ES2273704T3 - Procedimiento para utilizar un plataforma de deteccion. - Google Patents
Procedimiento para utilizar un plataforma de deteccion. Download PDFInfo
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- ES2273704T3 ES2273704T3 ES00943983T ES00943983T ES2273704T3 ES 2273704 T3 ES2273704 T3 ES 2273704T3 ES 00943983 T ES00943983 T ES 00943983T ES 00943983 T ES00943983 T ES 00943983T ES 2273704 T3 ES2273704 T3 ES 2273704T3
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
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- G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
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| US6771376B2 (en) | 1999-07-05 | 2004-08-03 | Novartis Ag | Sensor platform, apparatus incorporating the platform, and process using the platform |
| EP1192448B1 (en) | 1999-07-05 | 2006-09-27 | Novartis AG | Process of using a sensor platform |
| US8111401B2 (en) * | 1999-11-05 | 2012-02-07 | Robert Magnusson | Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats |
| US7167615B1 (en) | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
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| US7807447B1 (en) | 2000-08-25 | 2010-10-05 | Merck Sharp & Dohme Corp. | Compositions and methods for exon profiling |
| US7142296B2 (en) * | 2000-10-30 | 2006-11-28 | Sru Biosystems, Inc. | Method and apparatus for detecting biomolecular interactions |
| US7023544B2 (en) * | 2000-10-30 | 2006-04-04 | Sru Biosystems, Inc. | Method and instrument for detecting biomolecular interactions |
| US7217574B2 (en) * | 2000-10-30 | 2007-05-15 | Sru Biosystems, Inc. | Method and apparatus for biosensor spectral shift detection |
| US7153702B2 (en) * | 2000-10-30 | 2006-12-26 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
| US7070987B2 (en) * | 2000-10-30 | 2006-07-04 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
| US7615339B2 (en) | 2000-10-30 | 2009-11-10 | Sru Biosystems, Inc. | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces |
| US7264973B2 (en) * | 2000-10-30 | 2007-09-04 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant optical biosensor |
| AU2006201361B2 (en) * | 2000-10-30 | 2009-01-22 | Sru Biosystems, Inc. | A label-free high-throughput optical technique for detecting biomolecular interactions |
| US7175980B2 (en) | 2000-10-30 | 2007-02-13 | Sru Biosystems, Inc. | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities |
| US20030092075A1 (en) * | 2000-10-30 | 2003-05-15 | Sru Biosystems, Llc | Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors |
| US20030113766A1 (en) * | 2000-10-30 | 2003-06-19 | Sru Biosystems, Llc | Amine activated colorimetric resonant biosensor |
| US7575939B2 (en) * | 2000-10-30 | 2009-08-18 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
| US7094595B2 (en) * | 2000-10-30 | 2006-08-22 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US7306827B2 (en) * | 2000-10-30 | 2007-12-11 | Sru Biosystems, Inc. | Method and machine for replicating holographic gratings on a substrate |
| US7875434B2 (en) * | 2000-10-30 | 2011-01-25 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
| US7101660B2 (en) * | 2000-10-30 | 2006-09-05 | Sru Biosystems, Inc. | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces |
| US6951715B2 (en) * | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
| US7371562B2 (en) * | 2000-10-30 | 2008-05-13 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
| US7524625B2 (en) | 2000-10-30 | 2009-04-28 | Sru Biosystems, Inc. | Real time binding analysis of antigens on a biosensor surface |
| US7202076B2 (en) * | 2000-10-30 | 2007-04-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US7300803B2 (en) * | 2000-10-30 | 2007-11-27 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
| US20040069948A1 (en) * | 2000-12-18 | 2004-04-15 | Arno Feisst | Device and method for analysing the qualitative and/or quantitative composition of liquids |
| WO2002079765A2 (de) * | 2001-04-02 | 2002-10-10 | Zeptosens Ag | Optische struktur zur multi-photonen-anregung und deren verwendung |
| CA2460233A1 (en) | 2001-09-13 | 2003-03-20 | Axela Biosensors Inc. | Method and apparatus for assay based on light diffraction |
| US6922287B2 (en) * | 2001-10-12 | 2005-07-26 | Unaxis Balzers Aktiengesellschaft | Light coupling element |
| AU2008202728B2 (en) * | 2002-01-28 | 2011-04-07 | Sru Biosystems, Inc. | A guided mode resonant filter biosensor using a linear grating surface structure |
| AU2003210523B2 (en) * | 2002-01-28 | 2008-03-20 | Sru Biosystems, Inc. | A guided mode resonant filter biosensor using a linear grating surface structure |
| US7504364B2 (en) | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
| US7807348B2 (en) * | 2002-03-20 | 2010-10-05 | Wisconsin Alumni Research Foundation | Optical imaging of nanostructured substrates |
| US7074311B1 (en) | 2002-05-08 | 2006-07-11 | Sru Biosystems Inc. | Biosensor electrophoresis |
| US7429492B2 (en) * | 2002-09-09 | 2008-09-30 | Sru Biosystems, Inc. | Multiwell plates with integrated biosensors and membranes |
| US7927822B2 (en) | 2002-09-09 | 2011-04-19 | Sru Biosystems, Inc. | Methods for screening cells and antibodies |
| WO2005003326A2 (en) | 2003-03-28 | 2005-01-13 | Receptors Llc. | Artificial receptors including reversibly immobilized building blocks and methods |
| AU2003294535A1 (en) * | 2002-12-20 | 2004-07-14 | Fiso Technologies Inc. | Polarisation interferometric method and sensor for detecting a chemical substance |
| KR20050098268A (ko) * | 2003-01-27 | 2005-10-11 | 제테틱 인스티튜트 | 트렌치의 특성을 측정하는 간섭 공초점 현미경에 사용되는누설 유도파 모드 |
| US7545496B2 (en) * | 2003-06-25 | 2009-06-09 | Koninklijke Philips Electronics N.V. | Support with a surface structure for sensitive evanescent-field detection |
| US20050018944A1 (en) * | 2003-07-25 | 2005-01-27 | Mozdy Eric J. | Polarization modulation interrogation of grating-coupled waveguide sensors |
| EP1664780A2 (en) * | 2003-09-03 | 2006-06-07 | Receptors LLC | Sensors employing combinatorial artificial receptors |
| CA2537306A1 (en) * | 2003-09-03 | 2005-03-17 | Receptors Llc | Methods employing combinatorial artificial receptors |
| US8298780B2 (en) * | 2003-09-22 | 2012-10-30 | X-Body, Inc. | Methods of detection of changes in cells |
| WO2005031397A2 (en) * | 2003-09-26 | 2005-04-07 | Zetetic Institute | Catoptric and catadioptric imaging systems with pellicle and aperture-array beam-splitters and non-adaptive and adaptive catoptric surfaces |
| US20050070027A1 (en) | 2003-09-30 | 2005-03-31 | Jacques Gollier | Double resonance interrogation of grating-coupled waveguides |
| WO2005053835A2 (en) * | 2003-12-02 | 2005-06-16 | Receptors Llc | Artificial receptors including gradients |
| KR100579489B1 (ko) * | 2003-12-11 | 2006-05-12 | 이진우 | 생체물질 측정장치 및 그 제조방법 |
| WO2005064333A1 (ja) | 2003-12-25 | 2005-07-14 | National Institute Of Advanced Industrial Science And Technology | タンパク質と糖鎖との相互作用を分析する方法 |
| US20060068490A1 (en) * | 2004-03-05 | 2006-03-30 | Cha-Mei Tang | Flow-through chemical and biological sensor |
| US20050231728A1 (en) * | 2004-04-15 | 2005-10-20 | Anbo Wang | Q-point stabilization for linear interferometric sensors using tunable diffraction grating |
| JP4338590B2 (ja) | 2004-06-03 | 2009-10-07 | 独立行政法人科学技術振興機構 | 蛍光相関分光法による抗原の迅速検出及び/又は測定法。 |
| US7270543B2 (en) | 2004-06-29 | 2007-09-18 | Therametric Technologies, Inc. | Handpiece for caries detection |
| US20060004526A1 (en) * | 2004-07-01 | 2006-01-05 | Ambion, Inc. | System and method for processing results of a complex genetic test |
| JP2008505325A (ja) * | 2004-07-08 | 2008-02-21 | スウィンバーン ユニバーシティ オブ テクノロジー | ファイバーセンサー製造 |
| WO2006023406A2 (en) * | 2004-08-16 | 2006-03-02 | Zetetic Institute | Apparatus and method for joint and time delayed measurements of components of conjugated quadratures of fields of reflected/scattered and transmitted/scattered beams by an object in interferometry |
| WO2006023612A2 (en) * | 2004-08-19 | 2006-03-02 | Zetetic Institute | Sub-nanometer overlay, critical dimension, and lithography tool projection optic metrology systems based on measurement of exposure induced changes in photoresist on wafers |
| WO2006028930A2 (en) | 2004-09-03 | 2006-03-16 | Receptors Llc | Combinatorial artificial receptors including tether building blocks on scaffolds |
| WO2006029383A2 (en) | 2004-09-11 | 2006-03-16 | Receptors Llc | Combinatorial artificial receptors including peptide building blocks |
| WO2006034065A2 (en) * | 2004-09-20 | 2006-03-30 | Zetetic Institute | Catoptric imaging systems comprising pellicle and/or aperture-array beam-splitters and non-adaptive and /or adaptive catoptric surfaces |
| US7185753B2 (en) * | 2004-09-28 | 2007-03-06 | Hartness International, Inc. | Shuttle conveyor |
| GB0424458D0 (en) * | 2004-11-04 | 2004-12-08 | Mesophotonics Ltd | Metal nano-void photonic crystal for enhanced raman spectroscopy |
| EP2278301A1 (en) | 2004-11-04 | 2011-01-26 | Renishaw Diagnostics Limited | Metal nano-void photonic crystal for enhanced raman spectroscopy |
| WO2006065900A1 (en) * | 2004-12-13 | 2006-06-22 | Bayer Healthcare Llc | Size self-limiting compositions and test devices for measuring analytes in biological fluids |
| CN101500481B (zh) | 2005-04-05 | 2014-07-02 | 康宁股份有限公司 | 一种测定刺激事件对细胞产生的影响的方法 |
| US20060223051A1 (en) * | 2005-04-05 | 2006-10-05 | Ye Fang | System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors |
| US7790406B2 (en) | 2005-08-11 | 2010-09-07 | Sru Biosystems, Inc | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor |
| KR101006793B1 (ko) | 2005-08-11 | 2011-01-10 | 에스알유 바이오시스템즈, 인코포레이티드 | 라벨 없는 바인딩 검출 및 형광 증폭과 조합된 격자-기반센서 및 센서를 위한 판독 시스템 |
| US20070036682A1 (en) * | 2005-08-15 | 2007-02-15 | Honeywell International Inc. | Microoptic glucose detector |
| WO2007096459A1 (en) * | 2006-02-21 | 2007-08-30 | Haermae Harri | Separation-free assay method |
| RU2309959C1 (ru) * | 2006-02-22 | 2007-11-10 | Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук | Применение немодифицированных полимерных материалов для изготовления подложки биочипов, биочип на их основе и способ его изготовления, способ иммобилизации гидрогелей на немодифицированных полимерных материалах |
| JP2008102117A (ja) * | 2006-09-21 | 2008-05-01 | Fujifilm Corp | 表面プラズモン増強蛍光センサおよび蛍光検出方法 |
| EP2087353A2 (en) * | 2006-10-31 | 2009-08-12 | SRU Biosystems, Inc. | Method for blocking non-specific protein binding on a functionalized surface |
| CA2661661A1 (en) | 2006-11-21 | 2008-05-29 | Applied Biosystems, Llc | Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby |
| US8360771B2 (en) | 2006-12-28 | 2013-01-29 | Therametric Technologies, Inc. | Handpiece for detection of dental demineralization |
| US7943908B2 (en) * | 2007-01-22 | 2011-05-17 | University Of Maryland | Sensor system with surface-plasmon-polariton (SPP) enhanced selective fluorescence excitation and method |
| US7599055B2 (en) * | 2007-02-27 | 2009-10-06 | Corning Incorporated | Swept wavelength imaging optical interrogation system and method for using same |
| JP2008241305A (ja) * | 2007-03-26 | 2008-10-09 | Hokkaido Univ | 蛍光シグナルの増幅方法 |
| US20080240543A1 (en) * | 2007-03-30 | 2008-10-02 | Wolfgang Ernst Gustav Budach | Calibration and normalization method for biosensors |
| CA2683082A1 (en) * | 2007-04-19 | 2008-10-30 | Sru Biosystems, Inc. | Method for employing a biosensor to detect small molecules that bind directly to immobilized targets |
| JP2010524465A (ja) * | 2007-04-19 | 2010-07-22 | コーニング インコーポレイテッド | 病原体侵入の生細胞シグナルおよびその方法 |
| US7768640B2 (en) * | 2007-05-07 | 2010-08-03 | The Board Of Trustees Of The University Of Illinois | Fluorescence detection enhancement using photonic crystal extraction |
| US9134307B2 (en) | 2007-07-11 | 2015-09-15 | X-Body, Inc. | Method for determining ion channel modulating properties of a test reagent |
| CA2693700A1 (en) | 2007-07-11 | 2009-01-15 | Sru Biosystems, Inc. | Methods for identifying modulators of ion channels |
| CN103954595A (zh) * | 2007-07-12 | 2014-07-30 | 纳米识别技术股份公司 | 光电传感器系统 |
| DE102007033124B4 (de) * | 2007-07-16 | 2012-12-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung zur optischen Detektion von Substanzen in einem flüssigen oder gasförmigen Medium |
| US20090309617A1 (en) * | 2007-08-24 | 2009-12-17 | Ye Fang | Biosensor antibody functional mapping |
| US20090093011A1 (en) * | 2007-10-05 | 2009-04-09 | Ye Fang | Biosensors for ligand-directed functional selectivity |
| US20090325211A1 (en) * | 2007-10-06 | 2009-12-31 | Ye Fang | System and method for dual-detection of a cellular response |
| US8426148B2 (en) | 2007-10-06 | 2013-04-23 | Corning Incorporated | Label-free methods using a resonant waveguide grating biosensor to determine GPCR signaling pathways |
| US8703428B2 (en) * | 2007-10-06 | 2014-04-22 | Corning Incorporated | Single-cell label-free assay |
| KR100945387B1 (ko) * | 2007-11-14 | 2010-03-04 | 서강대학교산학협력단 | 시료의 비선형계수의 균질성 검사 장치 |
| US20090181409A1 (en) * | 2008-01-10 | 2009-07-16 | Ye Fang | Optical biosensor method for cell-cell interaction |
| US8846575B2 (en) | 2008-03-05 | 2014-09-30 | Corning Incorporated | High-throughput high-information content label-free cell biology screening methods |
| US8759013B2 (en) | 2008-03-05 | 2014-06-24 | Corning Incorporated | Dual-target biosensor cell assays |
| US8313898B2 (en) | 2008-03-05 | 2012-11-20 | Corning Incorporated | Dual-target biosensor cell assays |
| JP5094484B2 (ja) * | 2008-03-11 | 2012-12-12 | 富士フイルム株式会社 | 蛍光検出方法および蛍光検出装置 |
| EP2108938A1 (en) * | 2008-04-09 | 2009-10-14 | Koninklijke Philips Electronics N.V. | A carrier for optical detection in small sample volumes |
| US8257936B2 (en) * | 2008-04-09 | 2012-09-04 | X-Body Inc. | High resolution label free analysis of cellular properties |
| US20100015721A1 (en) * | 2008-06-04 | 2010-01-21 | Sru Biosystems, Inc. | Detection of Promiscuous Small Submicrometer Aggregates |
| US8173198B2 (en) | 2008-07-23 | 2012-05-08 | Life Technologies Corporation | Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers |
| WO2010018002A1 (de) | 2008-08-14 | 2010-02-18 | Cytolon Ag | Automatisiertes system zur auswahl und vermittlung von gelagerten allogenen biologischen zellen für transplantation, therapie und forschung |
| KR101226957B1 (ko) * | 2008-12-08 | 2013-02-07 | 한국전자통신연구원 | 일회용 진단 키트 |
| CN101769912B (zh) * | 2008-12-29 | 2014-05-28 | 北京卫星环境工程研究所 | 卫星整星表面热控材料原位测试探头调整平台 |
| ES2477890T3 (es) | 2009-02-06 | 2014-07-18 | Cytolon Ag | Sistema para facilitar datos de pacientes individuales o aunados, también anonimizados, basándose en datos moleculares de genoma, transcriptoma, proteoma, epigenoma o metaboloma |
| WO2010089158A1 (de) | 2009-02-06 | 2010-08-12 | Cytolon Ag | Automatisiertes system zum vergleich individueller genom-, transkriptom-, proteom-, epigenom und metabolomdaten mit daten aus knochenmarkspender-registern und blut, nabelschnurblut und gewebebanken |
| US20100273185A1 (en) * | 2009-04-27 | 2010-10-28 | Sru Biosystems, Inc. | Detection of Biased Agonist Activation |
| WO2010132890A1 (en) * | 2009-05-15 | 2010-11-18 | Sru Biosystems, Inc | Detection of changes in cell populations and mixed cell populations |
| BRPI1009628A2 (pt) * | 2009-05-22 | 2016-06-28 | 3M Innovative Properties Co | matriz para detectar opticamente um analito e método óptico para detectar um analito |
| CN101988893B (zh) | 2009-07-31 | 2012-02-08 | 长春吉大·小天鹅仪器有限公司 | 48通道阵列式等吸收波长检测系统 |
| CN101788473B (zh) * | 2009-12-29 | 2011-09-07 | 南京邮电大学 | 微型自相干生物化学传感器及其检测方法 |
| JP5544653B2 (ja) * | 2010-02-02 | 2014-07-09 | 独立行政法人産業技術総合研究所 | 抗原抗体反応の検出方法 |
| US20130041680A1 (en) | 2010-02-05 | 2013-02-14 | Cytolon Ag | Automated system for selecting and allocating stored allogeneic biological cells for transplantation, therapy and research |
| US20110207789A1 (en) * | 2010-02-19 | 2011-08-25 | Ye Fang | Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents |
| JP2013523095A (ja) * | 2010-03-26 | 2013-06-17 | エックス−ボディ インコーポレイテッド | 化合物ライブラリーをスクリーニングするための人工多能性細胞および他の細胞の使用法 |
| CN102258855A (zh) * | 2010-05-25 | 2011-11-30 | 上海薄荷信息科技有限公司 | 一种智能球类训练系统以及相应的控制方法 |
| ES2894833T3 (es) * | 2011-03-17 | 2022-02-16 | Valoya Oy | Dispositivo y método de iluminación de plantas para cámaras de crecimiento oscuras |
| EP2618130A1 (en) * | 2012-01-17 | 2013-07-24 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
| CN103063652B (zh) * | 2012-12-31 | 2014-09-03 | 济南大学 | 一种分子印迹电致发光检测抗生素残留的电压可控和多路转换的多通道传感纸芯片的制备 |
| EP3077799B1 (en) * | 2013-12-03 | 2021-01-06 | Koninklijke Philips N.V. | Biosensor comprising waveguide |
| CN105403694B (zh) * | 2015-11-05 | 2017-05-31 | 合肥学院 | 一种用于探测百草枯分子的PS@SiO2人工抗体的制备方法 |
| WO2018017129A1 (en) * | 2016-07-22 | 2018-01-25 | Hewlett-Packard Development Company, L.P. | Activatable surface enhanced raman spectroscopy sensor stage |
| US20180029074A1 (en) * | 2016-07-28 | 2018-02-01 | Aculon, Inc. | Coated articles having improved stability in aggressive environments |
| FR3067043B1 (fr) * | 2017-06-02 | 2021-06-25 | Univ De Lille 1 Sciences Et Technologies | Procede de detection optique |
| CN107481920B (zh) * | 2017-07-21 | 2020-03-10 | 上海科技大学 | 能够利用机械应力诱导细菌形貌伸长的材料及制备和应用 |
| KR20190041306A (ko) | 2017-10-12 | 2019-04-22 | 주식회사 엘지화학 | 이종 소재 접합체의 제조방법 |
| CN108344724B (zh) * | 2018-02-24 | 2021-05-04 | 南京智感环境科技有限公司 | 一种便携式湿地土壤监测装置 |
| CN108344723B (zh) * | 2018-02-24 | 2021-05-04 | 南京智感环境科技有限公司 | 一种湿地土壤的原位同步监测方法 |
| CN108827480B (zh) * | 2018-04-11 | 2020-03-27 | 山东师范大学 | 一种基于磷光发射的抗氧干扰温度传感器 |
| CN108802391B (zh) * | 2018-08-07 | 2021-03-16 | 福建师范大学 | 一种基于TiO2介晶诱导的共振能量转移型电化学发光及对卵巢癌标记物的免疫传感方法 |
| CN111822063B (zh) * | 2019-04-18 | 2022-04-12 | 京东方科技集团股份有限公司 | 一种微流控芯片、其制作方法及微流控装置 |
| CN112694887B (zh) * | 2020-12-07 | 2024-04-26 | 黑龙江省农业科学院植物保护研究所 | 一种发光型传感器及其构筑方法与在检测植物水杨酸含量中的应用 |
| CN114236659A (zh) * | 2021-12-21 | 2022-03-25 | 诚瑞光学(南宁)有限公司 | 光栅及其制备方法、光波导 |
| US12306442B2 (en) * | 2022-08-02 | 2025-05-20 | Globalfoundries U.S. Inc. | Structure including grating coupler with optofluidic grating channels |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1237645A (en) * | 1982-12-21 | 1988-06-07 | John H. Fisher | Assay technique |
| DE3577748D1 (de) | 1984-06-13 | 1990-06-21 | Unilever Nv | Vorrichtungen zur verwendung in chemischen analyseverfahren. |
| GB8423204D0 (en) * | 1984-09-14 | 1984-10-17 | Comtech Res Unit | Assay technique and equipment |
| GB8618133D0 (en) | 1986-07-24 | 1986-09-03 | Pa Consulting Services | Biosensors |
| GB8618159D0 (en) | 1986-07-25 | 1986-09-03 | Pa Consulting Services | Spectrometer based instruments |
| IL85137A (en) | 1987-01-21 | 1992-02-16 | Ares Serono Res & Dev Ltd | Method of assaying for a ligand using surface plasmon resonance effect |
| CA1305921C (en) * | 1987-01-30 | 1992-08-04 | Eric K. Gustafson | Diffraction immunoassay and reagents |
| US4952056A (en) | 1988-05-17 | 1990-08-28 | Entwicklungsgemeinschaft Asi | Method of determining the autocollimation angle of a grating coupler |
| GB8812213D0 (en) | 1988-05-24 | 1988-06-29 | Ares Serono Res & Dev Ltd | Method of assay |
| GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| SE8902043L (sv) | 1988-11-10 | 1990-05-11 | Pharmacia Ab | Foerfarande foer karakterisering av makromolekyler |
| SE8804074D0 (sv) | 1988-11-10 | 1988-11-10 | Pharmacia Ab | Sensorenhet och dess anvaendning i biosensorsystem |
| SE462408B (sv) | 1988-11-10 | 1990-06-18 | Pharmacia Ab | Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet |
| SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
| GB2227089A (en) | 1989-01-11 | 1990-07-18 | Plessey Co Plc | An optical biosensor |
| US5006716A (en) * | 1989-02-22 | 1991-04-09 | Research Corporation Technologies, Inc. | Method and system for directional, enhanced fluorescence from molecular layers |
| JP3390001B2 (ja) | 1989-04-11 | 2003-03-24 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ ベノートスハップ | 多分析物試験ビヒクル |
| GB8911462D0 (en) | 1989-05-18 | 1989-07-05 | Ares Serono Res & Dev Ltd | Devices for use in chemical test procedures |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5082629A (en) | 1989-12-29 | 1992-01-21 | The Board Of The University Of Washington | Thin-film spectroscopic sensor |
| EP0484472B1 (de) | 1990-04-12 | 1997-07-16 | SIGRIST, Hans, Dr. | Verfahren zur lichtinduzierten immobilisierung von biomolekülen an chemisch "inerten" oberflächen |
| DE59109246D1 (de) | 1990-05-03 | 2003-04-03 | Hoffmann La Roche | Mikrooptischer Sensor |
| US5830766A (en) | 1990-05-23 | 1998-11-03 | Ares-Serono Research & Development Ltd. Partnership | Enhanced signal-to-noise ratio and sensitivity optical immunoassay |
| US5478756A (en) | 1990-07-24 | 1995-12-26 | Fisons Plc | Chemical sensor for detecting binding reactions |
| WO1992003720A1 (en) | 1990-08-17 | 1992-03-05 | Fisons Plc | Analytical device |
| DE4026978A1 (de) | 1990-08-25 | 1992-02-27 | Bayer Ag | Auf traegern angebrachte ein- oder mehrlagige schichtelemente und ihre herstellung |
| GB9019123D0 (en) | 1990-09-01 | 1990-10-17 | Fisons Plc | Analytical device |
| SE501013C2 (sv) | 1990-10-01 | 1994-10-17 | Pharmacia Biosensor Ab | Förfarande för förbättring av analys med bindning till fast fas |
| EP1046421B8 (en) | 1990-12-06 | 2006-01-11 | Affymetrix, Inc. (a Delaware Corporation) | Methods and reagents for very large scale immobilized polymer synthesis |
| GB9102646D0 (en) | 1991-02-07 | 1991-03-27 | Fisons Plc | Analytical device |
| US5468620A (en) | 1991-03-09 | 1995-11-21 | Fisons Plc | Methods and device for glycosylation analysis |
| GB9105031D0 (en) | 1991-03-09 | 1991-04-24 | Fisons Plc | Processing analytical reagents |
| GB2256477B (en) | 1991-06-07 | 1995-03-08 | Marconi Gec Ltd | An optical sensor |
| DE4121426A1 (de) * | 1991-06-28 | 1993-01-14 | Basf Ag | Chemischer sensor |
| DE4228853C2 (de) | 1991-09-18 | 1993-10-21 | Schott Glaswerke | Optischer Wellenleiter mit einem planaren oder nur geringfügig gewölbten Substrat und Verfahren zu dessen Herstellung sowie Verwendung eines solchen |
| GB9200564D0 (en) | 1992-01-11 | 1992-03-11 | Fisons Plc | Analytical device with variable angle of incidence |
| GB9212416D0 (en) | 1992-06-11 | 1992-07-22 | Medical Res Council | Reversible binding substances |
| SE9201984D0 (sv) | 1992-06-29 | 1992-06-29 | Pharmacia Biosensor Ab | Improvement in optical assays |
| SE501108C2 (sv) | 1993-04-08 | 1994-11-14 | Pharmacia Lkb Biotech | Sätt och anordning för bestämning av brytningsindex |
| JPH09505135A (ja) | 1993-05-28 | 1997-05-20 | ファイソンズ ピーエルシー | 分析装置 |
| GB9314991D0 (en) * | 1993-07-20 | 1993-09-01 | Sandoz Ltd | Mechanical device |
| JPH08505951A (ja) | 1993-11-15 | 1996-06-25 | カール ツアイス イエーナ ゲゼルシャフト | 光学センサ表面に位置する物質を分析する装置 |
| US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| DE69505370T2 (de) | 1994-05-27 | 1999-04-01 | Novartis Ag, Basel | Verfahren und sensor zum nachweis abklingend angeregter lumineszenz |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| MX9708698A (es) | 1995-05-12 | 1998-02-28 | Novartis Ag | Plataforma de sensor y metodo para la deteccion paralela de una pluralidad de analitos utilizando luminescencia evanescentemente excitada. |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| SE9502608D0 (sv) | 1995-07-14 | 1995-07-14 | Pharmacia Biosensor Ab | Method for nucleic acid senquencing |
| SE9503028D0 (sv) | 1995-09-01 | 1995-09-01 | Pharmacia Biosensor Ab | Method of analysing chemical and physical interactions at a sensor surface |
| GB9518429D0 (en) | 1995-09-08 | 1995-11-08 | Pharmacia Biosensor | A rapid method for providing kinetic and structural data in molecular interaction analysis |
| SE9504046D0 (sv) | 1995-11-14 | 1995-11-14 | Pharmacia Ab | Method of determining affinity and kinetic properties |
| GB9602542D0 (en) | 1996-02-08 | 1996-04-10 | Fisons Plc | Analytical device |
| AT403745B (de) | 1996-02-29 | 1998-05-25 | Avl Verbrennungskraft Messtech | Messanordnung mit einem für anregungs- und messstrahlung transparentem trägerelement |
| JPH1019768A (ja) | 1996-03-19 | 1998-01-23 | Texas Instr Inc <Ti> | 表面プラズモン共鳴センサ |
| SE9601318D0 (sv) | 1996-04-04 | 1996-04-04 | Pharmacia Biosensor Ab | Method for nucleic acid analysis |
| EP0902885A4 (en) | 1996-05-16 | 2006-09-27 | Affymetrix Inc | SYSTEMS AND METHODS FOR DETECTION OF BRANDED PRODUCTS |
| US6111248A (en) | 1996-10-01 | 2000-08-29 | Texas Instruments Incorporated | Self-contained optical sensor system |
| US5946083A (en) | 1997-10-01 | 1999-08-31 | Texas Instruments Incorporated | Fixed optic sensor system and distributed sensor network |
| CA2270665A1 (en) | 1996-11-11 | 1998-05-22 | Novartis Ag | Use of biosensors to diagnose plant diseases |
| WO1998022799A2 (de) | 1996-11-18 | 1998-05-28 | Novartis Ag | Messvorrichtung und deren verwendung |
| US5846843A (en) * | 1996-11-18 | 1998-12-08 | The University Of Toledo | Sensor using long range surface plasmon resonance with diffraction double-grating |
| EP1007969A4 (en) | 1996-12-17 | 2006-12-13 | Affymetrix Inc | DESIGN OF LITHOGRAPHIC MASKS AND SYNTHESIS OF VARIOUS PROBES ON A SUBSTRATE |
| US6183696B1 (en) | 1997-01-22 | 2001-02-06 | Texas Instruments Incorporated | Optically based miniaturized sensor with integrated fluidics |
| US5898503A (en) | 1997-03-19 | 1999-04-27 | Texas Instruments Incorporated | Surface plasmon resonance sensor with interchangeable optical element |
| US6294327B1 (en) | 1997-09-08 | 2001-09-25 | Affymetrix, Inc. | Apparatus and method for detecting samples labeled with material having strong light scattering properties, using reflection mode light and diffuse scattering |
| EP1443320A3 (de) | 1997-09-10 | 2005-02-02 | Artificial Sensing Instruments ASI AG | Sensorchip zur Charakterisierung einer chemischen und/oder biochemischen Substanz |
| US5994150A (en) * | 1997-11-19 | 1999-11-30 | Imation Corp. | Optical assaying method and system having rotatable sensor disk with multiple sensing regions |
| US6200814B1 (en) | 1998-01-20 | 2001-03-13 | Biacore Ab | Method and device for laminar flow on a sensing surface |
| US6289286B1 (en) | 1998-05-29 | 2001-09-11 | Biacore Ab | Surface regeneration of biosensors and characterization of biomolecules associated therewith |
| US6111652A (en) | 1998-07-14 | 2000-08-29 | Texas Instruments Incorporated | High throughput surface plasmon resonance analysis system |
| US6203989B1 (en) | 1998-09-30 | 2001-03-20 | Affymetrix, Inc. | Methods and compositions for amplifying detectable signals in specific binding assays |
| AU5526500A (en) | 1999-06-05 | 2000-12-28 | Zeptosens Ag | Sensor platform and method for analysing multiple analytes |
| EP1192448B1 (en) | 1999-07-05 | 2006-09-27 | Novartis AG | Process of using a sensor platform |
-
2000
- 2000-07-03 EP EP00943983A patent/EP1192448B1/en not_active Expired - Lifetime
- 2000-07-03 HK HK02106408.1A patent/HK1046438B/en not_active IP Right Cessation
- 2000-07-03 DE DE60030978T patent/DE60030978T2/de not_active Expired - Lifetime
- 2000-07-03 JP JP2001508036A patent/JP4684507B2/ja not_active Expired - Fee Related
- 2000-07-03 CN CNB008112681A patent/CN100397068C/zh not_active Expired - Fee Related
- 2000-07-03 PT PT00943983T patent/PT1192448E/pt unknown
- 2000-07-03 AU AU58243/00A patent/AU5824300A/en not_active Abandoned
- 2000-07-03 ES ES00943983T patent/ES2273704T3/es not_active Expired - Lifetime
- 2000-07-03 KR KR1020017016811A patent/KR100883079B1/ko not_active Expired - Fee Related
- 2000-07-03 WO PCT/EP2000/006238 patent/WO2001002839A1/en not_active Ceased
- 2000-07-03 DK DK00943983T patent/DK1192448T3/da active
- 2000-07-03 AT AT00943983T patent/ATE340996T1/de active
- 2000-07-05 US US09/609,846 patent/US6707561B1/en not_active Expired - Lifetime
-
2006
- 2006-12-20 CY CY20061101827T patent/CY1107541T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20020019473A (ko) | 2002-03-12 |
| WO2001002839A1 (en) | 2001-01-11 |
| DE60030978D1 (de) | 2006-11-09 |
| KR100883079B1 (ko) | 2009-02-10 |
| CN1369059A (zh) | 2002-09-11 |
| DE60030978T2 (de) | 2007-06-14 |
| JP4684507B2 (ja) | 2011-05-18 |
| AU5824300A (en) | 2001-01-22 |
| HK1046438A1 (en) | 2003-01-10 |
| EP1192448A1 (en) | 2002-04-03 |
| EP1192448B1 (en) | 2006-09-27 |
| PT1192448E (pt) | 2007-01-31 |
| CY1107541T1 (el) | 2013-03-13 |
| ATE340996T1 (de) | 2006-10-15 |
| CN100397068C (zh) | 2008-06-25 |
| HK1046438B (en) | 2007-05-04 |
| JP2003503732A (ja) | 2003-01-28 |
| DK1192448T3 (da) | 2007-01-15 |
| US6707561B1 (en) | 2004-03-16 |
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