ES2342772T3 - Uso de aminas, aminoacidos o esteres de aminoacidos como modificadores de fase movil en cromatografia. - Google Patents

Uso de aminas, aminoacidos o esteres de aminoacidos como modificadores de fase movil en cromatografia. Download PDF

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Publication number
ES2342772T3
ES2342772T3 ES03776553T ES03776553T ES2342772T3 ES 2342772 T3 ES2342772 T3 ES 2342772T3 ES 03776553 T ES03776553 T ES 03776553T ES 03776553 T ES03776553 T ES 03776553T ES 2342772 T3 ES2342772 T3 ES 2342772T3
Authority
ES
Spain
Prior art keywords
mobile phase
proline
amino acid
amino acids
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03776553T
Other languages
English (en)
Spanish (es)
Inventor
Kent E. Goklen
Joseph Nti-Gyabaah
Firoz D. Antia
Mary Ellen Dahlgren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2342772T3 publication Critical patent/ES2342772T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/284—Porous sorbents based on alumina
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/283—Porous sorbents based on silica
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
ES03776553T 2002-10-30 2003-10-24 Uso de aminas, aminoacidos o esteres de aminoacidos como modificadores de fase movil en cromatografia. Expired - Lifetime ES2342772T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42235602P 2002-10-30 2002-10-30
US422356P 2002-10-30

Publications (1)

Publication Number Publication Date
ES2342772T3 true ES2342772T3 (es) 2010-07-14

Family

ID=32312493

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03776553T Expired - Lifetime ES2342772T3 (es) 2002-10-30 2003-10-24 Uso de aminas, aminoacidos o esteres de aminoacidos como modificadores de fase movil en cromatografia.

Country Status (12)

Country Link
US (1) US7241866B2 (https=)
EP (1) EP1558354B1 (https=)
JP (1) JP4549862B2 (https=)
AT (1) ATE457798T1 (https=)
AU (1) AU2003284163A1 (https=)
CY (1) CY1110296T1 (https=)
DE (1) DE60331338D1 (https=)
DK (1) DK1558354T3 (https=)
ES (1) ES2342772T3 (https=)
PT (1) PT1558354E (https=)
SI (1) SI1558354T1 (https=)
WO (1) WO2004042350A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPS264302A0 (en) * 2002-05-29 2002-06-20 Neopraxis Pty Ltd Implantable bladder sensor
CN103936837B (zh) * 2014-02-14 2016-05-25 博瑞生物医药泰兴市有限公司 一种提纯纽莫康定b0的方法
US10383550B2 (en) * 2014-07-17 2019-08-20 Elwha Llc Monitoring body movement or condition according to motion regimen with conformal electronics
CN105001305A (zh) * 2015-04-29 2015-10-28 利穗科技(苏州)有限公司 利用层析技术提取高纯度达托霉素的方法
CN108250274A (zh) * 2016-12-28 2018-07-06 浙江华谱新创科技有限公司 米卡芬净高效分离纯化方法
IL294319A (en) * 2020-01-08 2022-08-01 Regeneron Pharma Using amino acids to improve signals in mass spectrometry tests
CN111925421B (zh) * 2020-07-02 2022-05-10 北大方正集团有限公司 一种从发酵液中提取纽莫康定b0的方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812442A (en) 1984-05-29 1989-03-14 Merck & Co., Inc. Tripeptide renin inhibitors
IT1190433B (it) 1985-12-11 1988-02-16 Prodotti Antibiotici Spa Peptidi correlati al lisozima
US5202309A (en) 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
US5194377A (en) 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
GB9508195D0 (en) 1995-04-20 1995-06-07 Univ British Columbia Novel biologically active compounds and compositions,their use and derivation
EP0975560A4 (en) * 1997-03-18 2004-10-06 Chiral Technologies Inc CHIRAL SEPARATION OF AMINO ACIDS
JP3780638B2 (ja) * 1997-06-27 2006-05-31 東ソー株式会社 分離法及びこれを用いた装置

Also Published As

Publication number Publication date
ATE457798T1 (de) 2010-03-15
JP4549862B2 (ja) 2010-09-22
WO2004042350A2 (en) 2004-05-21
DK1558354T3 (da) 2010-05-25
EP1558354A2 (en) 2005-08-03
EP1558354B1 (en) 2010-02-17
SI1558354T1 (sl) 2010-05-31
US7241866B2 (en) 2007-07-10
PT1558354E (pt) 2010-04-20
JP2006504786A (ja) 2006-02-09
CY1110296T1 (el) 2015-01-14
AU2003284163A8 (en) 2004-06-07
EP1558354A4 (en) 2008-07-02
WO2004042350A3 (en) 2004-07-15
AU2003284163A1 (en) 2004-06-07
DE60331338D1 (de) 2010-04-01
US20060014933A1 (en) 2006-01-19

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