ATE440828T1 - 4-oxo-4,5-dihydro-furan-2-carbonsäure und derivate und verfahren zur behandlung von stoffwechselerkrankungen mit diesen verbindungen - Google Patents
4-oxo-4,5-dihydro-furan-2-carbonsäure und derivate und verfahren zur behandlung von stoffwechselerkrankungen mit diesen verbindungenInfo
- Publication number
- ATE440828T1 ATE440828T1 AT04811612T AT04811612T ATE440828T1 AT E440828 T1 ATE440828 T1 AT E440828T1 AT 04811612 T AT04811612 T AT 04811612T AT 04811612 T AT04811612 T AT 04811612T AT E440828 T1 ATE440828 T1 AT E440828T1
- Authority
- AT
- Austria
- Prior art keywords
- furan
- dihydro
- oxo
- derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52426903P | 2003-11-21 | 2003-11-21 | |
PCT/US2004/038920 WO2005051937A2 (en) | 2003-11-21 | 2004-11-18 | 4-oxo-4,5-dihydro-furan-2-carboxylic and acid derivatives and methods of treatment of metabolic-related disorders thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE440828T1 true ATE440828T1 (de) | 2009-09-15 |
Family
ID=34632884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04811612T ATE440828T1 (de) | 2003-11-21 | 2004-11-18 | 4-oxo-4,5-dihydro-furan-2-carbonsäure und derivate und verfahren zur behandlung von stoffwechselerkrankungen mit diesen verbindungen |
Country Status (10)
Country | Link |
---|---|
US (2) | US20070093545A1 (de) |
EP (1) | EP1701947B1 (de) |
JP (1) | JP2007512346A (de) |
CN (1) | CN1882557A (de) |
AT (1) | ATE440828T1 (de) |
AU (1) | AU2004293415A1 (de) |
CA (1) | CA2545823A1 (de) |
DE (1) | DE602004022864D1 (de) |
ES (1) | ES2331521T3 (de) |
WO (1) | WO2005051937A2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005311930B9 (en) | 2004-12-03 | 2009-09-10 | Merck Sharp & Dohme Corp. | Substituted piperazines as CB1 antagonists |
KR100826108B1 (ko) | 2006-08-04 | 2008-04-29 | 한국화학연구원 | 퓨란-2-카복실산 유도체 및 그의 제조 방법 |
US20110082202A1 (en) * | 2009-10-05 | 2011-04-07 | Milne Jill C | Fatty acid acifran derivatives and their uses |
AU2013290100A1 (en) | 2012-07-11 | 2015-01-29 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
WO2018006258A1 (en) * | 2016-07-05 | 2018-01-11 | Shenzhen Xpectvision Technology Co., Ltd. | Bonding materials of dissimilar coefficients of thermal expansion |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4169202A (en) * | 1978-06-05 | 1979-09-25 | American Home Products Corporation | Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives |
US4244958A (en) * | 1979-05-10 | 1981-01-13 | American Home Products Corporation | Hypolipidemic derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid |
US6902902B2 (en) * | 2001-11-27 | 2005-06-07 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders |
AU2003282679A1 (en) | 2002-10-04 | 2004-05-04 | Arena Pharmaceuticals, Inc. | Hydroxypyrazoles for use against metabolic-related disorders |
WO2004032928A1 (en) | 2002-10-10 | 2004-04-22 | Arena Pharmaceuticals, Inc. | 5-substituted 2h-pyrazone-3-carboxylic acid derivatives as antilipolytic agents for the treatment of metabolic-related disorders such as dyslipidemia |
WO2004041274A1 (en) | 2002-11-05 | 2004-05-21 | Arena Pharmaceuticals, Inc. | Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof |
AU2004260636A1 (en) * | 2003-06-13 | 2005-02-10 | Arena Pharmaceuticals, Inc. | 5-substituted 2H-pyrazole-3-carboxylic acid derivatives as agonists for the nicotinic acid receptor RUP25 for the treatment of dyslipidemia and related diseases |
PE20050483A1 (es) * | 2003-10-31 | 2005-08-25 | Arena Pharm Inc | Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas |
CN101076331A (zh) * | 2004-11-05 | 2007-11-21 | 艾尼纳制药公司 | 包含烟酸受体部分促效剂的用于治疗发红和脂质相关病症的组合物 |
PE20060949A1 (es) * | 2004-12-23 | 2006-10-11 | Arena Pharm Inc | Derivados fusionados de pirazol como agonistas del receptor de niacina |
JP2008538277A (ja) * | 2005-02-18 | 2008-10-23 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 脂質関連障害の治療用の組成物および方法 |
EP1899304A1 (de) | 2005-05-23 | 2008-03-19 | Arena Pharmaceuticals, Inc. | 5-amino-1h-pyrazol-3-carbonsäurederivate als agonisten des g-protein-gekoppelten rezeptors (gpcr) rup38 zur behandlung von stoffwechselerkrankungen damit |
US20090117559A1 (en) * | 2005-08-10 | 2009-05-07 | Liaw Chen W | Methods for Determining Probability of an Adverse or Favorable Reaction to a Niacin Receptor Agonist |
-
2004
- 2004-11-18 CA CA002545823A patent/CA2545823A1/en not_active Abandoned
- 2004-11-18 EP EP04811612A patent/EP1701947B1/de active Active
- 2004-11-18 US US10/578,732 patent/US20070093545A1/en not_active Abandoned
- 2004-11-18 AU AU2004293415A patent/AU2004293415A1/en not_active Abandoned
- 2004-11-18 AT AT04811612T patent/ATE440828T1/de not_active IP Right Cessation
- 2004-11-18 CN CNA2004800340741A patent/CN1882557A/zh active Pending
- 2004-11-18 ES ES04811612T patent/ES2331521T3/es active Active
- 2004-11-18 DE DE602004022864T patent/DE602004022864D1/de active Active
- 2004-11-18 WO PCT/US2004/038920 patent/WO2005051937A2/en active Application Filing
- 2004-11-18 JP JP2006541430A patent/JP2007512346A/ja active Pending
-
2006
- 2006-11-21 US US11/602,551 patent/US7803837B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20070161701A1 (en) | 2007-07-12 |
WO2005051937A3 (en) | 2005-09-15 |
EP1701947B1 (de) | 2009-08-26 |
CA2545823A1 (en) | 2005-06-09 |
US7803837B2 (en) | 2010-09-28 |
WO2005051937A8 (en) | 2006-08-31 |
ES2331521T3 (es) | 2010-01-07 |
JP2007512346A (ja) | 2007-05-17 |
WO2005051937A2 (en) | 2005-06-09 |
CN1882557A (zh) | 2006-12-20 |
DE602004022864D1 (de) | 2009-10-08 |
US20070093545A1 (en) | 2007-04-26 |
AU2004293415A1 (en) | 2005-06-09 |
EP1701947A2 (de) | 2006-09-20 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |