ES2193769T3 - Procedimiento y dispositivo para la seleccion de la proliferacion acelerada de celulas vivas en suspension. - Google Patents
Procedimiento y dispositivo para la seleccion de la proliferacion acelerada de celulas vivas en suspension.Info
- Publication number
- ES2193769T3 ES2193769T3 ES99961053T ES99961053T ES2193769T3 ES 2193769 T3 ES2193769 T3 ES 2193769T3 ES 99961053 T ES99961053 T ES 99961053T ES 99961053 T ES99961053 T ES 99961053T ES 2193769 T3 ES2193769 T3 ES 2193769T3
- Authority
- ES
- Spain
- Prior art keywords
- culture
- suspension
- culture vessel
- organisms
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/813—Continuous fermentation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Dispositivo para la selección de la proliferación acelerada de células vivas en suspensión con: (a) al menos un primero y al menos un segundo recipiente (4, 6) de cultivo para la acogida de un cultivo (38); (b) una fuente (12) de gas; (c) una fuente (18) del medio; (d) una fuente (20) para el agente (21) esterilizador; (e) un sistema de conductos para la interconexión de la fuente (12) de gas con los recipientes (4, 6) de cultivo y con elementos para la conexión discrecional de los dos recipientes (4, o 6) de cultivo con la fuente (18) del medio o con la fuente (20) para el agente (21) esterilizador, en donde el sistema de conductos para el suministro de gas, medio y/o agente esterilizador presenta en cada uno de los recipientes (4, 6) de cultivo individuales un tramo (8, 10) común; y (f) elementos para la interconexión entre sí de los dos recipientes (4, 6) de cultivo mediante dos conductos (30, 32) de conexión que presentan un tramo de conducto común.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19856136A DE19856136C2 (de) | 1998-12-04 | 1998-12-04 | Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2193769T3 true ES2193769T3 (es) | 2003-11-01 |
Family
ID=7890072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99961053T Expired - Lifetime ES2193769T3 (es) | 1998-12-04 | 1999-12-02 | Procedimiento y dispositivo para la seleccion de la proliferacion acelerada de celulas vivas en suspension. |
Country Status (15)
Country | Link |
---|---|
US (1) | US6686194B1 (es) |
EP (1) | EP1135460B1 (es) |
JP (1) | JP4615722B2 (es) |
AT (1) | ATE240388T1 (es) |
AU (1) | AU779542B2 (es) |
CA (1) | CA2358437C (es) |
DE (2) | DE19856136C2 (es) |
DK (1) | DK1135460T3 (es) |
ES (1) | ES2193769T3 (es) |
HK (1) | HK1039790B (es) |
IL (2) | IL143300A0 (es) |
MX (1) | MXPA01005523A (es) |
NZ (1) | NZ511961A (es) |
PT (1) | PT1135460E (es) |
WO (1) | WO2000034433A1 (es) |
Families Citing this family (55)
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EP1404846B1 (en) * | 2001-07-06 | 2013-09-11 | Institut Pasteur | Method for obtaining cells with new properties |
US20040214314A1 (en) | 2001-11-02 | 2004-10-28 | Friedrich Srienc | High throughput bioreactor |
EP1597364B1 (fr) | 2003-02-18 | 2013-07-24 | Metabolic Explorer | Procede de preparation de microorganismes evolues permettant la creation ou la modification de voies metaboliques |
FR2860510B1 (fr) * | 2003-10-01 | 2006-12-08 | Eco Solution | Procede et dispositif de culture de cellules vivantes par couplage d'un bioreacteur avec un automate de selection. |
BRPI0507983B1 (pt) * | 2004-02-23 | 2015-04-22 | Eudes François Marie De Crecy | Dispositivo e método que aumentam a taxa de reprodução de células vivas em suspensão ou de quaisquer organismos cultiváveis, incluíndo bactérias, archea, eucariotos, e vírus, pelo processo de seleção natural pela maior velocidade de reprodução e/ou maior rendimento reprodutivo |
US20070037276A1 (en) | 2004-02-23 | 2007-02-15 | Eudes Francois Marie De Crecy | Continuous culture apparatus with mobile vessel, allowing selection of fitter cell variants and producing a culture in a continuous manner |
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EP2262901B1 (en) | 2008-03-05 | 2018-11-21 | Genomatica, Inc. | Primary alcohol producing organisms |
CN103555643B (zh) * | 2008-03-27 | 2016-08-10 | 基因组股份公司 | 用于产生己二酸和其他化合物的微生物 |
JP2011519561A (ja) | 2008-05-01 | 2011-07-14 | ジェノマティカ, インコーポレイテッド | メタクリル酸の産生のための微生物 |
BRPI0913901A2 (pt) * | 2008-06-17 | 2016-12-13 | Genomatica Inc | micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato |
US20110306101A1 (en) * | 2008-07-11 | 2011-12-15 | De Crecy Eudes | method of producing fatty acids for biofuel, biodiesel, and other valuable chemicals |
US20100021978A1 (en) * | 2008-07-23 | 2010-01-28 | Genomatica, Inc. | Methods and organisms for production of 3-hydroxypropionic acid |
US20100184173A1 (en) * | 2008-11-14 | 2010-07-22 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
CN102307986A (zh) * | 2008-12-16 | 2012-01-04 | 基因组股份公司 | 用于将合成气和其他碳源转化成有用产品的微生物和方法 |
WO2010127182A1 (en) * | 2009-04-29 | 2010-11-04 | Evolugate, Llc | Adapting microorganisms for agricultural products |
KR20120068763A (ko) | 2009-04-30 | 2012-06-27 | 게노마티카 인코포레이티드 | 아이소프로판올, n-부탄올 및 아이소부탄올 생산 유기체 |
CA2759994C (en) * | 2009-04-30 | 2019-06-11 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
EP4273255A3 (en) | 2009-05-07 | 2024-01-03 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of hexamethylenediamine |
EP2429587A4 (en) * | 2009-05-15 | 2014-10-08 | Genomatica Inc | ORGANISMS FOR THE PREPARATION OF CYCLOHEXANONE |
EP2440669A4 (en) * | 2009-06-10 | 2013-08-28 | Genomatica Inc | MICROOGANISMS AND PROCEDURES FOR THE CARBON EFFECTIVE BIOSYNTHESIS MEK AND 2-BUTANOL |
DK2462221T3 (en) | 2009-08-05 | 2017-05-22 | Genomatica Inc | SEMISYNTHETIC TEREPHTHALIC ACID BY MICRO-ORGANISMS PRODUCING MUCONIC ACID |
US8715971B2 (en) | 2009-09-09 | 2014-05-06 | Genomatica, Inc. | Microorganisms and methods for the co-production of isopropanol and 1,4-butanediol |
CN105441374A (zh) | 2009-10-13 | 2016-03-30 | 基因组股份公司 | 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法 |
KR20180014240A (ko) | 2009-10-23 | 2018-02-07 | 게노마티카 인코포레이티드 | 아닐린의 제조를 위한 미생물 |
CA2783096A1 (en) * | 2009-12-10 | 2011-06-16 | Genomatica, Inc. | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
US8647850B2 (en) | 2009-12-23 | 2014-02-11 | E I Du Pont De Nemours And Company | Process for simultaneous saccharification and fermentation for production of ethanol |
CA2787314A1 (en) | 2010-01-29 | 2011-08-04 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of p-toluate and terephthalate |
US8048661B2 (en) * | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
US8445244B2 (en) * | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
US8721794B2 (en) | 2010-04-28 | 2014-05-13 | E I Du Pont De Nemours And Company | Production of high solids syrup from lignocellulosic biomass hydrolysate fermentation broth |
US8906235B2 (en) | 2010-04-28 | 2014-12-09 | E I Du Pont De Nemours And Company | Process for liquid/solid separation of lignocellulosic biomass hydrolysate fermentation broth |
US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
US8580543B2 (en) | 2010-05-05 | 2013-11-12 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
JP2013535203A (ja) | 2010-07-26 | 2013-09-12 | ジェノマティカ・インコーポレイテッド | 芳香族、2,4−ペンタジエノエートおよび1,3−ブタジエンを生合成するための微生物および方法 |
US8476048B2 (en) | 2010-12-17 | 2013-07-02 | E I Du Pont De Nemours And Company | Xylose utilizing zymomonas mobilis with improved ethanol production in biomass hydrolysate medium |
CN104685058B (zh) | 2012-06-04 | 2020-07-07 | 基因组股份公司 | 制造4-羟基丁酸酯、1,4-丁二醇和相关化合物的微生物和方法 |
US9657316B2 (en) | 2012-08-27 | 2017-05-23 | Genomatica, Inc. | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto |
CN115960720A (zh) | 2012-10-15 | 2023-04-14 | 基因组股份公司 | 用于生产特定长度脂肪醇及相关化合物的微生物和方法 |
US9932611B2 (en) | 2012-10-22 | 2018-04-03 | Genomatica, Inc. | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto |
US10150976B2 (en) | 2012-12-17 | 2018-12-11 | Genomatica, Inc. | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto |
MY187966A (en) | 2013-04-26 | 2021-11-02 | Genomatica Inc | Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds |
US9725363B2 (en) | 2013-10-10 | 2017-08-08 | E I Du Pont De Nemours And Company | Lignocellulosic biomass fermentation process co-product fuel for cement kiln |
US20150101377A1 (en) | 2013-10-10 | 2015-04-16 | E I Du Pont De Nemours And Company | Lignocellulosic biomass fermentation process co-product ash for land applications |
US9499451B2 (en) | 2013-10-10 | 2016-11-22 | E I Du Pont De Nemours And Company | Soil conditioner compositions containing lignocellulosic biomass fermentation process syrup |
EP3074504A4 (en) | 2013-11-25 | 2017-05-03 | Genomatica, Inc. | Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol |
US10487342B2 (en) | 2014-07-11 | 2019-11-26 | Genomatica, Inc. | Microorganisms and methods for the production of butadiene using acetyl-CoA |
GB201417362D0 (en) * | 2014-10-01 | 2014-11-12 | Hartley Brian S | Devices and methods for selection of microbial strains |
WO2020009017A1 (ja) | 2018-07-05 | 2020-01-09 | 富士フイルム株式会社 | 細胞培養装置及び撹拌方法 |
JP7481608B2 (ja) * | 2019-06-20 | 2024-05-13 | シンフォニアテクノロジー株式会社 | 細胞培養装置 |
FR3110596A1 (fr) | 2020-05-21 | 2021-11-26 | Altar | Procédé de culture cellulaire en continu de cellules vivantes pour l’évolution adaptative desdites cellules vivantes. |
US20220056394A1 (en) * | 2020-08-18 | 2022-02-24 | Upside Foods, Inc. | Systems, devices, and methods for sterilizing bioreactors and culture media |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2147271A (en) * | 1937-07-16 | 1939-02-14 | Schwarz Lab Inc | Pure yeast culture apparatus |
FR1064614A (fr) * | 1949-06-21 | 1954-05-17 | Procédé et dispositif pour la production de gaz méthane, dane les installations septiques rurales en particulier | |
JPS59173086A (ja) | 1983-03-24 | 1984-09-29 | Res Assoc Petroleum Alternat Dev<Rapad> | 固定化酵母を用いたアルコ−ル発酵方法 |
US5316905A (en) * | 1986-09-29 | 1994-05-31 | Suzuki Shokan Co., Ltd. | Culture medium supplying method and culture system |
US6022742A (en) * | 1986-11-26 | 2000-02-08 | Kopf; Henry B. | Culture device and method |
JP2677602B2 (ja) * | 1987-05-23 | 1997-11-17 | 武田薬品工業株式会社 | 継代シード培養によるl−ソルボースの製造法およびそれに用いる装置 |
US5242593A (en) * | 1988-12-09 | 1993-09-07 | Oberkofler Joerg | Method for reducing the build-up of slime and/or film in water circulation systems |
JP2983384B2 (ja) * | 1992-07-15 | 1999-11-29 | 株式会社日立製作所 | 生物細胞の継代懸濁培養方法及び培養装置 |
FR2702764B1 (fr) * | 1993-03-19 | 1995-04-28 | Gaz De France | Procédé et installation de fermentation anaérobie de matières organiques. |
DE4331409C1 (de) * | 1993-09-15 | 1994-11-10 | Bam Apparate Und Maschinenbau | Verfahren und Anlage zur Vermehrung von Bierhefe |
WO1995023845A1 (de) * | 1994-03-02 | 1995-09-08 | Bitop Gesellschaft Für Biotechnische Optimierung Mbh | Verfahren für die züchtung von mikroorganismen |
JPH0838157A (ja) * | 1994-08-03 | 1996-02-13 | Chikyu Kankyo Sangyo Gijutsu Kenkyu Kiko | 培養液移送装置 |
DE19501350C1 (de) * | 1995-01-18 | 1996-04-04 | Henkel Kgaa | Verfahren zur Herabsetzung der Ablagerung von Schleimstoffen in Kreislaufwässern |
FR2803853B1 (fr) * | 2000-01-17 | 2004-10-22 | Farzin Sarem | Dispositif de culture cellulaire et tissulaire a circulation perfectionnee de fluide de culture |
-
1998
- 1998-12-04 DE DE19856136A patent/DE19856136C2/de not_active Expired - Fee Related
-
1999
- 1999-12-02 DE DE59905586T patent/DE59905586D1/de not_active Expired - Lifetime
- 1999-12-02 DK DK99961053T patent/DK1135460T3/da active
- 1999-12-02 AU AU17799/00A patent/AU779542B2/en not_active Expired
- 1999-12-02 PT PT99961053T patent/PT1135460E/pt unknown
- 1999-12-02 EP EP99961053A patent/EP1135460B1/de not_active Expired - Lifetime
- 1999-12-02 AT AT99961053T patent/ATE240388T1/de active
- 1999-12-02 IL IL14330099A patent/IL143300A0/xx active IP Right Grant
- 1999-12-02 MX MXPA01005523A patent/MXPA01005523A/es active IP Right Grant
- 1999-12-02 NZ NZ511961A patent/NZ511961A/en not_active IP Right Cessation
- 1999-12-02 WO PCT/EP1999/009422 patent/WO2000034433A1/de active IP Right Grant
- 1999-12-02 CA CA002358437A patent/CA2358437C/en not_active Expired - Lifetime
- 1999-12-02 ES ES99961053T patent/ES2193769T3/es not_active Expired - Lifetime
- 1999-12-02 JP JP2000586867A patent/JP4615722B2/ja not_active Expired - Lifetime
- 1999-12-02 US US09/857,226 patent/US6686194B1/en not_active Expired - Lifetime
-
2001
- 2001-05-22 IL IL143300A patent/IL143300A/en not_active IP Right Cessation
-
2002
- 2002-02-22 HK HK02101360.8A patent/HK1039790B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE19856136C2 (de) | 2002-10-24 |
HK1039790B (zh) | 2004-01-21 |
MXPA01005523A (es) | 2003-07-14 |
JP4615722B2 (ja) | 2011-01-19 |
WO2000034433A1 (de) | 2000-06-15 |
AU1779900A (en) | 2000-06-26 |
ATE240388T1 (de) | 2003-05-15 |
PT1135460E (pt) | 2003-09-30 |
CA2358437A1 (en) | 2000-06-15 |
AU779542B2 (en) | 2005-01-27 |
IL143300A (en) | 2006-12-31 |
IL143300A0 (en) | 2002-04-21 |
HK1039790A1 (en) | 2002-05-10 |
US6686194B1 (en) | 2004-02-03 |
JP2002531114A (ja) | 2002-09-24 |
DE59905586D1 (de) | 2003-06-18 |
EP1135460B1 (de) | 2003-05-14 |
EP1135460A1 (de) | 2001-09-26 |
DK1135460T3 (da) | 2003-08-11 |
NZ511961A (en) | 2003-08-29 |
DE19856136A1 (de) | 2000-06-08 |
CA2358437C (en) | 2009-03-10 |
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