ES2402142T3 - Biomarcadores para la enfermedad del hígado graso y métodos que utilizan los mismos - Google Patents
Biomarcadores para la enfermedad del hígado graso y métodos que utilizan los mismos Download PDFInfo
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- ES2402142T3 ES2402142T3 ES08845659T ES08845659T ES2402142T3 ES 2402142 T3 ES2402142 T3 ES 2402142T3 ES 08845659 T ES08845659 T ES 08845659T ES 08845659 T ES08845659 T ES 08845659T ES 2402142 T3 ES2402142 T3 ES 2402142T3
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| US98494207P | 2007-11-02 | 2007-11-02 | |
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| US4245908P | 2008-04-04 | 2008-04-04 | |
| US42459P | 2008-04-04 | ||
| PCT/US2008/082013 WO2009059150A2 (en) | 2007-11-02 | 2008-10-31 | Biomarkers for fatty liver disease and methods using the same |
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| ES2402142T3 true ES2402142T3 (es) | 2013-04-29 |
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| ES08845659T Active ES2402142T3 (es) | 2007-11-02 | 2008-10-31 | Biomarcadores para la enfermedad del hígado graso y métodos que utilizan los mismos |
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| WO2009153136A2 (en) | 2008-05-28 | 2009-12-23 | Basf Se | Means and methods for assessing liver toxicity |
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| CN102265160B (zh) * | 2008-12-24 | 2014-07-23 | 学校法人庆应义塾 | 肝病标记物、其测定方法、装置和医药品的检验方法 |
| WO2011029899A1 (en) * | 2009-09-11 | 2011-03-17 | The Chinese University Of Hong Kong | Methods for assessing liver pathologies |
| JP2011232164A (ja) * | 2010-04-27 | 2011-11-17 | Keio Gijuku | 肝臓疾患マーカー、その測定方法、装置及び医薬品の検定方法 |
| EP2863227B1 (en) * | 2010-06-10 | 2017-09-27 | Metanomics Health GmbH | Means and methods for metabolic differentiation of non-alcoholic steatohepatitis from liver disease |
| US20130116148A1 (en) * | 2010-06-18 | 2013-05-09 | Keio University | Liver disease marker, method and apparatus for measuring the same, and method for assaying pharmaceutical preparation |
| US8728824B2 (en) | 2011-06-22 | 2014-05-20 | Quest Diagnostics Investments Inc. | Mass spectrometric determination of fatty acids |
| WO2013002381A1 (ja) * | 2011-06-30 | 2013-01-03 | 味の素株式会社 | 脂肪性肝疾患の評価方法、脂肪性肝疾患評価装置、脂肪性肝疾患評価方法、脂肪性肝疾患評価プログラム、脂肪性肝疾患評価システム、情報通信端末装置、および脂肪性肝疾患の予防・改善物質の探索方法 |
| BR112015006284A2 (pt) | 2012-09-21 | 2017-07-04 | Governing Council Univ Toronto | cpmf como um biomarcador para diabetes e métodos associados |
| WO2016049828A1 (zh) * | 2014-09-30 | 2016-04-07 | 深圳华大基因科技有限公司 | 肥胖人群特异性生物标志组合物及其用途 |
| EP3221463A4 (en) * | 2014-11-19 | 2018-07-25 | Metabolon, Inc. | Biomarkers for fatty liver disease and methods using the same |
| RU2617236C1 (ru) * | 2015-12-02 | 2017-04-24 | государственное бюджетное образовательное учреждение высшего профессионального образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения Российской Федерации | Способ определения целесообразности проведения иммунологического обследования у пациентов неалкогольной жировой болезнью печени |
| US12285464B2 (en) | 2016-04-18 | 2025-04-29 | The Trustees Of Columbia University In The City Of New York | Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (NASH) |
| CN115236166A (zh) | 2016-05-29 | 2022-10-25 | 深圳市绘云生物科技有限公司 | 肝病相关生物标志物和其使用方法 |
| EP3502703A1 (en) | 2017-12-22 | 2019-06-26 | Metanomics Health GmbH | Method for the assessment of nafld |
| CN109060977B (zh) * | 2018-07-13 | 2024-07-02 | 深圳市绘云生物科技有限公司 | 用于肝纤维化和肝硬化诊断的生物标志物和试剂盒及使用方法 |
| US11693005B2 (en) | 2018-08-07 | 2023-07-04 | Florida Atlantic University Board Of Trustees | Methods for identifying treatments that reduce the actions of substances of abuse and addiction |
| JP6998023B2 (ja) * | 2018-09-26 | 2022-02-10 | 株式会社島津製作所 | 非アルコール性脂肪肝疾患の検出方法、非アルコール性脂肪肝疾患検出用キットおよび非アルコール性脂肪肝疾患検出用バイオマーカー |
| WO2020154567A1 (en) * | 2019-01-25 | 2020-07-30 | Viscient Biosciences, Inc. | Compositions and methods for the diagnosis and treatment of diseases of the liver |
| US20230203583A1 (en) * | 2020-05-04 | 2023-06-29 | University Of Florida Research Foundation, Incorporated | Biomarkers for assessing liver disease |
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| CN116165385B (zh) * | 2023-04-25 | 2023-07-18 | 南方医科大学南方医院 | 用于肝癌诊断的血清代谢标志物及其筛选方法和应用 |
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| WO2002092768A2 (en) * | 2001-05-14 | 2002-11-21 | University Of Maryland, Baltimore | Novel alanine transaminase enzyme and methods of use |
| JP2003139753A (ja) * | 2001-11-02 | 2003-05-14 | Mitsubishi Pharma Corp | 胆汁酸１８成分の一斉分析法 |
| US20040121305A1 (en) * | 2002-12-18 | 2004-06-24 | Wiegand Roger Charles | Generation of efficacy, toxicity and disease signatures and methods of use thereof |
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| US7078064B2 (en) * | 2003-12-03 | 2006-07-18 | George Zabrecky | Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis |
| EP1739431A4 (en) * | 2004-04-23 | 2008-10-15 | Ajinomoto Kk | METHOD FOR ASSESSING NON-ALCOHOLIC STEATOHEPATITIS |
| EP1619257A1 (en) * | 2004-07-23 | 2006-01-25 | One Way Liver Genomics, S.L. | Method for the in vitro diagnosis of non-alcoholic steatohepatitis |
| US20060160237A1 (en) * | 2004-12-06 | 2006-07-20 | Applera Corporation | Method of screening urine for organic acids |
| US7860656B2 (en) * | 2005-02-03 | 2010-12-28 | Assistance Publique-Hopitaux De Paris (Ap-Hp) | Diagnosis method of hepatic steatosis using biochemical markers |
| US20070004045A1 (en) * | 2005-06-07 | 2007-01-04 | Xia Xu | Analysis of large numbers of estrogens and other steroids and applications thereof |
| US7972785B2 (en) * | 2006-01-24 | 2011-07-05 | Industrial Technology Research Institute (Itri) | Biomarkers for liver fibrotic injury |
| JP5227168B2 (ja) * | 2006-03-29 | 2013-07-03 | ヤマサ醤油株式会社 | 肝障害の検出方法、判定方法及び予測方法 |
| EP2009444B1 (en) * | 2006-04-06 | 2012-02-29 | Eisai R&D Management Co., Ltd. | Non-invasive test method for non-alcoholic steatohepatitis based on cytochrome-c quantification |
| WO2007136674A1 (en) | 2006-05-19 | 2007-11-29 | The Cleveland Clinic Foundation | Detection and monitoring of liver damage |
| ES2527438T3 (es) * | 2006-08-08 | 2015-01-26 | Metabolon, Inc. | Marcadores de la hepatopatía grasa no alcohólica (NAFLD) y de la esteatohepatitis no alcohólica (NASH) y métodos de uso de los mismos |
| US20090075284A1 (en) * | 2006-09-19 | 2009-03-19 | The Regents Of The University Of Michigan | Metabolomic profiling of prostate cancer |
| WO2008056480A1 (en) * | 2006-11-06 | 2008-05-15 | Yokohama City University | Diagnosis method for fatty liver disease, diagnosis apparatus, diagnosis program, diagnostic agent, and method for screening for therapeutic agent for fatty liver disease |
| WO2008156662A1 (en) * | 2007-06-14 | 2008-12-24 | George Mason Intellectual Properties, Inc. | Methods of diagnosing non-alcoholic steatohepatitis (nash) |
| BRPI0815095B1 (pt) * | 2007-07-17 | 2021-04-13 | Metabolon, Inc | Método de classificação de um indivíduo de acordo com a tolerância à glicose predita em tolerância à glicose normal (ngt), tolerância à glicose de jejum prejudicada (ifg), ou tolerância à glicose prejudicada (igt), para diabetes tipo 2, método de determinação da suscetibilidade de um indivíduo a diabetes tipo 2 e método de monitoramento da progressão ou regressão do pré- diabetes em um indivíduo |
| EP2546649B1 (en) * | 2007-11-02 | 2015-02-25 | Metabolon Inc. | Biomarkers for fatty liver disease and methods using the same |
| WO2010045180A1 (en) * | 2008-10-13 | 2010-04-22 | Metabolon, Inc. | Biomarkers for inflammatory bowel disease and methods using the same |
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| US20100279956A1 (en) | 2010-11-04 |
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| EP2546649B1 (en) | 2015-02-25 |
| US20150377910A1 (en) | 2015-12-31 |
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| EP2227689B1 (en) | 2012-12-26 |
| JP2011503547A (ja) | 2011-01-27 |
| EP2930512B1 (en) | 2018-01-31 |
| WO2009059150A2 (en) | 2009-05-07 |
| JP5270684B2 (ja) | 2013-08-21 |
| HK1216189A1 (en) | 2016-10-21 |
| EP2546649A3 (en) | 2013-03-27 |
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