JP5461423B2 - 新規風疹e1エンベロープタンパク質変異体および抗風疹抗体の検出におけるその使用 - Google Patents

新規風疹e1エンベロープタンパク質変異体および抗風疹抗体の検出におけるその使用 Download PDF

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JP5461423B2
JP5461423B2 JP2010537314A JP2010537314A JP5461423B2 JP 5461423 B2 JP5461423 B2 JP 5461423B2 JP 2010537314 A JP2010537314 A JP 2010537314A JP 2010537314 A JP2010537314 A JP 2010537314A JP 5461423 B2 JP5461423 B2 JP 5461423B2
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rubella
antigen
cys
disulfide
protein
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JP2011505811A5 (enExample
JP2011505811A (ja
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ショルツ,クリスティアン
ボルハーゲン,ラルフ
エンゲル,アルフレート
ファーツ,エルケ
シャールシュミット,ペーター
ウプマイアー,バルバラ
ツァルント,トラルフ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36211Rubivirus, e.g. rubella virus
    • C12N2770/36222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/18Togaviridae; Flaviviridae
    • G01N2333/19Rubella virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2010537314A 2007-12-13 2008-12-11 新規風疹e1エンベロープタンパク質変異体および抗風疹抗体の検出におけるその使用 Active JP5461423B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07024190 2007-12-13
EP07024190.6 2007-12-13
PCT/EP2008/010532 WO2009074318A2 (en) 2007-12-13 2008-12-11 Novel rubella e1 envelope protein variants and their use in the detection of anti-rubella antibodies

Publications (3)

Publication Number Publication Date
JP2011505811A JP2011505811A (ja) 2011-03-03
JP2011505811A5 JP2011505811A5 (enExample) 2011-06-30
JP5461423B2 true JP5461423B2 (ja) 2014-04-02

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JP2010537314A Active JP5461423B2 (ja) 2007-12-13 2008-12-11 新規風疹e1エンベロープタンパク質変異体および抗風疹抗体の検出におけるその使用

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Country Link
US (1) US8551696B2 (enExample)
EP (1) EP2222694B1 (enExample)
JP (1) JP5461423B2 (enExample)
CN (1) CN101939330B (enExample)
CA (1) CA2705716C (enExample)
ES (1) ES2450998T3 (enExample)
WO (1) WO2009074318A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2706115A1 (en) 2012-09-06 2014-03-12 Roche Diagnostics GmbH Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays
EA201500503A1 (ru) 2012-11-08 2015-10-30 Ф.Хоффманн-Ля Рош Аг Анти-her3/her4 антигенсвязывающие белки, связывающиеся с бета-шпилькой her3 и бета-шпилькой her4
MX2016014862A (es) 2014-05-14 2017-02-27 Hoffmann La Roche Her3 / her2 anticuerpos biespecificos que se unen a la horquilla beta de her3 y al dominio ii de her2.
CN108136000B (zh) * 2015-09-30 2022-11-08 勃林格殷格翰动物保健有限公司 经改良的模块化抗原转运分子及其在动物中的用途
BR112018012055A2 (pt) * 2015-12-15 2018-12-04 Hoffmann La Roche substrato de transglutaminase (tg) recombinante, método in vitro para marcar uma proteína de interesse, composição farmacêutica ou de diagnóstico e kit de diagnóstico
WO2020010009A1 (en) * 2018-07-02 2020-01-09 Siemens Healthcare Diagnostics Inc. Direct immunoassay measurement of autoantibodies
DE102019004812B4 (de) 2019-07-10 2021-03-18 Institut Virion-Serion GmbH Würzburg Rubella Virus Spike Konstrukt
CN115197941A (zh) * 2021-04-08 2022-10-18 中国科学院分子细胞科学卓越创新中心 具有分子伴侣功能的rna及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU736670B2 (en) 1996-09-26 2001-08-02 Medical Research Council Chaperone fragments
ATE289354T1 (de) * 1999-04-15 2005-03-15 Crucell Holland Bv Verwendung von adenovirus e1 protein sequenzen kodierenden, zur herstellung von rekombinanten proteinen in menschlichen zellen.
EP1103610A1 (en) * 1999-11-26 2001-05-30 Introgene B.V. Production of vaccines from immortalised mammalian cell lines
PL215170B1 (pl) 2001-06-22 2013-10-31 Hoffmann La Roche Sposób wytwarzania rozpuszczalnego kompleksu zawierajacego amyloidogenne bialko docelowe oraz bialko opiekuncze z klasy izomeraz peptydyloprolilowych
EP1780282B1 (en) * 2005-10-26 2010-12-08 Roche Diagnostics GmbH Recombinant expression of Rubella E1 envelope protein variants as chaperone fusion-proteins, and their use in the detection of anti-Rubella antibodies
CA2562738C (en) * 2005-10-26 2011-07-12 F. Hoffmann-La Roche Ag Soluble rubella e1 envelope antigens

Also Published As

Publication number Publication date
US20110059552A1 (en) 2011-03-10
CN101939330B (zh) 2014-06-04
CA2705716C (en) 2013-03-19
ES2450998T3 (es) 2014-03-26
EP2222694A2 (en) 2010-09-01
WO2009074318A3 (en) 2009-07-30
EP2222694B1 (en) 2014-01-15
CN101939330A (zh) 2011-01-05
CA2705716A1 (en) 2009-06-18
HK1148026A1 (en) 2011-08-26
JP2011505811A (ja) 2011-03-03
US8551696B2 (en) 2013-10-08
WO2009074318A2 (en) 2009-06-18

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