CN101939330B - 新型风疹e1包膜蛋白变体及其在检测抗风疹抗体中的用途 - Google Patents

新型风疹e1包膜蛋白变体及其在检测抗风疹抗体中的用途 Download PDF

Info

Publication number
CN101939330B
CN101939330B CN200880121328.1A CN200880121328A CN101939330B CN 101939330 B CN101939330 B CN 101939330B CN 200880121328 A CN200880121328 A CN 200880121328A CN 101939330 B CN101939330 B CN 101939330B
Authority
CN
China
Prior art keywords
rubella
antigen
cys
pro
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200880121328.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN101939330A (zh
Inventor
C·肖尔兹
R·博尔哈根
A·恩格尔
E·法茨
P·沙尔施米特
B·厄普迈耶
T·扎恩特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN101939330A publication Critical patent/CN101939330A/zh
Application granted granted Critical
Publication of CN101939330B publication Critical patent/CN101939330B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36211—Rubivirus, e.g. rubella virus
    • C12N2770/36222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G01N2333/19—Rubella virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880121328.1A 2007-12-13 2008-12-11 新型风疹e1包膜蛋白变体及其在检测抗风疹抗体中的用途 Active CN101939330B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07024190 2007-12-13
EP07024190.6 2007-12-13
PCT/EP2008/010532 WO2009074318A2 (en) 2007-12-13 2008-12-11 Novel rubella e1 envelope protein variants and their use in the detection of anti-rubella antibodies

Publications (2)

Publication Number Publication Date
CN101939330A CN101939330A (zh) 2011-01-05
CN101939330B true CN101939330B (zh) 2014-06-04

Family

ID=40671057

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880121328.1A Active CN101939330B (zh) 2007-12-13 2008-12-11 新型风疹e1包膜蛋白变体及其在检测抗风疹抗体中的用途

Country Status (7)

Country Link
US (1) US8551696B2 (enExample)
EP (1) EP2222694B1 (enExample)
JP (1) JP5461423B2 (enExample)
CN (1) CN101939330B (enExample)
CA (1) CA2705716C (enExample)
ES (1) ES2450998T3 (enExample)
WO (1) WO2009074318A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2706115A1 (en) 2012-09-06 2014-03-12 Roche Diagnostics GmbH Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays
EA201500503A1 (ru) 2012-11-08 2015-10-30 Ф.Хоффманн-Ля Рош Аг Анти-her3/her4 антигенсвязывающие белки, связывающиеся с бета-шпилькой her3 и бета-шпилькой her4
MX2016014862A (es) 2014-05-14 2017-02-27 Hoffmann La Roche Her3 / her2 anticuerpos biespecificos que se unen a la horquilla beta de her3 y al dominio ii de her2.
CN108136000B (zh) * 2015-09-30 2022-11-08 勃林格殷格翰动物保健有限公司 经改良的模块化抗原转运分子及其在动物中的用途
BR112018012055A2 (pt) * 2015-12-15 2018-12-04 Hoffmann La Roche substrato de transglutaminase (tg) recombinante, método in vitro para marcar uma proteína de interesse, composição farmacêutica ou de diagnóstico e kit de diagnóstico
WO2020010009A1 (en) * 2018-07-02 2020-01-09 Siemens Healthcare Diagnostics Inc. Direct immunoassay measurement of autoantibodies
DE102019004812B4 (de) 2019-07-10 2021-03-18 Institut Virion-Serion GmbH Würzburg Rubella Virus Spike Konstrukt
CN115197941A (zh) * 2021-04-08 2022-10-18 中国科学院分子细胞科学卓越创新中心 具有分子伴侣功能的rna及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1360638A (zh) * 1999-04-15 2002-07-24 荷兰克鲁塞尔公司 用编码腺病毒e1蛋白的序列在人体细胞中生产重组蛋白
CN1433472A (zh) * 1999-11-26 2003-07-30 克鲁塞尔荷兰公司 疫苗的生产
EP1780282A1 (en) * 2005-10-26 2007-05-02 Roche Diagnostics GmbH Recombinant expression of Rubella E1 envelope protein variants as chaperone fusion-proteins, and their use in the detection of anti-Rubella antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU736670B2 (en) 1996-09-26 2001-08-02 Medical Research Council Chaperone fragments
PL215170B1 (pl) 2001-06-22 2013-10-31 Hoffmann La Roche Sposób wytwarzania rozpuszczalnego kompleksu zawierajacego amyloidogenne bialko docelowe oraz bialko opiekuncze z klasy izomeraz peptydyloprolilowych
CA2562738C (en) * 2005-10-26 2011-07-12 F. Hoffmann-La Roche Ag Soluble rubella e1 envelope antigens

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1360638A (zh) * 1999-04-15 2002-07-24 荷兰克鲁塞尔公司 用编码腺病毒e1蛋白的序列在人体细胞中生产重组蛋白
CN1433472A (zh) * 1999-11-26 2003-07-30 克鲁塞尔荷兰公司 疫苗的生产
EP1780282A1 (en) * 2005-10-26 2007-05-02 Roche Diagnostics GmbH Recombinant expression of Rubella E1 envelope protein variants as chaperone fusion-proteins, and their use in the detection of anti-Rubella antibodies

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Analyses of Disulfides Present in the Rubella Virus E1 Glycoprotein;CHRISTOF GROS等;《VIROLOGY》;19970414;第230卷;第179-186页 *
Chaperone-Aided in Vitro Renaturation of an Engineered E1 Envelope Protein for Detection of Anti-Rubella Virus IgG Antibodies;Christian Scholz等;《Biochemistry》;20080311;第47卷;第4276-4287页 *
SlyD Proteins from Different Species Exhibit High Prolyl Isomerase and Chaperone Activities;Christian Scholz等;《Biochemistry》;20051208;第45卷;第20-33页 *

Also Published As

Publication number Publication date
US20110059552A1 (en) 2011-03-10
CA2705716C (en) 2013-03-19
ES2450998T3 (es) 2014-03-26
JP5461423B2 (ja) 2014-04-02
EP2222694A2 (en) 2010-09-01
WO2009074318A3 (en) 2009-07-30
EP2222694B1 (en) 2014-01-15
CN101939330A (zh) 2011-01-05
CA2705716A1 (en) 2009-06-18
HK1148026A1 (en) 2011-08-26
JP2011505811A (ja) 2011-03-03
US8551696B2 (en) 2013-10-08
WO2009074318A2 (en) 2009-06-18

Similar Documents

Publication Publication Date Title
CN101939330B (zh) 新型风疹e1包膜蛋白变体及其在检测抗风疹抗体中的用途
CN104080801B (zh) 可溶的免疫反应性的苍白密螺旋体TpN47抗原
US11567079B2 (en) Soluble and immunoreactive variants of HTLV capsid antigen P24
EP1780282B1 (en) Recombinant expression of Rubella E1 envelope protein variants as chaperone fusion-proteins, and their use in the detection of anti-Rubella antibodies
US7604935B2 (en) Soluble rubella E1 envelope protein variants
HK1148026B (en) Novel rubella e1 envelope protein variants and their use in the detection of antirubella antibodies
CN106699895A (zh) 一种新型融合抗原和包含其的检测试剂盒及应用
HK1202126B (en) Soluble immunoreactive treponema pallidum tpn47 antigens

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1148026

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1148026

Country of ref document: HK