ES2425068T3 - Compuestos de pirido[2,3-d]pirimidin-7-ona como inhibidores de PI3K-alfa para el tratamiento del cáncer - Google Patents
Compuestos de pirido[2,3-d]pirimidin-7-ona como inhibidores de PI3K-alfa para el tratamiento del cáncer Download PDFInfo
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- ES2425068T3 ES2425068T3 ES08742864T ES08742864T ES2425068T3 ES 2425068 T3 ES2425068 T3 ES 2425068T3 ES 08742864 T ES08742864 T ES 08742864T ES 08742864 T ES08742864 T ES 08742864T ES 2425068 T3 ES2425068 T3 ES 2425068T3
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/025—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus inorganic Tc complexes or compounds
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Pathology (AREA)
- Mycology (AREA)
- Radiology & Medical Imaging (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91116007P | 2007-04-11 | 2007-04-11 | |
| US911160P | 2007-04-11 | ||
| PCT/US2008/004807 WO2008127712A1 (en) | 2007-04-11 | 2008-04-11 | Pyrido [2, 3-d] pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2425068T3 true ES2425068T3 (es) | 2013-10-11 |
Family
ID=39642739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08742864T Active ES2425068T3 (es) | 2007-04-11 | 2008-04-11 | Compuestos de pirido[2,3-d]pirimidin-7-ona como inhibidores de PI3K-alfa para el tratamiento del cáncer |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20100209340A1 (show.php) |
| EP (1) | EP2142544B8 (show.php) |
| JP (1) | JP2010523681A (show.php) |
| KR (1) | KR20090130104A (show.php) |
| CN (1) | CN101711249A (show.php) |
| AU (1) | AU2008239596B2 (show.php) |
| BR (1) | BRPI0810175A2 (show.php) |
| CA (1) | CA2683820A1 (show.php) |
| CO (1) | CO6241119A2 (show.php) |
| CR (1) | CR11098A (show.php) |
| DO (1) | DOP2009000242A (show.php) |
| EA (1) | EA018964B1 (show.php) |
| EC (1) | ECSP099722A (show.php) |
| ES (1) | ES2425068T3 (show.php) |
| IL (1) | IL201209A0 (show.php) |
| MA (1) | MA31336B1 (show.php) |
| MX (1) | MX2009010815A (show.php) |
| MY (1) | MY150747A (show.php) |
| NI (1) | NI200900183A (show.php) |
| NZ (1) | NZ579945A (show.php) |
| SV (1) | SV2009003389A (show.php) |
| TN (1) | TN2009000389A1 (show.php) |
| UA (1) | UA101315C2 (show.php) |
| WO (1) | WO2008127712A1 (show.php) |
| ZA (1) | ZA200906648B (show.php) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767687B2 (en) * | 2004-12-13 | 2010-08-03 | Biogen Idec Ma Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors |
| UA116188C2 (uk) * | 2005-10-07 | 2018-02-26 | Екселіксіс, Інк. | Інгібітори фосфатидилінозит-3-кінази і способи їх застосування |
| EA016945B1 (ru) * | 2005-10-07 | 2012-08-30 | Экселиксис, Инк. | ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα |
| AU2007284562B2 (en) | 2006-08-16 | 2013-05-02 | Exelixis, Inc. | Using PI3K and MEK modulators in treatments of cancer |
| DK2074122T5 (da) | 2006-09-15 | 2014-03-17 | Pfizer Prod Inc | Pyrido (2, 3-d) pyrimidin0n-forbindelser og anvendelse deraf som pi3 inhibitorer |
| RS52939B (sr) | 2007-04-10 | 2014-02-28 | Exelixis Inc. | Postupci za lečenje kancera upotrebom piridopirimidinonskih inhibitora pi3k alfa |
| EP2142543B8 (en) * | 2007-04-11 | 2013-07-03 | Exelixis, Inc. | Pyrido [2, 3-d]pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer |
| US8101622B2 (en) * | 2008-09-30 | 2012-01-24 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of PI3Kα and mTOR |
| US20120040950A1 (en) * | 2009-12-22 | 2012-02-16 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
| AR080151A1 (es) | 2010-02-09 | 2012-03-14 | Exelixis Inc | Metodos para tratar cancer usando inhibidores de piridopirimidinona de pi 3k y mtor en combinacion con inhibidores de autofagia |
| ES2693257T3 (es) | 2010-09-14 | 2018-12-10 | Exelixis, Inc. | Inhibidores de PI3K-delta y métodos para su uso y fabricación |
| WO2013056067A1 (en) * | 2011-10-13 | 2013-04-18 | Exelixis, Inc. | Compounds for use in the treatment of basal cell carcinoma |
| HK1201480A1 (en) | 2011-11-01 | 2015-09-04 | Exelixis, Inc. | N-(3-{[(3-{[2-chloro-5-(methoxy)phenyl]amino}quinoxalin-2-yl)amino]sulfonyl}phenyl)-2-methylalaninamide as phosphatidylinositol 3-kinase inhibitor for the treatment of lymphoproliferative malignancies |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2937284A (en) * | 1958-05-01 | 1960-05-17 | Burroughs Wellcome Co | 2, 4-diamino-5, 6-dialkylpyrido (2, 3-d) pyrimidines and method |
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| US7019002B2 (en) * | 2001-12-11 | 2006-03-28 | Pharmacia & Upjohn, S.P.A. | Pyridopyrimidinones derivatives as telomerase inhibitors |
| ATE373659T1 (de) * | 2004-05-04 | 2007-10-15 | Warner Lambert Co | Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel |
| EA016945B1 (ru) * | 2005-10-07 | 2012-08-30 | Экселиксис, Инк. | ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα |
| AU2006302148B2 (en) * | 2005-10-07 | 2012-12-06 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of PI3Kalpha |
| AU2007284562B2 (en) * | 2006-08-16 | 2013-05-02 | Exelixis, Inc. | Using PI3K and MEK modulators in treatments of cancer |
| DK2074122T5 (da) * | 2006-09-15 | 2014-03-17 | Pfizer Prod Inc | Pyrido (2, 3-d) pyrimidin0n-forbindelser og anvendelse deraf som pi3 inhibitorer |
-
2008
- 2008-04-11 EP EP08742864.5A patent/EP2142544B8/en active Active
- 2008-04-11 MY MYPI20094194 patent/MY150747A/en unknown
- 2008-04-11 US US12/595,233 patent/US20100209340A1/en not_active Abandoned
- 2008-04-11 MX MX2009010815A patent/MX2009010815A/es active IP Right Grant
- 2008-04-11 EA EA200970936A patent/EA018964B1/ru not_active IP Right Cessation
- 2008-04-11 NZ NZ579945A patent/NZ579945A/en not_active IP Right Cessation
- 2008-04-11 ES ES08742864T patent/ES2425068T3/es active Active
- 2008-04-11 BR BRPI0810175-2A2A patent/BRPI0810175A2/pt not_active IP Right Cessation
- 2008-04-11 CA CA002683820A patent/CA2683820A1/en not_active Abandoned
- 2008-04-11 KR KR1020097023146A patent/KR20090130104A/ko not_active Ceased
- 2008-04-11 UA UAA200911451A patent/UA101315C2/ru unknown
- 2008-04-11 CN CN200880018758A patent/CN101711249A/zh active Pending
- 2008-04-11 AU AU2008239596A patent/AU2008239596B2/en not_active Ceased
- 2008-04-11 WO PCT/US2008/004807 patent/WO2008127712A1/en not_active Ceased
- 2008-04-11 JP JP2010503085A patent/JP2010523681A/ja active Pending
-
2009
- 2009-09-23 ZA ZA200906648A patent/ZA200906648B/xx unknown
- 2009-09-24 TN TNP2009000389A patent/TN2009000389A1/fr unknown
- 2009-09-29 IL IL201209A patent/IL201209A0/en unknown
- 2009-10-09 SV SV2009003389A patent/SV2009003389A/es not_active Application Discontinuation
- 2009-10-09 NI NI200900183A patent/NI200900183A/es unknown
- 2009-10-09 DO DO2009000242A patent/DOP2009000242A/es unknown
- 2009-10-30 MA MA32314A patent/MA31336B1/fr unknown
- 2009-11-09 CR CR11098A patent/CR11098A/es unknown
- 2009-11-09 CO CO09126919A patent/CO6241119A2/es not_active Application Discontinuation
- 2009-11-09 EC EC2009009722A patent/ECSP099722A/es unknown
-
2013
- 2013-01-03 US US13/694,772 patent/US20130343988A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2142544B8 (en) | 2013-07-03 |
| SV2009003389A (es) | 2010-04-27 |
| CA2683820A1 (en) | 2008-10-23 |
| EP2142544A1 (en) | 2010-01-13 |
| JP2010523681A (ja) | 2010-07-15 |
| EP2142544B1 (en) | 2013-05-22 |
| AU2008239596A1 (en) | 2008-10-23 |
| TN2009000389A1 (en) | 2010-12-31 |
| CR11098A (es) | 2010-01-27 |
| ECSP099722A (es) | 2009-12-28 |
| NI200900183A (es) | 2010-10-05 |
| US20130343988A1 (en) | 2013-12-26 |
| CO6241119A2 (es) | 2011-01-20 |
| MY150747A (en) | 2014-02-28 |
| WO2008127712A1 (en) | 2008-10-23 |
| CN101711249A (zh) | 2010-05-19 |
| EA200970936A1 (ru) | 2010-02-26 |
| UA101315C2 (ru) | 2013-03-25 |
| US20100209340A1 (en) | 2010-08-19 |
| BRPI0810175A2 (pt) | 2014-12-30 |
| EA018964B1 (ru) | 2013-12-30 |
| KR20090130104A (ko) | 2009-12-17 |
| NZ579945A (en) | 2012-05-25 |
| HK1139941A1 (en) | 2010-09-30 |
| MA31336B1 (fr) | 2010-04-01 |
| MX2009010815A (es) | 2009-10-29 |
| DOP2009000242A (es) | 2010-04-30 |
| IL201209A0 (en) | 2010-05-31 |
| AU2008239596B2 (en) | 2013-08-15 |
| ZA200906648B (en) | 2010-04-28 |
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