ES2187769T3 - Lactitol directamente comprensible y metodo de fabricacion del mismo. - Google Patents
Lactitol directamente comprensible y metodo de fabricacion del mismo.Info
- Publication number
- ES2187769T3 ES2187769T3 ES97919075T ES97919075T ES2187769T3 ES 2187769 T3 ES2187769 T3 ES 2187769T3 ES 97919075 T ES97919075 T ES 97919075T ES 97919075 T ES97919075 T ES 97919075T ES 2187769 T3 ES2187769 T3 ES 2187769T3
- Authority
- ES
- Spain
- Prior art keywords
- lactitol
- granulate
- physiologically acceptable
- directly compressible
- binder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Analogue/Digital Conversion (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UNOS GRANULADOS DE LACTITOL DIRECTAMENTE COMPRESIBLES Y A UNOS COMPRIMIDOS DE LACTITOL FABRICADOS A PARTIR DE ESTOS GRANULADOS. LOS GRANULADOS CONTIENEN LACTITOLES Y UN LIGANTE NO CARIOGENO FISIOLOGICAMENTE ACEPTABLE, QUE PUEDE ESTAR CONSTITUIDO POR UN ALCOHOL DE AZUCAR NO CARIOGENO, UN AZUCAR REDUCTOR POLIMERIZADO, UNA CARBOXIMETILOCELULOSA ALCALINA, UN HIDROLIZADO DE ALMIDON HIDROGENADO, UNA HIDROXIPROPILCELULOSA, UN DERIVADO DE CELULOSA FISIOLOGICAMENTE ACEPTABLE, POLIVINILPIRROLIDONA, GOMA ARABIGA U OTRA GOMA FISIOLOGICAMENTE ACEPTABLE. EL LIGANTE PREFERIDO ES EL LACTITOL. ESTA INVENCION SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA OBTENCION DE LOS GRANULADOS DE LACTITOL DIRECTAMENTE COMPRESIBLES Y SE PUEDEN UTILIZAR EN EL PRENSADO DE COMPRIMIDOS. LOS COMPRIMIDOS OBTENIDOS DE ESTA MANERA TIENEN UNA DUREZA ELEVADA Y UNA FRIABILIDAD BAJA. SON NO CARIOGENOS Y POSEEN EL PERFIL DE SABOR Y LAS PROPIEDADES METABOLICAS DEL LACTITOL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/715,825 US5846568A (en) | 1996-09-19 | 1996-09-19 | Directly compressible lactitol and method |
US715825 | 1996-09-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2187769T3 true ES2187769T3 (es) | 2003-06-16 |
ES2187769T5 ES2187769T5 (es) | 2006-08-16 |
Family
ID=24875641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97919075T Expired - Lifetime ES2187769T5 (es) | 1996-09-19 | 1997-09-16 | Lactitol directamente compresible y metodo de fabricacion del mismo. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5846568A (es) |
EP (1) | EP0938301B2 (es) |
JP (1) | JP2001502667A (es) |
KR (1) | KR20000036234A (es) |
AT (1) | ATE229797T1 (es) |
AU (1) | AU729040B2 (es) |
CA (1) | CA2263495A1 (es) |
DE (1) | DE69718046T3 (es) |
ES (1) | ES2187769T5 (es) |
PL (1) | PL332461A1 (es) |
RU (1) | RU2187999C2 (es) |
WO (1) | WO1998011878A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI107732B (fi) | 1998-03-18 | 2001-09-28 | Xyrofin Oy | Laktitolin kiteyttäminen, kiteinen laktitolituote ja sen käyttö |
NL1009350C2 (nl) * | 1998-06-09 | 1999-12-10 | Sara Lee De Nv | Zoetstoftablet. |
US20010055613A1 (en) * | 1998-10-21 | 2001-12-27 | Beth A. Burnside | Oral pulsed dose drug delivery system |
US6384020B1 (en) * | 1999-07-14 | 2002-05-07 | Shire Laboratories, Inc. | Rapid immediate release oral dosage form |
DE19943491B4 (de) * | 1999-09-10 | 2010-04-01 | Südzucker AG Mannheim/Ochsenfurt | Verbesserte Komprimate |
US6872414B1 (en) | 1999-09-20 | 2005-03-29 | Xyrofin Oy | Anhydrous lactitol crystals, a product containing the same and a process for the preparation thereof as well as use thereof |
JP3419729B2 (ja) * | 2000-03-16 | 2003-06-23 | 株式会社ファンケル | 錠剤およびその製造方法 |
DE60110666T2 (de) * | 2000-03-17 | 2006-02-02 | Shin-Etsu Chemical Co., Ltd. | Feste Zubereitung enthaltend niedersubstituierte Hydroxypropylcellulose und Herstellungsverfahren |
WO2002100548A2 (en) * | 2001-06-13 | 2002-12-19 | Inhale Therapeutic Systems, Inc. | Centrifuged rotating drum for treating cohesive powders |
US20040109889A1 (en) * | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
US7682833B2 (en) * | 2003-09-10 | 2010-03-23 | Abbott Point Of Care Inc. | Immunoassay device with improved sample closure |
CN1686089B (zh) * | 2005-05-08 | 2010-08-18 | 北京健健康康生物技术有限公司 | 一种可直接压片的木糖醇颗粒及其制备方法 |
US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
US8846100B2 (en) * | 2006-05-12 | 2014-09-30 | Shire Llc | Controlled dose drug delivery system |
US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
CN103314000B (zh) | 2010-11-19 | 2018-07-27 | 嘉吉公司 | 使用具有大孔中性吸附树脂的吸附-脱附色谱用于富集衍生自甜叶菊的糖苷组合物中的新蛇菊苷b和/或新蛇菊苷d的方法 |
EP3128996B1 (en) | 2014-04-07 | 2021-06-02 | University of Rochester | Novel 7-dehydrocholesterol derivatives and methods using same |
CN104447898B (zh) * | 2014-11-06 | 2017-03-29 | 山东绿健生物技术有限公司 | 一种固体乳糖醇及其制备方法与应用 |
CN105030707B (zh) * | 2015-07-10 | 2020-10-13 | 南京泽恒医药技术开发有限公司 | 一种基于改性葡萄糖全粉末直压法制备克霉唑含片的方法 |
US10806743B1 (en) | 2017-05-12 | 2020-10-20 | Braintree Laboratories, Inc. | Method of administering lactitol to reduce plasma concentration of lactitol |
US20200170291A1 (en) * | 2017-05-23 | 2020-06-04 | Particle Dynamics International, Llc | Processes for producing lactitol granulates and granulates produced thereby |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5536526A (en) * | 1988-01-11 | 1996-07-16 | Cultor Ltd. | Xylitol-based binding and diluting agent and a process for the production thereof |
US5021249A (en) * | 1989-11-09 | 1991-06-04 | Warner-Lambert Company | Method of making a savory flavor granule and a free flowing savory flavor granule |
GB8928196D0 (en) * | 1989-12-13 | 1990-02-14 | Merrell Dow Pharmaceuticals Li | Pharmaceutical lozenges |
US5204115A (en) * | 1990-12-12 | 1993-04-20 | Suomen Xyrofin Oy | Directly compressible xylitol and method |
DE69331839T2 (de) * | 1992-01-29 | 2002-12-12 | Takeda Chemical Industries, Ltd. | Schnellösliche Tablette und ihre Herstellung |
US5612053A (en) * | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
US5651988A (en) † | 1995-08-18 | 1997-07-29 | Xyrofin Oy | Combination osmotic and bulk forming laxatives |
-
1996
- 1996-09-19 US US08/715,825 patent/US5846568A/en not_active Expired - Lifetime
-
1997
- 1997-09-16 WO PCT/FI1997/000548 patent/WO1998011878A1/en not_active Application Discontinuation
- 1997-09-16 AU AU43042/97A patent/AU729040B2/en not_active Ceased
- 1997-09-16 AT AT97919075T patent/ATE229797T1/de not_active IP Right Cessation
- 1997-09-16 ES ES97919075T patent/ES2187769T5/es not_active Expired - Lifetime
- 1997-09-16 JP JP10514321A patent/JP2001502667A/ja active Pending
- 1997-09-16 EP EP97919075A patent/EP0938301B2/en not_active Expired - Lifetime
- 1997-09-16 RU RU99105852/14A patent/RU2187999C2/ru not_active IP Right Cessation
- 1997-09-16 CA CA002263495A patent/CA2263495A1/en not_active Abandoned
- 1997-09-16 DE DE69718046T patent/DE69718046T3/de not_active Expired - Lifetime
- 1997-09-16 PL PL97332461A patent/PL332461A1/xx unknown
- 1997-09-16 KR KR1019997002316A patent/KR20000036234A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL332461A1 (en) | 1999-09-13 |
CA2263495A1 (en) | 1998-03-26 |
AU729040B2 (en) | 2001-01-25 |
DE69718046T3 (de) | 2006-10-26 |
EP0938301B1 (en) | 2002-12-18 |
US5846568A (en) | 1998-12-08 |
RU2187999C2 (ru) | 2002-08-27 |
ATE229797T1 (de) | 2003-01-15 |
ES2187769T5 (es) | 2006-08-16 |
AU4304297A (en) | 1998-04-14 |
DE69718046T2 (de) | 2003-05-22 |
DE69718046D1 (de) | 2003-01-30 |
WO1998011878A1 (en) | 1998-03-26 |
EP0938301A1 (en) | 1999-09-01 |
EP0938301B2 (en) | 2006-02-22 |
KR20000036234A (ko) | 2000-06-26 |
JP2001502667A (ja) | 2001-02-27 |
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