ES2450998T3 - Nuevas variantes de proteína de cubierta E1 de rubéola y su utilización en la detección de anticuerpos anti-rubéola - Google Patents
Nuevas variantes de proteína de cubierta E1 de rubéola y su utilización en la detección de anticuerpos anti-rubéolaInfo
- Publication number
- ES2450998T3 ES2450998T3 ES08860033.3T ES08860033T ES2450998T3 ES 2450998 T3 ES2450998 T3 ES 2450998T3 ES 08860033 T ES08860033 T ES 08860033T ES 2450998 T3 ES2450998 T3 ES 2450998T3
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- rubella
- antigen
- disulfide
- protein
- chaperone
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- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
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Landscapes
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| EP07024190 | 2007-12-13 | ||
| EP07024190 | 2007-12-13 | ||
| PCT/EP2008/010532 WO2009074318A2 (en) | 2007-12-13 | 2008-12-11 | Novel rubella e1 envelope protein variants and their use in the detection of anti-rubella antibodies |
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| ES2450998T3 true ES2450998T3 (es) | 2014-03-26 |
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| EP2706115A1 (en) | 2012-09-06 | 2014-03-12 | Roche Diagnostics GmbH | Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays |
| EA201500503A1 (ru) | 2012-11-08 | 2015-10-30 | Ф.Хоффманн-Ля Рош Аг | Анти-her3/her4 антигенсвязывающие белки, связывающиеся с бета-шпилькой her3 и бета-шпилькой her4 |
| MX2016014862A (es) | 2014-05-14 | 2017-02-27 | Hoffmann La Roche | Her3 / her2 anticuerpos biespecificos que se unen a la horquilla beta de her3 y al dominio ii de her2. |
| CN108136000B (zh) * | 2015-09-30 | 2022-11-08 | 勃林格殷格翰动物保健有限公司 | 经改良的模块化抗原转运分子及其在动物中的用途 |
| BR112018012055A2 (pt) * | 2015-12-15 | 2018-12-04 | Hoffmann La Roche | substrato de transglutaminase (tg) recombinante, método in vitro para marcar uma proteína de interesse, composição farmacêutica ou de diagnóstico e kit de diagnóstico |
| WO2020010009A1 (en) * | 2018-07-02 | 2020-01-09 | Siemens Healthcare Diagnostics Inc. | Direct immunoassay measurement of autoantibodies |
| DE102019004812B4 (de) | 2019-07-10 | 2021-03-18 | Institut Virion-Serion GmbH Würzburg | Rubella Virus Spike Konstrukt |
| CN115197941A (zh) * | 2021-04-08 | 2022-10-18 | 中国科学院分子细胞科学卓越创新中心 | 具有分子伴侣功能的rna及其应用 |
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| AU736670B2 (en) | 1996-09-26 | 2001-08-02 | Medical Research Council | Chaperone fragments |
| ATE289354T1 (de) * | 1999-04-15 | 2005-03-15 | Crucell Holland Bv | Verwendung von adenovirus e1 protein sequenzen kodierenden, zur herstellung von rekombinanten proteinen in menschlichen zellen. |
| EP1103610A1 (en) * | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
| PL215170B1 (pl) | 2001-06-22 | 2013-10-31 | Hoffmann La Roche | Sposób wytwarzania rozpuszczalnego kompleksu zawierajacego amyloidogenne bialko docelowe oraz bialko opiekuncze z klasy izomeraz peptydyloprolilowych |
| EP1780282B1 (en) * | 2005-10-26 | 2010-12-08 | Roche Diagnostics GmbH | Recombinant expression of Rubella E1 envelope protein variants as chaperone fusion-proteins, and their use in the detection of anti-Rubella antibodies |
| CA2562738C (en) * | 2005-10-26 | 2011-07-12 | F. Hoffmann-La Roche Ag | Soluble rubella e1 envelope antigens |
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| US20110059552A1 (en) | 2011-03-10 |
| CN101939330B (zh) | 2014-06-04 |
| CA2705716C (en) | 2013-03-19 |
| JP5461423B2 (ja) | 2014-04-02 |
| EP2222694A2 (en) | 2010-09-01 |
| WO2009074318A3 (en) | 2009-07-30 |
| EP2222694B1 (en) | 2014-01-15 |
| CN101939330A (zh) | 2011-01-05 |
| CA2705716A1 (en) | 2009-06-18 |
| HK1148026A1 (en) | 2011-08-26 |
| JP2011505811A (ja) | 2011-03-03 |
| US8551696B2 (en) | 2013-10-08 |
| WO2009074318A2 (en) | 2009-06-18 |
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