ES2316193T3 - Procedimientos, sistemas y dispositivos implantables asociados para monitorizacion dinamica de tumores. - Google Patents
Procedimientos, sistemas y dispositivos implantables asociados para monitorizacion dinamica de tumores. Download PDFInfo
- Publication number
- ES2316193T3 ES2316193T3 ES99950017T ES99950017T ES2316193T3 ES 2316193 T3 ES2316193 T3 ES 2316193T3 ES 99950017 T ES99950017 T ES 99950017T ES 99950017 T ES99950017 T ES 99950017T ES 2316193 T3 ES2316193 T3 ES 2316193T3
- Authority
- ES
- Spain
- Prior art keywords
- tumor
- treatment
- sensor
- monitoring
- radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 302
- 238000000034 method Methods 0.000 title claims abstract description 111
- 238000012544 monitoring process Methods 0.000 title claims abstract description 105
- 238000011282 treatment Methods 0.000 claims abstract description 199
- 230000005855 radiation Effects 0.000 claims abstract description 91
- 230000005540 biological transmission Effects 0.000 claims abstract description 47
- 230000002349 favourable effect Effects 0.000 claims abstract description 34
- 239000003814 drug Substances 0.000 claims abstract description 27
- 229940079593 drug Drugs 0.000 claims abstract description 26
- 238000011065 in-situ storage Methods 0.000 claims abstract description 21
- 238000001727 in vivo Methods 0.000 claims abstract description 20
- 238000011269 treatment regimen Methods 0.000 claims abstract description 15
- 210000004027 cell Anatomy 0.000 claims description 70
- 238000012360 testing method Methods 0.000 claims description 49
- 238000002560 therapeutic procedure Methods 0.000 claims description 42
- 238000006213 oxygenation reaction Methods 0.000 claims description 40
- 230000004044 response Effects 0.000 claims description 34
- 230000004663 cell proliferation Effects 0.000 claims description 29
- 238000011156 evaluation Methods 0.000 claims description 26
- 230000001965 increasing effect Effects 0.000 claims description 26
- 238000002512 chemotherapy Methods 0.000 claims description 21
- 230000000694 effects Effects 0.000 claims description 18
- 238000004458 analytical method Methods 0.000 claims description 17
- 230000002829 reductive effect Effects 0.000 claims description 15
- 230000001225 therapeutic effect Effects 0.000 claims description 15
- 238000001959 radiotherapy Methods 0.000 claims description 14
- 210000004881 tumor cell Anatomy 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 13
- 238000004891 communication Methods 0.000 claims description 12
- 231100000433 cytotoxic Toxicity 0.000 claims description 10
- 230000001472 cytotoxic effect Effects 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 230000022131 cell cycle Effects 0.000 claims description 5
- 238000001050 pharmacotherapy Methods 0.000 claims description 5
- 230000002035 prolonged effect Effects 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 231100000331 toxic Toxicity 0.000 claims description 3
- 230000002588 toxic effect Effects 0.000 claims description 3
- 201000009030 Carcinoma Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 238000012552 review Methods 0.000 claims description 2
- 230000005577 local transmission Effects 0.000 claims 2
- 230000037237 body shape Effects 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 230000000771 oncological effect Effects 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000004590 computer program Methods 0.000 abstract description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 47
- 229910052760 oxygen Inorganic materials 0.000 description 47
- 239000001301 oxygen Substances 0.000 description 47
- 210000001519 tissue Anatomy 0.000 description 35
- 239000007943 implant Substances 0.000 description 24
- 239000000758 substrate Substances 0.000 description 24
- 238000013461 design Methods 0.000 description 17
- 230000006870 function Effects 0.000 description 15
- 230000006378 damage Effects 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 14
- 230000003211 malignant effect Effects 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 14
- 239000012528 membrane Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 206010020843 Hyperthermia Diseases 0.000 description 13
- 230000008859 change Effects 0.000 description 13
- 238000005516 engineering process Methods 0.000 description 13
- 230000036031 hyperthermia Effects 0.000 description 13
- 238000013459 approach Methods 0.000 description 12
- 238000010586 diagram Methods 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 206010021143 Hypoxia Diseases 0.000 description 11
- 230000000875 corresponding effect Effects 0.000 description 10
- 229940127089 cytotoxic agent Drugs 0.000 description 10
- 239000002254 cytotoxic agent Substances 0.000 description 10
- 231100000599 cytotoxic agent Toxicity 0.000 description 10
- 229920001817 Agar Polymers 0.000 description 9
- 230000006399 behavior Effects 0.000 description 9
- 239000003990 capacitor Substances 0.000 description 9
- 230000001419 dependent effect Effects 0.000 description 9
- 238000012545 processing Methods 0.000 description 9
- 239000004642 Polyimide Substances 0.000 description 8
- 238000005868 electrolysis reaction Methods 0.000 description 8
- 229920001721 polyimide Polymers 0.000 description 8
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 7
- 230000008901 benefit Effects 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 7
- 229910052744 lithium Inorganic materials 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 230000007423 decrease Effects 0.000 description 6
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 6
- 229910052737 gold Inorganic materials 0.000 description 6
- 239000010931 gold Substances 0.000 description 6
- 230000007954 hypoxia Effects 0.000 description 6
- 230000000737 periodic effect Effects 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
- 229920003223 poly(pyromellitimide-1,4-diphenyl ether) Polymers 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 5
- 238000001574 biopsy Methods 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 230000001413 cellular effect Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000002354 daily effect Effects 0.000 description 5
- 238000000151 deposition Methods 0.000 description 5
- 230000008021 deposition Effects 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 230000001146 hypoxic effect Effects 0.000 description 5
- 230000008520 organization Effects 0.000 description 5
- 230000035479 physiological effects, processes and functions Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000035755 proliferation Effects 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 229910052710 silicon Inorganic materials 0.000 description 5
- 239000010703 silicon Substances 0.000 description 5
- 238000012795 verification Methods 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 230000000670 limiting effect Effects 0.000 description 4
- YVUZUKYBUMROPQ-UHFFFAOYSA-N mercury zinc Chemical compound [Zn].[Hg] YVUZUKYBUMROPQ-UHFFFAOYSA-N 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 238000011275 oncology therapy Methods 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000003068 static effect Effects 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 239000000560 biocompatible material Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 239000000919 ceramic Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000007405 data analysis Methods 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- HTXDPTMKBJXEOW-UHFFFAOYSA-N dioxoiridium Chemical group O=[Ir]=O HTXDPTMKBJXEOW-UHFFFAOYSA-N 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 3
- 238000004070 electrodeposition Methods 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 239000002555 ionophore Substances 0.000 description 3
- 230000000236 ionophoric effect Effects 0.000 description 3
- 229910000457 iridium oxide Inorganic materials 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 229910000510 noble metal Inorganic materials 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- BSWGGJHLVUUXTL-UHFFFAOYSA-N silver zinc Chemical compound [Zn].[Ag] BSWGGJHLVUUXTL-UHFFFAOYSA-N 0.000 description 3
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 238000012307 MRI technique Methods 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000009529 body temperature measurement Methods 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 230000018486 cell cycle phase Effects 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 229940030792 clinac Drugs 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000009510 drug design Methods 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 230000001667 episodic effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- 229920002529 medical grade silicone Polymers 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 238000001139 pH measurement Methods 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 238000000206 photolithography Methods 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 231100001274 therapeutic index Toxicity 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000581444 Clinidae Species 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000011374 additional therapy Methods 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 229940009456 adriamycin Drugs 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 210000001874 anterior cell Anatomy 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 210000002565 arteriole Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000513 bioprotective effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000003831 deregulation Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000007772 electrode material Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 238000011990 functional testing Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229910021397 glassy carbon Inorganic materials 0.000 description 1
- JUWSSMXCCAMYGX-UHFFFAOYSA-N gold platinum Chemical compound [Pt].[Au] JUWSSMXCCAMYGX-UHFFFAOYSA-N 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000009217 hyperthermia therapy Methods 0.000 description 1
- 230000002977 hyperthermial effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 238000011337 individualized treatment Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000002219 manual therapy Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- FEBNTWHYQKGEIQ-BIMULSAOSA-N nardin Natural products C[C@H]1CC[C@H](C=C(/C)C(=O)O)C2=C(C)CC[C@@H]12 FEBNTWHYQKGEIQ-BIMULSAOSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- UUWCBFKLGFQDME-UHFFFAOYSA-N platinum titanium Chemical compound [Ti].[Pt] UUWCBFKLGFQDME-UHFFFAOYSA-N 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 238000011849 radiological investigation Methods 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000006903 response to temperature Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/08—Sensors provided with means for identification, e.g. barcodes or memory chips
- A61B2562/085—Sensors provided with means for identification, e.g. barcodes or memory chips combined with means for recording calibration data
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- General Business, Economics & Management (AREA)
- Business, Economics & Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Computer Networks & Wireless Communication (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Radiation-Therapy Devices (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10244798P | 1998-09-30 | 1998-09-30 | |
| US102447P | 1998-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2316193T3 true ES2316193T3 (es) | 2009-04-01 |
Family
ID=22289894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99950017T Expired - Lifetime ES2316193T3 (es) | 1998-09-30 | 1999-09-29 | Procedimientos, sistemas y dispositivos implantables asociados para monitorizacion dinamica de tumores. |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1867275B1 (enExample) |
| JP (1) | JP4365531B2 (enExample) |
| AT (2) | ATE490725T1 (enExample) |
| AU (1) | AU763446B2 (enExample) |
| CA (1) | CA2341724C (enExample) |
| DE (2) | DE69943029D1 (enExample) |
| DK (2) | DK1867275T3 (enExample) |
| ES (1) | ES2316193T3 (enExample) |
| PT (1) | PT1117328E (enExample) |
| WO (1) | WO2000018294A1 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US20050103624A1 (en) | 1999-10-04 | 2005-05-19 | Bhullar Raghbir S. | Biosensor and method of making |
| US20010027384A1 (en) * | 2000-03-01 | 2001-10-04 | Schulze Arthur E. | Wireless internet bio-telemetry monitoring system and method |
| US8909325B2 (en) | 2000-08-21 | 2014-12-09 | Biosensors International Group, Ltd. | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
| WO2002039112A2 (en) | 2000-11-09 | 2002-05-16 | Sicel Technologies, Inc. | In vivo detection of biomolecule concentrations using fluorescent tags |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US7011814B2 (en) * | 2001-04-23 | 2006-03-14 | Sicel Technologies, Inc. | Systems, methods and devices for in vivo monitoring of a localized response via a radiolabeled analyte in a subject |
| US7557353B2 (en) | 2001-11-30 | 2009-07-07 | Sicel Technologies, Inc. | Single-use external dosimeters for use in radiation therapies |
| WO2003063700A1 (en) | 2002-01-29 | 2003-08-07 | Sicel Technologies, Inc. | Implantable sensor housing and fabrication methods |
| US7736309B2 (en) * | 2002-09-27 | 2010-06-15 | Medtronic Minimed, Inc. | Implantable sensor method and system |
| US7244264B2 (en) | 2002-12-03 | 2007-07-17 | Roche Diagnostics Operations, Inc. | Dual blade lancing test strip |
| US7811231B2 (en) | 2002-12-31 | 2010-10-12 | Abbott Diabetes Care Inc. | Continuous glucose monitoring system and methods of use |
| JP4607859B2 (ja) | 2003-02-19 | 2011-01-05 | サイセル・テクノロジーズ,インコーポレイテッド | 蛍光分析物と連動して作動するインビボ蛍光センサ、システム及び関連方法 |
| EP1618768B1 (en) * | 2003-04-15 | 2013-06-12 | Senseonics, Incorporated | Implantable sensor processing system with integrated printed circuit board antenna |
| US8066639B2 (en) | 2003-06-10 | 2011-11-29 | Abbott Diabetes Care Inc. | Glucose measuring device for use in personal area network |
| US7968851B2 (en) | 2004-01-13 | 2011-06-28 | Spectrum Dynamics Llc | Dynamic spect camera |
| US9470801B2 (en) | 2004-01-13 | 2016-10-18 | Spectrum Dynamics Llc | Gating with anatomically varying durations |
| EP1709585B1 (en) | 2004-01-13 | 2020-01-08 | Spectrum Dynamics Medical Limited | Multi-dimensional image reconstruction |
| US9040016B2 (en) | 2004-01-13 | 2015-05-26 | Biosensors International Group, Ltd. | Diagnostic kit and methods for radioimaging myocardial perfusion |
| EP1718198A4 (en) | 2004-02-17 | 2008-06-04 | Therasense Inc | METHOD AND SYSTEM FOR PROVIDING DATA COMMUNICATION IN A CONTINUOUS BLOOD SUGAR MONITORING AND MANAGEMENT SYSTEM |
| WO2005112895A2 (en) | 2004-05-20 | 2005-12-01 | Spectrum Dynamics Llc | Ingestible device platform for the colon |
| EP1778957A4 (en) | 2004-06-01 | 2015-12-23 | Biosensors Int Group Ltd | OPTIMIZING THE MEASUREMENT OF RADIOACTIVE RADIATION ON SPECIAL BODY STRUCTURES |
| JP3950977B2 (ja) * | 2004-06-25 | 2007-08-01 | 国立大学法人東北大学 | 体内埋め込み型リアルタイム式マイクロ線量計装置ならびに測定方法 |
| US9316743B2 (en) | 2004-11-09 | 2016-04-19 | Biosensors International Group, Ltd. | System and method for radioactive emission measurement |
| US9943274B2 (en) | 2004-11-09 | 2018-04-17 | Spectrum Dynamics Medical Limited | Radioimaging using low dose isotope |
| EP2510874A3 (en) * | 2005-03-29 | 2012-11-28 | Martin Roche | Biometric sensor |
| US20110213221A1 (en) | 2005-03-29 | 2011-09-01 | Roche Martin W | Method for Detecting Body Parameters |
| CN103622725B (zh) | 2005-04-15 | 2018-02-02 | 塞基森斯公司 | 用于检测组织特性具有传感器的外科器械,和使用所述器械的系统 |
| US8837793B2 (en) | 2005-07-19 | 2014-09-16 | Biosensors International Group, Ltd. | Reconstruction stabilizer and active vision |
| US7766829B2 (en) | 2005-11-04 | 2010-08-03 | Abbott Diabetes Care Inc. | Method and system for providing basal profile modification in analyte monitoring and management systems |
| US7620438B2 (en) | 2006-03-31 | 2009-11-17 | Abbott Diabetes Care Inc. | Method and system for powering an electronic device |
| US8226891B2 (en) | 2006-03-31 | 2012-07-24 | Abbott Diabetes Care Inc. | Analyte monitoring devices and methods therefor |
| US8894974B2 (en) | 2006-05-11 | 2014-11-25 | Spectrum Dynamics Llc | Radiopharmaceuticals for diagnosis and therapy |
| US9275451B2 (en) | 2006-12-20 | 2016-03-01 | Biosensors International Group, Ltd. | Method, a system, and an apparatus for using and processing multidimensional data |
| US8732188B2 (en) | 2007-02-18 | 2014-05-20 | Abbott Diabetes Care Inc. | Method and system for providing contextual based medication dosage determination |
| US8930203B2 (en) | 2007-02-18 | 2015-01-06 | Abbott Diabetes Care Inc. | Multi-function analyte test device and methods therefor |
| US8123686B2 (en) | 2007-03-01 | 2012-02-28 | Abbott Diabetes Care Inc. | Method and apparatus for providing rolling data in communication systems |
| PL1972275T3 (pl) * | 2007-03-20 | 2016-04-29 | Hoffmann La Roche | Układ do pomiaru in vivo stężenia analitu |
| US8456301B2 (en) | 2007-05-08 | 2013-06-04 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
| US8665091B2 (en) | 2007-05-08 | 2014-03-04 | Abbott Diabetes Care Inc. | Method and device for determining elapsed sensor life |
| US8461985B2 (en) | 2007-05-08 | 2013-06-11 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
| US7928850B2 (en) | 2007-05-08 | 2011-04-19 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
| US20110245713A1 (en) * | 2008-11-11 | 2011-10-06 | Koninklijke Philips Electronics N.V. | Medical device comprising a probe for measuring temperature data in a patient's tissue |
| US8103456B2 (en) | 2009-01-29 | 2012-01-24 | Abbott Diabetes Care Inc. | Method and device for early signal attenuation detection using blood glucose measurements |
| US9226701B2 (en) | 2009-04-28 | 2016-01-05 | Abbott Diabetes Care Inc. | Error detection in critical repeating data in a wireless sensor system |
| WO2010138856A1 (en) | 2009-05-29 | 2010-12-02 | Abbott Diabetes Care Inc. | Medical device antenna systems having external antenna configurations |
| WO2010151843A2 (en) * | 2009-06-26 | 2010-12-29 | Cianna Medical, Inc. | Apparatus, systems, and methods for localizing markers or tissue structures within a body |
| WO2011026147A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Diabetes Care Inc. | Analyte signal processing device and methods |
| EP2473099A4 (en) | 2009-08-31 | 2015-01-14 | Abbott Diabetes Care Inc | ANALYTICAL SUBSTANCE MONITORING SYSTEM AND METHODS OF MANAGING ENERGY AND NOISE |
| US9320461B2 (en) | 2009-09-29 | 2016-04-26 | Abbott Diabetes Care Inc. | Method and apparatus for providing notification function in analyte monitoring systems |
| JP6443802B2 (ja) | 2011-11-07 | 2018-12-26 | アボット ダイアベティス ケア インコーポレイテッドAbbott Diabetes Care Inc. | 分析物モニタリング装置および方法 |
| US8795359B2 (en) | 2012-06-13 | 2014-08-05 | Elwha Llc | Breast implant with regionalized analyte sensors and internal power source |
| US9144489B2 (en) | 2012-06-13 | 2015-09-29 | Elwha Llc | Breast implant with covering, analyte sensors and internal power source |
| US8808373B2 (en) | 2012-06-13 | 2014-08-19 | Elwha Llc | Breast implant with regionalized analyte sensors responsive to external power source |
| US9144488B2 (en) | 2012-06-13 | 2015-09-29 | Elwha Llc | Breast implant with analyte sensors responsive to external power source |
| US8790400B2 (en) | 2012-06-13 | 2014-07-29 | Elwha Llc | Breast implant with covering and analyte sensors responsive to external power source |
| US9211185B2 (en) | 2012-06-13 | 2015-12-15 | Elwha Llc | Breast implant with analyte sensors and internal power source |
| US9968306B2 (en) | 2012-09-17 | 2018-05-15 | Abbott Diabetes Care Inc. | Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems |
| EP4079242B1 (en) | 2013-03-19 | 2025-10-08 | Surgisense Corporation | Apparatus, systems and methods for determining tissue oxygenation |
| JP6512623B2 (ja) * | 2014-02-07 | 2019-05-15 | 国立大学法人北海道大学 | 吸収線量測定システムおよび測定装置および方法 |
| WO2015154094A1 (en) | 2014-04-05 | 2015-10-08 | Zand Jason M | Apparatus, systems, and methods for mapping of tissue oxygenation |
| JP6385740B2 (ja) * | 2014-07-04 | 2018-09-05 | ルネサスエレクトロニクス株式会社 | 電子装置およびその製造方法 |
| CN104970806B (zh) * | 2015-07-12 | 2017-08-04 | 北京泱深生物信息技术有限公司 | 一种用于癌症复发实时动态监测的智能设备 |
| EP3681383A4 (en) * | 2017-09-13 | 2021-08-25 | Hologic, Inc. | WIRELESS ACTIVE SURVEILLANCE IMPLANT SYSTEM |
| GB2566463A (en) * | 2017-09-13 | 2019-03-20 | Univ Southampton | pH Sensor and Calibration method |
| SI25656A (sl) | 2018-06-01 | 2019-12-31 | Jože Abram | Mešalno brizgalna glava za tridimenzionalni tiskalnik za tiskanje sten zgradb in metoda tiskanja |
| JP7500594B2 (ja) * | 2019-03-07 | 2024-06-17 | プロセプト バイオロボティクス コーポレイション | 持続的患者監視および知的治療のためのインプラント |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3219558C2 (de) * | 1982-05-25 | 1986-10-23 | Norbert H.L. Dr.-Ing. 5173 Aldenhoven Koster | Vorrichtung zur Bestimmung der lokalen Temperatur in lebendem Gewebe |
| JPS61146230A (ja) * | 1984-12-19 | 1986-07-03 | 東洋通信機株式会社 | 係止具を設けた生体内埋込みセンサ |
| JPS62102733A (ja) * | 1985-10-31 | 1987-05-13 | 東洋通信機株式会社 | 生体内温度検出表示装置 |
| IL86470A (en) * | 1988-05-23 | 1994-11-28 | E M T Electro Magnetic Technol | Means and method for temperature control from a distance |
| JP2762283B2 (ja) * | 1988-10-31 | 1998-06-04 | 東洋通信機株式会社 | 生体内埋め込みセンサ |
| DE3932428A1 (de) * | 1989-09-28 | 1991-04-11 | Argumens Gmbh | Vorrichtung zur drahtlosen messung einer lokalen physikalischen groesse |
| US5791344A (en) | 1993-11-19 | 1998-08-11 | Alfred E. Mann Foundation For Scientific Research | Patient monitoring system |
| DE4341903A1 (de) * | 1993-12-09 | 1995-06-14 | Josef Prof Dr Rer Nat Binder | Implantierbares telemetrisches Endosystem |
| US5544661A (en) * | 1994-01-13 | 1996-08-13 | Charles L. Davis | Real time ambulatory patient monitor |
| US5593430A (en) * | 1995-01-27 | 1997-01-14 | Pacesetter, Inc. | Bus system for interconnecting an implantable medical device with a plurality of sensors |
| US5720771A (en) | 1995-08-02 | 1998-02-24 | Pacesetter, Inc. | Method and apparatus for monitoring physiological data from an implantable medical device |
| US5833603A (en) * | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
| JP2001505071A (ja) * | 1996-03-27 | 2001-04-17 | メドネティックス・アクチエンゲゼルシヤフト | 位置測定のための装置および方法 |
| US5814089A (en) * | 1996-12-18 | 1998-09-29 | Medtronic, Inc. | Leadless multisite implantable stimulus and diagnostic system |
| AU6942198A (en) * | 1997-03-27 | 1998-10-22 | Advanced Bionics, Inc. | System of implantable devices for monitoring and/or affecting body para meters |
| EP0990151A2 (en) * | 1997-06-16 | 2000-04-05 | ELAN CORPORATION, Plc | Methods of calibrating and testing a sensor for (in vivo) measurement of an analyte and devices for use in such methods |
| JP2000005136A (ja) * | 1998-06-26 | 2000-01-11 | Nippon Telegr & Teleph Corp <Ntt> | 温度測定装置およびインプラント |
| US9472410B2 (en) | 2014-03-05 | 2016-10-18 | Applied Materials, Inc. | Pixelated capacitance controlled ESC |
-
1999
- 1999-09-29 WO PCT/US1999/022638 patent/WO2000018294A1/en not_active Ceased
- 1999-09-29 EP EP07016983A patent/EP1867275B1/en not_active Expired - Lifetime
- 1999-09-29 EP EP99950017A patent/EP1117328B1/en not_active Expired - Lifetime
- 1999-09-29 AT AT07016983T patent/ATE490725T1/de not_active IP Right Cessation
- 1999-09-29 DK DK07016983.4T patent/DK1867275T3/da active
- 1999-09-29 DE DE69943029T patent/DE69943029D1/de not_active Expired - Lifetime
- 1999-09-29 DE DE69939592T patent/DE69939592D1/de not_active Expired - Lifetime
- 1999-09-29 DK DK99950017T patent/DK1117328T3/da active
- 1999-09-29 CA CA2341724A patent/CA2341724C/en not_active Expired - Fee Related
- 1999-09-29 AU AU62764/99A patent/AU763446B2/en not_active Ceased
- 1999-09-29 AT AT99950017T patent/ATE408369T1/de active
- 1999-09-29 PT PT99950017T patent/PT1117328E/pt unknown
- 1999-09-29 ES ES99950017T patent/ES2316193T3/es not_active Expired - Lifetime
- 1999-09-29 JP JP2000571817A patent/JP4365531B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6276499A (en) | 2000-04-17 |
| EP1867275A2 (en) | 2007-12-19 |
| DE69939592D1 (de) | 2008-10-30 |
| ATE408369T1 (de) | 2008-10-15 |
| CA2341724C (en) | 2010-12-21 |
| AU763446B2 (en) | 2003-07-24 |
| PT1117328E (pt) | 2008-12-02 |
| EP1867275B1 (en) | 2010-12-08 |
| JP4365531B2 (ja) | 2009-11-18 |
| WO2000018294A1 (en) | 2000-04-06 |
| EP1117328B1 (en) | 2008-09-17 |
| DE69943029D1 (de) | 2011-01-20 |
| EP1117328A1 (en) | 2001-07-25 |
| ATE490725T1 (de) | 2010-12-15 |
| DK1117328T3 (da) | 2009-01-19 |
| EP1867275A3 (en) | 2008-04-09 |
| JP2002525153A (ja) | 2002-08-13 |
| CA2341724A1 (en) | 2000-04-06 |
| DK1867275T3 (da) | 2011-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2316193T3 (es) | Procedimientos, sistemas y dispositivos implantables asociados para monitorizacion dinamica de tumores. | |
| US7171252B1 (en) | Methods, computer program products, and devices for calibrating chronically tissue implanted sensors using chronically tissue | |
| KR102746220B1 (ko) | 이식 가능한 의료 장치용 트랜스폰더 | |
| JP5714210B2 (ja) | 移植可能なワイヤ無し通信システム | |
| US8744544B2 (en) | System having wireless implantable sensor | |
| US20140163338A1 (en) | Analyte Sensor with Slot Antenna | |
| JP2022508169A (ja) | 埋め込み型血管アクセスデバイスのための無線充電、位置特定、およびデータ通信 | |
| KR20120094532A (ko) | 연속적인 비간섭 건강 검진 및 경보 시스템 | |
| US12102790B2 (en) | Connected drug delivery system for erythropoietin stimulating agents | |
| Mauron et al. | Improvements in glass encapsulation technology offer significant advantages for implantable medical devices | |
| HK1181629A (en) | Analyte sensor having a slot antenna |