ES2333282T3 - Complejos vesiculares y metodos para la preparacion y utilizacion de los mismos. - Google Patents
Complejos vesiculares y metodos para la preparacion y utilizacion de los mismos. Download PDFInfo
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- ES2333282T3 ES2333282T3 ES98920077T ES98920077T ES2333282T3 ES 2333282 T3 ES2333282 T3 ES 2333282T3 ES 98920077 T ES98920077 T ES 98920077T ES 98920077 T ES98920077 T ES 98920077T ES 2333282 T3 ES2333282 T3 ES 2333282T3
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| US20040180438A1 (en) * | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
| JP4868739B2 (ja) * | 2002-05-06 | 2012-02-01 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 核酸の送達法 |
| JP2005529959A (ja) * | 2002-06-14 | 2005-10-06 | マイラス コーポレイション | 細胞へのポリヌクレオチドの伝達をするための新規な方法 |
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| AU2005319306B9 (en) | 2004-12-22 | 2012-04-05 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
| PT1912675E (pt) | 2005-07-25 | 2014-05-09 | Emergent Product Dev Seattle | Moléculas de ligaçao especificas para cd37 e especificas para cd20 |
| MX380352B (es) | 2006-06-12 | 2025-03-12 | Aptevo Res & Development Llc | Proteinas de union multivalentes monocatenarias con funcion efectora. |
| CN101541950A (zh) | 2006-07-13 | 2009-09-23 | 惠氏公司 | 糖蛋白的产生 |
| DK2548438T3 (en) | 2006-11-08 | 2015-10-19 | Veritas Bio LLC | IN VIVO SUBMITTING DOUBLE-STRENGTH RNA TO A CELL |
| CN101990439A (zh) * | 2007-07-06 | 2011-03-23 | 特鲁比昂药品公司 | 具有置于c末端的特异性结合结构域的结合肽 |
| RS51975B (sr) | 2008-04-11 | 2012-02-29 | Emergent Product Development Seattle Llc. | Cd37 imunoterapeutski proizvod i njegova kombinacija sa bifunkcionalnim hemoterapeutskim sredstvom |
| CA2761106C (en) | 2009-05-05 | 2019-01-15 | Miragen Therapeutics | Lipophilic polynucleotide conjugates |
| AU2010258875A1 (en) | 2009-06-08 | 2012-01-19 | Miragen Therapeutics | Chemical modification motifs for miRNA inhibitors and mimetics |
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| EP2635681B8 (en) | 2010-11-05 | 2017-10-04 | Miragen Therapeutics, Inc. | Base modified oligonucleotides |
| AR084319A1 (es) | 2010-12-15 | 2013-05-08 | Miragen Therapeutics | INHIBIDORES DE microARN (miARN O miR) QUE COMPRENDEN NUCLEOTIDOS BLOQUEADOS |
| AU2012242761A1 (en) | 2011-04-12 | 2013-10-31 | Beth Israel Deaconess Medical Center, Inc. | Micro-RNA inhibitors and their uses in disease |
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| CN104685056A (zh) | 2012-06-21 | 2015-06-03 | 米拉根医疗股份有限公司 | 包含锁核酸基序的基于寡核苷酸的抑制剂 |
| CA2902571A1 (en) | 2013-03-15 | 2014-09-18 | MiRagen Therapeutics, Inc. | Bridged bicyclic nucleosides |
| US10172916B2 (en) | 2013-11-15 | 2019-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating heart failure with agonists of hypocretin receptor 2 |
| US10772974B2 (en) | 2013-11-18 | 2020-09-15 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for cardiac regeneration |
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| JP6837963B2 (ja) | 2014-09-08 | 2021-03-03 | ミラゲン セラピューティクス， インコーポレイテッド | Ｍｉｒ−２９模倣物およびその使用 |
| JP2018503646A (ja) | 2015-01-20 | 2018-02-08 | ミラゲン セラピューティクス， インコーポレイテッド | ｍｉＲ−９２阻害剤およびその使用 |
| WO2016197024A2 (en) | 2015-06-05 | 2016-12-08 | MiRagen Therapeutics, Inc. | Mir-155 inhibitors for treating cutaneous t cell lymphoma (ctcl) |
| BR112018005573A2 (pt) | 2015-09-21 | 2019-01-22 | Aptevo Research And Development Llc | ?polipeptídeos de ligação a cd3? |
| US10357543B2 (en) | 2015-11-16 | 2019-07-23 | Ohio State Innovation Foundation | Methods and compositions for treating disorders and diseases using Survival Motor Neuron (SMN) protein |
| NZ749593A (en) | 2016-06-20 | 2025-10-31 | Univ Leland Stanford Junior | Circular rnas and their use in immunomodulation |
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| JP2022511866A (ja) | 2018-12-10 | 2022-02-01 | アムジエン・インコーポレーテツド | 化学修飾されたＲＮＡｉコンストラクト及びその使用 |
| TW202111124A (zh) | 2019-05-30 | 2021-03-16 | 美商安進公司 | 用於抑制ｓｃａｐ表現之ｒｎａｉ構建體及其使用方法 |
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| EP3929295A1 (en) | 2020-06-26 | 2021-12-29 | Universitat Pompeu Fabra | Artificial rnas for modulating rna fragments |
| CR20230126A (es) | 2020-08-13 | 2023-05-03 | Amgen Inc | CONSTRUCCIONES DE iARN Y MÉTODOS PARA INHIBIR LA EXPRESIÓN DE MARC1 |
| KR20230104200A (ko) | 2020-11-05 | 2023-07-07 | 암젠 인크 | LPA-표적화된 RNAi 작제물을 이용하여 죽상경화성 심혈관질환을 치료하는 방법 |
| WO2023278295A1 (en) | 2021-06-29 | 2023-01-05 | The Broad Institute, Inc. | Compositions and methods for ameliorating anterodorsal thalamus hyperexcitability |
| CA3234369A1 (en) | 2021-10-05 | 2023-04-13 | Amgen Inc. | Compositions and methods for enhancing gene silencing activity of oligonucleotide compounds |
| WO2023069754A2 (en) | 2021-10-22 | 2023-04-27 | Amgen Inc. | Rnai constructs for inhibiting gpam expression and methods of use thereof |
| IL317825A (en) | 2022-07-25 | 2025-02-01 | Amgen Inc | RNA interference constructs and methods for inhibiting fam13a expression |
| EP4353823A1 (en) | 2022-10-12 | 2024-04-17 | Resalis Therapeutics S.r.l. | Inhibitors of micro-rna 22 |
| IL321194A (en) | 2022-12-16 | 2025-07-01 | Amgen Inc | RNA interference constructs for inhibiting TTR expression and methods for using them |
| WO2025260042A1 (en) | 2024-06-14 | 2025-12-18 | Amgen Inc. | Rnai constructs and methods for inhibiting cnr1 expression |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
| US5514788A (en) | 1993-05-17 | 1996-05-07 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of cell adhesion |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| DE69434469T2 (de) * | 1993-01-26 | 2006-06-14 | Univ Pennsylvania | Zusammensetzungen und verfahren zur verabreichung von genetischem material |
| WO1996021015A2 (en) * | 1994-12-30 | 1996-07-11 | Chiron Corporation | Combination gene delivery vehicles |
| KR20140137679A (ko) | 2013-05-23 | 2014-12-03 | 삼성전자주식회사 | 카드 소켓 장치 |
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1998
- 1998-04-30 AT AT98920077T patent/ATE446372T1/de not_active IP Right Cessation
- 1998-04-30 ES ES98920077T patent/ES2333282T3/es not_active Expired - Lifetime
- 1998-04-30 WO PCT/US1998/008799 patent/WO1998048780A1/en not_active Ceased
- 1998-04-30 JP JP54741798A patent/JP2002508747A/ja active Pending
- 1998-04-30 AU AU72724/98A patent/AU728115C/en not_active Ceased
- 1998-04-30 CN CN98810484A patent/CN1092045C/zh not_active Expired - Fee Related
- 1998-04-30 DE DE69841251T patent/DE69841251D1/de not_active Expired - Lifetime
- 1998-04-30 KR KR1019997009723A patent/KR100554344B1/ko not_active Expired - Fee Related
- 1998-04-30 CA CA 2285298 patent/CA2285298C/en not_active Expired - Fee Related
- 1998-04-30 BR BRPI9809006-2A patent/BR9809006B1/pt not_active IP Right Cessation
- 1998-04-30 EP EP19980920077 patent/EP0986372B1/en not_active Expired - Lifetime
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2000
- 2000-04-04 US US09/542,409 patent/US6383512B1/en not_active Expired - Fee Related
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|---|---|
| KR100554344B1 (ko) | 2006-02-22 |
| BR9809006B1 (pt) | 2010-02-09 |
| AU728115C (en) | 2004-01-22 |
| DE69841251D1 (de) | 2009-12-03 |
| US6217900B1 (en) | 2001-04-17 |
| AU7272498A (en) | 1998-11-24 |
| KR20010020161A (ko) | 2001-03-15 |
| CA2285298C (en) | 2008-12-23 |
| AU728115B2 (en) | 2001-01-04 |
| EP0986372A1 (en) | 2000-03-22 |
| BR9809006A (pt) | 2000-08-08 |
| WO1998048780A1 (en) | 1998-11-05 |
| CA2285298A1 (en) | 1998-11-05 |
| JP2002508747A (ja) | 2002-03-19 |
| EP0986372B1 (en) | 2009-10-21 |
| CN1277549A (zh) | 2000-12-20 |
| CN1092045C (zh) | 2002-10-09 |
| US6383512B1 (en) | 2002-05-07 |
| ATE446372T1 (de) | 2009-11-15 |
| EP0986372A4 (en) | 2002-06-19 |
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