ES2444011T3 - Procedimiento y dispositivos para la determinación electroquímica de inhibidores de factor Xa en muestras de sangre - Google Patents

Procedimiento y dispositivos para la determinación electroquímica de inhibidores de factor Xa en muestras de sangre Download PDF

Info

Publication number
ES2444011T3
ES2444011T3 ES07819390.1T ES07819390T ES2444011T3 ES 2444011 T3 ES2444011 T3 ES 2444011T3 ES 07819390 T ES07819390 T ES 07819390T ES 2444011 T3 ES2444011 T3 ES 2444011T3
Authority
ES
Spain
Prior art keywords
factor
reagent
sample
thrombin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07819390.1T
Other languages
English (en)
Spanish (es)
Inventor
Carina Horn
Liesel Doerge
Margarete Galm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2444011T3 publication Critical patent/ES2444011T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES07819390.1T 2006-10-31 2007-10-27 Procedimiento y dispositivos para la determinación electroquímica de inhibidores de factor Xa en muestras de sangre Active ES2444011T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06123234 2006-10-31
EP06123234A EP1918718A1 (de) 2006-10-31 2006-10-31 Verfahren und Vorrichtungen zur elektrochemischen Bestimmung von Faktor Xa-Inhibitoren in Blutproben
PCT/EP2007/009347 WO2008052718A1 (de) 2006-10-31 2007-10-27 Verfahren und vorrichtungen zur elektrochemischen bestimmung von faktor xa-inhibitoren in blutproben

Publications (1)

Publication Number Publication Date
ES2444011T3 true ES2444011T3 (es) 2014-02-21

Family

ID=37633621

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07819390.1T Active ES2444011T3 (es) 2006-10-31 2007-10-27 Procedimiento y dispositivos para la determinación electroquímica de inhibidores de factor Xa en muestras de sangre

Country Status (7)

Country Link
US (2) US8636894B2 (https=)
EP (2) EP1918718A1 (https=)
JP (1) JP5395669B2 (https=)
CN (1) CN101535498B (https=)
CA (1) CA2667957C (https=)
ES (1) ES2444011T3 (https=)
WO (1) WO2008052718A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2471945A1 (de) * 2010-12-30 2012-07-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung von Inhibitoren der Gerinnung
JP5946139B2 (ja) * 2011-03-16 2016-07-05 学校法人 芝浦工業大学 抗凝固薬測定用センサ
EP2818871A1 (en) 2013-06-28 2014-12-31 Roche Diagniostics GmbH Means and methods for universal calibration of anti-Factor Xa tests
WO2016049527A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Cartridge device with segmented fluidics for assaying coagulation in fluid samples
WO2016049506A1 (en) * 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Sensors for assaying coagulation in fluid samples
US10114031B2 (en) 2014-09-26 2018-10-30 Abbott Point Of Care Inc. Single channel cartridge device for coagulation assays in fluid samples
EP3198281B1 (en) 2014-09-26 2023-01-25 Abbott Point Of Care, Inc. Ellagic acid formulations for use in coagulation assays
WO2016049533A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Cartridge device with fluidic junctions for coagulation assays in fluid samples
WO2016049515A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples
CN107107057B (zh) 2014-09-26 2020-12-15 雅培医护站股份有限公司 用于流体样本中的凝结测定的盒设备识别
CN104714036B (zh) * 2015-04-01 2016-06-01 成都协和生物技术有限责任公司 抗凝血酶iii活性测定试剂盒的制备方法
CN105203479A (zh) * 2015-09-21 2015-12-30 山东万邦赛诺康生化制药股份有限公司 用血凝仪测定肝素或低分子量肝素效价的方法
EP3388838B1 (en) * 2016-01-29 2022-02-16 Sony Group Corporation Blood coagulation analysis
WO2018071982A1 (en) * 2016-10-20 2018-04-26 Universal Biosensors Pty Ltd Non-biohazardous solutions and methods for testing analysers
US12073926B2 (en) 2020-09-21 2024-08-27 Instrumentation Laboratory Company Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample
CN117309966A (zh) * 2022-06-22 2023-12-29 广州好芝生物科技有限公司 血液样本中Xa因子抑制剂的检测方法及装置
CN115032164B (zh) * 2022-08-10 2022-12-06 山东省食品药品检验研究院 一种肝素钠中是否含有凝血因子Xa直接抑制剂的检测方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093237A (en) 1988-03-03 1992-03-03 Nippon Shoji Kabushiki Kaisha Method and reagent for determining the biological activity of antithrombin iii by measuring coagulation time
CA2070813C (en) 1990-11-05 1996-10-29 Hendrik Coenraad Hemker A method to determine the concentration of anticoagulants
US5308756A (en) * 1991-11-20 1994-05-03 Baxter Diagnostics Inc. Protein S chromogenic assay
EP0738389A1 (en) * 1992-09-04 1996-10-23 Gradipore Limited Apparatus and method for detecting coagulation/lysis of liquids
EP0685069A4 (en) * 1993-02-17 2002-01-23 Cardiovascular Diagnostics Inc IMMUNOASSAY AND AFFINITY TEST BASED ON A DRY-CHEMICAL CASCADE
US5762770A (en) * 1994-02-21 1998-06-09 Boehringer Mannheim Corporation Electrochemical biosensor test strip
EP1384725A3 (en) * 1994-04-26 2007-02-21 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
NL1006429C2 (nl) * 1997-06-27 1998-12-29 Univ Maastricht Werkwijze voor het bepalen van het heparinegehalte.
US5997817A (en) * 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
JP2003530819A (ja) * 1999-06-14 2003-10-21 ノボ ノルディスク アクティーゼルスカブ ＦＶＩＩａ／ＴＦ活性阻害化合物
WO2001044493A2 (en) 1999-12-15 2001-06-21 Pentapharm Ag Hematological assay and reagent
US6438498B1 (en) * 2000-02-10 2002-08-20 I-Stat Corporation System, method and computer implemented process for assaying coagulation in fluid samples
CA2400651A1 (en) * 2000-02-21 2001-08-30 F. Hoffmann-La Roche Ag Electrochemical sensor for determining blood clotting, corresponding system for measuring blood clotting and method for determining blood clotting
US20030146113A1 (en) * 2000-02-21 2003-08-07 Volker Unkrig Electrochemical sensor for determining blood clotting, corresponding system for measuring blood clotting and method for determining blood clotting
US7166208B2 (en) * 2004-03-03 2007-01-23 Stephen Eliot Zweig Apoenzyme reactivation electrochemical detection method and assay
US6680177B2 (en) * 2001-12-07 2004-01-20 Cardiovascular Diagnostics, Inc. Low molecular weight heparin assay, system and reagent therefor
US7579000B2 (en) * 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
WO2005031303A2 (en) * 2003-09-22 2005-04-07 University Of North Carolina At Chapel Hill Soluble phospholipids for use in clotting factor assays

Also Published As

Publication number Publication date
JP2010508499A (ja) 2010-03-18
EP1918718A1 (de) 2008-05-07
WO2008052718A1 (de) 2008-05-08
US20090236238A1 (en) 2009-09-24
EP2079849A1 (de) 2009-07-22
US8636894B2 (en) 2014-01-28
US9594042B2 (en) 2017-03-14
CN101535498A (zh) 2009-09-16
US20140106383A1 (en) 2014-04-17
CA2667957C (en) 2013-03-05
EP2079849B1 (de) 2013-11-20
JP5395669B2 (ja) 2014-01-22
CN101535498B (zh) 2012-11-14
HK1137783A1 (en) 2010-08-06
CA2667957A1 (en) 2008-05-08

Similar Documents

Publication Publication Date Title
ES2444011T3 (es) Procedimiento y dispositivos para la determinación electroquímica de inhibidores de factor Xa en muestras de sangre
JP6147463B2 (ja) 電気化学検出のための装置および方法
US6352630B1 (en) Electrochemical system for determining blood coagulation time
JP2003524184A (ja) 血液凝固測定用の電気化学センサー、対応する血液凝固測定システム、および血液凝固測定方法
ES2255121T3 (es) Procedimiento para la determinacion del potencial anticoagulante de una muestra y procedimiento para la determinacion de la glicosilacion de trombomodulina.
CZ20022733A3 (cs) Elektrochemický koagulační test a zařízení pro jeho provádění
Bradley et al. Immobilization barrier effects on the dynamic response characteristics of potentiometric adenosine deaminase enzyme electrodes
US8906639B2 (en) Method of determining factor XIII with the aid of plasma-based reference material
HK1137783B (en) Methods and apparatuses for electrochemical determination of factor xa inhibitors in blood samples
de Peuriot et al. Electrochemical activity determination of trypsin-like enzymes II—Thrombin
JP2818673B2 (ja) 繊維素溶解系の主要成分を測定する包括的試験
Corretge et al. Electroanalytical assay of human prekallikrein activation from whole blood dilutions
WO2025132678A1 (en) Qualitative test for direct oral anticoagulants (doacs)
Daraio de Peuriot et al. The Electrochemical Activity Determination of Trypsin‐Like Enzymes: V. A Comparative Study of the Electrochemical Oxidation of the Marker, p‐aminodiphenylamine, and of Electrogenic Substrates in Human Plasma, Whole Blood, and Aqueous Solutions
Blood The Electrochemical Activity Determination of Trypsin-Like Enzymes
HK1146839B (en) Apparatus and method for electrochemical detection