ES2195331T3 - Tiodepsipeptidos para la lucha contra endoparasitos y un procedimiento para su obtencion. - Google Patents

Tiodepsipeptidos para la lucha contra endoparasitos y un procedimiento para su obtencion.

Info

Publication number
ES2195331T3
ES2195331T3 ES98917025T ES98917025T ES2195331T3 ES 2195331 T3 ES2195331 T3 ES 2195331T3 ES 98917025 T ES98917025 T ES 98917025T ES 98917025 T ES98917025 T ES 98917025T ES 2195331 T3 ES2195331 T3 ES 2195331T3
Authority
ES
Spain
Prior art keywords
sup
sub
alkyl
cycloalkyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98917025T
Other languages
English (en)
Inventor
Peter Jeschke
Achim Harder
Samson-Himmelstjerna Georg Von
Norbert Mencke
Gerhard Bonse
Katsuharu Iinuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2195331T3 publication Critical patent/ES2195331T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a tiodepsipéptidos cíclicos, especialmente ciclotiodepsipéptidos de 18-24 eslabones, tiodepsipéptidos cíclicos y sus sales. Estos tiodepsipéptidos cíclicos de fórmula general (I), en la que R{sup,1}, R{sup,4}, R{sup,7} y R{sup,10}, representan, independientemente, hidrógeno, alquilo C{sub,1-4} de cadena lineal o ramificada, R{sup,2}, R{sup,5}, R{sup,8} y R{sup,11}, representan, cada uno independientemente, hidrógeno, alquilo C{sub,1-8} de cadena lineal o ramificada, alquenilo C{sub,1-8}, cicloalquilo C{sub,3-6}, cicloalquilo C{sub,3-6}-alquilo C{sub,1-2}, arilalquilo C{sub,1-2}, heteroarilalquilo C{sub,1-2}, arilo o heteroarilo opcionalmente sustituidos, R{sup,9} y R{sup,10}, junto con los átomos a los que están enlazados, representan un anillo de 5 o 6 eslabones opcionalmente sustituido, R{sup,10} y R{sup,11}, junto con los átomos a los que están enlazados, representan un anillo de 5 o 6 eslabones opcionalmente interrumpido por oxígeno, azufre, sulfóxido o sulfonilo y está opcionalmente sustituido, R{sup,3} y R{sup,9}, representan, cada uno independientemente, hidrógeno, alquilo C{sub,1-8} o arilalquilo C{sub,1-2}, cicloalquilo C{sub,3-6}-alquilo C{sub,1-2}, R{sup,6} y R{sup,12}, representan, cada uno independientemente, hidrógeno, alquilo C{sub,1-8} de cadena lineal o ramificada, alquenilo C{sub,1-8}, cicloalquilo C{sub,3-6}, cicloalquilo C{sub,3-6}-alquilo C{sub,1-2}, arilalquilo C{sub,1-2}, heteroalquilo-alquilo C{sub,1-2}, arilo o heteroarilo, opcionalmente sustituidos, y X{sup,1}, X{sup,2}, X{sup,3} y X{sup,4}, representan, cada uno independientemente, oxígeno o azufre; al menos uno de los radicales X{sup,1}, X{sup,2}, X{sup,3} y X{sup,4} representa azufre. La invención también se refiere a los isómeros ópticos y racematos de los tiodepsipéptidos de la invención.
ES98917025T 1997-04-02 1998-03-20 Tiodepsipeptidos para la lucha contra endoparasitos y un procedimiento para su obtencion. Expired - Lifetime ES2195331T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19713626A DE19713626A1 (de) 1997-04-02 1997-04-02 Neue Thiodepsipeptide zur Bekämpfung von Endoparasiten und ein einfaches Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ES2195331T3 true ES2195331T3 (es) 2003-12-01

Family

ID=7825251

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98917025T Expired - Lifetime ES2195331T3 (es) 1997-04-02 1998-03-20 Tiodepsipeptidos para la lucha contra endoparasitos y un procedimiento para su obtencion.

Country Status (10)

Country Link
US (1) US6265537B1 (es)
EP (1) EP0973756B1 (es)
JP (1) JP2001524952A (es)
KR (1) KR20000076392A (es)
CN (1) CN1083445C (es)
AU (1) AU731789B2 (es)
DE (2) DE19713626A1 (es)
ES (1) ES2195331T3 (es)
NZ (1) NZ338102A (es)
WO (1) WO1998043965A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19828047A1 (de) * 1998-06-24 1999-12-30 Bayer Ag Substituierte Cyclooctadepsipeptide
DE19926622A1 (de) 1999-06-11 2000-12-14 Bayer Ag Thermoplastische Formmassen
DE19926620A1 (de) * 1999-06-11 2000-12-14 Bayer Ag Neue Cycloiminodepsipeptide, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Endoparasiten
US6828302B1 (en) 1999-12-08 2004-12-07 Xcyte Therapies, Inc. Therapeutic uses of depsipeptides and congeners thereof
EP1246839B1 (en) 1999-12-08 2004-06-16 Xcyte Therapies, Inc. Depsipeptide and congeners thereof for use as immunosuppressants
DE19962145A1 (de) * 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel/Depsipeptide
DE19962147A1 (de) * 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel / PF 1022-221
BRPI0508140B1 (pt) 2004-03-05 2015-03-17 Nissan Chemical Ind Ltd Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
DE102008030764A1 (de) * 2008-06-28 2009-12-31 Bayer Animal Health Gmbh Kombination von Amidin-Derivaten mit cyclischen Depsipeptiden
DE102009012423A1 (de) 2009-03-10 2010-09-16 Bayer Animal Health Gmbh Zubereitung auf Ölbasis
DE102010064245A1 (de) 2010-12-28 2012-06-28 Bayer Animal Health Gmbh Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances
RS62130B1 (sr) 2015-05-20 2021-08-31 Boehringer Ingelheim Animal Health Usa Inc Antihelmintička depsipeptidna jedinjenja
EP3397638B1 (en) 2015-12-28 2023-08-23 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
BR112019009977A2 (pt) 2016-11-16 2019-08-27 Boehringer Ingelheim Animal Health Usa Inc compostos depsipeptídicos anti-helmínticos
AU2018376146A1 (en) 2017-11-29 2020-05-28 Bayer Aktiengesellschaft Nitrogenous heterocycles as a pesticide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA781173B (en) 1977-03-21 1979-02-28 Zoecon Corp Novel compositions
US4243819A (en) 1978-02-16 1981-01-06 Zoecon Corporation Substituted amino acids
NO176766C (no) * 1989-02-07 1995-05-24 Meiji Seika Kaisha Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
JPH0570366A (ja) * 1991-03-08 1993-03-23 Meiji Seika Kaisha Ltd 薬用組成物
DK0634408T3 (da) 1992-03-17 2002-04-22 Fujisawa Pharmaceutical Co Depsipeptidderivater, fremstilling og anvendelse deraf
CN1073560C (zh) 1993-02-19 2001-10-24 明治制果株式会社 环缩酚酸肽pf1022衍生物
DE4317432A1 (de) * 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
DE4317457A1 (de) * 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
EP0718293B1 (en) * 1993-09-06 2002-03-13 Fujisawa Pharmaceutical Co., Ltd. Cyclodepsipeptide compound
DE4401389A1 (de) 1994-01-19 1995-07-20 Bayer Ag Verwendung von cyclischen Depsipeptiden mit 12 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 12 Ringatomen und Verfahren zu ihrer Herstellung
DE4437198A1 (de) * 1994-10-18 1996-04-25 Bayer Ag Verfahren zur Sulfonylierung, Sulfenylierung und Phosphorylierung von cyclischen Depsipeptiden

Also Published As

Publication number Publication date
EP0973756A1 (de) 2000-01-26
EP0973756B1 (de) 2003-03-26
US6265537B1 (en) 2001-07-24
NZ338102A (en) 2001-02-23
HK1029114A1 (en) 2001-03-23
JP2001524952A (ja) 2001-12-04
DE19713626A1 (de) 1998-10-08
DE59807652D1 (de) 2003-04-30
WO1998043965A1 (de) 1998-10-08
CN1259128A (zh) 2000-07-05
AU731789B2 (en) 2001-04-05
CN1083445C (zh) 2002-04-24
KR20000076392A (ko) 2000-12-26
AU7038898A (en) 1998-10-22

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