ES2194277T3 - Ensayos para medir fragmentos de proteina en medios biologicos. - Google Patents
Ensayos para medir fragmentos de proteina en medios biologicos.Info
- Publication number
- ES2194277T3 ES2194277T3 ES98309266T ES98309266T ES2194277T3 ES 2194277 T3 ES2194277 T3 ES 2194277T3 ES 98309266 T ES98309266 T ES 98309266T ES 98309266 T ES98309266 T ES 98309266T ES 2194277 T3 ES2194277 T3 ES 2194277T3
- Authority
- ES
- Spain
- Prior art keywords
- protein fragments
- tests
- biological media
- measure protein
- collagen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
LA INVENCION PROPORCIONA NUEVOS ANTICUERPOS Y VERSIONES DE LOS MISMOS TRATADAS POR INGENIERIA, ASI COMO UN PROCEDIMIENTO PARA SUPERVISAR LOS FRAGMENTOS DE PROTEINA DE MEDIOS BIOLOGICOS, ESPECIALMENTE LOS FRAGMENTOS DE COLAGENO RESULTANTES DE LA DESCOMPOSICION DE LA COLAGENASA DEL COLAGENO TIPO II.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6542397P | 1997-11-13 | 1997-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194277T3 true ES2194277T3 (es) | 2003-11-16 |
Family
ID=22062616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98309266T Expired - Lifetime ES2194277T3 (es) | 1997-11-13 | 1998-11-12 | Ensayos para medir fragmentos de proteina en medios biologicos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6030792A (es) |
EP (1) | EP0921395B1 (es) |
JP (1) | JP3258630B2 (es) |
AT (1) | ATE237133T1 (es) |
BR (1) | BR9804988A (es) |
CA (1) | CA2254010A1 (es) |
DE (1) | DE69813158T2 (es) |
DK (1) | DK0921395T3 (es) |
ES (1) | ES2194277T3 (es) |
PT (1) | PT921395E (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US6642007B1 (en) * | 1998-11-02 | 2003-11-04 | Pfizer Inc. | Assays for measurement of type II collagen fragments in urine |
DK1149111T3 (da) * | 1999-01-06 | 2009-12-14 | Univ Southern California | Fremgangsmåde og sammensætning til inhibering af angiogenese |
US20050281821A1 (en) * | 1999-01-06 | 2005-12-22 | Flavia Pernasetti | Method and composition for angiogenesis inhibition |
ES2327812T3 (es) * | 1999-07-13 | 2009-11-04 | University Of Southern California | Nuevos metodos y composiciones para inhibir la angiogenesis utilizando bases antagonistas de mmp-9 y/o integrinas beta-1. |
JP2004520011A (ja) * | 2000-08-21 | 2004-07-08 | スミスクライン・ビーチャム・コーポレイション | Rankリガンド介在障害の治療において有用な抗−rankリガンドモノクローナル抗体 |
AU2001292312A1 (en) * | 2000-09-29 | 2002-04-08 | Chugai Seiyaku Kabushiki Kaisha | Method of analyzing antibody molecule structure |
CA2438571A1 (en) * | 2001-02-12 | 2002-12-12 | Curagen Corporation | Novel proteins and nucleic acids encoding same |
US20030040027A1 (en) * | 2001-08-16 | 2003-02-27 | Gerd Ritter | Method for determining protein component in a biological sample |
WO2003021226A2 (en) * | 2001-08-31 | 2003-03-13 | Pharmacia Corporation | Peptide biomarker and method of identification |
US20040067882A1 (en) * | 2001-10-22 | 2004-04-08 | Alsobrook John P. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
US7390885B2 (en) * | 2001-11-26 | 2008-06-24 | Cell Matrix, Inc. | Humanized collagen antibodies and related methods |
US7365167B2 (en) * | 2001-11-26 | 2008-04-29 | Cell Matrix, Inc. | Humanized collagen antibodies and related methods |
US20030219843A1 (en) * | 2001-12-20 | 2003-11-27 | Welsch Dean J. | Methods of diagnosing and treating abnormal growth |
US8367013B2 (en) * | 2001-12-24 | 2013-02-05 | Kimberly-Clark Worldwide, Inc. | Reading device, method, and system for conducting lateral flow assays |
US20030119203A1 (en) * | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
BR0309877A (pt) | 2002-05-03 | 2005-04-26 | Millenium Biologix Inc | Peptìdeos estimuladores de tecido conectivo |
US7432061B2 (en) * | 2002-05-31 | 2008-10-07 | Biozyme, Inc. | Assays for measuring matrix metalloproteinase activities |
US7285424B2 (en) | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
US7432105B2 (en) * | 2002-08-27 | 2008-10-07 | Kimberly-Clark Worldwide, Inc. | Self-calibration system for a magnetic binding assay |
US7488792B2 (en) * | 2002-08-28 | 2009-02-10 | Burnham Institute For Medical Research | Collagen-binding molecules that selectively home to tumor vasculature and methods of using same |
US9701754B1 (en) | 2002-10-23 | 2017-07-11 | City Of Hope | Covalent disulfide-linked diabodies and uses thereof |
US20040101920A1 (en) * | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
US7781172B2 (en) * | 2003-11-21 | 2010-08-24 | Kimberly-Clark Worldwide, Inc. | Method for extending the dynamic detection range of assay devices |
US20040106190A1 (en) * | 2002-12-03 | 2004-06-03 | Kimberly-Clark Worldwide, Inc. | Flow-through assay devices |
US7247500B2 (en) * | 2002-12-19 | 2007-07-24 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in membrane-based assay devices |
US20040197819A1 (en) * | 2003-04-03 | 2004-10-07 | Kimberly-Clark Worldwide, Inc. | Assay devices that utilize hollow particles |
US7851209B2 (en) | 2003-04-03 | 2010-12-14 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in assay devices |
US7713748B2 (en) * | 2003-11-21 | 2010-05-11 | Kimberly-Clark Worldwide, Inc. | Method of reducing the sensitivity of assay devices |
US7943395B2 (en) * | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
US20050112703A1 (en) * | 2003-11-21 | 2005-05-26 | Kimberly-Clark Worldwide, Inc. | Membrane-based lateral flow assay devices that utilize phosphorescent detection |
US7943089B2 (en) * | 2003-12-19 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Laminated assay devices |
US20050136550A1 (en) * | 2003-12-19 | 2005-06-23 | Kimberly-Clark Worldwide, Inc. | Flow control of electrochemical-based assay devices |
US7521226B2 (en) * | 2004-06-30 | 2009-04-21 | Kimberly-Clark Worldwide, Inc. | One-step enzymatic and amine detection technique |
JP4683572B2 (ja) * | 2005-01-28 | 2011-05-18 | 塩野義製薬株式会社 | 組換え蛋白質の定量法 |
AU2006283174A1 (en) * | 2005-08-24 | 2007-03-01 | Cell-Matrix, Inc. | Combination therapies for inhibiting integrin-extracellular matrix interactions |
EP1996716B1 (en) * | 2006-03-20 | 2011-05-11 | The Regents of the University of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
US7858752B2 (en) | 2006-12-05 | 2010-12-28 | Abbott Laboratories | Recombinant antibodies against hepatitis C virus and methods of obtaining and using same |
CA2698343C (en) * | 2007-09-04 | 2018-06-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
US20100291113A1 (en) * | 2007-10-03 | 2010-11-18 | Cornell University | Treatment of Proliferative Disorders Using Antibodies to PSMA |
US20100069616A1 (en) * | 2008-08-06 | 2010-03-18 | The Regents Of The University Of California | Engineered antibody-nanoparticle conjugates |
ES2712732T3 (es) * | 2009-02-17 | 2019-05-14 | Cornell Res Foundation Inc | Métodos y kits para el diagnóstico de cáncer y la predicción de valor terapéutico |
KR20120064072A (ko) | 2009-09-16 | 2012-06-18 | 시오노기세야쿠 가부시키가이샤 | 콜라겐 네오에피토프 항체 |
RU2673908C2 (ru) | 2009-12-02 | 2018-12-03 | Имэджинэб, Инк. | Мини-антитела j591 и цис-диатела для направленной доставки простата-специфичного мембранного антигена (psma) человека и способы их применения |
DE102012107651A1 (de) * | 2012-08-21 | 2014-02-27 | Astrium Gmbh | Verfahren zur Durchführung einer biochemischen Analyse, insbesondere im Weltraum |
CA2994951A1 (en) | 2015-08-07 | 2017-02-16 | Imaginab, Inc. | Antigen binding constructs to target molecules |
WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
EP3773714A1 (en) * | 2018-04-12 | 2021-02-17 | Bristol-Myers Squibb Company | Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5300434A (en) * | 1987-11-06 | 1994-04-05 | Washington Research Foundation | Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide |
US5320970A (en) * | 1987-11-06 | 1994-06-14 | Washington Research Foundation | Detection of collagen degradation in vivo |
CA2148132A1 (en) * | 1992-12-04 | 1994-06-23 | Anthony Robin Poole | Immunoassay for the measurement of collagen cleavage in cartilage |
US5541295A (en) * | 1993-02-12 | 1996-07-30 | The Board Of Governors For Higher Education State Of Rhode Island And Providence Plantations | Detection of type II collagen and its peptides |
GB9702252D0 (en) * | 1997-02-06 | 1997-03-26 | Univ Sheffield Medical The Sch | Collagen assay |
-
1998
- 1998-11-02 US US09/184,658 patent/US6030792A/en not_active Expired - Fee Related
- 1998-11-10 CA CA002254010A patent/CA2254010A1/en not_active Abandoned
- 1998-11-12 PT PT98309266T patent/PT921395E/pt unknown
- 1998-11-12 AT AT98309266T patent/ATE237133T1/de not_active IP Right Cessation
- 1998-11-12 ES ES98309266T patent/ES2194277T3/es not_active Expired - Lifetime
- 1998-11-12 EP EP98309266A patent/EP0921395B1/en not_active Expired - Lifetime
- 1998-11-12 DE DE69813158T patent/DE69813158T2/de not_active Expired - Fee Related
- 1998-11-12 DK DK98309266T patent/DK0921395T3/da active
- 1998-11-12 JP JP32218498A patent/JP3258630B2/ja not_active Expired - Fee Related
- 1998-11-13 BR BR9804988-7A patent/BR9804988A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH11218532A (ja) | 1999-08-10 |
EP0921395B1 (en) | 2003-04-09 |
JP3258630B2 (ja) | 2002-02-18 |
CA2254010A1 (en) | 1999-05-13 |
PT921395E (pt) | 2003-06-30 |
EP0921395A3 (en) | 1999-09-01 |
EP0921395A2 (en) | 1999-06-09 |
US6030792A (en) | 2000-02-29 |
BR9804988A (pt) | 2000-03-28 |
DE69813158T2 (de) | 2003-11-27 |
DK0921395T3 (da) | 2003-07-07 |
ATE237133T1 (de) | 2003-04-15 |
DE69813158D1 (de) | 2003-05-15 |
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