ES2402142T3 - Biomarcadores para la enfermedad del hígado graso y métodos que utilizan los mismos - Google Patents

Biomarcadores para la enfermedad del hígado graso y métodos que utilizan los mismos Download PDF

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Publication number
ES2402142T3
ES2402142T3 ES08845659T ES08845659T ES2402142T3 ES 2402142 T3 ES2402142 T3 ES 2402142T3 ES 08845659 T ES08845659 T ES 08845659T ES 08845659 T ES08845659 T ES 08845659T ES 2402142 T3 ES2402142 T3 ES 2402142T3
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ES
Spain
Prior art keywords
metabolite
steatohepatitis
biomarkers
levels
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08845659T
Other languages
English (en)
Spanish (es)
Inventor
Bruce J. Mccreedy, Jr.
Alvin Berger
Yunfu Hu
Satish C. Kalhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cleveland Clinic Foundation
Metabolon Inc
Original Assignee
Cleveland Clinic Foundation
Metabolon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of ES2402142T3 publication Critical patent/ES2402142T3/es
Active legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/16—Phosphorus containing
    • Y10T436/163333—Organic [e.g., chemical warfare agents, insecticides, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
ES08845659T 2007-11-02 2008-10-31 Biomarcadores para la enfermedad del hígado graso y métodos que utilizan los mismos Active ES2402142T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US98494207P 2007-11-02 2007-11-02
US984942P 2007-11-02
US4245908P 2008-04-04 2008-04-04
US42459P 2008-04-04
PCT/US2008/082013 WO2009059150A2 (en) 2007-11-02 2008-10-31 Biomarkers for fatty liver disease and methods using the same

Publications (1)

Publication Number Publication Date
ES2402142T3 true ES2402142T3 (es) 2013-04-29

Family

ID=40591773

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08845659T Active ES2402142T3 (es) 2007-11-02 2008-10-31 Biomarcadores para la enfermedad del hígado graso y métodos que utilizan los mismos

Country Status (5)

Country Link
US (3) US20100279956A1 (https=)
EP (3) EP2930512B1 (https=)
JP (1) JP5270684B2 (https=)
ES (1) ES2402142T3 (https=)
WO (1) WO2009059150A2 (https=)

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CN102105793A (zh) * 2008-05-28 2011-06-22 巴斯夫欧洲公司 评估肝酶诱导的工具和方法
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EP2475781B1 (en) * 2009-09-11 2017-10-25 The Chinese University Of Hong Kong Methods for assessing liver pathologies
JP2011232164A (ja) * 2010-04-27 2011-11-17 Keio Gijuku 肝臓疾患マーカー、その測定方法、装置及び医薬品の検定方法
WO2012000770A1 (en) 2010-06-10 2012-01-05 Metanomics Health Gmbh Methods to diagnose liver diseases
WO2011158590A1 (ja) * 2010-06-18 2011-12-22 学校法人 慶應義塾 肝臓疾患マーカー、その測定方法、装置及び医薬品の検定方法
US8728824B2 (en) 2011-06-22 2014-05-20 Quest Diagnostics Investments Inc. Mass spectrometric determination of fatty acids
WO2013002381A1 (ja) * 2011-06-30 2013-01-03 味の素株式会社 脂肪性肝疾患の評価方法、脂肪性肝疾患評価装置、脂肪性肝疾患評価方法、脂肪性肝疾患評価プログラム、脂肪性肝疾患評価システム、情報通信端末装置、および脂肪性肝疾患の予防・改善物質の探索方法
MX2015003642A (es) 2012-09-21 2016-07-11 Univ Toronto Cmpf como biomarcador para diabetes y metodos asociados.
WO2016049828A1 (zh) * 2014-09-30 2016-04-07 深圳华大基因科技有限公司 肥胖人群特异性生物标志组合物及其用途
JP2018502286A (ja) * 2014-11-19 2018-01-25 メタボロン，インコーポレイテッド 脂肪肝疾患のバイオマーカーおよびその使用方法
RU2617236C1 (ru) * 2015-12-02 2017-04-24 государственное бюджетное образовательное учреждение высшего профессионального образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения Российской Федерации Способ определения целесообразности проведения иммунологического обследования у пациентов неалкогольной жировой болезнью печени
WO2017184586A1 (en) 2016-04-18 2017-10-26 The Trustees Of Columbia University In The City Of New York Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (nash)
WO2017210147A1 (en) 2016-05-29 2017-12-07 Wei Jia Liver disease-related biomarkers and methods of use thereof
EP3502703A1 (en) 2017-12-22 2019-06-26 Metanomics Health GmbH Method for the assessment of nafld
CN109060977B (zh) * 2018-07-13 2024-07-02 深圳市绘云生物科技有限公司 用于肝纤维化和肝硬化诊断的生物标志物和试剂盒及使用方法
US11693005B2 (en) 2018-08-07 2023-07-04 Florida Atlantic University Board Of Trustees Methods for identifying treatments that reduce the actions of substances of abuse and addiction
WO2020066162A1 (ja) * 2018-09-26 2020-04-02 株式会社島津製作所 非アルコール性脂肪肝疾患の検出方法、非アルコール性脂肪肝疾患検出用キットおよび非アルコール性脂肪肝疾患検出用バイオマーカー
WO2020154567A1 (en) * 2019-01-25 2020-07-30 Viscient Biosciences, Inc. Compositions and methods for the diagnosis and treatment of diseases of the liver
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Also Published As

Publication number Publication date
WO2009059150A2 (en) 2009-05-07
EP2546649A3 (en) 2013-03-27
EP2227689B1 (en) 2012-12-26
HK1216189A1 (en) 2016-10-21
EP2930512A2 (en) 2015-10-14
JP5270684B2 (ja) 2013-08-21
US9977034B2 (en) 2018-05-22
US20190120855A1 (en) 2019-04-25
US20150377910A1 (en) 2015-12-31
EP2227689A4 (en) 2011-03-30
EP2227689A2 (en) 2010-09-15
EP2930512A3 (en) 2015-12-02
JP2011503547A (ja) 2011-01-27
EP2930512B1 (en) 2018-01-31
EP2546649A2 (en) 2013-01-16
WO2009059150A3 (en) 2009-06-18
US20100279956A1 (en) 2010-11-04
EP2546649B1 (en) 2015-02-25

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