小分子抑制剂和应用
CN116593695B (zh) * 2022-12-29 2025-08-05 重庆澳龙生物制品有限公司 一种牛多杀性巴氏杆菌荚膜a型elisa抗体检测试剂盒及其制备方法和应用

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IL52815A (en) * 1977-08-24 1983-03-31 Israel State Fowl cholera vaccine and process for producing an attenuated non-virulent strain of pasteurella multocida
US5077044A (en) * 1980-05-19 1991-12-31 The Board Of Trustees Of The Leland Stanford Jr. University Novel non-reverting shigella live vaccines
US4735801A (en) * 1982-09-07 1988-04-05 Board Of Trustees Of Leland Stanford Jr. University Novel non-reverting salmonella live vaccines
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
DE3426532A1 (de) 1984-07-18 1986-01-30 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verwendung einer dna-sequenz zur expression sowie dna-struktur und expressionsvektor mit der dna-sequenz
SE8405493D0 (sv) 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US4877612A (en) 1985-05-20 1989-10-31 Frank M. Berger Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
ATE71303T1 (de) 1986-01-14 1992-01-15 Nederlanden Staat Verfahren zur herstellung immunologischer komplexe und diese enthaltende pharmazeutische zusammensetzung.
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US5840312A (en) * 1991-05-02 1998-11-24 Institut Pasteur Recombinant Bacillus anthracis strains unable to produce the lethal factor protein or edema factor protein
WO1994011024A1 (en) * 1992-11-06 1994-05-26 Regents Of The University Of Minnesota Composition protective against p. multocida pasteurellosis infection
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AU1662595A (en) 1994-01-28 1995-08-15 Herbert Altmann Method of determining the activity of a regulatory factor, and use of the method
JP3709564B2 (ja) 1994-08-30 2005-10-26 味の素株式会社 Ｌ−バリン及びｌ−ロイシンの製造法
DE69526377T2 (de) * 1994-12-09 2002-11-07 Microscience Ltd Virulenzgene in der VGC2-Region von Salmonella
CA2170839A1 (en) * 1995-03-01 1996-09-02 Janet Macinnes Bacterial preparations, method for producing same, and their use as vaccines
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US5925354A (en) 1995-11-30 1999-07-20 Michigan State University Riboflavin mutants as vaccines against Actinobacillus pleuropneumoniae
US5840556A (en) * 1996-05-08 1998-11-24 The United States Of America As Represented By The Department Of Agriculture Molecular genetic construction of vaccine strains of pasteurellaceae
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Also Published As

Publication number Publication date
HK1045856A1 (zh) 2002-12-13
EP2281834B1 (en) 2015-03-04
AR029622A1 (es) 2003-07-10
JP2010284165A (ja) 2010-12-24
CN1351653A (zh) 2002-05-29
JP5377433B2 (ja) 2013-12-25
AU2005203189B2 (en) 2007-12-20
EP2281835B1 (en) 2013-11-06
AU4077600A (en) 2000-11-14
EP2281833B1 (en) 2014-07-02
US20100322975A1 (en) 2010-12-23
JP4892134B2 (ja) 2012-03-07
MXPA01010207A (es) 2003-07-21
US20150182615A1 (en) 2015-07-02
AU2005203189A1 (en) 2005-08-18
AU780887B2 (en) 2005-04-21
EP1860117A3 (en) 2008-09-03
US8974798B2 (en) 2015-03-10
NZ530012A (en) 2005-10-28
ES2439645T3 (es) 2014-01-24
US9289486B2 (en) 2016-03-22
BR0009663A (pt) 2002-04-09
EP1860117A2 (en) 2007-11-28
KR20060134225A (ko) 2006-12-27
JP2013121347A (ja) 2013-06-20
NZ514883A (en) 2004-03-26
JP5973634B2 (ja) 2016-08-23
KR20060116041A (ko) 2006-11-13
US20120148625A1 (en) 2012-06-14
US20090202594A1 (en) 2009-08-13
CA2366520A1 (en) 2000-10-19
EP2281833A2 (en) 2011-02-09
EP2281835A3 (en) 2011-11-23
CA2366520C (en) 2013-10-01
JP2002541790A (ja) 2002-12-10
EP2281834A3 (en) 2011-11-23
WO2000061724A2 (en) 2000-10-19
EP1171577A2 (en) 2002-01-16
US20070237793A1 (en) 2007-10-11
KR20070011622A (ko) 2007-01-24
WO2000061724A3 (en) 2001-02-01
EP2281835A2 (en) 2011-02-09
JP2016019528A (ja) 2016-02-04
EP2281833A3 (en) 2011-11-30
EP2281834A2 (en) 2011-02-09
KR20010112937A (ko) 2001-12-22
US7763262B2 (en) 2010-07-27

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