ATE446372T1 - Vesikuläre komplexe und verfahren zu deren herstellung und verwendung - Google Patents
Vesikuläre komplexe und verfahren zu deren herstellung und verwendungInfo
- Publication number
- ATE446372T1 ATE446372T1 AT98920077T AT98920077T ATE446372T1 AT E446372 T1 ATE446372 T1 AT E446372T1 AT 98920077 T AT98920077 T AT 98920077T AT 98920077 T AT98920077 T AT 98920077T AT E446372 T1 ATE446372 T1 AT E446372T1
- Authority
- AT
- Austria
- Prior art keywords
- disclosed
- individuals
- methods
- production
- cells
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/905—Specially adapted for travel through blood circulatory system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/916—Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4512297P | 1997-04-30 | 1997-04-30 | |
| PCT/US1998/008799 WO1998048780A1 (en) | 1997-04-30 | 1998-04-30 | Vesicular complexes and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446372T1 true ATE446372T1 (de) | 2009-11-15 |
Family
ID=21936112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98920077T ATE446372T1 (de) | 1997-04-30 | 1998-04-30 | Vesikuläre komplexe und verfahren zu deren herstellung und verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6217900B1 (de) |
| EP (1) | EP0986372B1 (de) |
| JP (1) | JP2002508747A (de) |
| KR (1) | KR100554344B1 (de) |
| CN (1) | CN1092045C (de) |
| AT (1) | ATE446372T1 (de) |
| AU (1) | AU728115C (de) |
| BR (1) | BR9809006B1 (de) |
| CA (1) | CA2285298C (de) |
| DE (1) | DE69841251D1 (de) |
| ES (1) | ES2333282T3 (de) |
| WO (1) | WO1998048780A1 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999061032A1 (en) * | 1998-05-25 | 1999-12-02 | Nippon Shinyaku Co., Ltd. | Process for producing composite preparation containing nucleic acid |
| EP2314700A1 (de) * | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Zusammensetzung und Verfahren zur in vivo und in vitro Abschwächung der Genexpression mittels dobbelsträngiger RNA |
| EP1097993A3 (de) * | 1999-11-05 | 2004-01-07 | National Institute of Advanced Industrial Science and Technology | Funktionelle Ribozymchimermolekulen die schlittfähig sind |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7461046B2 (en) * | 2002-02-07 | 2008-12-02 | The University Of Utah Research Foundation | Method for creating and using a treatment protocol |
| US20040180438A1 (en) * | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
| WO2003093449A2 (en) * | 2002-05-06 | 2003-11-13 | Nucleonics, Inc. | Methods for delivery of nucleic acids |
| JP2005529959A (ja) * | 2002-06-14 | 2005-10-06 | マイラス コーポレイション | 細胞へのポリヌクレオチドの伝達をするための新規な方法 |
| EP1540004A4 (de) * | 2002-07-31 | 2007-10-03 | Nucleonics Inc | Doppelstrang-rna-strukturen und -konstrukte sowie verfahren zur erzeugung und verwendung davon |
| WO2004073631A2 (en) * | 2003-02-14 | 2004-09-02 | Combinatorx, Incorporated | Combination therapy for the treatment of neoplasms |
| HUE042261T2 (hu) | 2003-06-12 | 2019-06-28 | Alnylam Pharmaceuticals Inc | Gén kikapcsolásra alkalmas konzervált HBV és HCV szekvenciák |
| TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
| JP2008514202A (ja) | 2004-09-24 | 2008-05-08 | ニュークレオニクス・インコーポレイテッド | Rnaiによる一本鎖ウイルスの逆鎖複製中間体のターゲティング |
| EP2316942B1 (de) | 2004-12-22 | 2021-04-21 | Alnylam Pharmaceuticals, Inc. | Zum gen-silencing geeignete konservierte hbv- und hcv-sequenzen |
| HRP20140338T1 (hr) | 2005-07-25 | 2014-06-20 | Emergent Product Development Seattle, Llc | Smanjenje broja b-stanica upotrebom molekula koje se specifiäśno vežu na cd37 i cd20 |
| WO2007146968A2 (en) | 2006-06-12 | 2007-12-21 | Trubion Pharmaceuticals, Inc. | Single-chain multivalent binding proteins with effector function |
| DK2041270T3 (da) | 2006-07-13 | 2014-01-27 | Wyeth Llc | Fremstilling af glycoproteiner |
| EP2799547B1 (de) | 2006-11-08 | 2016-12-21 | Veritas Bio, LLC | In-vivo-Abgabe von RNA an eine Targetzelle |
| JP2010532764A (ja) * | 2007-07-06 | 2010-10-14 | トゥルビオン・ファーマシューティカルズ・インコーポレーテッド | C末端に配置された特異的結合性ドメインを有する結合性ペプチド |
| EP2365003A1 (de) | 2008-04-11 | 2011-09-14 | Emergent Product Development Seattle, LLC | CD37-Immuntherapeutikum und Kombination mit bifunktionellem Chemotherapeutikum davon |
| JP5883381B2 (ja) | 2009-05-05 | 2016-03-15 | ミラゲン セラピューティクス,インコーポレイテッド | 親油性ポリヌクレオチド接合体 |
| CA2765129A1 (en) | 2009-06-08 | 2010-12-16 | Miragen Therapeutics | Chemical modification motifs for mirna inhibitors and mimetics |
| WO2011121074A1 (en) * | 2010-04-01 | 2011-10-06 | Pharmanest Ab | Thermogelling anaesthetic compositions |
| WO2012061810A1 (en) | 2010-11-05 | 2012-05-10 | Miragen Therapeutics | Base modified oligonucleotides |
| EA201370139A1 (ru) | 2010-12-15 | 2013-10-30 | Мираген Терапеутикс | Ингибиторы микро-рнк, содержащие закрытые нуклеотиды |
| CA2832899A1 (en) | 2011-04-12 | 2012-10-18 | Beth Israel Deaconess Medical Center, Inc. | Micro-rna inhibitors and their uses in disease |
| EP2755663A4 (de) | 2011-09-13 | 2015-10-07 | Ottawa Hospital Res Inst | Microrna-inhibitoren |
| US9388408B2 (en) | 2012-06-21 | 2016-07-12 | MiRagen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| CA2902571A1 (en) | 2013-03-15 | 2014-09-18 | MiRagen Therapeutics, Inc. | Bridged bicyclic nucleosides |
| EP3068783B1 (de) | 2013-11-15 | 2020-09-23 | The Board of Trustees of the Leland Stanford Junior University | Agonisten des hypokretin-rezeptors 2 zur verwendung zur behandlung von herzversagen |
| US10772974B2 (en) | 2013-11-18 | 2020-09-15 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for cardiac regeneration |
| CN108064175A (zh) | 2014-08-04 | 2018-05-22 | 米拉根医疗股份有限公司 | Myh7b的抑制剂及其用途 |
| AU2015315298B2 (en) | 2014-09-08 | 2020-05-14 | MiRagen Therapeutics, Inc. | miR-29 mimics and uses thereof |
| US9885042B2 (en) | 2015-01-20 | 2018-02-06 | MiRagen Therapeutics, Inc. | miR-92 inhibitors and uses thereof |
| MX368314B (es) | 2015-06-05 | 2019-09-27 | Miragen Therapeutics Inc | Inhibidores del mir-155 para tratar linfoma cutáneo de células t (ctcl). |
| EP3352760B1 (de) | 2015-09-21 | 2026-03-11 | Aptevo Research and Development LLC | Cd3-bindende polypeptide |
| WO2017087486A1 (en) | 2015-11-16 | 2017-05-26 | Ohio State Innovation Foundation | Methods and compositions for treating disorders and diseases using survival motor neuron (smn) protein |
| EP3472193A4 (de) | 2016-06-20 | 2020-01-08 | The Board of Trustees of the Leland Stanford Junior University | Zirkuläre rna und deren verwendung in der immunmodulation |
| UY37376A (es) | 2016-08-26 | 2018-03-23 | Amgen Inc | Construcciones de arni para inhibir expresión de asgr1 y métodos para su uso |
| ES2659845B1 (es) | 2016-09-19 | 2019-01-04 | Univ Valencia | Modulación de microRNAs contra la distrofia miotónica tipo 1 y antagonistas de microRNAs para ello |
| AR113490A1 (es) | 2017-12-12 | 2020-05-06 | Amgen Inc | CONSTRUCCIONES DE ARNi PARA INHIBIR LA EXPRESIÓN DE PNPLA3 Y MÉTODOS DE USO DE LAS MISMAS |
| BR112020018705A2 (pt) | 2018-03-14 | 2021-01-05 | Beth Israel Deaconess Medical Center | Inibidores de microrna 22 |
| CN113166761B (zh) | 2018-12-10 | 2025-09-09 | 美国安进公司 | 用于抑制pnpla3表达的rnai构建体 |
| EP3894554A1 (de) | 2018-12-10 | 2021-10-20 | Amgen Inc. | Chemisch modifizierte rnai-konstrukte und deren verwendung |
| TW202111124A (zh) | 2019-05-30 | 2021-03-16 | 美商安進公司 | 用於抑制scap表現之rnai構建體及其使用方法 |
| WO2021030613A1 (en) | 2019-08-13 | 2021-02-18 | Amgen Inc. | Rnai constructs for inhibiting slc30a8 expression and methods of use thereof |
| US20230078200A1 (en) | 2019-12-09 | 2023-03-16 | Amgen Inc. | RNAi CONSTRUCTS AND METHODS FOR INHIBITING LPA EXPRESSION |
| WO2021234607A1 (en) | 2020-05-20 | 2021-11-25 | St. Jude Children's Research Hospital | Detection of alzheimer's disease using specific biomarkers |
| MX2022015169A (es) | 2020-06-01 | 2023-07-03 | Amgen Inc | Constructos de arni para inhibir la expresion de hsd17b13 y metodos de uso de los mismos. |
| EP3929295A1 (de) | 2020-06-26 | 2021-12-29 | Universitat Pompeu Fabra | Künstliche rnas zur modulation von rna-fragmenten |
| PE20230993A1 (es) | 2020-08-13 | 2023-06-23 | Amgen Inc | Construcciones de iarn y metodos para inhibir la expresion de marc1 |
| WO2022098841A1 (en) | 2020-11-05 | 2022-05-12 | Amgen Inc. | METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE WITH LPA-TARGETED RNAi CONSTRUCTS |
| WO2023278295A1 (en) | 2021-06-29 | 2023-01-05 | The Broad Institute, Inc. | Compositions and methods for ameliorating anterodorsal thalamus hyperexcitability |
| CN118556125A (zh) | 2021-10-05 | 2024-08-27 | 美国安进公司 | 用于增强寡核苷酸化合物的基因沉默活性的组合物和方法 |
| CA3235262A1 (en) | 2021-10-22 | 2023-04-27 | Amgen Inc. | Rnai constructs for inhibiting gpam expression and methods of use thereof |
| IL317825A (en) | 2022-07-25 | 2025-02-01 | Amgen Inc | RNA interference constructs and methods for inhibiting fam13a expression |
| EP4353823A1 (de) | 2022-10-12 | 2024-04-17 | Resalis Therapeutics S.r.l. | Inhibitoren von mikro-rna 22 |
| AR131389A1 (es) | 2022-12-16 | 2025-03-12 | Amgen Inc | CONSTRUCTOS DE ARNi PARA INHIBIR LA EXPRESIÓN DE TTR Y MÉTODOS DE USO DE LOS MISMOS |
| WO2025260042A1 (en) | 2024-06-14 | 2025-12-18 | Amgen Inc. | Rnai constructs and methods for inhibiting cnr1 expression |
| WO2026006275A2 (en) | 2024-06-26 | 2026-01-02 | Amgen Inc. | Rnai constructs and methods for inhibiting expression of inhbe |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
| US5514788A (en) | 1993-05-17 | 1996-05-07 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of cell adhesion |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| AU675702B2 (en) * | 1993-01-26 | 1997-02-13 | Leslie R. Coney | Compositions and methods for delivery of genetic material |
| DK0800579T3 (da) * | 1994-12-30 | 2002-09-09 | Chiron Corp | Kombinations-gen-leveringsvehikler |
| KR20140137679A (ko) | 2013-05-23 | 2014-12-03 | 삼성전자주식회사 | 카드 소켓 장치 |
-
1997
- 1997-04-30 US US09/402,507 patent/US6217900B1/en not_active Expired - Fee Related
-
1998
- 1998-04-30 JP JP54741798A patent/JP2002508747A/ja active Pending
- 1998-04-30 AT AT98920077T patent/ATE446372T1/de not_active IP Right Cessation
- 1998-04-30 BR BRPI9809006-2A patent/BR9809006B1/pt not_active IP Right Cessation
- 1998-04-30 CA CA002285298A patent/CA2285298C/en not_active Expired - Fee Related
- 1998-04-30 EP EP19980920077 patent/EP0986372B1/de not_active Expired - Lifetime
- 1998-04-30 KR KR1019997009723A patent/KR100554344B1/ko not_active Expired - Fee Related
- 1998-04-30 WO PCT/US1998/008799 patent/WO1998048780A1/en not_active Ceased
- 1998-04-30 CN CN98810484A patent/CN1092045C/zh not_active Expired - Fee Related
- 1998-04-30 DE DE69841251T patent/DE69841251D1/de not_active Expired - Lifetime
- 1998-04-30 ES ES98920077T patent/ES2333282T3/es not_active Expired - Lifetime
- 1998-04-30 AU AU72724/98A patent/AU728115C/en not_active Ceased
-
2000
- 2000-04-04 US US09/542,409 patent/US6383512B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0986372B1 (de) | 2009-10-21 |
| DE69841251D1 (de) | 2009-12-03 |
| AU728115B2 (en) | 2001-01-04 |
| AU728115C (en) | 2004-01-22 |
| EP0986372A1 (de) | 2000-03-22 |
| CA2285298A1 (en) | 1998-11-05 |
| WO1998048780A1 (en) | 1998-11-05 |
| CN1277549A (zh) | 2000-12-20 |
| AU7272498A (en) | 1998-11-24 |
| KR100554344B1 (ko) | 2006-02-22 |
| CA2285298C (en) | 2008-12-23 |
| US6217900B1 (en) | 2001-04-17 |
| CN1092045C (zh) | 2002-10-09 |
| ES2333282T3 (es) | 2010-02-18 |
| EP0986372A4 (de) | 2002-06-19 |
| BR9809006A (pt) | 2000-08-08 |
| BR9809006B1 (pt) | 2010-02-09 |
| US6383512B1 (en) | 2002-05-07 |
| KR20010020161A (ko) | 2001-03-15 |
| JP2002508747A (ja) | 2002-03-19 |
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