ES2421639T3 - Métodos para utilizar antagonistas de vasopresina con agentes quimioterapéuticos de antraciclina para reducir la cardiotoxicidad y/o mejorar la supervivencia - Google Patents

Métodos para utilizar antagonistas de vasopresina con agentes quimioterapéuticos de antraciclina para reducir la cardiotoxicidad y/o mejorar la supervivencia

Info

Publication number
ES2421639T3
ES2421639T3 ES08755284T ES08755284T ES2421639T3 ES 2421639 T3 ES2421639 T3 ES 2421639T3 ES 08755284 T ES08755284 T ES 08755284T ES 08755284 T ES08755284 T ES 08755284T ES 2421639 T3 ES2421639 T3 ES 2421639T3
Authority
ES
Spain
Prior art keywords
methods
chemotherapeutic agents
improve survival
vasopressin antagonists
anthracycline chemotherapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08755284T
Other languages
English (en)
Inventor
Yongge Liu
Junichi Kambayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2421639T3 publication Critical patent/ES2421639T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Tolvaptan o una sal farmacéuticamente aceptable del mismo para su uso en un método de reducción de la cardiotoxicidad y/o mejora de la supervivencia a la quimioterapia con doxorrubicina en el que el tolvaptan o una sal farmacéuticamente aceptable del mismo se administran simultáneamente o antes de la administración de la doxorrubicina.
ES08755284T 2007-05-15 2008-05-12 Métodos para utilizar antagonistas de vasopresina con agentes quimioterapéuticos de antraciclina para reducir la cardiotoxicidad y/o mejorar la supervivencia Active ES2421639T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93808907P 2007-05-15 2007-05-15
PCT/US2008/063374 WO2008144269A2 (en) 2007-05-15 2008-05-12 Methods for using vasopressin antagonists with anthracycline chemotherapy agents to reduce cardiotoxicity and/or improve survival

Publications (1)

Publication Number Publication Date
ES2421639T3 true ES2421639T3 (es) 2013-09-04

Family

ID=40122254

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08755284T Active ES2421639T3 (es) 2007-05-15 2008-05-12 Métodos para utilizar antagonistas de vasopresina con agentes quimioterapéuticos de antraciclina para reducir la cardiotoxicidad y/o mejorar la supervivencia

Country Status (25)

Country Link
US (1) US8372830B2 (es)
EP (1) EP2146721B1 (es)
KR (1) KR101508797B1 (es)
CN (2) CN103550233A (es)
AR (1) AR066544A1 (es)
AU (1) AU2008254273B2 (es)
BR (1) BRPI0811134A2 (es)
CA (1) CA2685186A1 (es)
CO (1) CO6280574A2 (es)
CY (1) CY1114163T1 (es)
DK (1) DK2146721T3 (es)
ES (1) ES2421639T3 (es)
HK (2) HK1138772A1 (es)
HR (1) HRP20130920T1 (es)
IL (1) IL202094A (es)
MX (1) MX2009012164A (es)
MY (1) MY150682A (es)
NZ (1) NZ581126A (es)
PL (1) PL2146721T3 (es)
PT (1) PT2146721E (es)
RU (1) RU2470643C2 (es)
SI (1) SI2146721T1 (es)
TW (1) TWI428131B (es)
UA (1) UA99914C2 (es)
WO (1) WO2008144269A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2211906A2 (en) * 2007-11-07 2010-08-04 Janssen Pharmaceutica, N.V. Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists
WO2013176955A1 (en) * 2012-05-21 2013-11-28 The General Hospital Corporation Cardioprotective compounds, their use with chemotherapy, and methods for identifying them
US20150238502A1 (en) * 2012-10-18 2015-08-27 University Of South Florida Compositions and Methods for Treating Stroke
EP2970311A4 (en) 2013-03-14 2016-11-23 Brigham & Womens Hospital BMP INHIBITORS AND METHODS OF USE
US11491154B2 (en) 2013-04-08 2022-11-08 Dennis M. Brown Therapeutic benefit of suboptimally administered chemical compounds
US10172911B2 (en) 2013-10-01 2019-01-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of modulating erythropoiesis with arginine vasopressin receptor 1B molecules
WO2016011019A1 (en) 2014-07-15 2016-01-21 The Brigham And Women's Hospital, Inc. Compositions and methods for inhibiting bmp
CN116063580A (zh) 2016-01-04 2023-05-05 艾得佩索拉公司 肽类似物
WO2017139154A1 (en) * 2016-02-09 2017-08-17 Adepthera Llc Dosing and use of long-acting clr/ramp agonists
WO2018226875A2 (en) * 2017-06-07 2018-12-13 University Of Kansas Methods and medicaments for the treatment of renal cell carcinoma
US20190153059A1 (en) 2017-06-30 2019-05-23 Adepthera Llc Peptide analogs
TWI737974B (zh) 2018-04-09 2021-09-01 美商標徑製藥公司 用於治療增生性失調的劑量方案

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US574455A (en) * 1897-01-05 Switch-lock
US5744455A (en) * 1988-01-27 1998-04-28 New York University Reduction of anthracycline-induced cardiotoxicity
TWI322689B (en) * 2003-02-24 2010-04-01 Otsuka Pharma Co Ltd Method for treating severe heart failure and medicament therefor

Also Published As

Publication number Publication date
HK1176318A1 (en) 2013-07-26
CA2685186A1 (en) 2008-11-27
HK1138772A1 (en) 2010-09-03
US8372830B2 (en) 2013-02-12
TW200916104A (en) 2009-04-16
KR101508797B1 (ko) 2015-04-06
SI2146721T1 (sl) 2013-10-30
KR20100019439A (ko) 2010-02-18
CO6280574A2 (es) 2011-05-20
EP2146721A4 (en) 2010-08-25
NZ581126A (en) 2012-04-27
BRPI0811134A2 (pt) 2014-09-30
RU2009146376A (ru) 2011-06-20
AU2008254273B2 (en) 2013-03-28
CN101808517A (zh) 2010-08-18
MX2009012164A (es) 2009-12-09
CN103550233A (zh) 2014-02-05
AU2008254273A1 (en) 2008-11-27
WO2008144269A2 (en) 2008-11-27
EP2146721A2 (en) 2010-01-27
IL202094A0 (en) 2010-06-16
AR066544A1 (es) 2009-08-26
UA99914C2 (ru) 2012-10-25
CY1114163T1 (el) 2016-08-31
RU2470643C2 (ru) 2012-12-27
TWI428131B (zh) 2014-03-01
DK2146721T3 (da) 2013-07-22
WO2008144269A3 (en) 2010-01-21
US20100249104A1 (en) 2010-09-30
MY150682A (en) 2014-02-28
PL2146721T3 (pl) 2013-12-31
HRP20130920T1 (hr) 2013-11-08
IL202094A (en) 2015-06-30
EP2146721B1 (en) 2013-07-10
PT2146721E (pt) 2013-07-18

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