ES2355891T3 - Derivado de ciclohexanona para el tratamiento de la neuropatía diabética. - Google Patents

Derivado de ciclohexanona para el tratamiento de la neuropatía diabética. Download PDF

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Publication number
ES2355891T3
ES2355891T3 ES02712380T ES02712380T ES2355891T3 ES 2355891 T3 ES2355891 T3 ES 2355891T3 ES 02712380 T ES02712380 T ES 02712380T ES 02712380 T ES02712380 T ES 02712380T ES 2355891 T3 ES2355891 T3 ES 2355891T3
Authority
ES
Spain
Prior art keywords
group
compound
diabetes
methyl
diabetic neuropathy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02712380T
Other languages
English (en)
Spanish (es)
Inventor
Masao Miyagawa
Takeshi Watanabe
Motoaki Saito
Bang Luu
Masashi Yamada
Hiroto Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Dairies Corp
Original Assignee
Meiji Dairies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Dairies Corp filed Critical Meiji Dairies Corp
Application granted granted Critical
Publication of ES2355891T3 publication Critical patent/ES2355891T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES02712380T 2001-02-19 2002-02-15 Derivado de ciclohexanona para el tratamiento de la neuropatía diabética. Expired - Lifetime ES2355891T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001041586A JP4861560B2 (ja) 2001-02-19 2001-02-19 糖尿病合併症治療剤
JP2001-41586 2001-02-19

Publications (1)

Publication Number Publication Date
ES2355891T3 true ES2355891T3 (es) 2011-04-01

Family

ID=18904008

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02712380T Expired - Lifetime ES2355891T3 (es) 2001-02-19 2002-02-15 Derivado de ciclohexanona para el tratamiento de la neuropatía diabética.

Country Status (8)

Country Link
US (1) US7838565B2 (enExample)
EP (1) EP1368013B1 (enExample)
JP (1) JP4861560B2 (enExample)
AT (1) ATE492274T1 (enExample)
CA (1) CA2438506C (enExample)
DE (1) DE60238666D1 (enExample)
ES (1) ES2355891T3 (enExample)
WO (1) WO2002066023A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2519178C (en) * 2003-03-28 2010-01-12 Meiji Dairies Corporation Process for producing cyclohexenone long-chain alcohols
CN101065119B (zh) * 2004-11-25 2010-08-25 明治乳业株式会社 肾功能不全的改良剂
CN101180041B (zh) * 2005-01-18 2011-04-13 明治乳业株式会社 感觉障碍治疗剂
US20080312336A1 (en) * 2005-05-26 2008-12-18 Keisuke Satoh Preventive and/or Therapeutic Agent for Diabetic Vascular Disorder and Respiratory Disorder
JP4986505B2 (ja) * 2005-05-26 2012-07-25 株式会社明治 糖尿病性血管障害および呼吸障害予防および／または治療剤
US8309611B2 (en) * 2010-09-20 2012-11-13 Golden Biotechnology Corporation Methods and compositions for treating lung cancer
US20130172424A1 (en) * 2011-12-30 2013-07-04 Golden Biotechnology Corporation Methods and compositions for treating diabetes
BR112018014841B1 (pt) 2016-01-22 2022-03-03 Taiho Pharmaceutical Co., Ltd. Álcoois de cadeia longa cicloexenona, seus usos e métodos para a produção dos mesmos com alta pureza

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69313316T2 (de) 1992-02-07 1998-02-19 Mitsubishi Gas Chemical Co Verwendung von Oxazopyrrolochinolinen und Pyrrolochinolonchinonen zur Herstellung von Produktionsbeschleunigern von Nervenwachstumsfaktoren g
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
DE69811905T2 (de) * 1997-08-13 2003-11-06 Meiji Milk Products Co. Ltd., Tokio/Tokyo Cyclohexenon langketten alkohol und diese enthaltendes arzneimittel
JP4469441B2 (ja) 1999-02-10 2010-05-26 明治乳業株式会社 神経変性疾患の予防又は治療薬
US20040115810A1 (en) * 2000-10-04 2004-06-17 Bang Luu Stem cell differentiation-inducing promoter
JP3836684B2 (ja) * 2001-02-19 2006-10-25 明治乳業株式会社 排尿障害治療剤
WO2002094252A1 (en) * 2001-05-24 2002-11-28 Meiji Dairies Corporation Preventive or remedy for diseases caused by cerebrovascular disturbances

Also Published As

Publication number Publication date
WO2002066023A1 (en) 2002-08-29
EP1368013B1 (en) 2010-12-22
US7838565B2 (en) 2010-11-23
ATE492274T1 (de) 2011-01-15
EP1368013A1 (en) 2003-12-10
JP2002241270A (ja) 2002-08-28
DE60238666D1 (de) 2011-02-03
CA2438506A1 (en) 2002-08-29
CA2438506C (en) 2010-04-20
JP4861560B2 (ja) 2012-01-25
US20040102527A1 (en) 2004-05-27

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