ES2121256T3 - Benzoilguanidinas perfluoroalquilo-sustituidas, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents

Benzoilguanidinas perfluoroalquilo-sustituidas, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Info

Publication number
ES2121256T3
ES2121256T3 ES95106922T ES95106922T ES2121256T3 ES 2121256 T3 ES2121256 T3 ES 2121256T3 ES 95106922 T ES95106922 T ES 95106922T ES 95106922 T ES95106922 T ES 95106922T ES 2121256 T3 ES2121256 T3 ES 2121256T3
Authority
ES
Spain
Prior art keywords
medicinal product
perfluoroalkyl
procedure
preparation
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95106922T
Other languages
English (en)
Inventor
Heinz-Werner Dr Kleemann
Hans-Jochen Dr Lang
Jan-Robert Dr Schwark
Andreas Dr Weichert
Wolfgang Dr Scholz
Udo Dr Albus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2121256T3 publication Critical patent/ES2121256T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE DESCRIBEN NUEVAS BENZOILO GUANIDINAS SUSTITUIDAS PERFLUORALQUILO DE LA FORMULA I CON R(1) IGUAL A (C{SUB,1} - C{SUB,6}) - PERFLUORALQUILO SO{SUB,M}; R(2), R(3) SON IGUALES A H, HALOGENO, ALQ(ILO)(OXI), FENOXI; R(4), R(5) SON IGUALES A H, ALQUILO, ESTABILIZADORES DE AMINAS, CN, OR(7), NR(8)R(9), - (CH{SUB,2}){SUB,N} (CF{SUB,2}){SUB,O} - CF{SUB,3}, ASI COMO SUS SALES ACEPTABLES FARMACOLOGICAMENTE, SE OBTIENEN LOS COMPUESTOS I MEDIANTE TRANSFORMACION DE UN COMPUESTO II CON GUANIDINA, DONDE L ES UN GRUPO SUSTITUIBLE POR UN NUCLEOFILO LIGERO.
ES95106922T 1994-05-13 1995-05-08 Benzoilguanidinas perfluoroalquilo-sustituidas, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico, asi como medicamento que las contiene. Expired - Lifetime ES2121256T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4417004A DE4417004A1 (de) 1994-05-13 1994-05-13 Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
ES2121256T3 true ES2121256T3 (es) 1998-11-16

Family

ID=6518126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95106922T Expired - Lifetime ES2121256T3 (es) 1994-05-13 1995-05-08 Benzoilguanidinas perfluoroalquilo-sustituidas, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Country Status (17)

Country Link
US (1) US5571842A (es)
EP (1) EP0686627B1 (es)
JP (1) JP3802582B2 (es)
KR (1) KR100376194B1 (es)
CN (1) CN1054373C (es)
AT (1) ATE169903T1 (es)
AU (1) AU687521B2 (es)
CA (1) CA2149285C (es)
DE (2) DE4417004A1 (es)
DK (1) DK0686627T3 (es)
ES (1) ES2121256T3 (es)
FI (1) FI952290A (es)
HU (1) HU223537B1 (es)
IL (1) IL113688A (es)
NO (1) NO304307B1 (es)
NZ (1) NZ272103A (es)
TW (1) TW418185B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4430916A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
DE19531138A1 (de) * 1995-08-24 1997-02-27 Merck Patent Gmbh Alkenyl-benzoylguanidin-Derivate
EP0765867A1 (de) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19608161A1 (de) 1996-03-04 1997-09-11 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19621319A1 (de) * 1996-05-28 1997-12-04 Hoechst Ag Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US20060025387A1 (en) * 1998-12-23 2006-02-02 Cytoscan Sciences Llc Compositions and methods for the treatment of disorders of the central and peripheral nervous systems
US8008283B2 (en) * 1998-12-23 2011-08-30 Neurotherapeutics Pharma, Inc. Methods and compositions for the treatment of neuropsychiatric disorders
US6495601B1 (en) 1998-12-23 2002-12-17 Cytoscan Sciences Llc Methods and compositions for treating conditions of the central and peripheral nervous systems using non-synaptic mechanisms
US8722668B2 (en) * 1998-12-23 2014-05-13 Daryl W. Hochman Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
WO2000037616A1 (en) * 1998-12-23 2000-06-29 Cytoscan Sciences L.L.C. Compounds, methods of screening and methods of treatment for central and peripheral nervous system disorders
US7214711B2 (en) * 1998-12-23 2007-05-08 Neurotherapeutics Pharma Llc Method of treating migraine headache without aura
US7375138B2 (en) * 2002-05-18 2008-05-20 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them
DE10222192A1 (de) * 2002-05-18 2003-11-27 Aventis Pharma Gmbh Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10226462A1 (de) * 2002-06-13 2003-12-24 Aventis Pharma Gmbh Fluorierte Cycloalkyl-derivatisierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
US6878748B2 (en) * 2002-06-13 2005-04-12 Aventis Pharma Deutschland Gmbh Fluorinated cycloalkyl-derivatized benzoylguanidines, process for their preparation, their uses as medicament, and medicament containing them
US7381841B2 (en) * 2003-08-22 2008-06-03 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE10338554A1 (de) * 2003-08-22 2005-03-31 Aventis Pharma Deutschland Gmbh Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
OA13285A (en) * 2003-11-13 2007-01-31 Sanofi Aventis Deutschland Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same.
DE10353204A1 (de) * 2003-11-13 2005-06-16 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von 4-Pentafluorsulfanyl-benzoylguanidinen
US20050124666A1 (en) * 2003-11-13 2005-06-09 Aventis Pharma Deutschland Gmbh Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same
WO2007047447A2 (en) * 2005-10-17 2007-04-26 Neurotherapeutics Pharma, Inc. Diuretic-like compound analogs useful for regulation of central nervous system disorders
KR200484534Y1 (ko) 2017-07-18 2017-09-20 김경학 조립식 베개

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780027A (en) * 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DK0556674T3 (da) * 1992-02-15 1996-10-14 Hoechst Ag 3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation
ATE158278T1 (de) * 1992-02-15 1997-10-15 Hoechst Ag Ortho-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
DK0577024T3 (es) * 1992-07-01 1997-02-24 Hoechst Ag
TW250477B (es) * 1992-12-15 1995-07-01 Hoechst Ag
DE4318658A1 (de) * 1993-06-04 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
CA2149285A1 (en) 1995-11-14
FI952290A (fi) 1995-11-14
JPH07304729A (ja) 1995-11-21
IL113688A (en) 1999-06-20
AU687521B2 (en) 1998-02-26
EP0686627B1 (de) 1998-08-19
KR950032098A (ko) 1995-12-20
EP0686627A3 (de) 1996-01-31
KR100376194B1 (ko) 2003-05-17
TW418185B (en) 2001-01-11
AU1799995A (en) 1995-11-23
DE4417004A1 (de) 1995-11-16
CN1126201A (zh) 1996-07-10
CN1054373C (zh) 2000-07-12
DK0686627T3 (da) 1999-05-25
NZ272103A (en) 1996-10-28
NO951891D0 (no) 1995-05-12
HUT71800A (en) 1996-02-28
NO304307B1 (no) 1998-11-30
ATE169903T1 (de) 1998-09-15
NO951891L (no) 1995-11-14
HU223537B1 (hu) 2004-08-30
CA2149285C (en) 2007-09-18
IL113688A0 (en) 1995-08-31
US5571842A (en) 1996-11-05
FI952290A0 (fi) 1995-05-11
HU9501407D0 (en) 1995-06-28
JP3802582B2 (ja) 2006-07-26
DE59503234D1 (de) 1998-09-24
EP0686627A2 (de) 1995-12-13

Similar Documents

Publication Publication Date Title
ES2121256T3 (es) Benzoilguanidinas perfluoroalquilo-sustituidas, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico, asi como medicamento que las contiene.
ES2122338T3 (es) Fenilsulfonilureas, procedimiento para su preparacion y su utilizacion como herbicidas y reguladores del crecimiento de las plantas.
ES2183848T3 (es) Dispositivo para obturar un conducto medico, por ejemplo un cateter.
ATE122653T1 (de) 2-alkyl-4-methoxy-5-aminophenol oder deren salz, oder 2-alkyl-4-methoxy-5-substituiertes aminophenol oder deren salz und färbemittel für keratinische fasern, die diese enthalten.
ATE32563T1 (de) Druckinfusionsapparat fuer medizinische anwendungen.
FI823274L (fi) Laekemedel, daeri innehaollna vicinala dihydroxialkylxantiner, framstaellningsfoerfaranden foer desxantinfoereningar och foer dessa laempade mellanprodukter
IL114216A0 (en) Phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups a process for their preparation their use as a medicament or diagnostic agent and also a medicament
ES2184770T3 (es) Guanididas de acido alquil-carboxilico sustituidas con fenilo y portadoras de grupos pperfluoralquilo, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico asi como medicamentos que las contienen.
FI905419A0 (fi) Icke-joniska roentgenkontrastmedel med hoeg jodhalt.
MX22124A (es) Derivados de fosfolipidos y procedimiento para su preparacion.
EP0481299A3 (en) N-phenyl-piperidyl-4-amines and drugs containing them
DE3782484D1 (de) Tropolon-derivate als anti-mycoplasmamittel.
BR8906377A (pt) Agente para a fixacao do penteado e para o tratamento dos cabelos
ATE4893T1 (de) Ionische 5-c-substituierte 2,4,6-trijodisophthals[ure-derivate, deren herstellung und diese enthaltende roentgenkontrastmittel.
NO306991B1 (no) Alkenylbenzoylguanidinderivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler
ES2045206T3 (es) Agentes para reducir la transpiracion de las plantas.
ES2055150T3 (es) N-benzoil-n'-trifluorofenilureas, su preparacion y empleo para el control de pestes.
Jirapaet et al. The efficacy of buddhist training program for the ability to utilize dhamma in working and job satisfaction in health care providers.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 686627

Country of ref document: ES