ATE492274T1 - Cyclohexenon derivate zur behandlung der diabetischen neuropathie - Google Patents
Cyclohexenon derivate zur behandlung der diabetischen neuropathieInfo
- Publication number
- ATE492274T1 ATE492274T1 AT02712380T AT02712380T ATE492274T1 AT E492274 T1 ATE492274 T1 AT E492274T1 AT 02712380 T AT02712380 T AT 02712380T AT 02712380 T AT02712380 T AT 02712380T AT E492274 T1 ATE492274 T1 AT E492274T1
- Authority
- AT
- Austria
- Prior art keywords
- diabetic neuropathy
- treatment
- preventive
- therapeutic agent
- diabetes complications
- Prior art date
Links
- FWFSEYBSWVRWGL-UHFFFAOYSA-N cyclohex-2-enone Chemical class O=C1CCCC=C1 FWFSEYBSWVRWGL-UHFFFAOYSA-N 0.000 title abstract 3
- 208000032131 Diabetic Neuropathies Diseases 0.000 title abstract 2
- 208000002249 Diabetes Complications Diseases 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 230000003449 preventive effect Effects 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000007830 nerve conduction Effects 0.000 abstract 1
- 210000000578 peripheral nerve Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001041586A JP4861560B2 (ja) | 2001-02-19 | 2001-02-19 | 糖尿病合併症治療剤 |
| PCT/JP2002/001291 WO2002066023A1 (en) | 2001-02-19 | 2002-02-15 | Use of a cyclohexenone derivatives in the manufacture of a medicament for treating diabetic complications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE492274T1 true ATE492274T1 (de) | 2011-01-15 |
Family
ID=18904008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02712380T ATE492274T1 (de) | 2001-02-19 | 2002-02-15 | Cyclohexenon derivate zur behandlung der diabetischen neuropathie |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7838565B2 (enExample) |
| EP (1) | EP1368013B1 (enExample) |
| JP (1) | JP4861560B2 (enExample) |
| AT (1) | ATE492274T1 (enExample) |
| CA (1) | CA2438506C (enExample) |
| DE (1) | DE60238666D1 (enExample) |
| ES (1) | ES2355891T3 (enExample) |
| WO (1) | WO2002066023A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2519178C (en) * | 2003-03-28 | 2010-01-12 | Meiji Dairies Corporation | Process for producing cyclohexenone long-chain alcohols |
| CN101065119B (zh) * | 2004-11-25 | 2010-08-25 | 明治乳业株式会社 | 肾功能不全的改良剂 |
| CN101180041B (zh) * | 2005-01-18 | 2011-04-13 | 明治乳业株式会社 | 感觉障碍治疗剂 |
| US20080312336A1 (en) * | 2005-05-26 | 2008-12-18 | Keisuke Satoh | Preventive and/or Therapeutic Agent for Diabetic Vascular Disorder and Respiratory Disorder |
| JP4986505B2 (ja) * | 2005-05-26 | 2012-07-25 | 株式会社明治 | 糖尿病性血管障害および呼吸障害予防および／または治療剤 |
| US8309611B2 (en) * | 2010-09-20 | 2012-11-13 | Golden Biotechnology Corporation | Methods and compositions for treating lung cancer |
| US20130172424A1 (en) * | 2011-12-30 | 2013-07-04 | Golden Biotechnology Corporation | Methods and compositions for treating diabetes |
| BR112018014841B1 (pt) | 2016-01-22 | 2022-03-03 | Taiho Pharmaceutical Co., Ltd. | Álcoois de cadeia longa cicloexenona, seus usos e métodos para a produção dos mesmos com alta pureza |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69313316T2 (de) | 1992-02-07 | 1998-02-19 | Mitsubishi Gas Chemical Co | Verwendung von Oxazopyrrolochinolinen und Pyrrolochinolonchinonen zur Herstellung von Produktionsbeschleunigern von Nervenwachstumsfaktoren g |
| US6113947A (en) * | 1997-06-13 | 2000-09-05 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
| DE69811905T2 (de) * | 1997-08-13 | 2003-11-06 | Meiji Milk Products Co. Ltd., Tokio/Tokyo | Cyclohexenon langketten alkohol und diese enthaltendes arzneimittel |
| JP4469441B2 (ja) | 1999-02-10 | 2010-05-26 | 明治乳業株式会社 | 神経変性疾患の予防又は治療薬 |
| US20040115810A1 (en) * | 2000-10-04 | 2004-06-17 | Bang Luu | Stem cell differentiation-inducing promoter |
| JP3836684B2 (ja) * | 2001-02-19 | 2006-10-25 | 明治乳業株式会社 | 排尿障害治療剤 |
| WO2002094252A1 (en) * | 2001-05-24 | 2002-11-28 | Meiji Dairies Corporation | Preventive or remedy for diseases caused by cerebrovascular disturbances |
-
2001
- 2001-02-19 JP JP2001041586A patent/JP4861560B2/ja not_active Expired - Lifetime
-
2002
- 2002-02-15 DE DE60238666T patent/DE60238666D1/de not_active Expired - Lifetime
- 2002-02-15 CA CA2438506A patent/CA2438506C/en not_active Expired - Fee Related
- 2002-02-15 ES ES02712380T patent/ES2355891T3/es not_active Expired - Lifetime
- 2002-02-15 AT AT02712380T patent/ATE492274T1/de not_active IP Right Cessation
- 2002-02-15 EP EP02712380A patent/EP1368013B1/en not_active Expired - Lifetime
- 2002-02-15 WO PCT/JP2002/001291 patent/WO2002066023A1/en not_active Ceased
- 2002-02-15 US US10/467,063 patent/US7838565B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002066023A1 (en) | 2002-08-29 |
| EP1368013B1 (en) | 2010-12-22 |
| US7838565B2 (en) | 2010-11-23 |
| EP1368013A1 (en) | 2003-12-10 |
| JP2002241270A (ja) | 2002-08-28 |
| DE60238666D1 (de) | 2011-02-03 |
| CA2438506A1 (en) | 2002-08-29 |
| CA2438506C (en) | 2010-04-20 |
| JP4861560B2 (ja) | 2012-01-25 |
| US20040102527A1 (en) | 2004-05-27 |
| ES2355891T3 (es) | 2011-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |