ES2193132T3 - Procedimiento para transplantar celulas en el cerebro y utilizaciones terapeuticas del mismo. - Google Patents
Procedimiento para transplantar celulas en el cerebro y utilizaciones terapeuticas del mismo.Info
- Publication number
- ES2193132T3 ES2193132T3 ES91919823T ES91919823T ES2193132T3 ES 2193132 T3 ES2193132 T3 ES 2193132T3 ES 91919823 T ES91919823 T ES 91919823T ES 91919823 T ES91919823 T ES 91919823T ES 2193132 T3 ES2193132 T3 ES 2193132T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- cell
- brain
- neural
- approximately
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 210000004556 brain Anatomy 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 10
- 239000011159 matrix material Substances 0.000 abstract 3
- 230000001537 neural effect Effects 0.000 abstract 3
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000001919 adrenal effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 230000004077 genetic alteration Effects 0.000 abstract 1
- 231100000118 genetic alteration Toxicity 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000007514 neuronal growth Effects 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 230000008736 traumatic injury Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0613—Cells from endocrine organs
- C12N5/0614—Adrenal gland
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/33—Fibroblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/10—Mineral substrates
- C12N2533/12—Glass
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
UN METODO PARA INJERTAR UNA CELULA EN EL CEREBRO DE UN SUJETO MAMIFERO SE REALIZA COLOCANDO LA CELULA EN UNA MATRIZ SOPORTE, DE FORMA QUE LAS CELULAS SE UNEN A LA SUPERFICIE EXTERIOR DE LA MATRIZ, E IMPLANTANDO LA MATRIZ SOPORTE CON LAS CELULAS UNIDAS EN EL CEREBRO. LAS MATRICES SOPORTE PREFERIDAS SON MICROPERLAS DE CRISTAL O DE PLASTICO QUE TIENEN UN DIAMETRO DESDE APROXIMADAMENTE 90 HASTA APROXIMADAMENTE 125 (MU)M. EL METODO EMPLEA CELULAS DE DIFERENTES TIPOS, CON PREFERENCIA CELULAS DE ORIGEN NEURAL O PARANEURAL, TAL COMO CELULAS DE CROMAFINA ADRENAL. TAMBIEN SON UTILES LINEAS DE CELULAS CRECIDAS IN VITRO. LAS CELULAS QUE NO SON DE ORIGEN NEURAL O PARANEURAL, TAL COMO FIBROBLASTOS, TAMBIEN SE PUEDEN USAR A CONTINUACION DE ALTERACIONES GENETICAS PARA EXPRESAR UN PRODUCTO NEURAL DESEADO TAL COMO UN NEUROTRANSMISOR O UN FACTOR DE CRECIMIENTO NEURONAL. EL METODO ES EMPLEADO PARA TRATAR ENFERMEDADES TALES COMO LA ENFERMEDAD DE PARKINSON, LA DE ALZHEIMER, LA DE HUNTINGTON, LA EPILEPSIA Y LESIONES TRAUMATICAS DEL CEREBRO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59980290A | 1990-10-19 | 1990-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2193132T3 true ES2193132T3 (es) | 2003-11-01 |
Family
ID=24401152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91919823T Expired - Lifetime ES2193132T3 (es) | 1990-10-19 | 1991-10-09 | Procedimiento para transplantar celulas en el cerebro y utilizaciones terapeuticas del mismo. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0554352B1 (es) |
JP (2) | JP3657001B2 (es) |
AT (1) | ATE233809T1 (es) |
AU (1) | AU665933B2 (es) |
CA (1) | CA2094280C (es) |
DE (1) | DE69133205T2 (es) |
DK (1) | DK0554352T3 (es) |
ES (1) | ES2193132T3 (es) |
HK (1) | HK1013802A1 (es) |
WO (1) | WO1992006702A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5618531A (en) | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
WO1993014790A1 (en) * | 1992-01-23 | 1993-08-05 | New York University | A method for transplanting cells into the brain and therapeutic uses therefor |
IL109280A0 (en) * | 1993-04-15 | 1994-07-31 | Regeneron Pharma | Neurotrophins for treatment of depression |
JP3841427B2 (ja) * | 1993-04-30 | 2006-11-01 | マサチューセッツ・インスティテュート・オブ・テクノロジー | 注入可能な多糖類−細胞組成物 |
US5709854A (en) * | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
EP2025353A2 (en) * | 1993-04-30 | 2009-02-18 | Massachusetts Institute of Technology | Injectable polysaccharide-cell compositions |
US5830460A (en) | 1995-03-13 | 1998-11-03 | University Of South Florida | Sertoli cells as transplantation facilitator for cell transplantation |
AU705932B2 (en) * | 1995-03-13 | 1999-06-03 | University Of South Florida | Sertoli cells as neurorecovery inducing cells for neurodegenerative disorders |
EP0814819B1 (en) * | 1995-03-13 | 2004-07-14 | University Of South Florida | Sertoli cells as transplantation facilitator for cell transplantation |
US5855610A (en) | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
US5741685A (en) * | 1995-06-07 | 1998-04-21 | Children's Medical Center Corporation | Parenchymal cells packaged in immunoprotective tissue for implantation |
US5944754A (en) * | 1995-11-09 | 1999-08-31 | University Of Massachusetts | Tissue re-surfacing with hydrogel-cell compositions |
WO1997026902A1 (fr) * | 1996-01-23 | 1997-07-31 | Srl, Inc. | Cellules destinees au traitement de la demence |
US6210664B1 (en) * | 1996-04-08 | 2001-04-03 | New York University Medical Center | Method for gene transfer to the central nervous system |
US6660301B1 (en) | 1998-03-06 | 2003-12-09 | Biosphere Medical, Inc. | Injectable microspheres for dermal augmentation and tissue bulking |
US6171610B1 (en) | 1998-04-24 | 2001-01-09 | University Of Massachusetts | Guided development and support of hydrogel-cell compositions |
US6027744A (en) * | 1998-04-24 | 2000-02-22 | University Of Massachusetts Medical Center | Guided development and support of hydrogel-cell compositions |
US7338657B2 (en) | 2001-03-15 | 2008-03-04 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
EP1656957B1 (en) * | 2000-03-20 | 2015-06-03 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
US6436424B1 (en) | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
AU2001249221A1 (en) | 2000-03-20 | 2001-10-03 | Biosphere Medical, Inc. | Injectable and swellable microspheres for tissue bulking |
ATE327783T1 (de) * | 2000-03-20 | 2006-06-15 | Biosphere Medical Inc | Injizierbare mikrokügelchen für den gewebeaufbau |
EP1627911A1 (en) | 2004-08-20 | 2006-02-22 | Schering Aktiengesellschaft | Washing apparatus |
US8382704B2 (en) | 2006-12-29 | 2013-02-26 | Medrad, Inc. | Systems and methods of delivering a dilated slurry to a patient |
KR20120089339A (ko) | 2009-11-12 | 2012-08-09 | 브이비아이 테크놀로지스, 엘엘씨 | 포자를 닮은 세포들의 계군 및 그 용도 |
EP2351779B1 (en) | 2010-01-27 | 2019-04-24 | Biosphere Medical, Inc. | Microspheres and method of making the microspheres |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
US20220023350A1 (en) * | 2018-11-04 | 2022-01-27 | Figene, Llc | Treatment of cerebral hypoxia including stroke, chronic traumatic encephalopathy, and traumatic brain injury |
WO2020212948A1 (en) | 2019-04-17 | 2020-10-22 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4748121A (en) * | 1984-11-30 | 1988-05-31 | Ppg Industries, Inc. | Porous glass fibers with immobilized biochemically active material |
US5032508A (en) * | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US4900553A (en) * | 1987-09-11 | 1990-02-13 | Case Western Reserve University | Method of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes |
US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
WO1990012604A1 (en) * | 1989-04-25 | 1990-11-01 | Vacanti Joseph P | Method for implanting large volumes of cells on polymeric matrices |
-
1991
- 1991-10-09 ES ES91919823T patent/ES2193132T3/es not_active Expired - Lifetime
- 1991-10-09 DK DK91919823T patent/DK0554352T3/da active
- 1991-10-09 EP EP91919823A patent/EP0554352B1/en not_active Expired - Lifetime
- 1991-10-09 DE DE69133205T patent/DE69133205T2/de not_active Expired - Fee Related
- 1991-10-09 AT AT91919823T patent/ATE233809T1/de not_active IP Right Cessation
- 1991-10-09 WO PCT/US1991/007443 patent/WO1992006702A1/en active IP Right Grant
- 1991-10-09 JP JP51806691A patent/JP3657001B2/ja not_active Expired - Fee Related
- 1991-10-09 CA CA002094280A patent/CA2094280C/en not_active Expired - Fee Related
- 1991-10-09 AU AU89235/91A patent/AU665933B2/en not_active Ceased
-
1998
- 1998-12-24 HK HK98115295A patent/HK1013802A1/xx not_active IP Right Cessation
-
2003
- 2003-08-28 JP JP2003304393A patent/JP3766668B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2094280A1 (en) | 1992-04-20 |
JP3657001B2 (ja) | 2005-06-08 |
JPH06502406A (ja) | 1994-03-17 |
EP0554352B1 (en) | 2003-03-05 |
DE69133205D1 (de) | 2003-04-10 |
EP0554352A4 (es) | 1994-04-27 |
AU8923591A (en) | 1992-05-20 |
JP3766668B2 (ja) | 2006-04-12 |
DK0554352T3 (da) | 2003-06-10 |
DE69133205T2 (de) | 2003-12-11 |
JP2004041757A (ja) | 2004-02-12 |
WO1992006702A1 (en) | 1992-04-30 |
ATE233809T1 (de) | 2003-03-15 |
AU665933B2 (en) | 1996-01-25 |
HK1013802A1 (en) | 1999-09-10 |
CA2094280C (en) | 2003-07-29 |
EP0554352A1 (en) | 1993-08-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2193132T3 (es) | Procedimiento para transplantar celulas en el cerebro y utilizaciones terapeuticas del mismo. | |
Fu et al. | Experience-dependent structural plasticity in the cortex | |
DE3779442T2 (de) | Nebel-zellkultur. | |
MX2021000391A (es) | Sistema y metodo de cultivo hidroponico. | |
ATE270323T1 (de) | Zusammensetzungen und verfahren zur stimulierung der proliferation und der differenzierung von menschlichen fetalen und erwachsenen pankreatischen zellen ex vivo | |
IL160445A (en) | Unit and process for carrying out high cell density fermentation | |
Yuri et al. | Mechanisms of neural network structures recovery in brain trauma | |
Singer | The trophic quality of the neuron: some theoretical considerations | |
Muffat et al. | CNS disease models with human pluripotent stem cells in the CRISPR age | |
MX2019015321A (es) | Composiciones tridimensionales de tejido y métodos de uso. | |
MX2020010335A (es) | Sistema de cultivo. | |
ATE57457T1 (de) | Poroeses produkt fuer die pflanzenkultur und verfahren zu dessen herstellung. | |
DE2551017C3 (de) | Erhaltungsmedium für Nierenzellen zur Gewinnung von Urokinase | |
DE19500498A1 (de) | Matrixkörper für die Messung isometrischer Kraftparameter von Zellgewebe, Verfahren zum Kultivieren von Muskelzellen in Kollagengel und zum gleichzeitigen Herstellen von Muskelgewebe enthaltenden Matrixkörpern für die Messung von isometrischen Kraftparametern an diesen Körpern, sowie Vorrichtung zur Durchführung des Verfahrens | |
CA2380943A1 (en) | Mechanically elongated neuronal cells and methods for producing and using these cells | |
Immelmann | Definition and use of the terms “ultimate factor”,“proximate factor” and “zeitgeber” | |
Girbardt | Lebendnachweis von Einzelelementen des endoplasmatischen Retikulums | |
Caprile et al. | Analyzing the role of extracellular matrix during nervous system development to advance new regenerative strategies | |
DE10208311B4 (de) | Vorrichtung und Verfahren zur Kultivierung von Gewebezellen | |
Zhu et al. | 4D biofabrication of branching multicellular structures: A morphogenesis simulation based on turing’s reaction-diffusion dynamics | |
de Grey | Commentary on some recent theses relevant to combating aging: June 2009 | |
EP1287118B1 (de) | Verfahren zur herstellung eines empfängerspezifischen gewebe-transplantats oder -implantats | |
CN209072973U (zh) | 一种芒果树高枝嫁接装置 | |
AT505008B1 (de) | Verfahren zum kultivieren von sehnenzellen aus nicht embryonalen pluripotenten zellen mesenchymaler herkunft | |
DE19732194C1 (de) | Verfahren zur Gewinnung eines epithelialen Zellverbandes |