ES2501592T3 - Estereoisómero (-) de 2,6-di-sec-butilfenol y análogos del mismo para fomentar el efecto antiemético, tratamiento de náuseas y vómitos y tratamiento de migraña - Google Patents
Estereoisómero (-) de 2,6-di-sec-butilfenol y análogos del mismo para fomentar el efecto antiemético, tratamiento de náuseas y vómitos y tratamiento de migraña Download PDFInfo
- Publication number
- ES2501592T3 ES2501592T3 ES10014318.9T ES10014318T ES2501592T3 ES 2501592 T3 ES2501592 T3 ES 2501592T3 ES 10014318 T ES10014318 T ES 10014318T ES 2501592 T3 ES2501592 T3 ES 2501592T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- stereoisomer
- butylphenol
- nausea
- vomiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- FHTGJZOULSYEOB-UHFFFAOYSA-N 2,6-di(butan-2-yl)phenol Chemical compound CCC(C)C1=CC=CC(C(C)CC)=C1O FHTGJZOULSYEOB-UHFFFAOYSA-N 0.000 title 1
- 208000019695 Migraine disease Diseases 0.000 title 1
- 206010047700 Vomiting Diseases 0.000 title 1
- 230000003474 anti-emetic effect Effects 0.000 title 1
- 206010027599 migraine Diseases 0.000 title 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/06—Alkylated phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
- C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
- C07C39/27—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms all halogen atoms being bound to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92829607P | 2007-05-09 | 2007-05-09 | |
| US92842907P | 2007-05-09 | 2007-05-09 | |
| US92832707P | 2007-05-09 | 2007-05-09 | |
| US928429P | 2007-05-09 | ||
| US928327P | 2007-05-09 | ||
| US928296P | 2007-05-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2501592T3 true ES2501592T3 (es) | 2014-10-02 |
Family
ID=39798084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10014318.9T Active ES2501592T3 (es) | 2007-05-09 | 2008-05-08 | Estereoisómero (-) de 2,6-di-sec-butilfenol y análogos del mismo para fomentar el efecto antiemético, tratamiento de náuseas y vómitos y tratamiento de migraña |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US8071818B2 (OSRAM) |
| EP (4) | EP2146946B1 (OSRAM) |
| JP (1) | JP5651009B2 (OSRAM) |
| KR (1) | KR20100017436A (OSRAM) |
| CN (1) | CN101715437B (OSRAM) |
| AT (1) | ATE487685T1 (OSRAM) |
| AU (1) | AU2008251482C1 (OSRAM) |
| BR (1) | BRPI0811220A2 (OSRAM) |
| CA (1) | CA2685570A1 (OSRAM) |
| DE (1) | DE602008003431D1 (OSRAM) |
| DK (2) | DK2301908T3 (OSRAM) |
| ES (1) | ES2501592T3 (OSRAM) |
| HR (1) | HRP20140896T1 (OSRAM) |
| IL (1) | IL201795A0 (OSRAM) |
| MX (1) | MX2009012124A (OSRAM) |
| NZ (1) | NZ580752A (OSRAM) |
| PL (2) | PL2146946T3 (OSRAM) |
| PT (1) | PT2146946E (OSRAM) |
| RU (1) | RU2470908C2 (OSRAM) |
| SI (1) | SI2301908T1 (OSRAM) |
| WO (1) | WO2008141097A2 (OSRAM) |
| ZA (1) | ZA201007603B (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2301908T3 (da) | 2007-05-09 | 2014-09-15 | Sowood Healthcare Llc | (-)-stereoisomer af 2,6-di-sec-butylphenol og analoger dertil til frembringelse af en antiemetisk effekt, behandling af kvalme og opkastning og behandling af migræne |
| JP5924539B2 (ja) * | 2010-08-03 | 2016-05-25 | 学校法人 久留米大学 | 実験用小動物の脳波測定用装置及び脳波測定方法 |
| CN102731265B (zh) * | 2012-06-12 | 2014-12-10 | 四川百利药业有限责任公司 | 一种高纯度丙泊酚的制备方法 |
| WO2017205632A1 (en) * | 2016-05-27 | 2017-11-30 | The Johns Hopkins University | Buccal, sublingual and intranasal delivery of fospropofol |
| RU2635532C1 (ru) * | 2016-09-06 | 2017-11-13 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ профилактики ажитационного синдрома у детей с онкологической патологией |
| CN115708819A (zh) * | 2022-11-24 | 2023-02-24 | 中国科学院深圳先进技术研究院 | 丙泊酚的抗焦虑制药用途及抗焦虑药物制剂 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US237213A (en) | 1881-02-01 | William j | ||
| US2747982A (en) * | 1955-05-11 | 1956-05-29 | Dow Chemical Co | Method and composition for the control of the growth of vegetation |
| GB1472793A (en) * | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
| US4798846A (en) | 1974-03-28 | 1989-01-17 | Imperial Chemical Industries Plc | Pharmaceutical compositions |
| SU1525139A1 (ru) * | 1987-11-10 | 1989-11-30 | Куйбышевский политехнический институт им.В.В.Куйбышева | Способ получени о-втор-бутилфенола |
| ES2087019B1 (es) * | 1994-02-08 | 1997-03-16 | Bobel246 S L | Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. |
| US5731355A (en) | 1994-03-22 | 1998-03-24 | Zeneca Limited | Pharmaceutical compositions of propofol and edetate |
| GB9405593D0 (en) | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| US6254853B1 (en) | 1998-05-08 | 2001-07-03 | Vyrex Corporation | Water soluble pro-drugs of propofol |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| US6140374A (en) * | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
| AU3000800A (en) | 1999-02-18 | 2000-09-04 | Supergen, Inc. | Phosphocholine linked prodrug derivatives |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6362234B1 (en) | 2000-08-15 | 2002-03-26 | Vyrex Corporation | Water-soluble prodrugs of propofol for treatment of migrane |
| US20020099013A1 (en) | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
| AU2002243204A1 (en) | 2000-10-06 | 2002-06-11 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| WO2002074200A1 (en) * | 2001-03-20 | 2002-09-26 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| ES2325918T3 (es) | 2001-12-28 | 2009-09-24 | Eisai Corporation Of North America | Formulaciones farmaceuticas de base acuosa de profarmacos de propofol solubles en agua. |
| EP1485082A4 (en) | 2002-02-19 | 2009-12-30 | Xenoport Inc | PROCESS FOR THE SYNTHESIS OF PROMEDICAMENTS FROM 1-ACYL-ALKYL DERIVATIVES AND CORRESPONDING COMPOSITIONS |
| JP5188003B2 (ja) | 2002-04-08 | 2013-04-24 | エーザイ インコーポレイテッド | プロポフォールの水溶性プロドラッグを含む薬学的組成物およびその投与方法 |
| AU2003273413A1 (en) | 2002-10-08 | 2004-05-04 | Fresenius Kabi Deutschland Gmbh | Pharmaceutically active oligosaccharide conjugates |
| DE20215415U1 (de) | 2002-10-08 | 2004-02-26 | Biotechnologie Gesellschaft Mittelhessen Mbh | Wasserlösliche Medikamentenvorstufen von Propofol |
| ZA200504940B (en) | 2003-01-28 | 2006-09-27 | Xenoport Inc | Amino acid derived prodrugs of propofol, compositions and uses thereof |
| AU2003901815A0 (en) | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
| WO2005023204A2 (en) | 2003-09-09 | 2005-03-17 | Xenoport, Inc. | Aromatic prodrugs of propofol, compositions and uses thereof |
| US20070043121A1 (en) * | 2003-09-29 | 2007-02-22 | Brown Milton L | Discovery of novel soluble crystalline anesthetics |
| WO2006017351A1 (en) | 2004-07-12 | 2006-02-16 | Xenoport, Inc. | Prodrugs of propofol, compositions and uses thereof |
| EP1791521A4 (en) | 2004-09-17 | 2009-10-21 | Eisai Corp North America | METHODS OF ADMINISTERING PROPOFOL PROMOTERS WITH WATER SOLUBLE |
| WO2006071995A1 (en) | 2004-12-23 | 2006-07-06 | Xenoport, Inc. | Serine amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof |
| DE102005033496A1 (de) * | 2005-07-19 | 2007-01-25 | Bayer Healthcare Ag | Desinfektionsmittel |
| WO2007071967A2 (en) | 2005-12-19 | 2007-06-28 | The University Of Liverpool | Substituted phenol derivatives as analgesics |
| US7535698B2 (en) | 2006-03-07 | 2009-05-19 | Panasonic Corporation | Case, portable information equipment using the same and manufacturing method of the case |
| US7731356B1 (en) * | 2006-07-24 | 2010-06-08 | Daniel Ayers Gilbert | Hanging eyeglasses |
| AU2008251484A1 (en) | 2007-05-09 | 2008-11-20 | Pharmacofore, Inc. | Therapeutic compounds |
| DK2301908T3 (da) | 2007-05-09 | 2014-09-15 | Sowood Healthcare Llc | (-)-stereoisomer af 2,6-di-sec-butylphenol og analoger dertil til frembringelse af en antiemetisk effekt, behandling af kvalme og opkastning og behandling af migræne |
-
2008
- 2008-05-08 DK DK10014318.9T patent/DK2301908T3/da active
- 2008-05-08 KR KR1020097024780A patent/KR20100017436A/ko not_active Ceased
- 2008-05-08 CA CA002685570A patent/CA2685570A1/en not_active Abandoned
- 2008-05-08 AU AU2008251482A patent/AU2008251482C1/en not_active Ceased
- 2008-05-08 DE DE602008003431T patent/DE602008003431D1/de active Active
- 2008-05-08 EP EP08769338A patent/EP2146946B1/en active Active
- 2008-05-08 DK DK08769338.8T patent/DK2146946T3/da active
- 2008-05-08 PL PL08769338T patent/PL2146946T3/pl unknown
- 2008-05-08 SI SI200831288T patent/SI2301908T1/sl unknown
- 2008-05-08 ES ES10014318.9T patent/ES2501592T3/es active Active
- 2008-05-08 BR BRPI0811220-7A2A patent/BRPI0811220A2/pt not_active IP Right Cessation
- 2008-05-08 MX MX2009012124A patent/MX2009012124A/es active IP Right Grant
- 2008-05-08 EP EP14173149.7A patent/EP2810927A1/en not_active Withdrawn
- 2008-05-08 RU RU2009145537/04A patent/RU2470908C2/ru not_active IP Right Cessation
- 2008-05-08 CN CN2008800153921A patent/CN101715437B/zh not_active Expired - Fee Related
- 2008-05-08 PT PT08769338T patent/PT2146946E/pt unknown
- 2008-05-08 AT AT08769338T patent/ATE487685T1/de active
- 2008-05-08 WO PCT/US2008/063082 patent/WO2008141097A2/en not_active Ceased
- 2008-05-08 JP JP2010507665A patent/JP5651009B2/ja not_active Expired - Fee Related
- 2008-05-08 US US12/596,800 patent/US8071818B2/en not_active Expired - Fee Related
- 2008-05-08 NZ NZ580752A patent/NZ580752A/en not_active IP Right Cessation
- 2008-05-08 EP EP10009233A patent/EP2292577A1/en not_active Withdrawn
- 2008-05-08 EP EP10014318.9A patent/EP2301908B8/en active Active
- 2008-05-08 PL PL10014318T patent/PL2301908T3/pl unknown
-
2009
- 2009-10-28 IL IL201795A patent/IL201795A0/en not_active IP Right Cessation
-
2010
- 2010-10-25 ZA ZA2010/07603A patent/ZA201007603B/en unknown
-
2011
- 2011-10-14 US US13/274,172 patent/US8242315B2/en not_active Expired - Fee Related
-
2012
- 2012-07-13 US US13/548,991 patent/US8575400B2/en not_active Expired - Fee Related
-
2013
- 2013-09-23 US US14/034,305 patent/US8871815B2/en not_active Expired - Fee Related
-
2014
- 2014-09-18 HR HRP20140896AT patent/HRP20140896T1/hr unknown
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