ES2494015T3 - Composiciones para tratar nauseas y vómitos de origen central - Google Patents

Composiciones para tratar nauseas y vómitos de origen central Download PDF

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Publication number
ES2494015T3
ES2494015T3 ES10805301.8T ES10805301T ES2494015T3 ES 2494015 T3 ES2494015 T3 ES 2494015T3 ES 10805301 T ES10805301 T ES 10805301T ES 2494015 T3 ES2494015 T3 ES 2494015T3
Authority
ES
Spain
Prior art keywords
vomiting
administered
nausea
patient
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10805301.8T
Other languages
English (en)
Spanish (es)
Inventor
Fabio Trento
Sergio Cantoreggi
Giorgia Rossi
Roberta Cannella
Daniele Bonadeo
Riccardo Braglia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helsinn Healthcare SA
Original Assignee
Helsinn Healthcare SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43608757&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2494015(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Helsinn Healthcare SA filed Critical Helsinn Healthcare SA
Application granted granted Critical
Publication of ES2494015T3 publication Critical patent/ES2494015T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/473Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Paints Or Removers (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES10805301.8T 2009-11-18 2010-11-18 Composiciones para tratar nauseas y vómitos de origen central Active ES2494015T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26247009P 2009-11-18 2009-11-18
US262470P 2009-11-18
US38270910P 2010-09-14 2010-09-14
US382709P 2010-09-14
PCT/IB2010/003106 WO2011061622A1 (en) 2009-11-18 2010-11-18 Compositions for treating centrally mediated nausea and vomiting

Publications (1)

Publication Number Publication Date
ES2494015T3 true ES2494015T3 (es) 2014-09-12

Family

ID=43608757

Family Applications (4)

Application Number Title Priority Date Filing Date
ES10805301.8T Active ES2494015T3 (es) 2009-11-18 2010-11-18 Composiciones para tratar nauseas y vómitos de origen central
ES14151676.5T Active ES2559475T3 (es) 2009-11-18 2010-11-18 Composiciones para tratar náuseas y vómitos de origen central
ES14151683.1T Active ES2595077T3 (es) 2009-11-18 2010-11-18 Composiciones para tratar náuseas y vómitos mediados centralmente
ES14151678.1T Active ES2623503T3 (es) 2009-11-18 2010-11-18 Composiciones para tratar náuseas y vómitos mediados centralmente

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES14151676.5T Active ES2559475T3 (es) 2009-11-18 2010-11-18 Composiciones para tratar náuseas y vómitos de origen central
ES14151683.1T Active ES2595077T3 (es) 2009-11-18 2010-11-18 Composiciones para tratar náuseas y vómitos mediados centralmente
ES14151678.1T Active ES2623503T3 (es) 2009-11-18 2010-11-18 Composiciones para tratar náuseas y vómitos mediados centralmente

Country Status (40)

Country Link
US (1) US12042494B2 (https=)
EP (3) EP2361090B1 (https=)
JP (1) JP5890780B2 (https=)
KR (1) KR101615108B1 (https=)
CN (6) CN102655864A (https=)
AP (1) AP3083A (https=)
AU (1) AU2010320598B2 (https=)
BR (1) BR112012011485B1 (https=)
CA (1) CA2778301C (https=)
CL (1) CL2012001276A1 (https=)
CO (1) CO6551693A2 (https=)
CR (1) CR20120216A (https=)
CU (1) CU24048B1 (https=)
CY (1) CY1118062T1 (https=)
DK (2) DK2361090T3 (https=)
DO (1) DOP2012000138A (https=)
EA (1) EA026815B1 (https=)
EC (1) ECSP12011907A (https=)
ES (4) ES2494015T3 (https=)
GE (1) GEP20156226B (https=)
GT (1) GT201200156A (https=)
HK (2) HK1214148A1 (https=)
HR (3) HRP20140759T1 (https=)
HU (1) HUE029677T2 (https=)
IL (1) IL219576A (https=)
LT (1) LT2722045T (https=)
MA (1) MA33810B1 (https=)
MX (1) MX2012005347A (https=)
MY (1) MY159393A (https=)
NI (1) NI201200090A (https=)
NZ (1) NZ599439A (https=)
PE (1) PE20121483A1 (https=)
PH (1) PH12012500887A1 (https=)
PL (3) PL2722044T3 (https=)
PT (2) PT2722045T (https=)
RS (2) RS53491B1 (https=)
SI (2) SI2361090T1 (https=)
SM (1) SMT201400112B (https=)
TN (1) TN2012000170A1 (https=)
WO (1) WO2011061622A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2722045B1 (en) 2009-11-18 2016-07-06 Helsinn Healthcare SA Compositions for treating centrally mediated nausea and vomiting
PT2722045T (pt) 2009-11-18 2016-10-18 Helsinn Healthcare Sa Composições para o tratamento de náuseas e vómitos mediadas centralmente
WO2013004766A1 (en) * 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
ES2579616T3 (es) * 2011-10-18 2016-08-12 Helsinn Healthcare Sa Combinaciones terapéuticas de netupitant y palonosetrón
US9403772B2 (en) 2011-11-29 2016-08-02 Helsinn Healthcare Sa 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator
US8426450B1 (en) 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
CN103520725B (zh) * 2012-07-05 2017-10-24 海思科医药集团股份有限公司 一种治疗呕吐的药物组合物
CA2978736C (en) 2015-03-04 2023-11-07 Vanda Pharmaceuticals Inc. Dosing regimen of tradipitant
CN106902086B (zh) * 2015-12-23 2020-10-20 江苏恒瑞医药股份有限公司 一种包含奈妥匹坦的固体组合物
GB201618425D0 (en) * 2016-11-01 2016-12-14 Acacia Pharma Ltd method
GB201702250D0 (en) 2017-02-10 2017-03-29 Acacia Pharma Ltd Method
CN108721214B (zh) * 2017-04-14 2020-06-16 和龙 奈妥吡坦和帕洛诺司琼复方纳米粒溶液、纳米粒及制备方法和用途
CN108853010A (zh) * 2017-05-15 2018-11-23 和龙 奈妥吡坦环糊精包合物、复方组合制剂及其制备方法和用途
CN109200018A (zh) * 2017-07-04 2019-01-15 南京诺瑞特医药科技有限公司 含有奈妥吡坦的微乳制剂
KR20250140655A (ko) * 2017-11-17 2025-09-25 반다 파마슈티칼즈, 인코퍼레이티드. 트라디피탄트를 이용한 위장 질환의 치료 방법
MX2020008137A (es) * 2018-02-02 2020-10-19 Eustralis Pharmaceuticals Ltd Trading As Pressura Neuro Formulaciones orales y usos de las mismas.
AU2021407138A1 (en) * 2020-12-25 2023-06-29 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Use of nk1 antagonist prodrug compound in combination with 5-ht3 receptor antagonist
EP4385500A1 (en) 2022-12-12 2024-06-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Fixed dose combination comprising netupitant and palonosetron
EP4633608A1 (en) 2022-12-12 2025-10-22 Alfred E. Tiefenbacher (GmbH & Co. KG) Antioxidant-free fixed dose combination of netupitant and palonosetron
KR20250125376A (ko) 2022-12-12 2025-08-21 알프레드 이. 티펜바흐어 게엠베하 운트 & 코. 카게 네투피탄트 및 팔로노세트론을 포함하는 고정 용량 복합제
EP4385497A1 (en) 2022-12-12 2024-06-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Antioxidant-free fixed dose combination of netupitant and palonosetron
WO2025246530A1 (en) * 2024-05-30 2025-12-04 The Chinese University Of Hong Kong Personalized anti-emetic treatment for chemotherapy-induced nausea and vomiting

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MXPA03005169A (es) 2000-12-14 2003-09-22 Hoffmann La Roche Matriz lipidica auto-emulsificante.
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PT2722045T (pt) 2009-11-18 2016-10-18 Helsinn Healthcare Sa Composições para o tratamento de náuseas e vómitos mediadas centralmente

Also Published As

Publication number Publication date
ES2559475T3 (es) 2016-02-12
LT2722045T (lt) 2016-09-26
HRP20140759T1 (hr) 2014-10-24
CN106421793B (zh) 2023-06-16
AP2012006278A0 (en) 2012-06-30
EA026815B1 (ru) 2017-05-31
CN104856998A (zh) 2015-08-26
US12042494B2 (en) 2024-07-23
DK2722045T3 (en) 2016-10-24
ECSP12011907A (es) 2012-10-30
EP2727590B1 (en) 2015-10-21
HK1214148A1 (zh) 2016-07-22
CR20120216A (es) 2012-07-24
KR101615108B1 (ko) 2016-05-12
CN106512010A (zh) 2017-03-22
CL2012001276A1 (es) 2012-12-07
HK1214147A1 (zh) 2016-07-22
KR20120101456A (ko) 2012-09-13
CN102655864A (zh) 2012-09-05
MX2012005347A (es) 2012-08-03
SI2361090T1 (sl) 2014-09-30
CU24048B1 (es) 2014-12-26
ES2623503T3 (es) 2017-07-11
PL2361090T3 (pl) 2014-10-31
MY159393A (en) 2016-12-30
IL219576A (en) 2017-08-31
SI2722045T1 (sl) 2017-02-28
GEP20156226B (en) 2015-01-26
AU2010320598A1 (en) 2012-06-14
AU2010320598B2 (en) 2016-06-16
CY1118062T1 (el) 2017-06-28
NI201200090A (es) 2012-11-13
PL2722045T3 (pl) 2017-03-31
ES2595077T3 (es) 2016-12-27
AP3083A (en) 2015-01-31
CO6551693A2 (es) 2012-10-31
CN104856999A (zh) 2015-08-26
PE20121483A1 (es) 2012-12-02
EP2722044B1 (en) 2017-01-04
PL2722044T3 (pl) 2017-08-31
RS55206B1 (sr) 2017-01-31
JP5890780B2 (ja) 2016-03-22
DOP2012000138A (es) 2012-11-15
RS53491B1 (sr) 2015-02-27
EP2361090B1 (en) 2014-05-21
HRP20161277T1 (hr) 2016-11-18
US20230263799A1 (en) 2023-08-24
CU20120078A7 (es) 2012-10-15
MA33810B1 (fr) 2012-12-03
IL219576A0 (en) 2012-06-28
CA2778301A1 (en) 2011-05-26
JP2013511507A (ja) 2013-04-04
BR112012011485A2 (pt) 2018-04-03
DK2361090T3 (da) 2014-08-25
CA2778301C (en) 2016-06-14
CN107050455A (zh) 2017-08-18
CN106421793A (zh) 2017-02-22
HRP20170419T1 (hr) 2017-06-02
HUE029677T2 (hu) 2017-03-28
CN107050455B (zh) 2020-09-29
GT201200156A (es) 2014-03-27
TN2012000170A1 (en) 2013-12-12
PH12012500887A1 (en) 2016-08-26
EA201290356A1 (ru) 2012-12-28
NZ599439A (en) 2014-06-27
BR112012011485B1 (pt) 2021-06-29
SMT201400112B (it) 2014-11-10
WO2011061622A1 (en) 2011-05-26
PT2361090E (pt) 2014-09-03
PT2722045T (pt) 2016-10-18
EP2727590A1 (en) 2014-05-07
EP2361090A1 (en) 2011-08-31
EP2722044A1 (en) 2014-04-23

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