ES2196012T3 - Derivados de acridinio y derivados conjugados. - Google Patents

Derivados de acridinio y derivados conjugados.

Info

Publication number
ES2196012T3
ES2196012T3 ES94101664T ES94101664T ES2196012T3 ES 2196012 T3 ES2196012 T3 ES 2196012T3 ES 94101664 T ES94101664 T ES 94101664T ES 94101664 T ES94101664 T ES 94101664T ES 2196012 T3 ES2196012 T3 ES 2196012T3
Authority
ES
Spain
Prior art keywords
group
derivatives
specific binding
acridinium compounds
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94101664T
Other languages
English (en)
Inventor
Naofumi Sato
Hiroshi Mochizuki
Toshinori Kanamori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2196012T3 publication Critical patent/ES2196012T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Peptides Or Proteins (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE ACRIDINIUM REPRESENTADOS POR LA FORMULA GENERAL (I) EN DONDE A ES UN GRUPO INTERVENTOR QUE NO TIENE ACTIVIDAD PARA UNIRSE CON UNA SUBSTANCIA DE UNION ESPECIFICA, Z ES UN GRUPO ACTIVO ETIQUETADOR QUE TIENE ACTIVIDAD PARA UNIRSE CON UNA SUBSTANCIA DE UNION ESPECIFICA, R1 ES UN ATOMO DE HALOGENO, UN GRUPO DE ALQUILO O UN GRUPO DE ARILO; R2, R3, R4 Y R5 SON CADA UNA UN ATOMO DE HIDROGENO, UN GRUPO DE ALQUILO, UN GRUPO DE ARILO, UN GRUPO DE ALCOXIDO, UN GRUPO DE NITRO, UN ATOMO DE HALOGENO O UN GRUPO DE CARBONILO; E Y ES UN CONTRAION. LOS COMPUESTOS DE ACRIDINIUM PUEDEN FORMAR CONJUGADOS CON SUBSTANCIAS DE UNION ESPECIFICA. LOS COMPUESTOS DE ACRIDINIUM TIENEN UNA ALTA EFICIENCIA DE EMISION Y UNA BUENA ESTABILIDAD, Y, POR LO TANTO, SON UTILES COMO AGENTES ETIQUETADORES QUIMIOLUMINISCENTES.
ES94101664T 1993-02-04 1994-02-03 Derivados de acridinio y derivados conjugados. Expired - Lifetime ES2196012T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP01746593A JP3584379B2 (ja) 1993-02-04 1993-02-04 アクリジニウム化合物およびアクリジニウム化合物複合体

Publications (1)

Publication Number Publication Date
ES2196012T3 true ES2196012T3 (es) 2003-12-16

Family

ID=11944776

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94101664T Expired - Lifetime ES2196012T3 (es) 1993-02-04 1994-02-03 Derivados de acridinio y derivados conjugados.

Country Status (7)

Country Link
US (2) US5438139A (es)
EP (1) EP0609885B1 (es)
JP (1) JP3584379B2 (es)
AT (1) ATE237592T1 (es)
CA (1) CA2114754A1 (es)
DE (1) DE69432497T2 (es)
ES (1) ES2196012T3 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414152B1 (en) * 1981-12-11 2002-07-02 University Of Wales College Of Medicine Of Heath Park Luminescent labelling material and procedures
US7122671B1 (en) * 1979-07-19 2006-10-17 University College Cardiff Consultants Limited Luminescent labelling materials and procedures
ATE111083T1 (de) * 1986-10-22 1994-09-15 Abbott Lab Chemilumineszierende acridinium- und phenantridiniumsalze.
US5656426A (en) * 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
US5593845A (en) * 1993-05-17 1997-01-14 Lumigen, Inc. Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection
GB2282222A (en) * 1993-09-09 1995-03-29 Univ Nottingham Detecting genetic material using labelled DNA
GB2289334B (en) * 1994-05-10 1998-08-26 Molecular Light Technology Lim Enzyme linked chemiluminescent assay
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
EP0761652A1 (en) * 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
EP1019379B1 (en) * 1997-08-21 2005-10-19 Maine Medical Center Peroxide-based chemiluminescent assays and chemiluminescent compounds used therein
AU5473999A (en) 1998-08-11 2000-03-06 Bayer Corporation Near infrared chemiluminescent acridinium compounds and uses thereof
US6673560B1 (en) 1998-11-25 2004-01-06 Bayer Corporation Measurement of hydride using chemiluminescent acridinium compounds and applications thereof
US6723851B2 (en) 2001-10-31 2004-04-20 Quest Diagnostics Investment Incorporated Chemiluminescent compounds and use thereof
GB0320236D0 (en) * 2003-08-29 2003-10-01 Molecular Light Tech Res Ltd Chemiluminescent compounds
JP5503969B2 (ja) * 2006-10-13 2014-05-28 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド 迅速に発光する安定なアクリジニウムエステル
WO2009067417A1 (en) * 2007-11-20 2009-05-28 Siemens Heathcare Diagnostics Inc. Facile n-alkylation of acridine compounds in ionic liquids
CN114245830A (zh) * 2019-08-07 2022-03-25 深圳华大基因科技有限公司 含吖啶酯的化合物及将其用于基于化学发光的单色测序的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110932A (en) * 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4918192A (en) * 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US5151518A (en) * 1987-10-02 1992-09-29 Abbott Laboratories N-arylation of isatins
NL8703075A (nl) * 1987-12-18 1989-07-17 Nederlanden Staat Acridiniumverbindingen als chemiluminescentie-merkstof.
US5283334A (en) * 1987-12-31 1994-02-01 London Diagnostics, Inc. Side-chain functional chemiluminescent labels and their conjugates, and assays therefrom
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
US5321136A (en) * 1987-12-31 1994-06-14 London Diagnostics, Inc. Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof

Also Published As

Publication number Publication date
EP0609885A1 (en) 1994-08-10
DE69432497T2 (de) 2003-10-30
JPH06228102A (ja) 1994-08-16
JP3584379B2 (ja) 2004-11-04
US5594112A (en) 1997-01-14
CA2114754A1 (en) 1994-08-05
DE69432497D1 (de) 2003-05-22
US5438139A (en) 1995-08-01
EP0609885B1 (en) 2003-04-16
ATE237592T1 (de) 2003-05-15

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