ES2234422A1 - Producing a carob based pharmaceutical consists of inversion of the saccharose after calcium and magnesium ions removal for demineralisation and separation of the reducer sugars - Google Patents
Producing a carob based pharmaceutical consists of inversion of the saccharose after calcium and magnesium ions removal for demineralisation and separation of the reducer sugarsInfo
- Publication number
- ES2234422A1 ES2234422A1 ES200302864A ES200302864A ES2234422A1 ES 2234422 A1 ES2234422 A1 ES 2234422A1 ES 200302864 A ES200302864 A ES 200302864A ES 200302864 A ES200302864 A ES 200302864A ES 2234422 A1 ES2234422 A1 ES 2234422A1
- Authority
- ES
- Spain
- Prior art keywords
- dotl
- weight
- preparation
- carob
- sugars
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 240000008886 Ceratonia siliqua Species 0.000 title claims abstract description 42
- 235000013912 Ceratonia siliqua Nutrition 0.000 title claims abstract description 40
- 235000000346 sugar Nutrition 0.000 title claims abstract description 21
- 150000008163 sugars Chemical class 0.000 title claims abstract description 14
- 229930006000 Sucrose Natural products 0.000 title claims abstract description 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 title claims abstract description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 5
- 239000011575 calcium Substances 0.000 title claims abstract description 5
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 title claims abstract description 4
- 229910001424 calcium ion Inorganic materials 0.000 title claims abstract description 4
- 229910001425 magnesium ion Inorganic materials 0.000 title claims abstract description 4
- 229960004793 sucrose Drugs 0.000 title abstract description 8
- 235000013681 dietary sucrose Nutrition 0.000 title abstract description 5
- 238000005115 demineralization Methods 0.000 title abstract description 3
- 238000000926 separation method Methods 0.000 title abstract description 3
- 239000003638 chemical reducing agent Substances 0.000 title abstract 2
- DSCFFEYYQKSRSV-UHFFFAOYSA-N 1L-O1-methyl-muco-inositol Natural products COC1C(O)C(O)C(O)C(O)C1O DSCFFEYYQKSRSV-UHFFFAOYSA-N 0.000 claims abstract description 6
- VJXUJFAZXQOXMJ-UHFFFAOYSA-N D-1-O-Methyl-muco-inositol Natural products CC12C(OC)(C)OC(C)(C)C2CC(=O)C(C23OC2C(=O)O2)(C)C1CCC3(C)C2C=1C=COC=1 VJXUJFAZXQOXMJ-UHFFFAOYSA-N 0.000 claims abstract description 6
- DSCFFEYYQKSRSV-KLJZZCKASA-N D-pinitol Chemical compound CO[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]1O DSCFFEYYQKSRSV-KLJZZCKASA-N 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 18
- 239000002537 cosmetic Substances 0.000 claims description 13
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- 229920005989 resin Polymers 0.000 claims description 11
- 230000000699 topical effect Effects 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 230000002829 reductive effect Effects 0.000 claims description 10
- 229930091371 Fructose Natural products 0.000 claims description 8
- 239000005715 Fructose Substances 0.000 claims description 8
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
- 125000002091 cationic group Chemical group 0.000 claims description 8
- 239000008103 glucose Substances 0.000 claims description 8
- 239000002453 shampoo Substances 0.000 claims description 6
- 230000001256 tonic effect Effects 0.000 claims description 6
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- 239000008267 milk Substances 0.000 claims description 5
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- 239000000344 soap Substances 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 239000000499 gel Substances 0.000 claims description 4
- 239000002674 ointment Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 244000062730 Melissa officinalis Species 0.000 claims description 3
- 235000010654 Melissa officinalis Nutrition 0.000 claims description 3
- 239000004909 Moisturizer Substances 0.000 claims description 3
- 125000000129 anionic group Chemical group 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- 238000005342 ion exchange Methods 0.000 claims description 3
- 239000000865 liniment Substances 0.000 claims description 3
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- 239000002253 acid Substances 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 238000006911 enzymatic reaction Methods 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 239000011252 protective cream Substances 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000000419 plant extract Substances 0.000 claims 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 239000003205 fragrance Substances 0.000 description 12
- 239000003755 preservative agent Substances 0.000 description 12
- 230000002335 preservative effect Effects 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 5
- 230000036571 hydration Effects 0.000 description 5
- 238000006703 hydration reaction Methods 0.000 description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 244000098338 Triticum aestivum Species 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 4
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 4
- 229940008099 dimethicone Drugs 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 235000017367 Guainella Nutrition 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 210000000245 forearm Anatomy 0.000 description 3
- 229940057995 liquid paraffin Drugs 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 3
- 229960001173 oxybenzone Drugs 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- 244000303965 Cyamopsis psoralioides Species 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- 125000005250 alkyl acrylate group Chemical group 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 229940085262 cetyl dimethicone Drugs 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 229920006037 cross link polymer Polymers 0.000 description 2
- 229950003988 decil Drugs 0.000 description 2
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
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- 238000005259 measurement Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 229960001679 octinoxate Drugs 0.000 description 2
- OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 description 2
- 230000036620 skin dryness Effects 0.000 description 2
- 230000037067 skin hydration Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- JHDBMHFWQRTXLV-UHFFFAOYSA-N 1-dodecoxydodecane;2-sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC JHDBMHFWQRTXLV-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- ZQCIPRGNRQXXSK-UHFFFAOYSA-N 1-octadecoxypropan-2-ol Chemical compound CCCCCCCCCCCCCCCCCCOCC(C)O ZQCIPRGNRQXXSK-UHFFFAOYSA-N 0.000 description 1
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- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 206010001488 Aggression Diseases 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
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- 206010013911 Dysgeusia Diseases 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
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- 230000003712 anti-aging effect Effects 0.000 description 1
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- 239000006286 aqueous extract Substances 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 229940067573 brown iron oxide Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
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- 230000002328 demineralizing effect Effects 0.000 description 1
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Abstract
Description
Procedimiento de obtención de un preparado a partir de algarroba y composiciones farmacéutica y cosmética que lo contienen.Procedure for obtaining a preparation from carob and pharmaceutical and cosmetic compositions that they contain.
La presente invención se refiere a un procedimiento de obtención de un preparado a partir de algarroba, al preparado obtenido según el procedimiento anterior y a unas composiciones farmacéutica y cosmética que contienen dicho preparado, las cuales son útiles para aumentar la hidratación de la piel.The present invention relates to a procedure for obtaining a preparation from carob, to the preparation obtained according to the previous procedure and about pharmaceutical and cosmetic compositions containing said prepared, which are useful for increasing the hydration of the skin.
La utilización de la algarroba como producto alimentario y/o cosmético se conoce desde hace muchos años. La algarroba es el fruto del algarrobo (Ceratonia Siliqua), un árbol de crecimiento lento, tamaño medio, hoja perenne y de origen mediterráneo. Su semilla está formada por granos marrones-rojizos, muy duros y resistentes, que están en el interior de una vaina.The use of carob as a food and / or cosmetic product has been known for many years. The carob tree is the fruit of the carob tree ( Ceratonia Siliqua ), a slow growing tree, medium size, evergreen and of Mediterranean origin. Its seed is formed by brown-reddish grains, very hard and resistant, which are inside a pod.
La algarroba contiene una pulpa alrededor de la semilla que es muy rica en azúcares. La cantidad media de sacarosa, glucosa y fructosa en la algarroba es de 40 a 50% en peso de la materia seca total. La obtención de jarabes procedentes de la algarroba se conoce desde la antigüedad en Italia, Grecia, Portugal y España. Del estado de la técnica, se conocen procedimientos de obtención de jarabes ricos en azúcares, los cuales presentan un color muy oscuro, un olor desagradable y un sabor entre dulce y amargo. La patente ES 2060544 suministra un procedimiento para obtener un jarabe incoloro, de olor agradable y rico en azúcares, mediante la purificación del extracto acuoso de algarroba.Carob contains a pulp around the seed that is very rich in sugars. The average amount of sucrose, Glucose and fructose in carob is 40 to 50% by weight of the total dry matter Obtaining syrups from the carob has been known since ancient times in Italy, Greece, Portugal and Spain. From the prior art, known procedures are known. obtaining sugar-rich syrups, which have a very dark color, an unpleasant smell and a sweet and sweet taste bitter. Patent ES 2060544 provides a method for get a colorless syrup, with a pleasant smell and rich in sugars, by purifying the aqueous extract of carob.
Por otro lado, se conoce la necesidad de suministrar productos para el cuidado y protección de la piel, a partir de plantas y vegetales. Continuamente, se está investigando en la obtención de nuevos productos de origen natural, para disminuir la sequedad cutánea, independientemente de cual sea su causa.On the other hand, the need for supply products for skin care and protection, to from plants and vegetables. Continuously, it is being investigated in obtaining new products of natural origin, for decrease skin dryness, regardless of its cause.
Se ha descubierto ahora que, sorprendentemente, un preparado a partir de algarroba, con un contenido reducido de azúcares, obtenido según el procedimiento suministrado por la presente invención, aumenta la hidratación de la piel. Por tanto, se suministra un producto que asegura plenamente la función fisiológica de la piel y que actúa como barrera contra las agresiones externas, tales como temperaturas muy frías o elevadas, humedad ambiental reducida y contaminación medio-ambiental.It has now been discovered that, surprisingly, a preparation made from carob, with a reduced content of sugars, obtained according to the procedure supplied by the present invention, increases skin hydration. So, a product that fully ensures the function is supplied physiological of the skin and that acts as a barrier against external aggressions, such as very cold or high temperatures, reduced environmental humidity and pollution environmental
En este sentido, según un primer aspecto, la presente invención suministra un procedimiento de obtención de un preparado a partir de algarroba, con un contenido reducido de azúcares, que comprende extraer pulpa de algarroba con agua y, a partir del extracto obtenido, las etapas de:In this sense, according to a first aspect, the The present invention provides a method of obtaining a prepared from carob, with a reduced content of sugars, which includes extracting carob pulp with water and from the extract obtained, the steps of:
a) eliminar los iones de calcio y magnesio;a) remove calcium and magnesium ions;
b) invertir la sacarosa presente en dicho extracto en glucosa y fructosa;b) invert the sucrose present in said glucose and fructose extract;
c) desmineralizar y decolorar mediante una primera y una segunda fases de intercambio iónico que emplean respectivamente una resina catiónica fuerte y una resina aniónica fuerte;c) demineralize and discolor by first and second phases of ion exchange that employ respectively a strong cationic resin and an anionic resin strong;
d) separar los azúcares reductores mediante cromatografía de lecho móvil simulado mejorado, a una temperatura comprendida entre 40 y 80ºC.d) separate reducing sugars by enhanced simulated mobile bed chromatography, at a temperature between 40 and 80 ° C.
La extracción inicial de la pulpa de algarroba se realiza como sigue: la algarroba, limpia y seca, se muele y se separa la pulpa de la semilla. La pulpa se extrae con agua (15-35ºC) y pH 4,6-5,4. Posteriormente, el extracto de algarroba obtenido se filtra.The initial extraction of carob pulp is performs as follows: the carob, clean and dry, is ground and separate the pulp from the seed. The pulp is extracted with water (15-35 ° C) and pH 4.6-5.4. Subsequently, the carob extract obtained is filtered.
Según una realización preferida del procedimiento de la invención, la etapa a) se efectúa mediante una resina de intercambio iónico catiónica fuerte.According to a preferred embodiment of the process of the invention, step a) is carried out by means of a resin of strong cationic ion exchange.
Según otra realización preferida, la etapa b) se efectúa por métodos enzimáticos.According to another preferred embodiment, step b) is carried out by enzymatic methods.
Según otra realización, la etapa b) se efectúa mediante resinas catiónicas ácidas.According to another embodiment, step b) is carried out by acid cationic resins.
La desmineralización y decoloración se realiza haciendo pasar el extracto obtenido inicialmente, a una concentración de 20-30 Brix, a través de una resina catiónica fuerte, forma protónica y, posteriormente, a través de una resina aniónica fuerte, forma hidroxilo.Demineralization and discoloration is performed by passing the initially obtained extract, to a 20-30 Brix concentration, through a resin strong cationic, proton form and, subsequently, through a strong anionic resin, hydroxyl form.
Según otra realización preferente, la etapa d) se efectúa a una temperatura comprendida entre 55 y 65ºC, para evitar las contaminaciones microbiológicas. En dicha etapa se emplean resinas catiónicas fuertes que están salificadas en forma sódica, potásica, cálcica, preferentemente, en forma sádica y, como fase móvil, se emplea agua destilada. Se puede reutilizar la columna sin necesidad de tratamiento adicional para regenerarla. Por lo tanto, en esta etapa se utiliza la técnica desarrollada por Mitsubishi Kasey Corp., conocida como "Improved Simulated Moving Bed" (ISMB), funcionando en continuo y con una recirculación parcial. Así, se separa el extracto en dos partes: una parte que es rica en azúcares reductores, y una parte que es rica en el resto de sustancias.According to another preferred embodiment, step d) is carried out at a temperature between 55 and 65 ° C, to avoid Microbiological contamination In this stage they are used strong cationic resins that are salified in sodium form, potassium, calcium, preferably, in sadistic form and, as a phase mobile, distilled water is used. The column can be reused without need for additional treatment to regenerate it. Thus, at this stage the technique developed by Mitsubishi is used Kasey Corp., known as "Improved Simulated Moving Bed" (ISMB), running continuously and with partial recirculation. Thus, the extract is separated into two parts: a part that is rich in reducing sugars, and a part that is rich in the rest of substances
Según un segundo aspecto de la invención, se proporciona un preparado a partir de algarroba con un contenido reducido de azúcares, obtenible mediante el procedimiento mencionado anteriormente.According to a second aspect of the invention, provides a preparation made from carob with a content reduced sugar, obtainable by the procedure previously mentioned.
Dicho preparado comprende: de 0,1 a 2,5% en peso de sacarosa; de 0,1 a 2,5% en peso de glucosa; de 0,1 a 2% en peso de fructosa; de 1 a 60% en peso de primeverosa y de 40 a 92% en peso de pinitol.Said preparation comprises: from 0.1 to 2.5% by weight sucrose; from 0.1 to 2.5% by weight glucose; from 0.1 to 2% by weight fructose; from 1 to 60% by weight of primeverosa and from 40 to 92% in pinitol weight
La composición del preparado obtenido según el procedimiento de la invención puede variar en un amplio intervalo, dependiendo del tipo y origen de la algarroba empleada como materia prima.The composition of the preparation obtained according to The process of the invention may vary over a wide range, depending on the type and origin of the carob used as matter cousin.
El preparado puede utilizarse en forma líquida, según se obtiene directamente mediante el procedimiento de la invención, o en forma sólida, extrayéndole el agua y secándolo, mediante técnicas de precipitación, evaporación, liofilización, atomización, etc.The preparation can be used in liquid form, as obtained directly by the procedure of the invention, or in solid form, by extracting the water and drying it, by precipitation, evaporation, lyophilization techniques, atomization, etc.
Según un tercer aspecto de la invención, se proporciona una composición farmacéutica de aplicación tópica, que comprende de 0,1 a 90% en peso de dicho preparado.According to a third aspect of the invention, provides a topical application pharmaceutical composition, which It comprises 0.1 to 90% by weight of said preparation.
Preferiblemente, dicha composición farmacéutica comprende de 0,1 a 10% en peso de dicho preparado.Preferably, said pharmaceutical composition It comprises 0.1 to 10% by weight of said preparation.
Dicha composición puede estar en forma de emulsiones, leche corporal, loción capilar, gel, pomada, champú, jabón, aceite corporal, spray (en forma pulverizada).Said composition may be in the form of emulsions, body milk, hair lotion, gel, ointment, shampoo, soap, body oil, spray (in powdered form).
Según un cuarto aspecto de la invención, se proporciona el uso de dicho preparado en la elaboración de un medicamento.According to a fourth aspect of the invention, provides the use of said preparation in the preparation of a medicine.
Según un quinto aspecto de la invención, se proporciona una composición cosmética tópica que comprende de 0,1 a 90% en peso del preparado.According to a fifth aspect of the invention, provides a topical cosmetic composition comprising from 0.1 to 90% by weight of the preparation.
Preferiblemente, dicha composición cosmética tópica comprende de 0,1 a 10% en peso del preparado.Preferably, said cosmetic composition Topical comprises 0.1 to 10% by weight of the preparation.
Según una realización de la invención, la composición cosmética tópica comprende además uno o más de los siguientes componentes: lípidos de extracción y/o síntesis, polímeros gelificantes y viscosantes, agentes tensoactivos, agentes emulsionantes, principios activos hidro o liposolubles, extractos vegetales, titulares y marinos.According to an embodiment of the invention, the topical cosmetic composition further comprises one or more of the following components: lipids of extraction and / or synthesis, gelling and viscous polymers, surface active agents, agents emulsifiers, hydro or fat soluble active ingredients, extracts Vegetables, holders and marine.
La composición cosmética tópica está en forma de leche corporal, tónico capilar, tónico facial, gel, pomada, champú, jabón, aceite corporal, spray (en forma pulverizada), bálsamo para después del afeitado, crema protectora, crema hidratante.The topical cosmetic composition is in the form of body milk, hair tonic, facial tonic, gel, ointment, shampoo, soap, body oil, spray (in powdered form), balm for After shave, protective cream, moisturizer.
Las composiciones farmacéuticas y cosméticas que comprenden el preparado a partir de algarroba, con un contenido reducido de azúcares, se utilizan para el cuidado de la piel, mucosas, cuero cabelludo, cabellos y, especialmente, frente a la sequedad cutánea de cualquier origen, produciendo efectos antienvejecimiento y antiarrugas y, por tanto, prolongando la suavidad y función protectora de la piel.The pharmaceutical and cosmetic compositions that comprise the preparation made from carob, with a content reduced sugars, are used for skin care, mucous, scalp, hair and, especially, in front of the skin dryness of any origin, producing effects anti-aging and anti-wrinkle and, therefore, prolonging the softness and protective function of the skin.
La invención será descrita ahora, solo a título ilustrativo, por medio de los siguientes ejemplos que de ningún modo deberán ser considerados como limitativos del alcance de la invención.The invention will now be described, only by way of illustrative, by means of the following examples of any mode should be considered as limiting the scope of the invention.
El extracto de algarroba, una vez invertido, decolorado y desmineralizado, como se ha descrito anteriormente, a la concentración de alrededor de 60 Brix, presentaba la siguiente composición:Carob extract, once inverted, discolored and demineralized, as described above, to the concentration of about 60 Brix, presented the following composition:
Primeverosa
\dotl4,34%Primeverosa
\ dotl4.34%
Pinitol
\dotl11,23%Pinitol
\ dotl11.23%
Sacarosa
\dotl0,87%Saccharose
\ dotl0.87%
Glucosa
\dotl40,99%Glucose
\ dotl40.99%
Fructosa
\dotl41,51%Fructose
\ dotl41.51%
Otros
\dotl1,06%Others
\ dotl1.06%
Dicho extracto se alimenta a una instalación de ISMB, la cual se caracteriza por los siguientes parámetros de trabajo:Said extract is fed to an installation of ISMB, which is characterized by the following parameters of job:
Resina
\dotlUBK 530Resin
\ dotlUBK 530
Volumen de resina
\dotl4 mcResin volume
\ dotl4 mc
Alimentación
\dotl0,016 1/hFeeding
\ dotl0.016 1 / h
W/F
\dotl6,430 v/vW / f
\ dotl6,430 v / v
P/R
\dotl2.000 v/vP / R
\ dotl2,000 v / v
Temperatura
\dotl65ºCTemperature
\ dotl65 ° C
Donde W significa agua, F significa alimentación, P significa producto y R significa producto refinado.Where W means water, F means food, P means product and R means refined product.
A través de dicha instalación se obtiene, por un lado, una fracción "baja en azúcares", la cual constituye el preparado a partir de algarroba con un contenido reducido de azúcares, con la siguiente composición:Through this installation you get, by a side, a fraction "low in sugars", which constitutes the prepared from carob with a reduced content of sugars, with the following composition:
Primeverosa
\dotl24,69%Primeverosa
\ dotl24.69%
Pinitol
\dotl64,90%Pinitol
\ dotl64.90%
Sacarosa
\dotl1,82%Saccharose
\ dotl1.82%
Glucosa
\dotl2,25%Glucose
\ dotl2.25%
Fructosa
\dotl1,04%Fructose
\ dotl1.04%
Otros
\dotl5,30%Others
\ dotl5.30%
y, por el otro, se obtiene una fracción secundaria, rica en azúcares reductores, que presenta la siguiente composición:and, on the other hand, you get a fraction secondary, rich in reducing sugars, which has the following composition:
Primeverosa
\dotl0,66%Primeverosa
\ dotl0.66%
Pinitol
\dotl1,91%Pinitol
\ dotl1.91%
Sacarosa
\dotl0,45%Saccharose
\ dotl0.45%
Glucosa
\dotl49,09%Glucose
\ dotl49.09%
Fructosa
\dotl47,09%Fructose
\ dotl47.09%
Otros
\dotl0,24%Others
\ dotl0.24%
Para evaluar objetivamente la eficacia del tratamiento del preparado con un contenido reducido de azúcares, obtenido según la presente invención, es necesario cuantificar la cantidad de agua retenida en la superficie cutánea y en los estratos más externos de la córnea.To objectively assess the effectiveness of the treatment of the preparation with a reduced sugar content, obtained according to the present invention, it is necessary to quantify the amount of water retained on the skin surface and in the outermost strata of the cornea.
El agua libre presente en la capa córnea y localizada en los espacios intersticiales actúa como elemento transmisor capaz de definir una capacitancia característica que se puede medir en la superficie cutánea. Mediante técnicas biofísicas no invasivas, podemos medir estos valores de agua libre y conocer los niveles de hidratación cutánea y la eficacia de un tratamiento hidratante.The free water present in the corneal layer and located in the interstitial spaces acts as an element transmitter capable of defining a characteristic capacitance that is It can measure on the skin surface. Through biophysical techniques Non-invasive, we can measure these free water values and know skin hydration levels and the effectiveness of a treatment moisturizing.
Para medir la hidratación de la superficie cutánea, el método registra los valores de capacitancia de la superficie de la piel, mediante un Corneómetro (CM 825 Courage & Khazaka).To measure surface hydration cutaneous, the method records the capacitance values of the skin surface, using a Corneometer (CM 825 Courage & Khazaka).
La medición realizada ha sido de tipo puntual, en la zona predeterminada (antebrazo). El número de mediciones siempre ha sido superior a diez, a partir de las cuales, se ha obtenido el valor promedio.The measurement has been of the punctual type, in the default zone (forearm). The number of measurements it has always been greater than ten, from which, it has been obtained the average value.
Se formularon dos productos:Two products were formulated:
1: el producto P o placebo (Agua destilada)1: the product P or placebo (Distilled water)
2: el producto A (preparado obtenido a partir de algarroba, con un contenido reducido de azúcares) al 5%.2: product A (preparation obtained from carob, with a reduced sugar content) to 5%.
El ensayo se inició tomando la lectura basal de las zonas de tratamiento (antebrazos derecho e izquierdo). A continuación, se realizó una aplicación única de los productos P y A, en las zonas seleccionadas aleatoriamente y, desde este momento, se efectuaron lecturas puntuales después de 30 minutos, 1 y 3 horas del tratamiento. Dichas lecturas se efectuaron en condiciones de 20 +/-2ºC de temperatura y una humedad relativa del 60-70%.The trial began by taking the baseline reading of the treatment areas (right and left forearms). TO Then, a single application of the P products and A, in the randomly selected areas and, from this moment, punctual readings were made after 30 minutes, 1 and 3 hours of treatment These readings were made under conditions of 20 +/- 2ºC temperature and relative humidity of 60-70%
El experimento se ha diseñado como un estudio randomizado y doble ciego.The experiment has been designed as a study randomized and double blind.
A partir de los valores obtenidos con el corneómetro, se calculó el porcentaje de incremento del índice de hidratación, para el producto activo (A) y el placebo (P), en cada uno de los tiempos de lectura, citados antes.From the values obtained with the corneometer, the percentage increase in the index of hydration, for the active product (A) and placebo (P), in each one of the reading times, cited before.
La zona seleccionada para la aplicación de las formulaciones a testar fue la zona central de los antebrazos izquierdo y derecho. Los resultados obtenidos se muestran en las tablas 2 y 3.The area selected for the application of the formulations to test was the central area of the forearms left and right. The results obtained are shown in the Tables 2 and 3.
En la tabla 2, se muestran los valores promedio obtenidos con el corneómetro para cada individuo y tiempo de lectura, tanto para el placebo (P) como para el producto A (activo).In table 2, the average values are shown obtained with the corneometer for each individual and time of reading, both for placebo (P) and for product A (active).
En la tabla 3 se muestran los aumentos en porcentaje de los índices de hidratación, calculados a partir de los datos de la tabla 2.Table 3 shows the increases in percentage of hydration rates, calculated from the data in table 2.
La aplicación del preparado a partir de algarroba, según la invención, a una concentración de 5% en peso, produce aumentos significativos del nivel de hidratación cutánea.Application of the preparation from carob, according to the invention, at a concentration of 5% by weight, produces significant increases in hydration level cutaneous
A continuación, se muestran una serie de ejemplos de composiciones farmacéuticas y cosméticas que comprenden el preparado obtenido según el procedimiento de la presente invención.A series of examples are shown below. of pharmaceutical and cosmetic compositions comprising the prepared obtained according to the procedure herein invention.
Preparado a partir dePrepared from
algarroba según la invención
\dotl2,00%carob according to the invention
\ dotl2.00%
Laurilétersulfato de sodio
\dotl55,00%Sodium lauryl ether sulfate
\ dotl55.00%
Cocamidopropil betaina 30%
\dotl16,00%Cocamidopropyl betaine 30%
\ dotl16.00%
Glicerilcocoato de PEG-7
\dotl1,00%PEG-7 glycerylcocoate
\ dotl1.00%
Perfume
\dotl0,50%Fragrance
\ dotl0.50%
PEG-4 colzaamida
\dotl0,30%PEG-4 colzaamide
\ dotl0.30%
Conservante
\dotl0,05%Preservative
\ dotl0.05%
Trietanolamina 99%
\dotl0,06%99% Triethanolamine
\ dotl0.06%
CI 19140
\dotl0,20%CI 19140
\ dotl0.20%
Cloruro sódico
\dotl0,15%Sodium chloride
\ dotl0.15%
CI 16035
\dotl0,04%CI 16035
\ dotl0.04%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
algarroba según la invención
\dotl2,00%carob according to the invention
\ dotl2.00%
Lauril sulfato de TEA 40%
\dotl30,00%TEA lauryl sulfate 40%
\ dotl30.00%
Cocamidopropil Betaina 30%
\dotl8,00%Cocamidopropyl Betaine 30%
\ dotl8.00%
Decil poliglucosa 50%
\dotl2,00%50% polyglucose decil
\ dotl2.00%
Cloruro de hidroxipropil GuarGuar Hydroxypropyl Chloride
Hidroxipropiltrimonio
\dotl0,20%Hydroxypropyltrimony
\ dotl0.20%
Acido cítrico
\dotl0,03%Citric acid
\ dotl0.03%
Conservante
\dotl0,50%Preservative
\ dotl0.50%
Copoliol de dimeticona
\dotl0,50%Dimethicone copolyol
\ dotl0.50%
Cocoato de glicerilo PEG-7
\dotl0,50%PEG-7 glyceryl cocoate
\ dotl0.50%
Perfume
\dotl0,40%Fragrance
\ dotl0.40%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
algarroba según la invención
\dotl2,00%carob according to the invention
\ dotl2.00%
Laurilétersulfosuccinato de sodio 30%
\dotl17,00%Sodium Lauryl Ether Sulphosuccinate 30%
\ dotl17.00%
Olefin sulfonato de sodio 37%
\dotl12,00%Olefin Sulphonate Sodium 37%
\ dotl12.00%
Óxido de cocamidopropilamina 30%
\dotl5,00%Cocamidopropylamine Oxide 30%
\ dotl5.00%
Cocamidopropilbetaina 30%
\dotl4,00%Cocamidopropyl betaine 30%
\ dotl4.00%
Cocamido MEA
\dotl1,30%Cocamido MEA
\ dotl1.30%
Conservante
\dotl0,50%Preservative
\ dotl0.50%
Cloruro sódico
\dotl0,50%Sodium chloride
\ dotl0.50%
Perfume
\dotl0,50%Fragrance
\ dotl0.50%
Ácido láctico
\dotl0,10%Lactic acid
\ dotl0.10%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
algarroba según la invención
\dotl3,00%carob according to the invention
\ dotl3.00%
Lauriléter-sulfato de sodio 27%
\dotl32,00%Sodium Lauryl Ether Sulfate 27%
\ dotl32.00%
Cocamidopropilbetaina 30%
\dotl6,00%Cocamidopropyl betaine 30%
\ dotl6.00%
Decil Poliglucosa 50%
\dotl5,00%50% Polyglucose Decil
\ dotl5.00%
Diestearato de Glicol (20%);Glycol Diestearate (20%);
LESS (5)%; Cocamido DEA (10%)
\dotl2,00%LESS (5)%; Cocamido DEA (10%)
\ dotl2.00%
Polyquaternium-39
\dotl1,50%Polyquaternium-39
\ dotl1.50%
Óxido de estearamina 25%
\dotl1,50%Stearamine Oxide 25%
\ dotl1.50%
Oleato de propilenglicol Peg-55 (50%)
\dotl0,80%Propylene Glycol Oleate Peg-55 (50%)
\ dotl0.80%
Cloruro sódico
\dotl0,70%Sodium chloride
\ dotl0.70%
Conservante
\dotl0,50%Preservative
\ dotl0.50%
Copolímero de estireno/acrilato
\dotl0,50%Styrene / Acrylate Copolymer
\ dotl0.50%
Perfume
\dotl0,30%Fragrance
\ dotl0.30%
Ácido láctico
\dotl0,20%Lactic acid
\ dotl0.20%
Hidroxipropil GuarGuar hydroxypropyl
Cloruro de hidroxipropyltrimonio
\dotl0,10%Hydroxypropyltrimony Chloride
\ dotl0.10%
CI 19140
\dotl0,07%CI 19140
\ dotl0.07%
Agua
\dotlc.s.p 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
algarroba según la invención
\dotl1,50%carob according to the invention
\ dotl1.50%
Alcohol desnat
\dotl30,00%Naked alcohol
\ dotl30.00%
Copolímero de PVP/VA
\dotl2,50%PVP / VA copolymer
\ dotl2.50%
Aceite de castor hidrogenado PEG-40
\dotl0,50%PEG-40 Hydrogenated Castor Oil
\ dotl0.50%
Conservante
\dotl0,20%Preservative
\ dotl0.20%
Perfume
\dotl0,10%Fragrance
\ dotl0.10%
CI 16225,CI 47005, CI 42051
\dotl0,06%CI 16225, CI 47005, CI 42051
\ dotl0.06%
Trietanolamina 50%
\dotl0,02%Triethanolamine 50%
\ dotl0.02%
CI 19140
\dotl0,01%CI 19140
\ dotl0.01%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
Algarroba según la invención
\dotl2,00%Carob according to the invention
\ dotl2.00%
Alcohol desnat
\dotl10,00%Naked alcohol
\ dotl10.00%
Aloe barbadensis
\dotl8,00% Aloe barbadensis
\ dotl8.00%
Éter de estearilo PPG-15
\dotl3,00%PPG-15 Stearyl Ether
\ dotl3.00%
Glicerina
\dotl2,00%Glycerin
\ dotl2.00%
Perfume
\dotl1,25%Fragrance
\ dotl1.25%
Conservante
\dotl0,50%Preservative
\ dotl0.50%
Acrilatos/C10-30 Alquil AcrilatosAcrylates / C10-30 Alkyl Acrylates
Polímero reticulado
\dotl0,30%Crosslinked polymer
\ dotl0.30%
Mentol
\dotl0,20%Menthol
\ dotl0.20%
Trietanolamina 99%
\dotl0,15%99% Triethanolamine
\ dotl0.15%
Bisabolol
\dotl0,10%Bisabolol
\ dotl0.10%
EDTA disódico
\dotl0,10%Disodium EDTA
\ dotl0.10%
BHT
\dotl0,05%B HT
\ dotl0.05%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
\newpage\ newpage
Preparado a partir dePrepared from
algarroba según la invención
\dotl2,00%carob according to the invention
\ dotl2.00%
Parafina Líquida
\dotl9,00%Liquid Paraffin
\ dotl9.00%
Octil Metoxicinamato
\dotl9,00%Octyl Methoxycinnamate
\ dotl9.00%
PEG-100 estearato 50%; Glyceril-estearato 50%
\dotl6,00%PEG-100 stearate 50%; Glyceril Stearate 50%
\ dotl6.00%
Petrolatum
\dotl5,00% Petrolatum
\ dotl5.00%
Benzofenona-3
\dotl3,50%Benzophenone-3
\ dotl3.50%
Dióxido de titanio
\dotl3,00%Titanium dioxide
\ dotl3.00%
Alcohol cetílico
\dotl2,50%Cetyl alcohol
\ dotl2.50%
Propilenglicol
\dotl2,00%Propylene glycol
\ dotl2.00%
Triticum vulgare
\dotl1,50% Triticum vulgare
\ dotl1.50%
Conservante
\dotl0,70%Preservative
\ dotl0.70%
Perfume
\dotl0,30%Fragrance
\ dotl0.30%
BHT
\dotl0,10%B HT
\ dotl0.10%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
algarroba según la invención
\dotl1,00%carob according to the invention
\ dotl1.00%
Parafina Líquida
\dotl7,00%Liquid Paraffin
\ dotl7.00%
Octal Metoxicinamato
\dotl4,00%Octal Methoxycinnamate
\ dotl4.00%
Caprílico/Caprico Triglicérido
\dotl4,00%Caprilic / Caprico Triglyceride
\ dotl4.00%
Estearato de glicerilo; Cetato-20
\dotl3,00%Glyceryl stearate; Cetate-20
\ dotl3.00%
Triticum vulgare
\dotl3,00% Triticum vulgare
\ dotl3.00%
Estearil alcohol; Estearato 7; Estearato 10
\dotl2,50%Stearyl alcohol; Stearate 7; Stearate 10
\ dotl2.50%
Alcohol cetílico
\dotl1,00%Cetyl alcohol
\ dotl1.00%
Benzofenona-3
\dotl1,00%Benzophenone-3
\ dotl1.00%
Conservante
\dotl0,70%Preservative
\ dotl0.70%
Perfume
\dotl0,35%Fragrance
\ dotl0.35%
BHT
\dotl0,10%B HT
\ dotl0.10%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
algarroba según la invención
\dotl2,00%carob according to the invention
\ dotl2.00%
Rosa canina
\dotl15,00%canine rose
\ dotl15.00%
Propilenglicol
\dotl2,50%Propylene glycol
\ dotl2.50%
PEG-40 aceite de castor hidrogenado
\dotl0,60%PEG-40 hydrogenated castor oil
\ dotl0.60%
Conservante
\dotl0,50%Preservative
\ dotl0.50%
Perfume
\dotl0,10%Fragrance
\ dotl0.10%
CI 16035
\dotlc.s.CI 16035
\ dotlcs
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
algarroba según la invención
\dotl2,00%carob according to the invention
\ dotl2.00%
PEG-15 Estearil éter
\dotl4,00%PEG-15 Stearyl Ether
\ dotl4.00%
Cetil alcohol
\dotl3,00%Cetil alcohol
\ dotl3.00%
Parafina líquida
\dotl3,00%Liquid paraffin
\ dotl3.00%
Propilenglicol
\dotl2,50%Propylene glycol
\ dotl2.50%
Estearato-2
\dotl2,40%Stearate-2
\ dotl2.40%
Copoliol de dimeticona
\dotl2,00%Dimethicone copolyol
\ dotl2.00%
Estearato-21
\dotl1,60%Stearate-21
\ dotl1.60%
Triticum vulgare
\dotl1,00% Triticum vulgare
\ dotl1.00%
Cera alba
\dotl1,00%Wax Alba
\ dotl1.00%
Conservante
\dotl0,60%Preservative
\ dotl0.60%
Benzofenona-3
\dotl0,50%Benzophenone-3
\ dotl0.50%
Perfume
\dotl0,40%Fragrance
\ dotl0.40%
BHT
\dotl0,10%B HT
\ dotl0.10%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
algarroba según la invención
\dotl5,00%carob according to the invention
\ dotl5.00%
Cocoato de octilo
\dotl6,00%Octyl Cocoate
\ dotl6.00%
Triglicérido Caprílico/Cáprico
\dotl3,00%Capric / Capric Triglyceride
\ dotl3.00%
Triticum vulgare
\dotl3,00% Triticum vulgare
\ dotl3.00%
Glicerina
\dotl2,50%Glycerin
\ dotl2.50%
Copolyol de dimeticona
\dotl1,00%Dimethicone copolyol
\ dotl1.00%
Trietanolamina (99%)
\dotl0,65%Triethanolamine (99%)
\ dotl0.65%
Conservante
\dotl0,50%Preservative
\ dotl0.50%
Acrilatos C/10-30 Alkil-AcrilatoAcrylates C / 10-30 Alkil Acrylate
Polímero reticulado
\dotl0,40%Crosslinked polymer
\ dotl0.40%
Carbomero
\dotl0,35%Carbomer
\ dotl0.35%
Perfume
\dotl0,20%Fragrance
\ dotl0.20%
BHT
\dotl0,10%B HT
\ dotl0.10%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Preparado a partir dePrepared from
algarroba según la invención
\dotl2,00%carob according to the invention
\ dotl2.00%
Ciclometicona
\dotl15,00%Cyclomethicone
\ dotl15.00%
Palmitato de octilo
\dotl3,00%Octyl Palmitate
\ dotl3.00%
Estearato de octilo
\dotl3,00%Octyl Stearate
\ dotl3.00%
Dióxido de titanio rojo, amarillo, negro
\dotl2,10%Titanium dioxide red, yellow, black
\ dotl2.10%
Propilenglicol
\dotl2,00%Propylene glycol
\ dotl2.00%
Dimeticona de cetilo
\dotl2,00%Cetyl Dimethicone
\ dotl2.00%
Cetil dimeticona copoliol
\dotl2,00%Cetyl dimethicone copolyol
\ dotl2.00%
Oleato de decilo
\dotl1,00%Decyl oleate
\ dotl1.00%
Beeswax
\dotl0,80%Beeswax
\ dotl0.80%
Oleato de Poliglicerilo-3
\dotl0,75%Polyglyceryl Oleate-3
\ dotl0.75%
Cloruro sódico
\dotl0,50%Sodium chloride
\ dotl0.50%
Aceite de castor hidrogenado
\dotl0,40%Hydrogenated Castor Oil
\ dotl0.40%
Óxide de hierro marrón
\dotl0,30%Brown iron oxide
\ dotl0.30%
Dimeticona 350 cst
\dotl0,25%Dimethicone 350 cst
\ dotl0.25%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
\newpage\ newpage
Preparado a partir dePrepared from
algarroba según la invención
\dotl6,00%carob according to the invention
\ dotl6.00%
Aceite de castor hidrogenado PEG-40
\dotl1,10%PEG-40 Hydrogenated Castor Oil
\ dotl1.10%
Trietanolamina (99%)
\dotl0,75%Triethanolamine (99%)
\ dotl0.75%
Copoliol de dimeticona
\dotl0,40%Dimethicone copolyol
\ dotl0.40%
Perfume
\dotl0,20%Fragrance
\ dotl0.20%
Polímero reticulado de Acrilatos C/10-30Crosslinked Acrylate Polymer C / 10-30
Alquil-acrilato
\dotl0,05%Alkyl acrylate
\ dotl0.05%
Conservante
\dotl0,05%Preservative
\ dotl0.05%
Quarternium-15
\dotl0,05%Quarternium-15
\ dotl0.05%
Agua
\dotlc.s.p. 100Water
\ dotlcsp 100
Claims (15)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200302864A ES2234422B1 (en) | 2003-12-04 | 2003-12-04 | PROCEDURE FOR OBTAINING A PREPARED FROM ALGARROBA AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200302864A ES2234422B1 (en) | 2003-12-04 | 2003-12-04 | PROCEDURE FOR OBTAINING A PREPARED FROM ALGARROBA AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2234422A1 true ES2234422A1 (en) | 2005-06-16 |
ES2234422B1 ES2234422B1 (en) | 2006-12-16 |
Family
ID=34707569
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200302864A Expired - Fee Related ES2234422B1 (en) | 2003-12-04 | 2003-12-04 | PROCEDURE FOR OBTAINING A PREPARED FROM ALGARROBA AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM. |
Country Status (1)
Country | Link |
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ES (1) | ES2234422B1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2322883A1 (en) * | 2007-01-24 | 2009-06-30 | Universitat De Valencia, Estudi Genera | Procedure of extraction and purification of pinitol and extract enriched in the same (Machine-translation by Google Translate, not legally binding) |
WO2020225665A1 (en) * | 2019-05-03 | 2020-11-12 | Bono & Ditta S.P.A. | Process for the separation of pinitol from a carob extract |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2060544A1 (en) * | 1993-03-26 | 1994-11-16 | Cia Gral Del Algarrobo De Espa | A syrup consisting of natural carob sugars and a process for its production. |
FR2733150A1 (en) * | 1995-04-24 | 1996-10-25 | Taleb Amar | Wart treatment |
ES2179767A1 (en) * | 2001-03-16 | 2003-01-16 | Compania General Del Algarrobo | Method of obtaining pinitol from carob extracts |
-
2003
- 2003-12-04 ES ES200302864A patent/ES2234422B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2060544A1 (en) * | 1993-03-26 | 1994-11-16 | Cia Gral Del Algarrobo De Espa | A syrup consisting of natural carob sugars and a process for its production. |
FR2733150A1 (en) * | 1995-04-24 | 1996-10-25 | Taleb Amar | Wart treatment |
ES2179767A1 (en) * | 2001-03-16 | 2003-01-16 | Compania General Del Algarrobo | Method of obtaining pinitol from carob extracts |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2322883A1 (en) * | 2007-01-24 | 2009-06-30 | Universitat De Valencia, Estudi Genera | Procedure of extraction and purification of pinitol and extract enriched in the same (Machine-translation by Google Translate, not legally binding) |
WO2020225665A1 (en) * | 2019-05-03 | 2020-11-12 | Bono & Ditta S.P.A. | Process for the separation of pinitol from a carob extract |
Also Published As
Publication number | Publication date |
---|---|
ES2234422B1 (en) | 2006-12-16 |
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