ES2474693T3 - Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa - Google Patents
Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa Download PDFInfo
- Publication number
- ES2474693T3 ES2474693T3 ES08736361.0T ES08736361T ES2474693T3 ES 2474693 T3 ES2474693 T3 ES 2474693T3 ES 08736361 T ES08736361 T ES 08736361T ES 2474693 T3 ES2474693 T3 ES 2474693T3
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- Prior art keywords
- methyl
- alkyl
- cyano
- imidazol
- propyl
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title claims description 175
- 108010081484 glutaminyl-peptide cyclotransferase Proteins 0.000 title description 17
- 102000003642 glutaminyl-peptide cyclotransferase Human genes 0.000 title description 17
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- 150000001875 compounds Chemical class 0.000 claims abstract description 168
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 14
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- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 claims description 6
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- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 6
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 claims description 5
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| US91252807P | 2007-04-18 | 2007-04-18 | |
| US912528P | 2007-04-18 | ||
| PCT/EP2008/054712 WO2008128983A1 (en) | 2007-04-18 | 2008-04-18 | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
Publications (1)
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| ES2474693T3 true ES2474693T3 (es) | 2014-07-09 |
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| WO2009034158A2 (en) * | 2007-09-12 | 2009-03-19 | Probiodrug Ag | Transgenic mice |
| JP2011511622A (ja) * | 2008-01-14 | 2011-04-14 | プロビオドルグ エージー | グルタミニルシクラーゼ遺伝子のノックアウト変異を有するマウスモデル |
| BRPI0916366B1 (pt) | 2008-07-21 | 2021-08-10 | Probiodrug Ag | Anticorpo que se liga às variantes de peptídeos abeta, sua composição, seu uso, seu kit de diagnóstico, e linhagem celular de hibridoma |
| KR101755737B1 (ko) | 2009-09-11 | 2017-07-07 | 프로비오드룩 아게 | 글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체 |
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| EP2742062A2 (en) * | 2011-08-12 | 2014-06-18 | Probiodrug AG | In vivo screening models for treatment of qc-related disorders |
| JP6397407B2 (ja) | 2012-07-19 | 2018-09-26 | ドレクセル ユニバーシティ | 細胞タンパク質ホメオスタシスを調節するためのシグマ受容体リガンド |
| EP3234611A1 (en) | 2014-12-19 | 2017-10-25 | Probiodrug AG | Novel method for the detection of pglu-abeta peptides |
| EP3747438A1 (en) | 2017-07-24 | 2020-12-09 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Treating pathological conditions by direct and indirect targeting of sirpa - cd47 interaction |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| US11117870B2 (en) | 2017-11-01 | 2021-09-14 | Drexel University | Compounds, compositions, and methods for treating diseases |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| JP7751894B2 (ja) * | 2021-03-30 | 2025-10-09 | ナミックス株式会社 | 硬化触媒、樹脂組成物、封止材、接着剤、及び硬化物 |
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| DE3044566A1 (de) * | 1980-11-26 | 1982-07-15 | Basf Ag, 6700 Ludwigshafen | N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung |
| ATE237585T1 (de) * | 1997-05-07 | 2003-05-15 | Novo Nordisk As | Substituierte 3,3-diamino-2-propennitrile, ihre herstellung und verwendung |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| US8338120B2 (en) | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| DE602004026712D1 (de) | 2003-05-05 | 2010-06-02 | Probiodrug Ag | Medizinische verwendung von hemmern von glutaminyl und glutamatcyclasen |
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| KR101099206B1 (ko) | 2004-02-05 | 2011-12-27 | 프로비오드룩 아게 | 신규한 글루타미닐 시클라제 저해제 |
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| US20080267912A1 (en) | 2008-10-30 |
| WO2008128983A1 (en) | 2008-10-30 |
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