ES2195136T3 - Derivados de d-pentofuranosa y proceso para prepararlos. - Google Patents

Derivados de d-pentofuranosa y proceso para prepararlos.

Info

Publication number
ES2195136T3
ES2195136T3 ES97919673T ES97919673T ES2195136T3 ES 2195136 T3 ES2195136 T3 ES 2195136T3 ES 97919673 T ES97919673 T ES 97919673T ES 97919673 T ES97919673 T ES 97919673T ES 2195136 T3 ES2195136 T3 ES 2195136T3
Authority
ES
Spain
Prior art keywords
group
compound
formula
lower alkyl
sugar moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97919673T
Other languages
English (en)
Inventor
Makoto Nomura
Hideki Kazuno
Tsutomu Sato
Masato Washinosu
Motoaki Tanaka
Akira Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2195136T3 publication Critical patent/ES2195136T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE LA D PENTOFURANOSA REPRESENTADOS POR LAS SIGUIENTES FORMULAS (1) A (4): (DONDE A REPRESENTA UN GRUPO CLOROBENZOIL; R SUP,1} REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALIFATICO ACIL INFERIOR, UN GRUPO BENZOILO SUSTITUIDO O NO SUSTITUIDO; X E Y REPRESENTAN UN GRUPO ALQUIL INFERIOR CADA UNO; Z REPRESENTA UN GRUPO ETINIL O UN GRUPO ALQUIL SILILETINIL TRIPLE INFERIOR; EL NUCLEO DE AZUCAR EN LA FORMULA (1) REPRESENTA XILOSA; Y EL NUCLEO DE AZUCAR DE CADA UNA DE LAS FORMULAS (3) Y (4) REPRESENTA RIBOSA). LA PRESENTE INVENCION TAMBIEN SE REFIERE A UN PROCESO PARA LA PREPARACION DEL COMPUESTO (2) CARACTERIZADO POR LA OXIDACION DEL COMPUESTO DE FORMULA (1) CON UN HIPOCLORITO EN PRESENCIA DE UNA CANTIDAD CATALITICA DEL COMPUESTO 2,2,6,6 NOXI. ESTOS COMPUESTOS SON UTILES COMO INTERMEDIARIOS EN LA SINTESIS DE DERIVADOS DE RIBONUCLEOSIDOS SUSTITUIDOS EN 3 TIENEN EXCELENTES ACTIVIDADES ANTITUMORALES.
ES97919673T 1996-05-16 1997-04-24 Derivados de d-pentofuranosa y proceso para prepararlos. Expired - Lifetime ES2195136T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12137296 1996-05-16

Publications (1)

Publication Number Publication Date
ES2195136T3 true ES2195136T3 (es) 2003-12-01

Family

ID=14809610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97919673T Expired - Lifetime ES2195136T3 (es) 1996-05-16 1997-04-24 Derivados de d-pentofuranosa y proceso para prepararlos.

Country Status (10)

Country Link
US (1) US5880294A (es)
EP (1) EP0842942B1 (es)
JP (1) JP3046359B2 (es)
KR (1) KR100247734B1 (es)
AT (1) ATE234318T1 (es)
AU (1) AU693741B2 (es)
CA (1) CA2226363C (es)
DE (1) DE69719673T2 (es)
ES (1) ES2195136T3 (es)
WO (1) WO1997043295A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA012844B1 (ru) * 2003-02-19 2009-12-30 Йельский Университет Аналоги противовирусных нуклеозидов и способы лечения вирусных инфекций, в частности вич-инфекций
JP5613168B2 (ja) * 2008-11-17 2014-10-22 アナディス ファーマシューティカルズ インク デオキシリボフラノース化合物の製造方法
CA2802294C (en) 2010-06-11 2016-05-10 Rhodes Technologies Process for n-dealkylation of tertiary amines
ES2671478T3 (es) 2012-08-31 2018-06-06 Novartis Ag Derivados de 2'-etinil nucleósidos para el tratamiento de infecciones virales

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480613A (en) * 1967-07-03 1969-11-25 Merck & Co Inc 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
JPH0753586A (ja) * 1993-08-23 1995-02-28 Sankyo Co Ltd ピリミジンヌクレオシド誘導体の製法

Also Published As

Publication number Publication date
KR19990028434A (ko) 1999-04-15
CA2226363C (en) 2001-03-13
US5880294A (en) 1999-03-09
WO1997043295A1 (fr) 1997-11-20
DE69719673T2 (de) 2003-12-18
ATE234318T1 (de) 2003-03-15
EP0842942B1 (en) 2003-03-12
DE69719673D1 (de) 2003-04-17
KR100247734B1 (ko) 2000-03-15
CA2226363A1 (en) 1997-11-20
AU2405997A (en) 1997-12-05
EP0842942A1 (en) 1998-05-20
AU693741B2 (en) 1998-07-02
EP0842942A4 (en) 1999-01-13
JP3046359B2 (ja) 2000-05-29

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