ES2193112T3 - Metodo para el tratamiento de insuficiencias venosas cronicas utilizando un extracto de hojas de vid roja. - Google Patents
Metodo para el tratamiento de insuficiencias venosas cronicas utilizando un extracto de hojas de vid roja.Info
- Publication number
- ES2193112T3 ES2193112T3 ES00974420T ES00974420T ES2193112T3 ES 2193112 T3 ES2193112 T3 ES 2193112T3 ES 00974420 T ES00974420 T ES 00974420T ES 00974420 T ES00974420 T ES 00974420T ES 2193112 T3 ES2193112 T3 ES 2193112T3
- Authority
- ES
- Spain
- Prior art keywords
- leaves
- red vine
- chronic venous
- treatment
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000978499 Brunnichia ovata Species 0.000 title abstract 4
- 239000000284 extract Substances 0.000 title abstract 3
- 201000002282 venous insufficiency Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000001684 chronic effect Effects 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000006286 aqueous extract Substances 0.000 abstract 2
- 201000002816 chronic venous insufficiency Diseases 0.000 abstract 2
- 229930003935 flavonoid Natural products 0.000 abstract 2
- 150000002215 flavonoids Chemical class 0.000 abstract 2
- 235000017173 flavonoids Nutrition 0.000 abstract 2
- 210000003141 lower extremity Anatomy 0.000 abstract 2
- 239000012141 concentrate Substances 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000005325 percolation Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Cardiology (AREA)
- Polymers & Plastics (AREA)
- Heart & Thoracic Surgery (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
El uso de una composición en una forma adecuada para administración oral, que consiste en un principio activo que es capaz de prevenir o tratar la molestia asociada con la insuficiencia venosa crónica leve a moderada de las extremidades inferiores y un vehículo farmacéuticamente, cosméticamente o dietéticamente aceptable, en el que el principio activo consiste esencialmente en un extracto acuoso de hojas de vid roja que contienen de 2 a 20% de flavonoides, en el que dicho extracto acuoso de hojas de vid roja es obtenible a partir de un método que comprende las etapas de: a) Recolectar las hojas de vid roja en el momento en que el contenido en flavonoides ha alcanzado un nivel óptimo; b) secar y moler las hojas; c) cortar las hojas en trozos; d) extraer las hojas con agua a temperaturas desde 60 a 80ºC durante 6 a 10 horas en una percolación exhaustiva; e) opcionalmente concentrar el extracto obtenido; para la preparación de un suplemento dietético para la prevención y/o tratamiento de la molestia asociada con la insuficiencia venosa crónica leve a moderada de las extremidades inferiores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16051899P | 1999-10-20 | 1999-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2193112T3 true ES2193112T3 (es) | 2003-11-01 |
Family
ID=22577208
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00974420T Expired - Lifetime ES2193112T3 (es) | 1999-10-20 | 2000-10-19 | Metodo para el tratamiento de insuficiencias venosas cronicas utilizando un extracto de hojas de vid roja. |
| ES03000403T Expired - Lifetime ES2261796T3 (es) | 1999-10-20 | 2000-10-19 | Composicion para el tratamiento de insuficiencias venosas cronicas que comprende un extracto de hojas de vid roja. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03000403T Expired - Lifetime ES2261796T3 (es) | 1999-10-20 | 2000-10-19 | Composicion para el tratamiento de insuficiencias venosas cronicas que comprende un extracto de hojas de vid roja. |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US6485727B1 (es) |
| EP (4) | EP2286676A1 (es) |
| JP (2) | JP2001122791A (es) |
| CN (1) | CN1197481C (es) |
| AR (2) | AR031533A1 (es) |
| AT (2) | ATE235167T1 (es) |
| AU (1) | AU1273701A (es) |
| BR (1) | BRPI0014874B8 (es) |
| CA (1) | CA2386215C (es) |
| CO (1) | CO5251468A1 (es) |
| CY (1) | CY1105049T1 (es) |
| DE (2) | DE60001857T2 (es) |
| DK (2) | DK1300084T3 (es) |
| ES (2) | ES2193112T3 (es) |
| HK (1) | HK1048580B (es) |
| MX (1) | MXPA02003595A (es) |
| PE (1) | PE20010677A1 (es) |
| PT (2) | PT1225810E (es) |
| SA (1) | SA00210550B1 (es) |
| WO (1) | WO2001028363A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001122791A (ja) * | 1999-10-20 | 2001-05-08 | Boehringer Ingelheim Internatl Gmbh | 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤 |
| JP2003342184A (ja) * | 2002-05-31 | 2003-12-03 | Ichimaru Pharcos Co Ltd | ヒアルロニダーゼ活性阻害剤及び化粧料組成物 |
| US20040151794A1 (en) * | 2002-12-31 | 2004-08-05 | Boehringer Ingelheim International Gmbh | Method of improvement of blood circulation |
| EP1435242A1 (en) * | 2002-12-31 | 2004-07-07 | Pharmaton S.A. | Method of improvement of blood circulation |
| US20040151769A1 (en) * | 2002-12-31 | 2004-08-05 | Boehringer Ingelheim International Gmbh | Film coated tablet containing an extract of red vine leaves |
| PT1581195E (pt) * | 2002-12-31 | 2010-07-07 | Boehringer Ingelheim Int | Comprimido revestido com pelcula compreendendo um extracto de folhas de videira vermelha |
| EP1550450A1 (en) * | 2003-12-29 | 2005-07-06 | Boehringer Ingelheim International GmbH | Composition comprising an aqueous extract of red vine leaves and a blood circulating-improving agent for the treatment of chronic venous insufficiencies |
| EP1550451A1 (en) * | 2003-12-29 | 2005-07-06 | Boehringer Ingelheim International GmbH | Composition comprising an aqueous extract of red vine leaves and a diuretic for the treatment of chronic venous insufficiencies |
| EP1550452A1 (en) * | 2003-12-29 | 2005-07-06 | Boehringer Ingelheim International GmbH | Composition comprising an aqueous extract of red vine leaves and a antthrombotic agent for the treatment of chronic venous insufficiencies |
| JP2007523110A (ja) * | 2004-02-19 | 2007-08-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 赤ブドウ葉の抽出物および抗炎症剤を含む、慢性静脈疾患を治療するための組成物 |
| US20060293258A1 (en) * | 2005-06-23 | 2006-12-28 | Peter Rohdewald | Method and composition to treat skin ulcers |
| EP1993522A2 (en) | 2005-10-26 | 2008-11-26 | Kao Corporation | Resveratrol and/or grape leaf extract as i.a. endurance improver, anti-aging agent, muscle strength improver |
| JP2011512320A (ja) * | 2007-08-31 | 2011-04-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 赤ブドウの葉の抽出物を含む噴霧可能な組成物 |
| DE102008012908A1 (de) * | 2008-03-06 | 2009-09-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methode zum anti-inflammatorischen und anti-ödematösen Schutz von explantiertem biologischen Material bis zu seiner Transplantation in Patienten |
| DE102008012909A1 (de) * | 2008-03-06 | 2009-09-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Flavonoidverbindungen für die Prophylaxe und Therapie ischämischer oder entzündlicher Herz- und Kreislauferkrankungen |
| WO2011147989A1 (de) * | 2010-05-28 | 2011-12-01 | Finzelberg Gmbh & Co. Kg | Verfahren zur herstellung eines angereicherten extraktes aus blättern von weinrebengewächsen |
| US20130210754A1 (en) * | 2010-05-28 | 2013-08-15 | Uwe Scheuring | Method for producing an enriched extract from vitis vinifera l. leaves |
| JP6321908B2 (ja) * | 2013-02-19 | 2018-05-09 | エスエス製薬株式会社 | むくみ治療用経口組成物 |
| DE202014006415U1 (de) * | 2014-08-12 | 2015-11-13 | Boehringer Ingelheim International Gmbh | Wasserlösliches Granulat zur Herstellung einer Trinklösung |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE617039A (es) * | 1961-05-13 | |||
| FR2276059A1 (fr) | 1974-06-25 | 1976-01-23 | Agronomique Inst Nat Rech | Procede d'extraction de pigments vegetaux de la classe des facteurs vitaminiques p a partir de plantes en contenant |
| JPS55111791A (en) * | 1979-02-22 | 1980-08-28 | Japan Synthetic Rubber Co Ltd | Antitumor substance |
| FR2556969B1 (fr) * | 1983-12-27 | 1986-04-25 | Oreal | Composition cosmetique ou pharmaceutique a base d'extraits vegetaux ayant une action sur la fragilite capillaire |
| GB8524001D0 (en) * | 1985-09-30 | 1985-11-06 | Glaxo Group Ltd | Pharmaceutical composition |
| CH680854A5 (es) | 1990-05-09 | 1992-11-30 | Nestle Sa | |
| FR2715582B1 (fr) * | 1994-02-02 | 1996-03-15 | Centre Nat Rech Scient | Microcapsules à paroi de flavonoïde réticulée et compositions en contenant. |
| IT1270999B (it) | 1994-07-26 | 1997-05-26 | Indena Spa | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
| FR2726273B1 (fr) * | 1994-10-26 | 1996-12-06 | Adir | Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant |
| CH690817A5 (de) * | 1996-09-03 | 2001-01-31 | Flachsmann Ag Emil | Verfahren zur Herstellung eines stabilen, homogenen, von Folgeprodukten freien oder nahezu freien Extraktes. |
| US20020165270A1 (en) * | 1997-05-13 | 2002-11-07 | Jose Remacle | Use of a pharmaceutical composition for treating and/or preventing ischemia |
| ZA987800B (en) * | 1997-08-27 | 1999-06-09 | Hexal Ag | Pharmaceutical composition of meloxicam |
| IT1296920B1 (it) * | 1997-12-04 | 1999-08-03 | Indena Spa | Uso di complessi di estratti vitis vinifera con fosfolipidi come agenti anti-aterosclerotici |
| US6342255B1 (en) * | 1998-09-15 | 2002-01-29 | Codex V S.R.L. | Topical pharmaceutical compositions useful for the treatment of cutaneous of circulatory pathologies on inflammatory, immune, proliferative of degenerative basis |
| US6210680B1 (en) * | 1999-06-11 | 2001-04-03 | Univera Pharmaceuticals, Inc. | Method for the prevention and treatment of chronic venous insufficiency |
| JP2003509344A (ja) * | 1999-09-10 | 2003-03-11 | セテリス・ホールディング・ベスローテン・フェンノートシャップ−アムステルダム（オランダ）−スックルサーレ・ディ・ルガーノ | 循環系および過脂肪症の問題を処置するための、植物抽出物を基にした抗オキシダントの調製 |
| JP2001122791A (ja) | 1999-10-20 | 2001-05-08 | Boehringer Ingelheim Internatl Gmbh | 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤 |
| FR2804319B1 (fr) * | 2000-01-28 | 2002-10-25 | Clarins Lab | Composition cosmetique amincissante comprenant en tant qu'agent actif un extrait de plante contenant de l'anp |
| US6689161B2 (en) * | 2000-04-28 | 2004-02-10 | Baylor College Of Medicine | Decellularized vascular prostheses resistant to thrombus occlusion and immunologic rejection |
| JP4750340B2 (ja) * | 2000-05-25 | 2011-08-17 | ファルマトン ソシエテ アノニム | 細胞保護を改善する方法 |
| BRPI0106382B1 (pt) | 2001-03-13 | 2017-07-11 | Universidade Do Estado Do Rio De Janeiro - Uerj | Process for obtaining decocts from vitis labrusca and vitis vinifera casts, process for obtaining the hydro-alcoholic extract, process for obtaining the hydro-alcoholic extract-ethyl acetate and pharmaceutical compositions |
| US20020192834A1 (en) * | 2001-03-23 | 2002-12-19 | Sand Bruce J. | Analysis of caffeine |
| US8936588B2 (en) * | 2001-09-21 | 2015-01-20 | Fred Herz Patents, LLC | Device and method for prevention and treatment of deep venous thrombosis |
| EP1438059A4 (en) * | 2001-10-26 | 2008-01-23 | Angiolab Inc | COMPOSITION CONTAINING EXTRACT OF BROWN FROM INDIA PREPARED FOR ANTI-ANGIOGENIC ACTIVITY AND INHIBITOR OF MATRIX METALLOPROTEINASE |
| US6579543B1 (en) * | 2002-02-22 | 2003-06-17 | Jackie H. McClung | Composition for topical application to skin |
| DE20209650U1 (de) | 2002-06-21 | 2002-09-12 | Sterken Brigitte | Venen-Aktiv-Balm |
| US20040151794A1 (en) * | 2002-12-31 | 2004-08-05 | Boehringer Ingelheim International Gmbh | Method of improvement of blood circulation |
| US20040151769A1 (en) * | 2002-12-31 | 2004-08-05 | Boehringer Ingelheim International Gmbh | Film coated tablet containing an extract of red vine leaves |
| US20040146539A1 (en) * | 2003-01-24 | 2004-07-29 | Gupta Shyam K. | Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits |
| US20040223962A1 (en) * | 2003-05-07 | 2004-11-11 | Riordan Neil H. | Method and composition for preventing or reducing edema, deep vein thrombosis and/or pulmonary embolism |
| EP1550451A1 (en) * | 2003-12-29 | 2005-07-06 | Boehringer Ingelheim International GmbH | Composition comprising an aqueous extract of red vine leaves and a diuretic for the treatment of chronic venous insufficiencies |
| EP1550450A1 (en) * | 2003-12-29 | 2005-07-06 | Boehringer Ingelheim International GmbH | Composition comprising an aqueous extract of red vine leaves and a blood circulating-improving agent for the treatment of chronic venous insufficiencies |
| EP1550452A1 (en) * | 2003-12-29 | 2005-07-06 | Boehringer Ingelheim International GmbH | Composition comprising an aqueous extract of red vine leaves and a antthrombotic agent for the treatment of chronic venous insufficiencies |
| JP2007523110A (ja) * | 2004-02-19 | 2007-08-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 赤ブドウ葉の抽出物および抗炎症剤を含む、慢性静脈疾患を治療するための組成物 |
-
2000
- 2000-01-18 JP JP2000008453A patent/JP2001122791A/ja active Pending
- 2000-10-18 PE PE2000001109A patent/PE20010677A1/es not_active Application Discontinuation
- 2000-10-18 US US09/691,003 patent/US6485727B1/en not_active Expired - Lifetime
- 2000-10-19 DK DK03000403T patent/DK1300084T3/da active
- 2000-10-19 EP EP10180221A patent/EP2286676A1/en not_active Withdrawn
- 2000-10-19 DK DK00974420T patent/DK1225810T3/da active
- 2000-10-19 DE DE60001857T patent/DE60001857T2/de not_active Revoked
- 2000-10-19 AT AT00974420T patent/ATE235167T1/de active
- 2000-10-19 AT AT03000403T patent/ATE323427T1/de active
- 2000-10-19 PT PT00974420T patent/PT1225810E/pt unknown
- 2000-10-19 CO CO00079759A patent/CO5251468A1/es not_active Application Discontinuation
- 2000-10-19 CA CA002386215A patent/CA2386215C/en not_active Expired - Lifetime
- 2000-10-19 BR BRPI0014874A patent/BRPI0014874B8/pt not_active IP Right Cessation
- 2000-10-19 MX MXPA02003595A patent/MXPA02003595A/es active IP Right Grant
- 2000-10-19 EP EP00974420A patent/EP1225810B1/en not_active Revoked
- 2000-10-19 CN CNB008145938A patent/CN1197481C/zh not_active Expired - Lifetime
- 2000-10-19 WO PCT/EP2000/010292 patent/WO2001028363A1/en active IP Right Grant
- 2000-10-19 ES ES00974420T patent/ES2193112T3/es not_active Expired - Lifetime
- 2000-10-19 EP EP03000403A patent/EP1300084B1/en not_active Revoked
- 2000-10-19 EP EP06001091A patent/EP1649761A1/en not_active Ceased
- 2000-10-19 AU AU12737/01A patent/AU1273701A/en not_active Abandoned
- 2000-10-19 ES ES03000403T patent/ES2261796T3/es not_active Expired - Lifetime
- 2000-10-19 PT PT03000403T patent/PT1300084E/pt unknown
- 2000-10-19 JP JP2001530967A patent/JP2003511476A/ja active Pending
- 2000-10-19 DE DE60027481T patent/DE60027481T2/de not_active Expired - Lifetime
- 2000-10-20 AR ARP000105543A patent/AR031533A1/es not_active Application Discontinuation
- 2000-11-21 SA SA00210550A patent/SA00210550B1/ar unknown
-
2002
- 2002-10-02 US US10/262,703 patent/US20030031739A1/en not_active Abandoned
-
2003
- 2003-02-06 HK HK03100834.7A patent/HK1048580B/zh not_active IP Right Cessation
- 2003-09-30 US US10/675,630 patent/US6991816B2/en not_active Expired - Lifetime
-
2005
- 2005-11-14 US US11/272,841 patent/US7270838B2/en not_active Expired - Lifetime
-
2006
- 2006-06-13 CY CY20061100789T patent/CY1105049T1/el unknown
-
2007
- 2007-06-27 AR ARP070102846A patent/AR061707A2/es unknown
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