ES2182841T3 - Preparacion en microemulsion conteniendo una substancia dificilmente absorbible. - Google Patents

Preparacion en microemulsion conteniendo una substancia dificilmente absorbible.

Info

Publication number
ES2182841T3
ES2182841T3 ES94912700T ES94912700T ES2182841T3 ES 2182841 T3 ES2182841 T3 ES 2182841T3 ES 94912700 T ES94912700 T ES 94912700T ES 94912700 T ES94912700 T ES 94912700T ES 2182841 T3 ES2182841 T3 ES 2182841T3
Authority
ES
Spain
Prior art keywords
microemulsion
preparation
substance
physiologically active
aqueous phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94912700T
Other languages
English (en)
Inventor
Masao Takahashi
Hiroshi Matsushita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute for Advanced Skin Research Inc
Original Assignee
Institute for Advanced Skin Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute for Advanced Skin Research Inc filed Critical Institute for Advanced Skin Research Inc
Application granted granted Critical
Publication of ES2182841T3 publication Critical patent/ES2182841T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PREPARADO EN MICROEMULSION EN LA QUE GOTITAS DE LA FASE ACUOSA, QUE CONTIENEN UNA SUSTANCIA ACTIVA FISIOLOGICAMENTE, ESCASAMENTE ABSORBIBLE Y CON UN TAMAÑO PARTICULAR MEDIO DE 0.4 A 100 NM. SON DISPERSADAS EN UNA DISPERSION DE FASE GRASA CON EL USO COMBINADO DE CIERTOS SURFACTANTES ESPECIFICOS. PARA MEJORAR LA ESCASA ABSORBILIDAD PERCUTANEA/PERMUCOSA DE LA SUSTANCIA ACTIVA FISIOLOGICAMENTE, DICHA SUSTANCIA SE DISUELVE EN GOTITAS DE LA FASE ACUOSA DE UNA MICROEMULSION W/O (AGUA EN ACEITE). EN ESTA MICROEMULSIO NO SE USA NINGUN ALCOHOL DE GRADO ALTO QUE TENGA OLOR DESAGRADABLE NI TAMPOCO PROMOTORES DE ABSORCION CONVENCIONALES, SIENDO POSIBLE OFRECER UN PREPARADO EN MICROEMULSION CON ESCASA IRRITACION LOCAL.
ES94912700T 1993-04-19 1994-04-19 Preparacion en microemulsion conteniendo una substancia dificilmente absorbible. Expired - Lifetime ES2182841T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9143893 1993-04-19

Publications (1)

Publication Number Publication Date
ES2182841T3 true ES2182841T3 (es) 2003-03-16

Family

ID=14026380

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94912700T Expired - Lifetime ES2182841T3 (es) 1993-04-19 1994-04-19 Preparacion en microemulsion conteniendo una substancia dificilmente absorbible.

Country Status (9)

Country Link
US (1) US5948825A (es)
EP (1) EP0753311B1 (es)
AT (1) ATE223231T1 (es)
AU (1) AU686149B2 (es)
CA (1) CA2160681A1 (es)
DE (1) DE69431310T2 (es)
ES (1) ES2182841T3 (es)
TW (1) TW438603B (es)
WO (1) WO1994023749A1 (es)

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US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DE10164531A1 (de) * 2001-12-31 2003-07-17 Pharmatech Gmbh Zubereitung zur Oberflächenanästhesie der Haut
DE10226990A1 (de) * 2002-06-18 2004-03-18 Sanguibiotech Ag Topisch applizierbare Mikro-Emulsionen mit binärer Phasen- und Wirkstoffdifferenzierbarkeit, deren Herstellung und deren Verwendung, insbesondere zur Versorgung der Haut mit bioverfügbarem Sauerstoff
US20050075416A1 (en) * 2003-02-21 2005-04-07 Seiko Epson Corporation Process for preparing microencapsulated pigment, microencapsulated pigment, aqueous dispersion, and ink for ink jet recording
US20060140990A1 (en) * 2003-09-19 2006-06-29 Drugtech Corporation Composition for topical treatment of mixed vaginal infections
WO2005027807A1 (en) 2003-09-19 2005-03-31 Drugtech Corporation Pharmaceutical delivery system
PE20050596A1 (es) * 2003-12-19 2005-10-18 Novartis Ag Microemulsion que comprende un inhibidor renina
US7357957B2 (en) * 2004-05-07 2008-04-15 Fractec Research & Development Inc. Spreadable food product
DE102004049574A1 (de) 2004-10-12 2006-04-20 Doris Dr. Barnikol-Keuten Arzneimittel und System zur perkutanen Arzneistoffverabreichung
JP2006232755A (ja) * 2005-02-25 2006-09-07 Dai Ichi Kogyo Seiyaku Co Ltd 油中水型マイクロエマルション
AU2006244260A1 (en) * 2005-05-09 2006-11-16 Drugtech Corporation Modified-release pharmaceutical compositions
US9743680B2 (en) * 2005-10-14 2017-08-29 Wild Flavors, Inc. Microemulsions for use in food and beverage products
US20070154516A1 (en) * 2006-01-05 2007-07-05 Drugtech Corporation Drug delivery system
AU2006332518A1 (en) * 2006-01-05 2007-07-12 Drugtech Corporation Composition and method of use thereof
AU2007353340A1 (en) 2006-12-01 2008-11-20 Anterios, Inc. Peptide nanoparticles and uses therefor
FR2916966B1 (fr) * 2007-06-11 2011-01-14 Galderma Res & Dev Compositions comprenant au moins un compose retinoide, un compose anti-irritant et du peroxyde de benzoyle, et leurs utilisations
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
EP2515865B1 (en) 2009-12-22 2016-12-14 Leo Pharma A/S Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9168309B2 (en) 2010-12-01 2015-10-27 Omnis Biotechnology Inc. Thixotropic compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2013182688A1 (en) 2012-06-08 2013-12-12 Leo Laboratories Limited A topical gel composition comprising an ingenol derivative and a solvent mixture
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
CN106604722A (zh) * 2014-12-19 2017-04-26 积水化学工业株式会社 制剂
WO2018098501A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy

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US4731384A (en) * 1983-07-01 1988-03-15 Troponwerke Gmbh & Co, Kg Etofenamate formulation
JPS6061535A (ja) * 1983-08-24 1985-04-09 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 製薬学的組成物
DE3406497A1 (de) * 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
JPS60199833A (ja) * 1984-03-26 1985-10-09 Meiji Milk Prod Co Ltd 医薬品、化粧品等用ｗ／ｏ／ｗ型複合エマルジヨンの製造法
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JP3090353B2 (ja) * 1991-09-17 2000-09-18 旭化成工業株式会社 パラチロイドホルモン類含有経鼻投与用乳剤
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WO1994019000A1 (en) * 1993-02-17 1994-09-01 Smithkline Beecham Corporation Microemulsions containing pharmaceutical compositions
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Also Published As

Publication number Publication date
AU686149B2 (en) 1998-02-05
TW438603B (en) 2001-06-07
EP0753311A4 (en) 1997-05-21
DE69431310T2 (de) 2003-05-22
US5948825A (en) 1999-09-07
DE69431310D1 (de) 2002-10-10
ATE223231T1 (de) 2002-09-15
AU6513494A (en) 1994-11-08
EP0753311A1 (en) 1997-01-15
EP0753311B1 (en) 2002-09-04
WO1994023749A1 (en) 1994-10-27
CA2160681A1 (en) 1994-10-27

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