ES2213628T3 - Hidrogeles asociativos para la sustitucion del nucleo pulposo en discos intervertebrales. - Google Patents
Hidrogeles asociativos para la sustitucion del nucleo pulposo en discos intervertebrales.Info
- Publication number
- ES2213628T3 ES2213628T3 ES00976709T ES00976709T ES2213628T3 ES 2213628 T3 ES2213628 T3 ES 2213628T3 ES 00976709 T ES00976709 T ES 00976709T ES 00976709 T ES00976709 T ES 00976709T ES 2213628 T3 ES2213628 T3 ES 2213628T3
- Authority
- ES
- Spain
- Prior art keywords
- pva
- hydrogels
- disc
- pvp
- associative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 37
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 42
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 42
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 35
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 35
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 35
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 208000002193 Pain Diseases 0.000 claims description 14
- 238000002513 implantation Methods 0.000 claims description 9
- 206010061246 Intervertebral disc degeneration Diseases 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 239000007943 implant Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 description 14
- 239000000463 material Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 229920000642 polymer Polymers 0.000 description 10
- 238000007654 immersion Methods 0.000 description 8
- 230000004927 fusion Effects 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 5
- 230000006835 compression Effects 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000007850 degeneration Effects 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 210000005036 nerve Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000008930 Low Back Pain Diseases 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 229920002239 polyacrylonitrile Polymers 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 206010033425 Pain in extremity Diseases 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 208000018180 degenerative disc disease Diseases 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000238413 Octopus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical class [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000003738 black carbon Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- -1 polyethylene core Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920006124 polyolefin elastomer Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Paper (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16233899P | 1999-10-29 | 1999-10-29 | |
| US162338P | 1999-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2213628T3 true ES2213628T3 (es) | 2004-09-01 |
Family
ID=22585202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00976709T Expired - Lifetime ES2213628T3 (es) | 1999-10-29 | 2000-10-27 | Hidrogeles asociativos para la sustitucion del nucleo pulposo en discos intervertebrales. |
Country Status (11)
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE228021T1 (de) | 1998-09-11 | 2002-12-15 | Gerhard Dr Schmidmaier | Biologisch aktive implantate |
| US6723335B1 (en) * | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
| CA2416334C (en) | 2000-06-09 | 2008-10-28 | Synthes (U.S.A.) | Osteosynthesis implant from a plastic material |
| BR0017279B1 (pt) | 2000-06-30 | 2013-11-19 | Dispositivo para a injeção de cimento de ossos | |
| MY133943A (en) | 2000-08-22 | 2007-11-30 | Synthes Gmbh | Bone replacement material |
| TW200400062A (en) | 2002-04-03 | 2004-01-01 | Mathys Medizinaltechnik Ag | Kneadable, pliable bone replacement material |
| US7001433B2 (en) | 2002-05-23 | 2006-02-21 | Pioneer Laboratories, Inc. | Artificial intervertebral disc device |
| US8388684B2 (en) | 2002-05-23 | 2013-03-05 | Pioneer Signal Technology, Inc. | Artificial disc device |
| US7745532B2 (en) | 2002-08-02 | 2010-06-29 | Cambridge Polymer Group, Inc. | Systems and methods for controlling and forming polymer gels |
| US7485670B2 (en) | 2002-08-02 | 2009-02-03 | Cambridge Polymer Group, Inc. | Systems and methods for controlling and forming polymer gels |
| US6951562B2 (en) | 2002-11-13 | 2005-10-04 | Ralph Fritz Zwirnmann | Adjustable length tap and method for drilling and tapping a bore in bone |
| AU2004208821B2 (en) * | 2003-01-31 | 2009-01-15 | Zimmer Orthobiologics Inc. | Hydrogel compositions comprising nucleus pulposus tissue |
| ES2340587T3 (es) | 2003-04-30 | 2010-06-07 | Drexel University | Mezclas de polimeros termogelificantes para su aplicacion en biomateriales. |
| KR101050957B1 (ko) | 2003-08-08 | 2011-07-20 | 신세스 게엠바하 | 다공성골대체물을 포화시키는 방법 |
| EP3498312A1 (en) | 2003-09-05 | 2019-06-19 | Synthes GmbH | Bone cement compositions having fiber-reinforcement and/or increased flowability |
| US7632294B2 (en) | 2003-09-29 | 2009-12-15 | Promethean Surgical Devices, Llc | Devices and methods for spine repair |
| US9445916B2 (en) | 2003-10-22 | 2016-09-20 | Pioneer Surgical Technology, Inc. | Joint arthroplasty devices having articulating members |
| US7910124B2 (en) | 2004-02-06 | 2011-03-22 | Georgia Tech Research Corporation | Load bearing biocompatible device |
| US8002830B2 (en) * | 2004-02-06 | 2011-08-23 | Georgia Tech Research Corporation | Surface directed cellular attachment |
| US20050209602A1 (en) | 2004-03-22 | 2005-09-22 | Disc Dynamics, Inc. | Multi-stage biomaterial injection system for spinal implants |
| US8211351B2 (en) | 2004-05-13 | 2012-07-03 | Synthes Usa, Llc | Resorbable polymeric medical goods with improved mechanical properties and method for producing same |
| AU2005245017A1 (en) * | 2004-05-21 | 2005-12-01 | Synthes Gmbh | Replacement of nucleus pulposus using a hydrogel |
| AU2004320279A1 (en) | 2004-06-03 | 2005-12-15 | Synthes Gmbh | Device for impregnating a porous bone replacement material |
| US8012501B2 (en) | 2004-06-10 | 2011-09-06 | Synthes Usa, Llc | Flexible bone composite |
| CA2574933C (en) | 2004-07-26 | 2015-05-19 | Synthes (U.S.A.) | Biocompatible, biodegradable polyurethane materials with controlled hydrophobic to hydrophilic ratio |
| EP1778134A1 (en) * | 2004-07-27 | 2007-05-02 | Synthes USA | Supplementation or replacement of a nucleus pulposus, of an intervertebral disc |
| EP1861033B1 (en) | 2005-03-24 | 2012-06-13 | Synthes GmbH | Device for the cement augmentation of bone implants |
| US7914810B2 (en) | 2005-05-06 | 2011-03-29 | Synthes Usa, Llc | Methods for the in situ treatment of bone cancer |
| JP4857437B2 (ja) | 2005-06-13 | 2012-01-18 | 日本メディカルマテリアル株式会社 | 髄核用脊椎椎間板置換材料およびその製造方法 |
| US8287595B2 (en) * | 2005-08-26 | 2012-10-16 | Synthes Usa, Llc | Hydrogel balloon prosthesis for nucleus pulposus |
| US8900620B2 (en) | 2005-10-13 | 2014-12-02 | DePuy Synthes Products, LLC | Drug-impregnated encasement |
| US8641667B2 (en) | 2005-10-20 | 2014-02-04 | DePuy Synthes Products, LLC | Perfusion device and method |
| GB0523999D0 (en) * | 2005-11-25 | 2006-01-04 | Univ Manchester | Microgel particle |
| US8715350B2 (en) | 2006-09-15 | 2014-05-06 | Pioneer Surgical Technology, Inc. | Systems and methods for securing an implant in intervertebral space |
| US8197491B2 (en) | 2006-12-19 | 2012-06-12 | Synthes Usa, Llc | Injectable fastener system and method |
| WO2012162552A1 (en) | 2011-05-26 | 2012-11-29 | Cartiva, Inc. | Tapered joint implant and related tools |
| US9198769B2 (en) | 2011-12-23 | 2015-12-01 | Pioneer Surgical Technology, Inc. | Bone anchor assembly, bone plate system, and method |
| TWI590843B (zh) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | 膜及其製造方法 |
| US10350072B2 (en) | 2012-05-24 | 2019-07-16 | Cartiva, Inc. | Tooling for creating tapered opening in tissue and related methods |
| DE202013012321U1 (de) | 2012-12-26 | 2016-04-25 | Scott A. Koss | Anordnung, Kit und Wirbelimplantat zur perkutanen Bandscheibenwiederherstellung |
| US20160144067A1 (en) | 2013-06-21 | 2016-05-26 | DePuy Synthes Products, Inc. | Films and methods of manufacture |
| EP3277219B1 (en) | 2015-03-31 | 2020-07-29 | Cartiva, Inc. | Hydrogel implants with porous materials |
| EP3892241A1 (en) | 2015-03-31 | 2021-10-13 | Cartiva, Inc. | Drill bit for carpometacarpal implant |
| US11147682B2 (en) | 2017-09-08 | 2021-10-19 | Pioneer Surgical Technology, Inc. | Intervertebral implants, instruments, and methods |
| USD907771S1 (en) | 2017-10-09 | 2021-01-12 | Pioneer Surgical Technology, Inc. | Intervertebral implant |
| US11419733B2 (en) | 2018-01-12 | 2022-08-23 | Percheron Spine, Llc | Spinal disc implant and device and method for percutaneous delivery of the spinal disc implant |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0286838A (ja) * | 1988-09-22 | 1990-03-27 | Terumo Corp | 水不溶性ヒドロゲルおよびその製造方法 |
| US5143071A (en) * | 1989-03-30 | 1992-09-01 | Nepera, Inc. | Non-stringy adhesive hydrophilic gels |
| US5192326A (en) * | 1990-12-21 | 1993-03-09 | Pfizer Hospital Products Group, Inc. | Hydrogel bead intervertebral disc nucleus |
| JP3007903B2 (ja) * | 1991-03-29 | 2000-02-14 | 京セラ株式会社 | 人工椎間板 |
| US5262475A (en) * | 1992-05-12 | 1993-11-16 | Film Specialties, Inc. | Hydrophilic compositions which are fog-resistant |
| US5534028A (en) * | 1993-04-20 | 1996-07-09 | Howmedica, Inc. | Hydrogel intervertebral disc nucleus with diminished lateral bulging |
| EP0700671B1 (en) * | 1994-09-08 | 2001-08-08 | Stryker Technologies Corporation | Hydrogel intervertebral disc nucleus |
| US5824093A (en) * | 1994-10-17 | 1998-10-20 | Raymedica, Inc. | Prosthetic spinal disc nucleus |
| US5846214A (en) * | 1996-03-29 | 1998-12-08 | Nichiban Company Limited | PVA hydrogel, hydrogel laminate using the same and hydrogel wound-dressing material using the same |
| JPH09262279A (ja) * | 1996-03-29 | 1997-10-07 | Japan Atom Energy Res Inst | 粘着性ハイドロゲルの製造方法 |
| US5981826A (en) * | 1997-05-05 | 1999-11-09 | Georgia Tech Research Corporation | Poly(vinyl alcohol) cryogel |
| US6428576B1 (en) * | 1999-04-16 | 2002-08-06 | Endospine, Ltd. | System for repairing inter-vertebral discs |
-
2000
- 2000-10-27 WO PCT/US2000/029874 patent/WO2001032100A2/en active IP Right Grant
- 2000-10-27 AU AU14444/01A patent/AU782208B2/en not_active Ceased
- 2000-10-27 AT AT00976709T patent/ATE257397T1/de active
- 2000-10-27 EP EP00976709A patent/EP1229873B1/en not_active Expired - Lifetime
- 2000-10-27 DK DK00976709T patent/DK1229873T3/da active
- 2000-10-27 DE DE60007656T patent/DE60007656T2/de not_active Expired - Lifetime
- 2000-10-27 ES ES00976709T patent/ES2213628T3/es not_active Expired - Lifetime
- 2000-10-27 JP JP2001534312A patent/JP4833475B2/ja not_active Expired - Lifetime
- 2000-10-27 PT PT00976709T patent/PT1229873E/pt unknown
- 2000-10-27 CA CA002389232A patent/CA2389232C/en not_active Expired - Fee Related
-
2006
- 2006-11-22 US US11/562,847 patent/US20070106387A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1229873A4 (en) | 2003-01-15 |
| US20070106387A1 (en) | 2007-05-10 |
| DE60007656D1 (de) | 2004-02-12 |
| WO2001032100A3 (en) | 2001-11-22 |
| AU1444401A (en) | 2001-05-14 |
| DK1229873T3 (da) | 2004-05-17 |
| ATE257397T1 (de) | 2004-01-15 |
| JP2003513685A (ja) | 2003-04-15 |
| PT1229873E (pt) | 2004-03-31 |
| AU782208B2 (en) | 2005-07-14 |
| DE60007656T2 (de) | 2004-06-24 |
| WO2001032100A2 (en) | 2001-05-10 |
| EP1229873B1 (en) | 2004-01-07 |
| JP4833475B2 (ja) | 2011-12-07 |
| CA2389232A1 (en) | 2001-05-10 |
| EP1229873A2 (en) | 2002-08-14 |
| CA2389232C (en) | 2008-07-29 |
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