ES2184792T3 - Poliqueladores. - Google Patents
Poliqueladores.Info
- Publication number
- ES2184792T3 ES2184792T3 ES95910609T ES95910609T ES2184792T3 ES 2184792 T3 ES2184792 T3 ES 2184792T3 ES 95910609 T ES95910609 T ES 95910609T ES 95910609 T ES95910609 T ES 95910609T ES 2184792 T3 ES2184792 T3 ES 2184792T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- preferibly
- sub
- domain
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000282693 Cercopithecidae Species 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000013467 fragmentation Methods 0.000 abstract 1
- 238000006062 fragmentation reaction Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
- A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/16—Dendrimers and dendritic polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Polyethers (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Abstract
ESTA INVENCION CONSISTE EN COMPUESTOS POLIQUELANTES QUE RESULTAN UTILES, POR EJEMPLO, EN LOS PROCEDIMIENTOS DE DIAGNOSTICO POR IMAGENES Y QUE SON DEGRADABLES IN VIVO Y PRODUCEN FRAGMENTOS EXCRETABLES. ESTOS COMPUESTOS TIENEN UNA FORMULA (I): R{SUP,1}(X{SUP,1}R{SUP,2}((X{SUP,2}){SUB,P}L){SUB,N}){SUB,M} (DONDE X{SUP,1} ES UN DOMINIO DE ENLACE METABOLICAMENTE FRAGMENTABLE PARA PRODUCIR R{SUP,1}X{SUP,3}{SUB,M} Y X{SUP,4}R{SUP,2}((X{SUP,2}){SUB,P}L){SUB,N}, DONDE X{SUP,3} Y X{SUP,4} SON LOS RESIDUOS DE LA FRAGMENTACION DE X{SUP,1}; R{SUP,1}X{SUP,3}{SUB,M} ES UN POLIMERO BIOTOLERADO, PREFERIBLEMENTE UN POLIMERO BASICAMENTE MONODISPERSO Y EN ESPECIAL, UNO CON UN PESO MOLECULAR INFERIOR A 40.000 D, PREFERIBLEMENTE INFERIOR A 30.000 D, Y ESPECIALMENTE, INFERIOR A 20.000 D, POR EJEMPLO, UN DENDRIMERO DE LA PRIMERA A LA SEXTA GENERACION. X{SUP,4}R{SUP,2}((X{SUP,2}){SUB,P}L){SUB,N} ES UN FRAGMENTO POLIQUELANTE CON UN PESO MOLECULAR INFERIOR A 40.000 D, PREFERIBLEMENTE INFERIOR A 30.000 D, Y ESPECIALMENTE, INFERIOR A 20.000 D, EN EL QUE CADA DOMINIO ES PREFERIBLEMENTE EL MISMO; P ES 0 O 1; X{SUP,2}, CUANDO EXISTEN ES UN DOMINIO DE ENLACE METABOLICAMENTE FRAGMENTABLE QUE PRODUCE UN FRAGMENTO MONOQUELANTE. CADA L ES UN DOMINIO QUELANTE MACROCICLICO, EN EL QUE EL ESQUELETO MACROCICLICO TIENE PREFERIBLEMENTE ENTRE 9 Y 25 ELEMENTOS EN EL ANILLO Y, PREFERIBLEMENTE, ES UN POLIAZACICLOALCANO INTERRUMPIDO POR OXIGENO O AZUFRE. R{SUP,2}((X{SUP,2}){SUB,P}){SUB,N} ES UNA CADENA LINEAL O UN DOMINIO RAMIFICADO, PREFERIBLEMENTE CON UNA CADENA DE HASTA 20 ATOMOS ENTRE CADA GRUPO L Y EL DOMINIO X{SUP,1} AL QUE ESTA UNIDO, Y UNA CADENA DE HASTA 25 ATOMOS ENTRE CADA PAR DE GRUPOS L UNIDOS POR ELLA. ESTAS CADENAS DEBERIAN SER CADENAS DE CARBONOS INTERRUMPIDAS POR NITROGENO, OXIGENO O AZUFRE. CADA N ES UN ENTERO CON UN VALOR DE AL MENOS 2, Y PREFERIBLEMENTE UN VALOR ENTRE 2 Y 25, ESPECIALMENTE ENTRE 2 Y 12 U CADA M ES UN ENTERO CON UN VALOR DE AL MENOS 2, PREFERIBLEMENTE UN VALOR INFERIOR A 200 Y ESPECIALMENTE ENTRE 3 Y 100, DE MANERA QUE EL NUMERO TOTAL DE GRUPOS L EN EL POLIQUELANTE DE FORMULA (I) ES 20, Y PREFERIBLEMENTE, DE 50 A 200). LOS COMPUESTOS TIENEN UN PESO MOLECULAR DE AL MENOS 30.000 D, PREFERIBLEMENTE DE AL MENOS 40.000 D, Y, EN EL MEJOR DE LOS CASOS, ENTRE 50.000 Y 150.000 D Y CONTIENEN, ADEMAS, QUELANTES METALICOS Y SALES DE ESTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9404208A GB9404208D0 (en) | 1994-03-04 | 1994-03-04 | Chelants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2184792T3 true ES2184792T3 (es) | 2003-04-16 |
Family
ID=10751305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95910609T Expired - Lifetime ES2184792T3 (es) | 1994-03-04 | 1995-03-03 | Poliqueladores. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5976493A (es) |
| EP (1) | EP0748229B1 (es) |
| JP (1) | JPH09510239A (es) |
| CN (1) | CN1139882A (es) |
| AU (1) | AU1852995A (es) |
| CA (1) | CA2181070A1 (es) |
| DE (1) | DE69528046T2 (es) |
| ES (1) | ES2184792T3 (es) |
| GB (1) | GB9404208D0 (es) |
| MX (1) | MX9603679A (es) |
| WO (1) | WO1995024225A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| US6166200A (en) * | 1995-07-04 | 2000-12-26 | Schering Aktiengesellschaft | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes |
| DE19525924A1 (de) | 1995-07-04 | 1997-01-09 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| DE19549286A1 (de) * | 1995-12-22 | 1997-06-26 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| US5874061A (en) * | 1995-12-22 | 1999-02-23 | Schering Aktiengesellschaft | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes |
| WO1999025389A2 (en) | 1997-11-17 | 1999-05-27 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| US6896874B2 (en) | 1998-05-26 | 2005-05-24 | Wisconsin Alumni Research Foundation | MR-signal emitting coatings |
| US6361759B1 (en) * | 1998-05-26 | 2002-03-26 | Wisconsin Alumni Research Foundation | MR signal-emitting coatings |
| US20030004236A1 (en) * | 2001-04-20 | 2003-01-02 | Meade Thomas J. | Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances |
| WO2002087632A1 (en) * | 2001-05-02 | 2002-11-07 | Metaprobe, Inc. | High throughput screening methods using magnetic resonance imaging agents |
| WO2003001218A2 (en) * | 2001-06-25 | 2003-01-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Macromolecular imaging agents for liver imaging |
| ITMI20011708A1 (it) * | 2001-08-03 | 2003-02-03 | Bracco Imaging Spa | Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m |
| US20030198597A1 (en) * | 2002-04-22 | 2003-10-23 | Meade Thomas J. | Novel macrocyclic activatible magnetic resonance imaging contrast agents |
| US7199268B2 (en) | 2003-12-16 | 2007-04-03 | Schering Aktiengesellschaft | Process for the production of dendritic trimesic acid triamides |
| US20060204443A1 (en) * | 2005-03-11 | 2006-09-14 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for tumor treatment using dendrimer conjugates |
| US8457712B2 (en) | 2005-12-30 | 2013-06-04 | Wisconsin Alumni Research Foundation | Multi-mode medical device system and methods of manufacturing and using same |
| US8532742B2 (en) | 2006-11-15 | 2013-09-10 | Wisconsin Alumni Research Foundation | System and method for simultaneous 3DPR device tracking and imaging under MR-guidance for therapeutic endovascular interventions |
| US8412306B2 (en) | 2007-02-28 | 2013-04-02 | Wisconsin Alumni Research Foundation | Voltage standing wave suppression for MR-guided therapeutic interventions |
| US20090169480A1 (en) * | 2007-12-31 | 2009-07-02 | Industrial Technology Research Institute | Dendritic polymers and magnetic resonance imaging contrast agent employing the same |
| JP6032729B2 (ja) * | 2012-05-08 | 2016-11-30 | 国立研究開発法人理化学研究所 | イメージングマーカーおよびその利用 |
| RU2528414C1 (ru) | 2013-01-25 | 2014-09-20 | Закрытое Акционерное Общество "Фарм-Синтез" | Циклический октапептид, радиофармацевтическое средство на его основе и способ применения радиофармацевтического средства для получения лекарственных (фармацевтических) средств для лечения новообразований, экспрессирующих соматостатиновые рецепторы |
| JP7544704B2 (ja) * | 2018-11-28 | 2024-09-03 | キューブ バイオテック ゲーエムベーハー | 固相キレート材、その製造方法およびタンパク質の精製におけるその使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338532A (en) * | 1986-08-18 | 1994-08-16 | The Dow Chemical Company | Starburst conjugates |
| US5364613A (en) * | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| US5914095A (en) * | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| SG49726A1 (en) * | 1989-10-23 | 1998-06-15 | Nycomed Salutar Inc | Compounds |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4115789A1 (de) * | 1991-05-10 | 1992-11-12 | Schering Ag | Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| GB9318550D0 (en) * | 1993-09-07 | 1993-10-20 | Nycomed Salutar Inc | Chelants |
-
1994
- 1994-03-04 GB GB9404208A patent/GB9404208D0/en active Pending
-
1995
- 1995-03-03 MX MX9603679A patent/MX9603679A/es unknown
- 1995-03-03 JP JP7523292A patent/JPH09510239A/ja active Pending
- 1995-03-03 AU AU18529/95A patent/AU1852995A/en not_active Abandoned
- 1995-03-03 ES ES95910609T patent/ES2184792T3/es not_active Expired - Lifetime
- 1995-03-03 US US08/702,693 patent/US5976493A/en not_active Expired - Lifetime
- 1995-03-03 WO PCT/GB1995/000464 patent/WO1995024225A1/en not_active Ceased
- 1995-03-03 EP EP95910609A patent/EP0748229B1/en not_active Expired - Lifetime
- 1995-03-03 DE DE69528046T patent/DE69528046T2/de not_active Expired - Fee Related
- 1995-03-03 CA CA002181070A patent/CA2181070A1/en not_active Abandoned
- 1995-03-03 CN CN95191470A patent/CN1139882A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1139882A (zh) | 1997-01-08 |
| AU1852995A (en) | 1995-09-25 |
| EP0748229A1 (en) | 1996-12-18 |
| WO1995024225A1 (en) | 1995-09-14 |
| GB9404208D0 (en) | 1994-04-20 |
| MX9603679A (es) | 1997-06-28 |
| CA2181070A1 (en) | 1995-09-14 |
| EP0748229B1 (en) | 2002-09-04 |
| US5976493A (en) | 1999-11-02 |
| DE69528046T2 (de) | 2003-04-24 |
| DE69528046D1 (de) | 2002-10-10 |
| JPH09510239A (ja) | 1997-10-14 |
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