ES2532089T3 - GH e IGF-1 para el tratamiento de trastornos del crecimiento - Google Patents
GH e IGF-1 para el tratamiento de trastornos del crecimiento Download PDFInfo
- Publication number
- ES2532089T3 ES2532089T3 ES06784529.7T ES06784529T ES2532089T3 ES 2532089 T3 ES2532089 T3 ES 2532089T3 ES 06784529 T ES06784529 T ES 06784529T ES 2532089 T3 ES2532089 T3 ES 2532089T3
- Authority
- ES
- Spain
- Prior art keywords
- igf
- subject
- idb
- growth
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract description 45
- 238000011282 treatment Methods 0.000 title abstract description 10
- 208000037824 growth disorder Diseases 0.000 title abstract description 7
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 title description 36
- 108010051696 Growth Hormone Proteins 0.000 abstract description 65
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- 239000000122 growth hormone Substances 0.000 abstract description 61
- 230000036765 blood level Effects 0.000 abstract description 15
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- 230000011664 signaling Effects 0.000 abstract description 7
- 238000011221 initial treatment Methods 0.000 abstract description 3
- 101150088952 IGF1 gene Proteins 0.000 abstract description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 40
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- 102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 description 20
- 229910052757 nitrogen Inorganic materials 0.000 description 20
- 230000037396 body weight Effects 0.000 description 11
- 102000002265 Human Growth Hormone Human genes 0.000 description 8
- 108010000521 Human Growth Hormone Proteins 0.000 description 8
- 239000000854 Human Growth Hormone Substances 0.000 description 8
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- 206010020772 Hypertension Diseases 0.000 description 1
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- 108700038030 Insulin-Like Growth Factor I Deficiency Proteins 0.000 description 1
- 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
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- 208000022967 Short stature due to partial GHR deficiency Diseases 0.000 description 1
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- 229940011871 estrogen Drugs 0.000 description 1
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- 208000019622 heart disease Diseases 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
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- 230000006872 improvement Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
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- 230000037356 lipid metabolism Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000009247 menarche Effects 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68761705P | 2005-06-02 | 2005-06-02 | |
| US687617P | 2005-06-02 | ||
| PCT/US2006/021282 WO2006130769A2 (en) | 2005-06-02 | 2006-06-01 | Methods for treatment of growth disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2532089T3 true ES2532089T3 (es) | 2015-03-24 |
Family
ID=37482318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06784529.7T Active ES2532089T3 (es) | 2005-06-02 | 2006-06-01 | GH e IGF-1 para el tratamiento de trastornos del crecimiento |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8158582B2 (enExample) |
| EP (1) | EP1901770B1 (enExample) |
| JP (2) | JP2008545752A (enExample) |
| ES (1) | ES2532089T3 (enExample) |
| WO (1) | WO2006130769A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008153929A1 (en) | 2007-06-08 | 2008-12-18 | Massachusetts Institute Of Technology | Igf for the treatment of rett syndrome and synaptic disorders |
| BR112012001363A2 (pt) | 2009-07-22 | 2016-11-08 | Ipsen Pharma Sas | análogo de igf-1, composição farmacêutica,e, método para tratar condições ou doenças mediadas pela ligação do receptor de igf-1 |
| RU2558821C2 (ru) * | 2009-11-17 | 2015-08-10 | Ипсен Фарма С.А.С. | ЛЕКАРСТВЕННАЯ ФОРМА ДЛЯ КОМБИНАЦИИ hGH И rhIGF-1 |
| EP2863897B1 (en) | 2012-06-21 | 2019-06-19 | Phosphorex Inc. | Nanoparticles of indirubin, derivatives thereof and methods of making and using same |
| BR112017012792A2 (pt) * | 2014-12-16 | 2018-01-02 | Puretein Bioscience Llc | métodos para aumentar a concentração de igf, para tratar uma condição, para melhorar ou manter a saúde e para melhorar uma característica |
| CN111344003B (zh) * | 2017-08-24 | 2024-05-07 | 建新公司 | 酸性鞘磷脂酶缺乏症患者中异常骨病症的治疗 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
| US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
| US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
| SE9002731D0 (sv) * | 1990-08-24 | 1990-08-24 | Kabivitrum Ab | Product comprising growth factor |
| TW267102B (enExample) * | 1992-03-13 | 1996-01-01 | Ciba Geigy | |
| IL106546A0 (en) | 1993-08-01 | 1993-12-08 | Zvi Rozenberg | Apparatus for a bicycle and a two wheel vehicle |
| US5824642A (en) * | 1994-04-07 | 1998-10-20 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
| US5646113A (en) * | 1994-04-07 | 1997-07-08 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
| US5741776A (en) * | 1995-05-22 | 1998-04-21 | Genentech, Inc. | Method of administration of IGF-I |
| ES2373783T3 (es) * | 2003-09-12 | 2012-02-08 | Tercica, Inc. | Métodos para el tratamiento de la deficiencia de factor 1 de crecimiento similar a la insulina (igf-1). |
| RU2558821C2 (ru) | 2009-11-17 | 2015-08-10 | Ипсен Фарма С.А.С. | ЛЕКАРСТВЕННАЯ ФОРМА ДЛЯ КОМБИНАЦИИ hGH И rhIGF-1 |
-
2006
- 2006-06-01 ES ES06784529.7T patent/ES2532089T3/es active Active
- 2006-06-01 US US11/915,978 patent/US8158582B2/en not_active Expired - Fee Related
- 2006-06-01 EP EP06784529.7A patent/EP1901770B1/en not_active Not-in-force
- 2006-06-01 JP JP2008514854A patent/JP2008545752A/ja active Pending
- 2006-06-01 WO PCT/US2006/021282 patent/WO2006130769A2/en not_active Ceased
-
2012
- 2012-03-12 US US13/417,983 patent/US8440616B2/en not_active Expired - Fee Related
-
2014
- 2014-03-05 JP JP2014043298A patent/JP2014129405A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20120232009A1 (en) | 2012-09-13 |
| US8440616B2 (en) | 2013-05-14 |
| WO2006130769A3 (en) | 2009-04-16 |
| US8158582B2 (en) | 2012-04-17 |
| JP2014129405A (ja) | 2014-07-10 |
| EP1901770A4 (en) | 2010-11-03 |
| EP1901770B1 (en) | 2014-12-24 |
| WO2006130769A2 (en) | 2006-12-07 |
| WO2006130769A9 (en) | 2007-01-18 |
| JP2008545752A (ja) | 2008-12-18 |
| US20100137200A1 (en) | 2010-06-03 |
| EP1901770A2 (en) | 2008-03-26 |
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