ES2286843T3 - Receptores 6 alfa y 6 beta del factor de necrosis tumoral. - Google Patents
Receptores 6 alfa y 6 beta del factor de necrosis tumoral. Download PDFInfo
- Publication number
- ES2286843T3 ES2286843T3 ES98901699T ES98901699T ES2286843T3 ES 2286843 T3 ES2286843 T3 ES 2286843T3 ES 98901699 T ES98901699 T ES 98901699T ES 98901699 T ES98901699 T ES 98901699T ES 2286843 T3 ES2286843 T3 ES 2286843T3
- Authority
- ES
- Spain
- Prior art keywords
- polypeptide
- tnfr
- sequence
- baselineskip
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3549697P | 1997-01-14 | 1997-01-14 | |
| US35496P | 1997-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2286843T3 true ES2286843T3 (es) | 2007-12-01 |
Family
ID=21883066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98901699T Expired - Lifetime ES2286843T3 (es) | 1997-01-14 | 1998-01-13 | Receptores 6 alfa y 6 beta del factor de necrosis tumoral. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8003386B1 (https=) |
| EP (1) | EP1007659B1 (https=) |
| JP (1) | JP2001507937A (https=) |
| KR (1) | KR20000070174A (https=) |
| CN (1) | CN1247567A (https=) |
| AT (1) | ATE365796T1 (https=) |
| AU (1) | AU729062C (https=) |
| BR (1) | BR9806954A (https=) |
| CA (1) | CA2277925A1 (https=) |
| DE (1) | DE69837996T2 (https=) |
| ES (1) | ES2286843T3 (https=) |
| WO (1) | WO1998030694A2 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| KR20000070174A (ko) | 1997-01-14 | 2000-11-25 | 벤슨 로버트 에이치. | 종양 괴사 인자 수용체 6α 및 6β |
| US7285267B2 (en) | 1997-01-14 | 2007-10-23 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6α & 6β |
| WO1999004001A1 (en) * | 1997-07-21 | 1999-01-28 | Zymogenetics, Inc. | Tumor necrosis factor receptor ztnfr-5 |
| JP2001512667A (ja) * | 1997-08-06 | 2001-08-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトオーファンレセプターntr−1 |
| WO1999011791A2 (en) * | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| WO1999014330A1 (en) | 1997-09-18 | 1999-03-25 | Genentech, Inc. | DcR3 POLYPEPTIDE, A TNFR HOMOLOG |
| WO1999026977A1 (en) * | 1997-11-24 | 1999-06-03 | Biogen, Inc. | Novel receptors opg-2 |
| WO1999031128A2 (en) * | 1997-12-16 | 1999-06-24 | Incyte Pharmaceuticals, Inc. | Human tumor necrosis factor-r2-like proteins |
| DE19809978A1 (de) * | 1998-03-09 | 1999-09-16 | Basf Ag | Neuer Rezeptor aus der menschlichen Lunge |
| TR200002824T2 (tr) * | 1998-03-30 | 2000-12-21 | Eli Lilly And Company | TNF reseptörü üst-ailesinin bir unsuru olan gelişmiş FLINT (mFLINT) polipeptitlerin veya OPG3'ün tedavi amaçlı uygulamaları. |
| US6916907B1 (en) * | 1998-10-23 | 2005-07-12 | Curagen Corporation | Nucleic acids encoding osteoprotegern-like proteins and methods of using same |
| CO5241360A1 (es) * | 1998-12-09 | 2003-01-31 | Lilly Co Eli | Composiciones de flint y usos de estas |
| AU2211100A (en) * | 1998-12-22 | 2000-07-12 | Eli Lilly And Company | Therapeutic applications of flint polypeptides |
| WO2000046247A1 (en) * | 1999-02-05 | 2000-08-10 | Merck & Co., Inc. | Methods of use for dna molecules encoding m68, a tnf receptor-related protein |
| EP2357192A1 (en) | 1999-02-26 | 2011-08-17 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
| CA2362929A1 (en) * | 1999-03-04 | 2000-09-08 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6.alpha. and 6.beta. |
| AU2495200A (en) * | 1999-03-08 | 2000-09-28 | Genentech Inc. | Compositions and methods for the treatment of tumor |
| US6835814B1 (en) | 1999-03-30 | 2004-12-28 | Eli Lilly And Company | Protease resistant flint analogs |
| EP1165780A2 (en) * | 1999-03-30 | 2002-01-02 | Eli Lilly And Company | Flint polypeptide analogs |
| US6965012B1 (en) * | 1999-03-30 | 2005-11-15 | Eli Lilly And Company | Flint polypeptide analogs |
| EP1165781B1 (en) * | 1999-03-30 | 2007-08-29 | Eli Lilly And Company | Protease resistant flint analogs |
| US6627199B1 (en) | 1999-07-09 | 2003-09-30 | Amgen Inc | Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family |
| AU6517800A (en) * | 1999-08-04 | 2001-03-05 | Amgen, Inc. | Ntr3, a member of the tnf-receptor supergene family |
| AU783682B2 (en) | 1999-08-04 | 2005-11-24 | Amgen, Inc. | Fhm, a novel member of the TNF ligand supergene family |
| WO2001018055A1 (en) * | 1999-09-10 | 2001-03-15 | Eli Lilly And Company | Flint analog compounds and formulations thereof |
| WO2001018202A2 (en) * | 1999-09-10 | 2001-03-15 | Eli Lilly And Company | Flint analog compounds and formulations thereof |
| WO2001018041A2 (en) * | 1999-09-10 | 2001-03-15 | Eli Lilly And Company | Flint proteins and formulations thereof |
| CA2413160A1 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
| AU2001268427B2 (en) | 2000-06-16 | 2007-03-29 | Glaxosmithkline Intellectual Property Limited | Antibodies that immunospecifically bind to blys |
| CN1331125A (zh) * | 2000-06-26 | 2002-01-16 | 上海博德基因开发有限公司 | 一种新的多肽——人含细胞色素c结构域的tnfr/ngfr蛋白9.02和编码这种多肽的多核苷酸 |
| AU2001286688A1 (en) * | 2000-08-25 | 2002-03-13 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6alpha and 6beta |
| MXPA03010747A (es) | 2001-05-25 | 2004-03-02 | Human Genome Sciences Inc | Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral. |
| EP2261250B1 (en) | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin fusion proteins |
| SI1543038T2 (sl) * | 2002-09-11 | 2020-12-31 | Genentech, Inc. | Čiščenje proteinov |
| EA015860B1 (ru) | 2005-10-13 | 2011-12-30 | Хьюман Дженом Сайенсиз, Инк. | Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа |
| US20090269345A1 (en) * | 2005-12-23 | 2009-10-29 | Rong Fan | CLN248 Antibody Compositions and Methods of Use |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| CA2755198A1 (en) * | 2009-03-13 | 2010-09-16 | Mark L. Tykocinski | Ox40/trail fusion proteins |
| SG10201509499RA (en) | 2010-11-19 | 2015-12-30 | Eisai R&D Man Co Ltd | Neutralizing anti-ccl20 antibodies |
| KR102343212B1 (ko) | 2013-03-27 | 2021-12-23 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| WO2014186878A1 (en) | 2013-05-24 | 2014-11-27 | Cashman Neil R | Cell senescence markers as diagnostic and therapeutic targets |
| WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| US11186872B2 (en) | 2016-03-17 | 2021-11-30 | Cedars-Sinai Medical Center | Methods of diagnosing inflammatory bowel disease through RNASET2 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| CA2067031C (en) | 1991-04-26 | 2003-02-18 | Shigekazu Nagata | Dna coding for human cell surface antigen |
| NZ275711A (en) | 1993-10-14 | 1998-03-25 | Immunex Corp | Monoclonal antibodies and binding proteins which bind to human fas antigen (nerve growth factor/tumour necrosis factor receptor type) |
| US5830469A (en) | 1993-10-14 | 1998-11-03 | Immunex Corporation | Fas antagonists and uses thereof |
| US5663070A (en) | 1993-11-15 | 1997-09-02 | Lxr Biotechnology Inc. | Recombinant production of a soluble splice variant of the Fas (Apo-1) antigen, fas TM |
| US5741667A (en) * | 1994-05-27 | 1998-04-21 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
| US5632994A (en) | 1994-06-14 | 1997-05-27 | La Jolla Cancer Research Foundation | Fas associated proteins |
| WO1996034095A1 (en) * | 1995-04-27 | 1996-10-31 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptors |
| US5985614A (en) * | 1996-08-30 | 1999-11-16 | Human Genome Sciences, Inc. | Polynucleotides encoding interleukin-19 |
| KR20000070174A (ko) | 1997-01-14 | 2000-11-25 | 벤슨 로버트 에이치. | 종양 괴사 인자 수용체 6α 및 6β |
| US5885800A (en) * | 1997-02-04 | 1999-03-23 | Smithkline Beecham Corporation | DNA encoding tumor necrosis related receptor, TR4 |
| WO1998056892A1 (en) | 1997-06-11 | 1998-12-17 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor tr9 |
| WO1999004001A1 (en) | 1997-07-21 | 1999-01-28 | Zymogenetics, Inc. | Tumor necrosis factor receptor ztnfr-5 |
| JP2001512667A (ja) | 1997-08-06 | 2001-08-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトオーファンレセプターntr−1 |
| WO1999011791A2 (en) | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| WO1999014330A1 (en) * | 1997-09-18 | 1999-03-25 | Genentech, Inc. | DcR3 POLYPEPTIDE, A TNFR HOMOLOG |
| WO1999026977A1 (en) | 1997-11-24 | 1999-06-03 | Biogen, Inc. | Novel receptors opg-2 |
| WO1999031128A2 (en) | 1997-12-16 | 1999-06-24 | Incyte Pharmaceuticals, Inc. | Human tumor necrosis factor-r2-like proteins |
| WO1999033980A2 (en) | 1997-12-30 | 1999-07-08 | Chiron Corporation | Members of tnf and tnfr families |
| US6297367B1 (en) | 1997-12-30 | 2001-10-02 | Chiron Corporation | Polynucleotide encoding TNFL1 |
| DE19809978A1 (de) | 1998-03-09 | 1999-09-16 | Basf Ag | Neuer Rezeptor aus der menschlichen Lunge |
| TR200002824T2 (tr) | 1998-03-30 | 2000-12-21 | Eli Lilly And Company | TNF reseptörü üst-ailesinin bir unsuru olan gelişmiş FLINT (mFLINT) polipeptitlerin veya OPG3'ün tedavi amaçlı uygulamaları. |
| AU4818599A (en) | 1998-07-06 | 2000-01-24 | Schering Corporation | Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12),md-1, md2 and cyclin e2, related reagents and methods |
| KR100529270B1 (ko) | 1998-12-01 | 2005-11-21 | 제넨테크, 인크. | 혈관신생 및 심혈관형성의 촉진 또는 억제 |
| CO5241360A1 (es) | 1998-12-09 | 2003-01-31 | Lilly Co Eli | Composiciones de flint y usos de estas |
| AU2211100A (en) | 1998-12-22 | 2000-07-12 | Eli Lilly And Company | Therapeutic applications of flint polypeptides |
| WO2000046247A1 (en) | 1999-02-05 | 2000-08-10 | Merck & Co., Inc. | Methods of use for dna molecules encoding m68, a tnf receptor-related protein |
| CA2362929A1 (en) | 1999-03-04 | 2000-09-08 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6.alpha. and 6.beta. |
| CA2362427A1 (en) | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| AU2495200A (en) | 1999-03-08 | 2000-09-28 | Genentech Inc. | Compositions and methods for the treatment of tumor |
| AU3623700A (en) | 1999-03-11 | 2000-09-28 | Reinhard Ebner | Apoptosis inducing molecule ii and methods of use |
| EP1165781B1 (en) | 1999-03-30 | 2007-08-29 | Eli Lilly And Company | Protease resistant flint analogs |
| EP1165780A2 (en) | 1999-03-30 | 2002-01-02 | Eli Lilly And Company | Flint polypeptide analogs |
| CA2384713A1 (en) | 1999-09-29 | 2001-04-05 | Human Genome Sciences, Inc. | Colon and colon cancer associated polynucleotides and polypeptides |
| EP1225908A2 (en) | 1999-10-20 | 2002-07-31 | Eli Lilly And Company | Therapeutic applications of flint polypeptides |
| AU1915201A (en) | 1999-12-07 | 2001-06-18 | Eli Lilly And Company | Improving stability of flint through o-linked glycosylation |
| CA2395378A1 (en) | 1999-12-09 | 2001-06-14 | Merck & Co. Inc. | Dna molecules encoding human nhl, a dna helicase |
| AU2001248352A1 (en) | 2000-03-15 | 2001-09-24 | Epigenomics Ag | Diagnosis of diseases associated with the cell cycle |
| AU2001266787A1 (en) | 2000-06-07 | 2002-01-08 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| WO2002000926A2 (en) | 2000-06-30 | 2002-01-03 | Epigenomics Ag | Diagnosis of diseases associated with signal transduction |
| AU2001280460A1 (en) | 2000-08-02 | 2002-02-13 | Eli Lilly And Company | Pulmonary administration of flint |
| WO2002060317A2 (en) | 2001-01-30 | 2002-08-08 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of pancreatic cancer |
| US20040176279A1 (en) | 2001-02-01 | 2004-09-09 | Nigel Jenkins | Flint glycoforms |
| WO2002060947A2 (en) | 2001-02-01 | 2002-08-08 | Eli Lilly And Company | Glycoforms a fas ligand inhibitory protein analog |
| US20040236091A1 (en) | 2001-03-28 | 2004-11-25 | Chicz Roman M. | Translational profiling |
| FR2908832B1 (fr) | 2006-11-20 | 2011-08-26 | Valeo Systemes Thermiques | Carter pour echangeur de chaleur |
-
1998
- 1998-01-13 KR KR1019997006400A patent/KR20000070174A/ko not_active Ceased
- 1998-01-13 WO PCT/US1998/000153 patent/WO1998030694A2/en not_active Ceased
- 1998-01-13 CN CN98801836A patent/CN1247567A/zh active Pending
- 1998-01-13 EP EP98901699A patent/EP1007659B1/en not_active Expired - Lifetime
- 1998-01-13 BR BR9806954A patent/BR9806954A/pt not_active IP Right Cessation
- 1998-01-13 JP JP53103798A patent/JP2001507937A/ja not_active Withdrawn
- 1998-01-13 AU AU58157/98A patent/AU729062C/en not_active Ceased
- 1998-01-13 AT AT98901699T patent/ATE365796T1/de not_active IP Right Cessation
- 1998-01-13 CA CA002277925A patent/CA2277925A1/en not_active Abandoned
- 1998-01-13 DE DE69837996T patent/DE69837996T2/de not_active Expired - Fee Related
- 1998-01-13 US US09/006,352 patent/US8003386B1/en active Active
- 1998-01-13 ES ES98901699T patent/ES2286843T3/es not_active Expired - Lifetime
-
2000
- 2000-03-03 US US09/518,931 patent/US7186800B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BR9806954A (pt) | 2000-03-21 |
| JP2001507937A (ja) | 2001-06-19 |
| DE69837996D1 (de) | 2007-08-09 |
| EP1007659B1 (en) | 2007-06-27 |
| EP1007659A2 (en) | 2000-06-14 |
| US7186800B1 (en) | 2007-03-06 |
| WO1998030694A3 (en) | 1998-11-12 |
| ATE365796T1 (de) | 2007-07-15 |
| WO1998030694A2 (en) | 1998-07-16 |
| CA2277925A1 (en) | 1998-07-16 |
| US8003386B1 (en) | 2011-08-23 |
| KR20000070174A (ko) | 2000-11-25 |
| DE69837996T2 (de) | 2008-02-28 |
| AU729062B2 (en) | 2001-01-25 |
| AU5815798A (en) | 1998-08-03 |
| AU729062C (en) | 2004-03-25 |
| CN1247567A (zh) | 2000-03-15 |
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