ES2196303T3 - Administracion de nicotina por el colon para tratar enfermedades intestinales inflamatorias. - Google Patents
Administracion de nicotina por el colon para tratar enfermedades intestinales inflamatorias.Info
- Publication number
- ES2196303T3 ES2196303T3 ES97904516T ES97904516T ES2196303T3 ES 2196303 T3 ES2196303 T3 ES 2196303T3 ES 97904516 T ES97904516 T ES 97904516T ES 97904516 T ES97904516 T ES 97904516T ES 2196303 T3 ES2196303 T3 ES 2196303T3
- Authority
- ES
- Spain
- Prior art keywords
- nicotine
- colon
- administration
- treat inflammatory
- intestinal diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title abstract 4
- 229960002715 nicotine Drugs 0.000 title abstract 4
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title abstract 4
- 210000001072 colon Anatomy 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title 1
- 208000028774 intestinal disease Diseases 0.000 title 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
Abstract
SE PROPORCIONA UN PROCEDIMIENTO PARA TRATAR LA ENFERMEDAD INFLAMATORIA DEL INTESTINO POR ADMINISTRACION LOCAL AL COLON DE UNA CANTIDAD EFECTIVA DE NICOTINA, O DE UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LA MISMA, PREFERENTEMENTE A TRAVES DE FORMULACIONES ADAPTADAS PARA LIBERACION ORAL RETARDADA O ADMINISTRACION RECTAL. SE PROPORCIONA, ADEMAS, UNA NUEVA FORMULA PARA LA ADMINISTRACION ORAL DE NICOTINA, QUE COMPRENDE UN COPOLIMERO POLIACRILICO COMPLEXADO CON NICOTINA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/605,319 US5846983A (en) | 1996-02-09 | 1996-02-09 | Colonic delivery of nicotine to treat inflammatory bowel disease |
US605319 | 1996-02-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2196303T3 true ES2196303T3 (es) | 2003-12-16 |
ES2196303T5 ES2196303T5 (es) | 2008-05-01 |
Family
ID=24423169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97904516T Expired - Lifetime ES2196303T5 (es) | 1996-02-09 | 1997-02-07 | Administracion de nicotina por el colon para tratar enfermedades intestinales inflamatorias. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5846983A (es) |
EP (1) | EP0893998B2 (es) |
JP (1) | JP4283340B2 (es) |
KR (1) | KR100458636B1 (es) |
CN (1) | CN1127340C (es) |
AT (1) | ATE237330T1 (es) |
AU (1) | AU718971C (es) |
CA (1) | CA2246235C (es) |
CZ (1) | CZ293616B6 (es) |
DE (1) | DE69720985T3 (es) |
DK (1) | DK0893998T4 (es) |
ES (1) | ES2196303T5 (es) |
HK (1) | HK1019043A1 (es) |
HU (1) | HUP9900950A3 (es) |
MX (1) | MX9806354A (es) |
MY (1) | MY122023A (es) |
PL (1) | PL187914B1 (es) |
PT (1) | PT893998E (es) |
SK (1) | SK284539B6 (es) |
WO (1) | WO1997028801A1 (es) |
ZA (1) | ZA971020B (es) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
US6268386B1 (en) * | 1998-06-25 | 2001-07-31 | Marshall Anlauf Thompson | Nicotine beverage |
JP2002522381A (ja) * | 1998-08-06 | 2002-07-23 | ストレンメル,ボルフガング | 粘膜保護用医薬としてのホスファチジルコリン |
JP2002536404A (ja) * | 1999-02-12 | 2002-10-29 | ワシントン ユニバーシティー | 炎症性腸疾患を治療するための好中球機能の刺激 |
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
CZ299726B6 (cs) * | 1999-11-01 | 2008-11-05 | Lécivo pro lécení zácpy a syndromu dráždivého tracníku | |
US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
IT1318625B1 (it) | 2000-07-14 | 2003-08-27 | Roberto Valducci | Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente. |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
ATE355854T1 (de) * | 2000-08-03 | 2007-03-15 | Antares Pharma Ipl Ag | Neue zusammensetzung zur transdermalen und/oder transmukosalen wirkstoffanwendung mit geeignetem therapeutischen spiegel |
CA2341952A1 (en) * | 2001-03-23 | 2002-09-23 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases |
US20050130990A1 (en) * | 2001-03-23 | 2005-06-16 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory diseases |
US20100160376A1 (en) * | 2001-12-10 | 2010-06-24 | Marshall Anlauf Thompson | Nicotine-alternative compositions and methods of producing such compositions |
US20050131031A1 (en) * | 2001-12-10 | 2005-06-16 | Thompson Marshall A. | Method of producing a nicotine composition |
US20060204598A1 (en) * | 2001-12-10 | 2006-09-14 | Thompson Marshall A | Nicotine-alternative compositions and methods of producing such compositions |
US20030108592A1 (en) * | 2001-12-10 | 2003-06-12 | Thompson Marshall Anlauf | Method of producing a nicotine composition |
US7091357B2 (en) | 2001-12-26 | 2006-08-15 | University Of Kentucky Research Foundation | Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies |
US8557804B2 (en) | 2002-03-25 | 2013-10-15 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory diseases |
US8039459B2 (en) * | 2004-07-15 | 2011-10-18 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory diseases |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
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ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
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CN101141885A (zh) * | 2005-01-27 | 2008-03-12 | 马歇尔·安劳夫·汤普森 | 生产尼古丁组合物的方法 |
WO2007124250A2 (en) | 2006-04-21 | 2007-11-01 | Antares Pharma Ipl Ag | Methods of treating hot flashes with formulations for transdermal or transmucosal application |
WO2006125642A1 (en) | 2005-05-27 | 2006-11-30 | Antares Pharma Ipl Ag | Methods and apparatus for transdermal or transmucosal application of testosterone |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
WO2008103818A1 (en) * | 2007-02-21 | 2008-08-28 | University Of Louisville Research Foundation | Therapeutic cotinine compositions |
GB2468424B (en) * | 2007-04-02 | 2011-11-09 | Parkinson S Inst | Methods and compositions for reduction of side effects of therapeutic treatments |
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EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
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US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
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US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
US10029013B2 (en) | 2009-10-02 | 2018-07-24 | Foamix Pharmaceuticals Ltd. | Surfactant-free, water-free formable composition and breakable foams and their uses |
EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
US20130017259A1 (en) | 2011-07-06 | 2013-01-17 | The Parkinson's Institute | Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients |
US10426765B2 (en) * | 2012-06-15 | 2019-10-01 | Conaris Research Institute Ag | Pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota |
SG11201604759UA (en) | 2013-12-13 | 2016-07-28 | Conaris Res Inst Ag | A pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation |
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MX2020012139A (es) | 2016-09-08 | 2021-01-29 | Vyne Pharmaceuticals Inc | Composiciones y metodos para tratar rosacea y acne. |
WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
AU2019279884A1 (en) | 2018-05-29 | 2020-12-10 | Morningside Venture Investments Limited | Drug delivery methods and systems |
CN115089641B (zh) * | 2022-05-25 | 2023-07-25 | 西安交通大学医学院第一附属医院 | 一种难治型溃疡性结肠炎灌肠剂及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3645036A1 (de) * | 1986-11-18 | 1989-01-05 | Forschungsgesellschaft Rauchen | Nikotinhaltiges mittel |
US4855142A (en) * | 1987-02-27 | 1989-08-08 | Ciba-Geigy Corporation | Pharmaceutical plaster |
IE62662B1 (en) * | 1989-01-06 | 1995-02-22 | Elan Corp Plc | Use of nicotine in the treatment of conditions susceptible to said treatment |
US5843482A (en) * | 1990-07-20 | 1998-12-01 | Tillotts Pharma Ag | Products and processes for the treatment of the alimentary canal |
GEP19971086B (en) * | 1991-02-22 | 1997-12-02 | Tillotts Pharma Ag | Peroral Pharmaceutically Dispensed Form for Selective Introducing of the Medicine into the Intestine |
GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
KR0121127B1 (ko) * | 1994-05-09 | 1997-11-13 | 강박광 | 이온성 고분자 네트웍을 갖는 피부약물전달체계 |
US5604231A (en) * | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
US5532254A (en) † | 1995-06-07 | 1996-07-02 | Eli Lilly And Company | Modulation of calcium channels using benzothiophenes |
GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
-
1996
- 1996-02-09 US US08/605,319 patent/US5846983A/en not_active Expired - Fee Related
-
1997
- 1997-02-06 MY MYPI97000462A patent/MY122023A/en unknown
- 1997-02-07 ES ES97904516T patent/ES2196303T5/es not_active Expired - Lifetime
- 1997-02-07 CA CA002246235A patent/CA2246235C/en not_active Expired - Fee Related
- 1997-02-07 HU HU9900950A patent/HUP9900950A3/hu unknown
- 1997-02-07 DK DK97904516T patent/DK0893998T4/da active
- 1997-02-07 DE DE69720985T patent/DE69720985T3/de not_active Expired - Fee Related
- 1997-02-07 AU AU17294/97A patent/AU718971C/en not_active Ceased
- 1997-02-07 PL PL32843097A patent/PL187914B1/pl not_active IP Right Cessation
- 1997-02-07 SK SK1068-98A patent/SK284539B6/sk unknown
- 1997-02-07 WO PCT/GB1997/000369 patent/WO1997028801A1/en active IP Right Grant
- 1997-02-07 KR KR10-1998-0706162A patent/KR100458636B1/ko not_active IP Right Cessation
- 1997-02-07 CN CN97192177A patent/CN1127340C/zh not_active Expired - Fee Related
- 1997-02-07 AT AT97904516T patent/ATE237330T1/de not_active IP Right Cessation
- 1997-02-07 JP JP52830797A patent/JP4283340B2/ja not_active Expired - Fee Related
- 1997-02-07 ZA ZA9701020A patent/ZA971020B/xx unknown
- 1997-02-07 CZ CZ19982451A patent/CZ293616B6/cs not_active IP Right Cessation
- 1997-02-07 PT PT97904516T patent/PT893998E/pt unknown
- 1997-02-07 EP EP97904516A patent/EP0893998B2/en not_active Expired - Lifetime
-
1998
- 1998-08-06 MX MX9806354A patent/MX9806354A/es unknown
-
1999
- 1999-05-31 HK HK99102424A patent/HK1019043A1/xx not_active IP Right Cessation
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