ES2185750T3 - Derivados de acido hidroxamico utiles para la inhibicion gelatinasa. - Google Patents
Derivados de acido hidroxamico utiles para la inhibicion gelatinasa.Info
- Publication number
- ES2185750T3 ES2185750T3 ES96305805T ES96305805T ES2185750T3 ES 2185750 T3 ES2185750 T3 ES 2185750T3 ES 96305805 T ES96305805 T ES 96305805T ES 96305805 T ES96305805 T ES 96305805T ES 2185750 T3 ES2185750 T3 ES 2185750T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- rent
- hydrogen
- diseases
- hydroxamic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A: (I) DERIVADOS DE ACIDO HIDROXAMICO DE FORMULA (I), EN LA QUE R{SUP,1} ES HIDROGENO, O ALQUILO C1-4; R{SUP,2} ES HIDROGENO, ALQUILO C1-8, FENILO, ALQUILO C1-4 SUSTITUIDO POR FENILO; E ES -CONR{SUP,3}-, DONDE R{SUP,3} ES HIDROGENO, ALQUILO C1-4, ETC., -NR{SUP,3}CO-, -CO-O-, -O-CO-, ETC.; A ES HIDROGENO, ALQUILO C1-8, CICLOALQUILO C3-7, O AR; J ES ENLACE, ALQUILENO C2-4, ETC.; G ES -(CH{SUB,2}){SUB,M}-, DONDE M ES 2,3, O 4, O EN DONDE R{SUP,6} Y R{SUP,7} ES HIDROGENO, ALQUILO C1-8, ETC.; Y SALES DE LOS MISMOS NO TOXICAS; (II) PROCEDIMIENTOS DE PREPARACION DE LOS MISMOS, Y (III) AGENTES FARMACEUTICOS QUE LOS CONTIENEN. LOS COMPUESTOS DE FORMULA (I), SON UTILES PARA LA PREVENCION Y/O TRATAMIENTO DE ENFERMEDADES INDUCIDAS POR SOBREEXPRESION O ACTIVIDAD EXCESIVA DE LAS GELATINASAS, POR EJEMPLO, ENFERMEDADES REUMATOIDES, ARTROSTEITIS, RESORCION INUSUAL DEL HUESO, OSTEOPOROSIS, PERIODONTITIS, NEFRITIS INTERSTICIAL, ARTERIOSCLEROSIS, ENFISEMA PULMONAR, CIRROSIS, LESIONES EN LA CORNEA, METASTASIS, INVASION, O CRECIMIENTO DE CELULAS TUMORALES, ENFERMEDADES AUTOINMUNES (ENFERMEDAD DE CROHN, SINDROME DE SJOGREN, ETC.), ENFERMEDADES CAUSADAS POR EMIGRACION VASCULAR O INFILTRACION DE LEUCOCITOS, O ARTERIALIZACION EN ANIMALES, INCLUYENDO AL SER HUMANO, ESPECIALMENTE EN SERES HUMANOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22267395 | 1995-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2185750T3 true ES2185750T3 (es) | 2003-05-01 |
Family
ID=16786144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96305805T Expired - Lifetime ES2185750T3 (es) | 1995-08-08 | 1996-08-07 | Derivados de acido hidroxamico utiles para la inhibicion gelatinasa. |
Country Status (8)
Country | Link |
---|---|
US (1) | US6022893A (es) |
EP (1) | EP0757984B1 (es) |
KR (1) | KR100231230B1 (es) |
AT (1) | ATE226936T1 (es) |
DE (1) | DE69624536T2 (es) |
DK (1) | DK0757984T3 (es) |
ES (1) | ES2185750T3 (es) |
PT (1) | PT757984E (es) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU725831C (en) * | 1995-12-08 | 2002-10-17 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation |
US6500948B1 (en) | 1995-12-08 | 2002-12-31 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof |
US6919375B1 (en) | 1996-01-23 | 2005-07-19 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
CA2242416C (en) * | 1996-01-23 | 2006-03-21 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
TR199801419T2 (xx) | 1996-01-23 | 1998-10-21 | Shionogi & Co.Ltd. | S�lfone amino asit t�revleri ve ayn� i�erikte metaloproteinez �nleyicileri. |
US5977408A (en) * | 1996-10-16 | 1999-11-02 | American Cyanamid Company | Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
US6548524B2 (en) | 1996-10-16 | 2003-04-15 | American Cyanamid Company | Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
US5929097A (en) * | 1996-10-16 | 1999-07-27 | American Cyanamid Company | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
US5962481A (en) * | 1996-10-16 | 1999-10-05 | American Cyanamid Company | Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
US6228869B1 (en) | 1996-10-16 | 2001-05-08 | American Cyanamid Company | Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
US5804593A (en) * | 1996-10-22 | 1998-09-08 | Pharmacia & Upjohn Company | α-Amino sulfonyl hydroxamic acids as matrix metalloproteinase inhibitors |
US6174915B1 (en) | 1997-03-25 | 2001-01-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
US6087359A (en) * | 1997-03-04 | 2000-07-11 | Getman; Daniel P. | Thioaryl sulfonamide hydroxamic acid compounds |
US6451791B1 (en) * | 1997-03-04 | 2002-09-17 | Monsanto Company | Amidoaromatic ring sulfonamide hydroxamic acid compounds |
GB9706255D0 (en) | 1997-03-26 | 1997-05-14 | Smithkline Beecham Plc | Novel compounds |
NZ338082A (en) * | 1997-04-01 | 2000-06-23 | Agouron Pharma | Metalloproteinase and Tumor Necrosis Factor-alpha convertase inhibitors, pharmaceutical compositions and their use in treating disease mediated by metalloproteinase activity. |
US5985900A (en) * | 1997-04-01 | 1999-11-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
AU7294098A (en) * | 1997-05-09 | 1998-11-27 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
ID29293A (id) * | 1997-07-22 | 1999-01-28 | Shionogi & Co | KOMPOSISI UNTUK MENGOBATI ATAU MENCEGAH GLOMERULOPATI (Pecahan dari No. W20000054) |
KR100352316B1 (ko) * | 1997-07-31 | 2002-09-12 | 더 프록터 앤드 갬블 캄파니 | 메탈로프로테아제억제제로서사용되는술포닐아미노치환히드록삼산유도체 |
US6420427B1 (en) | 1997-10-09 | 2002-07-16 | Ono Pharmaceutical Co., Ltd. | Aminobutyric acid derivatives |
WO1999051572A1 (fr) | 1998-04-03 | 1999-10-14 | Sankyo Company, Limited | Derives de sulfonamide |
US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
US6762178B2 (en) | 1999-01-27 | 2004-07-13 | Wyeth Holdings Corporation | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
US6200996B1 (en) | 1999-01-27 | 2001-03-13 | American Cyanamid Company | Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors |
US6946473B2 (en) | 1999-01-27 | 2005-09-20 | Wyeth Holdings Corporation | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors |
US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
US6326516B1 (en) | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
US6277885B1 (en) | 1999-01-27 | 2001-08-21 | American Cyanamid Company | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
US6753337B2 (en) | 1999-01-27 | 2004-06-22 | Wyeth Holdings Corporation | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
US6358980B1 (en) | 1999-01-27 | 2002-03-19 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
US6506936B1 (en) | 1999-02-25 | 2003-01-14 | Fibrogen, Inc. | N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production |
NZ513831A (en) * | 1999-03-03 | 2001-09-28 | Procter & Gamble | Alkenyl- and alkynyl-containing metalloprotease inhibitors |
US6541521B1 (en) | 1999-07-12 | 2003-04-01 | Warner-Lambert Company | Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
AU6049800A (en) * | 1999-07-16 | 2001-02-05 | G.D. Searle & Co. | Method of changing conformation of a matrix metalloproteinase |
US6869951B1 (en) | 1999-07-16 | 2005-03-22 | Pharmacia Corporation | Method of changing conformation of a matrix metalloproteinase |
EP1088815A1 (en) * | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
US6465508B1 (en) | 2000-02-25 | 2002-10-15 | Wyeth | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors |
WO2002003994A1 (en) * | 2000-07-12 | 2002-01-17 | G.D. Searle & Co. | N sulfonyl aminoacid derivatives as inhibitors of metalloproteinase |
JP2004359546A (ja) * | 2001-03-15 | 2004-12-24 | Ono Pharmaceut Co Ltd | ヒドロキサム酸誘導体、それらの非毒性塩およびそれらのプロドラッグ体を有効成分として含有する、固形癌の予防および/または治療剤 |
US20050119305A1 (en) * | 2001-03-21 | 2005-06-02 | Masao Naka | Il-6 production inhibitors |
EP1801240A1 (en) * | 2001-06-05 | 2007-06-27 | Auckland Uniservices Limited | Methods and compositions for assessment of pulmonary function and disorders |
ITMI20011733A1 (it) * | 2001-08-07 | 2003-02-07 | Italfarmaco Spa | Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc |
EP1440057A1 (en) | 2001-11-01 | 2004-07-28 | Wyeth Holdings Corporation | Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors |
IL165259A0 (en) * | 2002-05-29 | 2005-12-18 | Merck & Co Inc | Compounds useful in the treatment of anthraxa and inhibiting lethal factor |
KR100529845B1 (ko) * | 2002-09-16 | 2005-11-22 | 한국식품연구원 | 배를 주재로 한 발효음료의 제조방법 |
AU2003304456A1 (en) | 2002-12-23 | 2005-03-16 | Wyeth Holdings Corporation | Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors |
US7524938B2 (en) | 2003-04-04 | 2009-04-28 | Yeda Research And Development Co., Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
AU2005250351A1 (en) | 2004-05-11 | 2005-12-15 | Merck & Co., Inc. | Process for making n-sulfonated-amino acid derivatives |
US20100003276A1 (en) * | 2004-12-07 | 2010-01-07 | Hermes Jeffery D | Methods for treating anthrax and inhibiting lethal factor |
AU2006244683A1 (en) * | 2005-05-10 | 2006-11-16 | Synergenz Bioscience Limited | Methods and compositions for assessment of pulmonary function and disorders |
AU2006248201A1 (en) * | 2005-05-19 | 2006-11-23 | Synergenz Bioscience Limited | Methods for the assesssment of risk of developing lung cancer using analysis of genetic polymorphisms |
EP1888779A4 (en) * | 2005-05-20 | 2009-06-10 | Synergenz Bioscience Ltd | METHOD FOR THE ANALYSIS OF POLYMORPHISMS AND USES THEREOF |
CA2678304A1 (en) | 2007-02-23 | 2008-08-28 | Yeda Research And Development Co. Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
US20100286149A1 (en) * | 2007-11-26 | 2010-11-11 | Antonio Nardi | Novel benzamide derivatives useful as potassium channel modulators |
US20100120013A1 (en) * | 2008-11-07 | 2010-05-13 | Mb Research Laboratories, Inc. | Procedure for long term corneal culture |
KR102632439B1 (ko) * | 2022-10-31 | 2024-02-05 | 나리찬주식회사 농업회사법인 | 백김치 음료의 제조방법 및 이에 따라 제조된 백김치 음료 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE555319A (es) * | 1956-03-21 | 1900-01-01 | ||
US3095355A (en) * | 1961-10-12 | 1963-06-25 | Revlon | Aerosol composition |
DE1251765B (de) * | 1963-07-23 | 1967-10-12 | Dr Karl Thomae Gesellschaft mit beschrankter Haftung Biberach/Riß | Verfahren zur Herstellung von neuen 5H - Dihydrothiopyrano [4 3 d] pynmidinen |
GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
ZA782648B (en) * | 1977-05-23 | 1979-06-27 | Ici Australia Ltd | The prevention,control or eradication of infestations of ixodid ticks |
FI824314L (fi) * | 1981-12-16 | 1983-06-17 | Sankyo Co | Thienopyrimidin-derivater, deras framstaellning och deras medicinska anvaendning |
NL8300656A (nl) * | 1982-02-25 | 1983-09-16 | Maruko Pharmaceutical Co | Thiopyranopyrimidineverbindingen en zuuradditiezouten daarvan. |
DD228811A1 (de) * | 1984-04-17 | 1985-10-23 | Hydrierwerk Rodleben Veb | Verfahren zur herstellung von neuen triazolopyrimidinen |
ZA873934B (en) * | 1986-06-05 | 1987-12-02 | Merrell Dow Pharmaceuticals Inc. | 2,3-dihydro-1-(8-methyl-1,2,4-triazolo(4,3-b)pyridazin-6-yl)-4(1h)-pyridinone |
CA1340191C (en) * | 1988-06-13 | 1998-12-15 | Katsuhiro Imaki | Derivatives of p-substituted phenyl ester of pivalic acid |
ES2058527T3 (es) * | 1988-06-16 | 1994-11-01 | Smith Kline French Lab | Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen. |
US5011835A (en) * | 1990-02-07 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Substituted triazolopyridazines, pharmaceutical compositions and use |
DE4008726A1 (de) * | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
AU651337B2 (en) * | 1990-03-30 | 1994-07-21 | Dowelanco | Thienopyrimidine derivatives |
PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | 4−アミノキナゾリン誘導体およびそれを含有する医薬品 |
US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
PH31122A (en) * | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
DK0822186T3 (da) * | 1994-01-20 | 2000-06-26 | British Biotech Pharm | L-tert-leucin-2-pyridylamid |
CN1151157A (zh) * | 1994-06-22 | 1997-06-04 | 英国生物技术药物有限公司 | 金属蛋白酶抑制剂 |
-
1996
- 1996-08-07 DE DE69624536T patent/DE69624536T2/de not_active Expired - Fee Related
- 1996-08-07 AT AT96305805T patent/ATE226936T1/de not_active IP Right Cessation
- 1996-08-07 DK DK96305805T patent/DK0757984T3/da active
- 1996-08-07 EP EP96305805A patent/EP0757984B1/en not_active Expired - Lifetime
- 1996-08-07 US US08/694,473 patent/US6022893A/en not_active Expired - Fee Related
- 1996-08-07 KR KR1019960032819A patent/KR100231230B1/ko not_active IP Right Cessation
- 1996-08-07 PT PT96305805T patent/PT757984E/pt unknown
- 1996-08-07 ES ES96305805T patent/ES2185750T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0757984T3 (da) | 2003-03-03 |
US6022893A (en) | 2000-02-08 |
KR970010741A (ko) | 1997-03-27 |
PT757984E (pt) | 2003-02-28 |
DE69624536T2 (de) | 2003-06-05 |
EP0757984A1 (en) | 1997-02-12 |
DE69624536D1 (de) | 2002-12-05 |
ATE226936T1 (de) | 2002-11-15 |
KR100231230B1 (ko) | 1999-11-15 |
EP0757984B1 (en) | 2002-10-30 |
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