ES2333400T3 - Composiciones y procedimientos para tratar linfonas. - Google Patents
Composiciones y procedimientos para tratar linfonas. Download PDFInfo
- Publication number
- ES2333400T3 ES2333400T3 ES00920004T ES00920004T ES2333400T3 ES 2333400 T3 ES2333400 T3 ES 2333400T3 ES 00920004 T ES00920004 T ES 00920004T ES 00920004 T ES00920004 T ES 00920004T ES 2333400 T3 ES2333400 T3 ES 2333400T3
- Authority
- ES
- Spain
- Prior art keywords
- lymphoma
- liposome
- vincristine
- administration
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
- 229960001278 teniposide Drugs 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229960000303 topotecan Drugs 0.000 description 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000440 toxicity profile Toxicity 0.000 description 1
- 229940043263 traditional drug Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 229940034331 vincristine liposome Drugs 0.000 description 1
- 229950009832 vinleurosine Drugs 0.000 description 1
- 229950003670 vinrosidine Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12744499P | 1999-04-01 | 1999-04-01 | |
| US127444P | 1999-04-01 | ||
| US13719499P | 1999-06-02 | 1999-06-02 | |
| US137194P | 1999-06-02 |
Publications (1)
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|---|---|
| ES2333400T3 true ES2333400T3 (es) | 2010-02-22 |
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| ES00920004T Expired - Lifetime ES2333400T3 (es) | 1999-04-01 | 2000-03-31 | Composiciones y procedimientos para tratar linfonas. |
| ES10011105.3T Expired - Lifetime ES2524141T3 (es) | 1999-04-01 | 2000-03-31 | Composiciones para tratar el cáncer |
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| ES10011105.3T Expired - Lifetime ES2524141T3 (es) | 1999-04-01 | 2000-03-31 | Composiciones para tratar el cáncer |
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|---|---|
| EP (3) | EP2266537B1 (enExample) |
| JP (3) | JP2002541088A (enExample) |
| AT (1) | ATE442839T1 (enExample) |
| AU (1) | AU777572B2 (enExample) |
| BR (1) | BRPI0009448B8 (enExample) |
| CA (1) | CA2366787C (enExample) |
| CY (1) | CY1109641T1 (enExample) |
| DE (1) | DE60042968D1 (enExample) |
| DK (2) | DK2266537T3 (enExample) |
| ES (2) | ES2333400T3 (enExample) |
| IL (4) | IL145720A0 (enExample) |
| PT (1) | PT1169021E (enExample) |
| WO (1) | WO2000059473A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6723338B1 (en) | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| DK2266537T3 (en) * | 1999-04-01 | 2014-12-15 | Talon Therapeutics Inc | Compositions for treating cancer |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| JP4776843B2 (ja) | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
| GB0000313D0 (en) | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| PT1389089E (pt) * | 2001-03-27 | 2009-11-30 | Phares Pharm Res Nv | Processo e composição para solubilizar um composto biologicamente activo com uma baixa solubilidade em água |
| ES2340027T3 (es) * | 2002-05-17 | 2010-05-28 | Celgene Corporation | Combinaciones para tratar el mieloma multiple. |
| US6890558B2 (en) | 2002-05-31 | 2005-05-10 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
| FR2840203B1 (fr) * | 2002-05-31 | 2004-08-27 | Scherer Technologies Inc R P | Composition pharmaceutique orale pour capsules molles contenant vinorelbine et methode de traitement |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| RU2252764C2 (ru) * | 2003-03-04 | 2005-05-27 | Российский научный центр рентгенорадиологии МЗ РФ | Способ комплексного лечения лимфогранулематоза |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| WO2005011698A1 (en) * | 2003-07-28 | 2005-02-10 | Inex Pharmaceuticals Corporation | Combination comprising a liposome-encapsulated vinca alkaloid and a topoisomerase ii inhibitor and the use thereof for treating neoplasia |
| KR101250127B1 (ko) * | 2004-07-09 | 2013-04-02 | 바이엘 파마 악티엔게젤샤프트 | Ｂ-세포 림프종의 치료를 위한 방사성표지된 안티-ｃｄ20항체와의 병용요법 |
| CA2576222C (en) * | 2004-08-10 | 2014-09-30 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| CA2736563C (en) * | 2007-09-10 | 2016-01-26 | Boston Biomedical, Inc. | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
| CN110251670B (zh) | 2008-03-18 | 2023-11-14 | 健泰科生物技术公司 | 抗her2抗体-药物偶联物和化疗剂的组合，及使用方法 |
| WO2010047714A1 (en) * | 2008-10-24 | 2010-04-29 | Gloucester Pharmaceuticals | Cancer therapy |
| AU2013347990B2 (en) * | 2012-11-20 | 2018-01-18 | Arbutus Biopharma Corp. | Improved method for the preparation of liposome encapsulated vincristine for therapeutic use |
| ES2824074T3 (es) * | 2013-01-24 | 2021-05-11 | Memorial Sloan Kettering Cancer Center | Método para diagnosticar o tratar tumores mediante el uso de liposomas que contienen esfingomielina |
| MX2015014181A (es) | 2013-04-09 | 2016-05-24 | Boston Biomedical Inc | 2-acetilnafto [2,3-b]furano -4,9-diona para uso en el tratamiento del cáncer. |
| TWI678213B (zh) * | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物 |
| US11299469B2 (en) | 2016-11-29 | 2022-04-12 | Sumitomo Dainippon Pharma Oncology, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| US10646464B2 (en) | 2017-05-17 | 2020-05-12 | Boston Biomedical, Inc. | Methods for treating cancer |
| SI26542A (sl) | 2023-09-12 | 2025-03-31 | Univerza V Ljubljani | Nove liposomske formulacije in postopek za njihovo pripravo |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4603044A (en) | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
| US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5059421A (en) | 1985-07-26 | 1991-10-22 | The Liposome Company, Inc. | Preparation of targeted liposome systems of a defined size distribution |
| US5171578A (en) | 1985-06-26 | 1992-12-15 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
| US4885172A (en) | 1985-06-26 | 1989-12-05 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4952408A (en) * | 1988-05-23 | 1990-08-28 | Georgetown University | Liposome-encapsulated vinca alkaloids and their use in combatting tumors |
| US4957773A (en) | 1989-02-13 | 1990-09-18 | Syracuse University | Deposition of boron-containing films from decaborane |
| WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5165922A (en) * | 1990-05-22 | 1992-11-24 | Bristol-Myers Squibb Company | Synergistic tumor therapy with combinations of biologically active anti-tumor antibodies and chemotherapy |
| GB9304745D0 (en) * | 1993-03-09 | 1993-04-28 | Oncholab Ab | Use of pharmaceutical formulations |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5741516A (en) * | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5543152A (en) * | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5714163A (en) * | 1994-06-27 | 1998-02-03 | Nexstar Pharmaceuticals, Inc. | Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5837282A (en) | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| DK2266537T3 (en) * | 1999-04-01 | 2014-12-15 | Talon Therapeutics Inc | Compositions for treating cancer |
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2000
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- 2000-03-31 CA CA2366787A patent/CA2366787C/en not_active Expired - Lifetime
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- 2000-03-31 DK DK00920004T patent/DK1169021T3/da active
- 2000-03-31 EP EP10011105.3A patent/EP2266537B1/en not_active Expired - Lifetime
- 2000-03-31 WO PCT/US2000/008669 patent/WO2000059473A1/en not_active Ceased
- 2000-03-31 EP EP08003804A patent/EP1985285A3/en not_active Withdrawn
- 2000-03-31 PT PT00920004T patent/PT1169021E/pt unknown
- 2000-03-31 IL IL14572000A patent/IL145720A0/xx unknown
- 2000-03-31 JP JP2000609037A patent/JP2002541088A/ja active Pending
- 2000-03-31 DE DE60042968T patent/DE60042968D1/de not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2524141T3 (es) | 2014-12-04 |
| EP2266537A3 (en) | 2012-02-22 |
| DE60042968D1 (de) | 2009-10-29 |
| BR0009448A (pt) | 2002-01-08 |
| HK1152246A1 (en) | 2012-02-24 |
| JP2002541088A (ja) | 2002-12-03 |
| IL145720A0 (en) | 2002-07-25 |
| EP2266537A2 (en) | 2010-12-29 |
| BRPI0009448B8 (pt) | 2021-05-25 |
| CA2366787C (en) | 2013-03-12 |
| JP2012158602A (ja) | 2012-08-23 |
| CA2366787A1 (en) | 2000-10-12 |
| JP2015071631A (ja) | 2015-04-16 |
| IL212389A0 (en) | 2011-06-30 |
| DK2266537T3 (en) | 2014-12-15 |
| CY1109641T1 (el) | 2014-08-13 |
| EP1985285A2 (en) | 2008-10-29 |
| IL212390A (en) | 2014-08-31 |
| DK1169021T3 (da) | 2010-01-11 |
| BRPI0009448B1 (pt) | 2018-09-11 |
| PT1169021E (pt) | 2009-11-18 |
| IL145720A (en) | 2011-05-31 |
| EP1169021A1 (en) | 2002-01-09 |
| JP5981214B2 (ja) | 2016-08-31 |
| ATE442839T1 (de) | 2009-10-15 |
| EP1985285A3 (en) | 2009-08-12 |
| WO2000059473A1 (en) | 2000-10-12 |
| AU4060600A (en) | 2000-10-23 |
| IL212389A (en) | 2015-07-30 |
| EP2266537B1 (en) | 2014-09-03 |
| IL212390A0 (en) | 2011-06-30 |
| EP1169021B1 (en) | 2009-09-16 |
| AU777572B2 (en) | 2004-10-21 |
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