ES2312499T3 - Compuesto de lipoxina y su uso en el tratamiento y su uso en el tratamiento de los trastornos poliferativos de celulas. - Google Patents
Compuesto de lipoxina y su uso en el tratamiento y su uso en el tratamiento de los trastornos poliferativos de celulas. Download PDFInfo
- Publication number
- ES2312499T3 ES2312499T3 ES02001564T ES02001564T ES2312499T3 ES 2312499 T3 ES2312499 T3 ES 2312499T3 ES 02001564 T ES02001564 T ES 02001564T ES 02001564 T ES02001564 T ES 02001564T ES 2312499 T3 ES2312499 T3 ES 2312499T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- baselineskip
- lxa4
- inclusive
- lipoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/712,610 US6048897A (en) | 1993-06-15 | 1996-09-13 | Lipoxin compounds and their use in treating cell proliferative disorders |
US712610 | 1996-09-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2312499T3 true ES2312499T3 (es) | 2009-03-01 |
Family
ID=24862848
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02001564T Expired - Lifetime ES2312499T3 (es) | 1996-09-13 | 1997-09-15 | Compuesto de lipoxina y su uso en el tratamiento y su uso en el tratamiento de los trastornos poliferativos de celulas. |
ES97941078T Expired - Lifetime ES2175460T3 (es) | 1996-09-13 | 1997-09-15 | Compuesto de lipoxinas y su utilizacion en el tratamiento de patologias con proliferacion celular. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97941078T Expired - Lifetime ES2175460T3 (es) | 1996-09-13 | 1997-09-15 | Compuesto de lipoxinas y su utilizacion en el tratamiento de patologias con proliferacion celular. |
Country Status (11)
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
US6887901B1 (en) * | 1993-06-15 | 2005-05-03 | Brigham & Women's Hospital, Inc. | Lipoxin compounds and their use in treating cell proliferative disorders |
CA2336807C (en) * | 1998-07-08 | 2010-04-13 | Aventis Pharma Deutschland Gmbh | Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
CA2367909C (en) | 1999-03-18 | 2008-02-12 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response |
EP1616566A1 (en) * | 1999-03-18 | 2006-01-18 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds for treating TNF-alpha initiated inflammation |
WO2000055109A1 (en) | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Lipoxin compounds and their use |
EP1586550A1 (en) * | 1999-03-18 | 2005-10-19 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds and their use |
AU2004235617B2 (en) * | 1999-03-18 | 2008-06-05 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds and their use |
ATE258791T1 (de) | 1999-11-09 | 2004-02-15 | Alcon Inc | Lipoxin-a4 und deren analoge zur behandlung von trockenen augen |
CN1951899B (zh) | 2000-02-16 | 2012-02-01 | 布里格姆及妇女医院股份有限公司 | 阿司匹林触发的脂质介体 |
EP1268393A2 (en) | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
ATE412448T1 (de) * | 2001-03-02 | 2008-11-15 | Brigham & Womens Hospital | Lipoxin analoge als neue inhibitoren der angiogenese |
ATE468157T1 (de) * | 2001-03-02 | 2010-06-15 | Brigham & Womens Hospital | Lipoxinanaloge als neuartige restenose-hemmer |
US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
GB0119583D0 (en) * | 2001-08-10 | 2001-10-03 | Unilever Plc | Cosmetic composition and method of treating skin |
WO2003039533A1 (en) * | 2001-11-06 | 2003-05-15 | The Brigham And Women's Hospital, Inc. | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
EP1911448B1 (en) * | 2001-11-06 | 2013-01-02 | The Brigham and Women's Hospital, Inc. | Lipoxins and Aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
US6831186B2 (en) * | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
EP1941875B1 (en) * | 2001-12-18 | 2012-09-12 | The Brigham and Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
US7030159B2 (en) * | 2001-12-18 | 2006-04-18 | The Brigham And Women's Hospital, Inc. | Approach to anti-microbial host defense with molecular shields with EPA and DHA analogs |
AU2002360660A1 (en) * | 2001-12-18 | 2003-06-30 | The Brigham And Women's Hospital, Inc. | Use of lipoxin analogs to promote cell defense against gram-negative infections |
US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
EP3584235A3 (en) | 2002-08-12 | 2020-04-22 | Brigham and Women's Hospital | Resolvins: biotemplates for novel therapeutic interventions |
US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
GB0313259D0 (en) * | 2003-06-09 | 2003-07-16 | Consejo Superior Investigacion | Magnetic nanoparticles |
US20050250694A1 (en) * | 2003-10-10 | 2005-11-10 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
US20050130897A1 (en) * | 2003-12-11 | 2005-06-16 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
EP1755537A4 (en) * | 2004-04-14 | 2009-12-09 | Univ Boston | METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA |
CN101052387A (zh) * | 2004-11-09 | 2007-10-10 | 爱尔康公司 | 用于治疗眼部疾病以及与过度增生和血管生成反应有关的疾病的5,6,7-三羟基庚酸及类似物 |
US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
US8245230B2 (en) * | 2005-03-14 | 2012-08-14 | Qnx Software Systems Limited | Adaptive partitioning scheduler for multiprocessing system |
WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
US20100029504A1 (en) | 2007-01-16 | 2010-02-04 | Phigenix, Inc. | Detecting pax2 for the diagnosis of breast cancer |
JP2009515991A (ja) | 2005-11-18 | 2009-04-16 | トラスティーズ オブ ボストン ユニバーシティ | レゾルビンを使用する骨喪失の処置および防止 |
US20070254897A1 (en) * | 2006-04-28 | 2007-11-01 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
CL2007003468A1 (es) | 2006-12-04 | 2008-07-04 | Bayer Schering Pharma Ag | Sal de potasio cristalina de analogos de lipoxina a4; metodode sintesis; composicion farmaceutica; y uso en el tratamiento de trastornos inflamatorios o autoinmunes. |
US20080287341A1 (en) * | 2007-05-18 | 2008-11-20 | Danyang Chen | Treatment of vascular abnormalities using nanoparticles |
JP2009026126A (ja) * | 2007-07-20 | 2009-02-05 | Nec Electronics Corp | 半導体装置 |
CN101843622B (zh) * | 2010-04-27 | 2011-09-14 | 黄波 | 脂氧素在制备女性避孕药物中的应用 |
WO2013056092A1 (en) | 2011-10-12 | 2013-04-18 | Case Western Reserve University | Multi-component nanochains |
EP2917738A1 (de) | 2012-11-12 | 2015-09-16 | BIOCRATES Life Sciences AG | Verwendung von qualitätsindikatoren zum nachweis von auftauprozessen in gefrorenen gewebeproben |
CN105439813B (zh) * | 2014-08-08 | 2017-10-27 | 广州丹康医药生物有限公司 | 化合物的合成方法 |
KR102437682B1 (ko) | 2016-06-03 | 2022-08-29 | 테티스 파마수티컬스 엘엘씨 | 특화된 사전 해소 매개체의 염에 관한 조성물 및 방법 |
WO2018098244A1 (en) * | 2016-11-22 | 2018-05-31 | The Brigham And Women's Hospital, Inc. | Personalized metabolomic profiling of specialized pro-resolving mediators |
US11439615B2 (en) | 2017-03-09 | 2022-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
WO2023168245A2 (en) | 2022-03-03 | 2023-09-07 | Thetis Pharmaceuticals Llc | Cyclodextrin complexes of specialized proresolving mediators |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4560514A (en) * | 1984-05-04 | 1985-12-24 | Bengt Samuelsson | Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds |
US4576758A (en) * | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
US4780281A (en) | 1985-06-14 | 1988-10-25 | Wayne State University | Method for assay of peroxidase enzyme or reducing substrate activity |
JPS62198677A (ja) | 1986-02-26 | 1987-09-02 | Nissan Chem Ind Ltd | テトラオ−ル誘導体 |
JPH0739368B2 (ja) | 1986-10-01 | 1995-05-01 | 旭硝子株式会社 | 20,20,20−トリフルオロアラキドン酸誘導体およびその製造法 |
CA1329809C (en) * | 1987-07-08 | 1994-05-24 | Nissan Chemical Industries, Ltd. | Optically active allyl alcohol and process for producing leucotriene b_ using thereof |
JPH01228994A (ja) | 1988-03-10 | 1989-09-12 | Fumie Satou | γ−シリルアリルアルコール及びその製造法 |
US5079261A (en) * | 1989-04-28 | 1992-01-07 | Brigham And Women's Hospital | Use of lipoxin a4 and its derivatives as antagonists for slow-reacting substances of anaphylaxis |
JP2834512B2 (ja) | 1990-01-30 | 1998-12-09 | 帝人株式会社 | リポキシン誘導体を有効成分とする疾患治療剤 |
US5322699A (en) | 1991-02-04 | 1994-06-21 | The Rockefeller University | Leukocyte-derived CR3 modulator, integrin modulating factor-1 (IMF-1) |
US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
JP3227922B2 (ja) | 1993-01-20 | 2001-11-12 | 富士電機株式会社 | 自動販売機 |
US6048897A (en) * | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
JPH08512023A (ja) * | 1993-06-15 | 1996-12-17 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物 |
AU7215294A (en) | 1993-06-29 | 1995-01-24 | Brigham And Women's Hospital | Modulation of inflammation related to columnar epithelia |
US5998487A (en) | 1998-04-08 | 1999-12-07 | Colgate-Palmolive Company | Anti-inflammatory and antibacterial benzyl phenol agents and their use in oral compositions |
EP1109553B1 (en) | 1998-09-08 | 2006-04-26 | Cornell Research Foundation, Inc. | Use of cyclooxygenase-2 inhibitors for the treatment of inflammatory diseases of the head and neck |
EP1268393A2 (en) | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
-
1996
- 1996-09-13 US US08/712,610 patent/US6048897A/en not_active Expired - Lifetime
-
1997
- 1997-09-15 AU AU42710/97A patent/AU723321B2/en not_active Ceased
- 1997-09-15 AT AT02001564T patent/ATE404522T1/de active
- 1997-09-15 ES ES02001564T patent/ES2312499T3/es not_active Expired - Lifetime
- 1997-09-15 CA CA002265708A patent/CA2265708C/en not_active Expired - Fee Related
- 1997-09-15 ES ES97941078T patent/ES2175460T3/es not_active Expired - Lifetime
- 1997-09-15 DE DE69711894T patent/DE69711894T2/de not_active Expired - Lifetime
- 1997-09-15 EP EP08014341A patent/EP2058293A1/en not_active Withdrawn
- 1997-09-15 PT PT97941078T patent/PT927150E/pt unknown
- 1997-09-15 PT PT02001564T patent/PT1201639E/pt unknown
- 1997-09-15 AT AT97941078T patent/ATE215924T1/de active
- 1997-09-15 WO PCT/US1997/016342 patent/WO1998011049A1/en active IP Right Grant
- 1997-09-15 EP EP02001564A patent/EP1201639B1/en not_active Expired - Lifetime
- 1997-09-15 DK DK02001564T patent/DK1201639T3/da active
- 1997-09-15 DE DE69738918T patent/DE69738918D1/de not_active Expired - Lifetime
- 1997-09-15 EP EP97941078A patent/EP0927150B1/en not_active Expired - Lifetime
- 1997-09-15 JP JP51396298A patent/JP4060366B2/ja not_active Expired - Fee Related
- 1997-09-15 DK DK97941078T patent/DK0927150T3/da active
-
1999
- 1999-05-11 US US09/309,423 patent/US6316648B1/en not_active Expired - Fee Related
-
2001
- 2001-03-09 US US09/803,549 patent/US6653493B2/en not_active Expired - Fee Related
- 2001-03-09 US US09/803,402 patent/US20020091279A1/en not_active Abandoned
- 2001-03-09 US US09/803,552 patent/US20010031882A1/en not_active Abandoned
- 2001-03-09 US US09/803,347 patent/US6750360B2/en not_active Expired - Fee Related
- 2001-10-01 US US09/968,445 patent/US6569075B2/en not_active Expired - Fee Related
-
2002
- 2002-06-19 US US10/175,268 patent/US6620919B2/en not_active Expired - Fee Related
- 2002-12-02 US US10/307,811 patent/US6635776B2/en not_active Expired - Fee Related
Also Published As
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