ES2300692T3 - Procedimiento de preparacion de valsartan e intrmedios del mismo. - Google Patents

Procedimiento de preparacion de valsartan e intrmedios del mismo. Download PDF

Info

Publication number
ES2300692T3
ES2300692T3 ES04026903T ES04026903T ES2300692T3 ES 2300692 T3 ES2300692 T3 ES 2300692T3 ES 04026903 T ES04026903 T ES 04026903T ES 04026903 T ES04026903 T ES 04026903T ES 2300692 T3 ES2300692 T3 ES 2300692T3
Authority
ES
Spain
Prior art keywords
group
procedure
compound
formula
valsartan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04026903T
Other languages
English (en)
Spanish (es)
Inventor
Giancarlo Verardo
Paola Geatti
Graziano Castaldi
Nicoletta Toniutti
Pietro Allegrini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dipharma Francis SRL
Original Assignee
Dipharma Francis SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34430775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2300692(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dipharma Francis SRL filed Critical Dipharma Francis SRL
Application granted granted Critical
Publication of ES2300692T3 publication Critical patent/ES2300692T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
ES04026903T 2003-11-21 2004-11-12 Procedimiento de preparacion de valsartan e intrmedios del mismo. Expired - Lifetime ES2300692T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI03A2267 2003-11-21
IT002267A ITMI20032267A1 (it) 2003-11-21 2003-11-21 Procdimento per la preparzione di valsartan e suoi intermedi

Publications (1)

Publication Number Publication Date
ES2300692T3 true ES2300692T3 (es) 2008-06-16

Family

ID=34430775

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04026903T Expired - Lifetime ES2300692T3 (es) 2003-11-21 2004-11-12 Procedimiento de preparacion de valsartan e intrmedios del mismo.

Country Status (8)

Country Link
US (1) US7439261B2 (enExample)
EP (1) EP1533305B1 (enExample)
JP (1) JP2005154442A (enExample)
AT (1) ATE386027T1 (enExample)
DE (1) DE602004011730D1 (enExample)
ES (1) ES2300692T3 (enExample)
IT (1) ITMI20032267A1 (enExample)
PT (1) PT1533305E (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0514206D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
EP1764365A1 (en) * 2005-09-20 2007-03-21 KRKA, D.D., Novo Mesto A process for the preparation of sartan derivates and intermediates useful in such process
ES2288376B1 (es) * 2005-10-20 2008-11-01 Inke, S.A. Procedimiento para la obtencion de intermedios utiles en la obtencion de un compuesto farmaceuticamente activo.
ES2316281B1 (es) * 2007-05-14 2010-02-09 Quimica Sintetica, S.A. Procedimiento para la preparacion de valsartan.
EP2316821A1 (en) * 2009-10-27 2011-05-04 Novartis AG Process for the manufacture of organic compounds
AU2011287616A1 (en) * 2010-08-03 2013-02-28 Novartis Ag Highly crystalline valsartan
CN104662008B (zh) * 2012-09-26 2017-03-08 株式会社Api 四唑化合物的脱保护方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122010000024I1 (de) * 1990-02-19 2010-07-08 Novartis Ag Acylverbindungen
US6869970B2 (en) * 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan

Also Published As

Publication number Publication date
US20050131038A1 (en) 2005-06-16
EP1533305B1 (en) 2008-02-13
DE602004011730D1 (de) 2008-03-27
US7439261B2 (en) 2008-10-21
JP2005154442A (ja) 2005-06-16
ATE386027T1 (de) 2008-03-15
ITMI20032267A1 (it) 2005-05-22
EP1533305A1 (en) 2005-05-25
PT1533305E (pt) 2008-04-22

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