ES2331521T3 - Derivados de acido 4-oxo-4,5-dihidro-furan-2-carboxilico y procedimientos de tratamiento de trastornos metabolicos relacionados del mismo. - Google Patents
Derivados de acido 4-oxo-4,5-dihidro-furan-2-carboxilico y procedimientos de tratamiento de trastornos metabolicos relacionados del mismo. Download PDFInfo
- Publication number
- ES2331521T3 ES2331521T3 ES04811612T ES04811612T ES2331521T3 ES 2331521 T3 ES2331521 T3 ES 2331521T3 ES 04811612 T ES04811612 T ES 04811612T ES 04811612 T ES04811612 T ES 04811612T ES 2331521 T3 ES2331521 T3 ES 2331521T3
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- thiophene
- furan
- oxo
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Neurology (AREA)
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- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US52426903P | 2003-11-21 | 2003-11-21 | |
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| EP (1) | EP1701947B1 (enExample) |
| JP (1) | JP2007512346A (enExample) |
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| DE (1) | DE602004022864D1 (enExample) |
| ES (1) | ES2331521T3 (enExample) |
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| JP5254620B2 (ja) | 2004-12-03 | 2013-08-07 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｃｂ１アンタゴニストとしての置換ピペラジン |
| KR100826108B1 (ko) * | 2006-08-04 | 2008-04-29 | 한국화학연구원 | 퓨란-2-카복실산 유도체 및 그의 제조 방법 |
| US20110082202A1 (en) * | 2009-10-05 | 2011-04-07 | Milne Jill C | Fatty acid acifran derivatives and their uses |
| WO2014011926A1 (en) | 2012-07-11 | 2014-01-16 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| WO2018006258A1 (en) * | 2016-07-05 | 2018-01-11 | Shenzhen Xpectvision Technology Co., Ltd. | Bonding materials of dissimilar coefficients of thermal expansion |
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| US4169202A (en) * | 1978-06-05 | 1979-09-25 | American Home Products Corporation | Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives |
| US4244958A (en) * | 1979-05-10 | 1981-01-13 | American Home Products Corporation | Hypolipidemic derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid |
| US6902902B2 (en) * | 2001-11-27 | 2005-06-07 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders |
| WO2004033431A2 (en) | 2002-10-04 | 2004-04-22 | Arena Pharmaceuticals, Inc. | Hydroxypyrazoles for use against metabolic-related disorders |
| AU2003300014A1 (en) | 2002-10-10 | 2004-05-04 | Arena Pharmaceuticals, Inc. | 5-substituted 2h-pyrazone-3-carboxylic acid derivatives as antilipolytic agents for the treatment of metabolic-related disorders such as dyslipidemia |
| WO2004041274A1 (en) | 2002-11-05 | 2004-05-21 | Arena Pharmaceuticals, Inc. | Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof |
| AU2004260636A1 (en) | 2003-06-13 | 2005-02-10 | Arena Pharmaceuticals, Inc. | 5-substituted 2H-pyrazole-3-carboxylic acid derivatives as agonists for the nicotinic acid receptor RUP25 for the treatment of dyslipidemia and related diseases |
| TWI258478B (en) | 2003-10-31 | 2006-07-21 | Arena Pharm Inc | Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof |
| CA2584225A1 (en) | 2004-11-05 | 2006-05-18 | Arena Pharmaceuticals, Inc. | Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists |
| PE20060949A1 (es) | 2004-12-23 | 2006-10-11 | Arena Pharm Inc | Derivados fusionados de pirazol como agonistas del receptor de niacina |
| JP2008538277A (ja) | 2005-02-18 | 2008-10-23 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 脂質関連障害の治療用の組成物および方法 |
| WO2006127595A1 (en) | 2005-05-23 | 2006-11-30 | Arena Pharmaceuticals, Inc. | 5-aminopyrazole carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof |
| EP1924709A1 (en) | 2005-08-10 | 2008-05-28 | Arena Pharmaceuticals, Inc. | Methods for determining probability of an adverse or favorable reaction to a niacin receptor agonist |
-
2004
- 2004-11-18 AU AU2004293415A patent/AU2004293415A1/en not_active Abandoned
- 2004-11-18 AT AT04811612T patent/ATE440828T1/de not_active IP Right Cessation
- 2004-11-18 DE DE602004022864T patent/DE602004022864D1/de not_active Expired - Lifetime
- 2004-11-18 JP JP2006541430A patent/JP2007512346A/ja active Pending
- 2004-11-18 CA CA002545823A patent/CA2545823A1/en not_active Abandoned
- 2004-11-18 EP EP04811612A patent/EP1701947B1/en not_active Expired - Lifetime
- 2004-11-18 CN CNA2004800340741A patent/CN1882557A/zh active Pending
- 2004-11-18 ES ES04811612T patent/ES2331521T3/es not_active Expired - Lifetime
- 2004-11-18 US US10/578,732 patent/US20070093545A1/en not_active Abandoned
- 2004-11-18 WO PCT/US2004/038920 patent/WO2005051937A2/en not_active Ceased
-
2006
- 2006-11-21 US US11/602,551 patent/US7803837B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7803837B2 (en) | 2010-09-28 |
| CN1882557A (zh) | 2006-12-20 |
| AU2004293415A1 (en) | 2005-06-09 |
| EP1701947B1 (en) | 2009-08-26 |
| DE602004022864D1 (de) | 2009-10-08 |
| WO2005051937A3 (en) | 2005-09-15 |
| CA2545823A1 (en) | 2005-06-09 |
| EP1701947A2 (en) | 2006-09-20 |
| US20070161701A1 (en) | 2007-07-12 |
| US20070093545A1 (en) | 2007-04-26 |
| WO2005051937A2 (en) | 2005-06-09 |
| JP2007512346A (ja) | 2007-05-17 |
| ATE440828T1 (de) | 2009-09-15 |
| WO2005051937A8 (en) | 2006-08-31 |
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